Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2007



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Regulatory T Cells (B3)


Organizer(s) Ethan M. Shevach, Fiona M. Powrie and Alexander Y. Rudensky
February 1—6, 2007
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Oct 2, 2006
Late Abstract Deadline: Nov 1, 2006
Scholarship Deadline: Oct 2, 2006
Early Registration Deadline: Dec 1, 2006

Supported by the Director's Fund

Summary of Meeting:
Although immune regulation by T suppressor cells was first proposed more than 30 years ago, recent studies in both man and experimental animals now provide a solid basis for the role of T cells in immune regulation. It is now widely accepted that the major T effector functions are mediated by two distinct subpopulations of T cells -- Th1 and Th2 -- cells which produce distinct cytokine profiles. In addition, both naturally occurring and adaptive T suppressor/regulatory T cells have been shown to play major roles in the control of all immune responses. This meeting will review the molecular basis for the differentiation of Th1/Th2 cells from naive precursors. The second goal is to present the most up to date information on the development, function, mechanism of action, and homeostasis of regulatory T cells. Modulation of both Th1/Th2 differentiation and regulatory T cell function are about to be translated to the clinic. Several presentations will address the approaches used and the results of preclincal and clinical trials involving manipulation of regulatory T cell function.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 1

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Shimon Sakaguchi, Osaka University, Japan
The Rebirth of Suppressor/Regulatory T Cells


FRIDAY, FEBRUARY 2

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Molecular Determinants of T Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Genetic and Epigenetic Mechanisms Influencing T Cell Differentiation

Mark I. Greene, University of Pennsylvania, USA
FOXP3 Interactions with Histone Acetyltransferase and Class II Histone Deacetylases are Required for Repression

Shohei Hori, RIKEN Research Center for Allergy and Immunology, Japan
How Foxp3 Controls Dominant Tolerance: Lessons Learned from Naturally Occurring foxp3 Gene Mutations

Ming O. Li, Memorial Sloan Kettering Cancer Center, USA
Regulatory T Cells, TGF-beta and Immune Suppression

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop 1

British/Columbia Ballroom
* Fiona M. Powrie, University of Oxford, UK

Allison L. Bayer, University of Miami School of Medicine, USA
Dominant Role for IL-2 in the Thymic Production and Peripheral Maintenance of CD4+CD25+ FoxP3+ T Regulatory Cells

Rosa Bacchetta, Stanford University, USA
Influence of Human FOXP3 Mutations on Effector T Cell Functions and on the In Vitro Differentiation of IL-10 Producing Tr1 Cells

Tobias Bopp, University Medical Center of the Johannes Gutenberg-University, Germany
cAMP is Crucial for Regulatory T Cell-Mediated Suppression

Talal A. Chatila, University of California, Los Angeles, USA
Development and Differentiated Functions of Regulatory T cell Precursors in the Absence of a Functional Foxp3 Protein

Michael A. Farrar, University of Minnesota, USA
Gamma c Receptor-dependent Cytokines in Regulatory T Cell Development

Deborah J. Fowell, University of Rochester, USA
Rapid Shutdown of the CD4 T Cell Activation Program by Naturally Occurring CD4+CD25+ Tregs

Christian W. Grant, NINDS, National Institutes of Health, USA
Impairment of Treg-Specific Foxp3 Expression by Virus-Induced Dysregulation of TGF-beta Signaling

Stacey N. Walters, Garvan Institute of Medical Research, Australia
BAFF Promotes the Expansion of FoxP3+ T Regulatory Cells

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Development of Regulatory T Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Foxp3 as the Regulatory T Cell Lineage Specification Factor

* Harald von Boehmer, Harvard Medical School, USA
Positive Selection of Regulatory T cells

Christophe Benoist, Harvard Medical School, USA
Cells on Regulatory T Cell Repertoire and FoxP3 as a Master Regulator of Regulatory T Cells

Leszek Ignatowicz, Georgia Regents University, USA
Short Talk: On the origin and self-reactivity of CD4+CD25+Foxp3+ T cells.

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

SATURDAY, FEBRUARY 3

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Mechanism of Action of Regulatory T Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Ethan M. Shevach, NIAID, National Institutes of Health, USA
Mechanisms of Action of T Regulatory Cells in vivo

Haruhiko Suzuki, Nagoya University Graduate School of Medicine, Japan
Essential Roles of CD8+CD122+ Regulatory T Cells in Immune Homeostasis and Their Application to Disease

* Juan J. Lafaille, New York University School of Medicine, USA
Regulatory T Cells Control T Cell Homeostasid

Lauren W. Collison, St. Jude Children's Research Hospital, USA
Short Talk: IL-34, A Novel Inhibitory Cytokine, Is Specifically Made By Regulatory T Cells And Is Required For Their Suppressive Activity

Stephanie K. Lathrop, Rocky Mountain Laboratories, USA
Short Talk: Antigen Specific Peripheral Generation of “Natural” Regulatory T Cells

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop 2

British Columbia Ballroom
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA

Ana M. Izcue, Max Planck Institute of Immunobiology and Epigenetics, Germany
Regulatory T Cell Function, But Not Persistense, Depends on CTLA-4

Shuo Li, MacFarlane Burnet Institute, Australia
Defining Target Antigen for CD25+FOXP3+IFN-Gamma- Regulatory T Cells in Chronic Hepatitis C Virus Infection

Wendy P. Loomis, Harvard Medical School, USA
Reduced T cell Activation During Chlamydia Trachomatis Infection

Lara Myers, Rocky Mountain Laboratories, USA
Tissue Specific Localization of Virus-Induced Regulatory T Cells Correlates with CD8+ T Cell Dysfunction

Stephen D. Miller, Northwestern University Medical School, USA
Regulation of Susceptibility/Resistance to the Theiler’s Virus-Induced Demyelinating Disease Model of MS by CD4+CD25+ Regulatory T Cells

Ciriaco A. Piccirillo, McGill University, Canada
Impact of Idd3 Alleles on the Function of CD4+ Foxp3+ Treg Cells and Resistance to Autoimmune Diabetes

Francisco J. Quintana, Harvard Medical School, USA
FoxP3-Mediated Immunoregulation in Zebrafish

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Immune Regulation by Unconventional T Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Regulatory T cells:Therapeutic Aspects

Albert S. Bendelac, University of Chicago, USA
NKT cell Development

Adrian C. Hayday, King's College London School of Medicine, UK
The Phenotype and the Development of TCRgammadelta+ and TCRalphbeta+ Regulatory T Cells

Craig L. Maynard, University of Alabama at Birmingham, USA
Short Talk: On the in Vivo Development of Adaptive/Induced IL-10-producing Regulatory T Cells

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

SUNDAY, FEBRUARY 4

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Immune Regulation of Infectious Diseases
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Kingston H.G. Mills, Trinity College Dublin, Ireland
The Balance Between Regulatory and Effector/Pathogenic Cells in Infection – Implications for Autoimmunity and Cancer

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Antigen Specificity and Origin of Foxp3+Treg during Parasitic Infections

* Kim J. Hasenkrug, NIAID, National Institutes of Health, USA
Enabling the CTL Response in the Presence of Virus-Induced Regulatory T Cells

Christophe M. Filippi, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Viral infection enables CD4+CD25+ regulatory T cells to protect from autoimmune diabetes

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop 3

British Columbia Ballroom
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Silvia Deaglio, University of Turin, Italy
T Regulatory Cells Co-Express CD39 and CD73 Ecto-Nucleotidases and Generate Adenosine to Catalyze Immunoregulation

Fu-Dong Shi, St. Joseph's Hospital - CHW, USA
Critical Role of IL-21 on Homeostasis of CD4+CD25+ Regulatory T Cell During Autoimmunity

Machteld Tiemessen, Janssen Vaccines & Prevention, Netherlands
Monocytes/Macrophages as Targets for CD4+CD25+ Treg-Mediated Suppression

Michael S. Turner, University of Pittsburgh School of Medicine, USA
Differential Induction of MUC1-Specific Helper and Regulatory CD4+ T Cells by Mature and Immature DC Populations

Maitee Urbieta, University of Miami, USA
Regulation of Hematopoietic Colony Forming Cells by CD4+CD25+ T Cells: A Role for T Regulatory Cells in Hematopoiesis

Elizabeth A. Wohlfert, NIAID, National Institutes of Health, USA
How PPARγ Mediates Immunoregulation: An Integral Role for PPARγ in Regulatory T Cells

Scott Snapper, Boston Children’s Hospital, USA
The Wiskott-Aldrich Syndrome Protein is Required for the Function of CD4+CD25+Foxp3+ Regulatory T cells

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
T Cell Mediated Control of Regional Immune Responses
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Fiona M. Powrie, University of Oxford, UK
Immune Regulation in the Intestine: A Balancing Act Between Effector and Regulatory T Cells

* Dale T. Umetsu, Harvard Medical School, Children's Hospital Boston, USA
The Regulation of Immune Responses in the Lung by CD4+ T Cells

Alf Hamann, Charité University Medicine Berlin, Germany
Migration of Regulatory T Cells

Nancy A. Hosken, University of Washington, USA
Short Talk: Il27-Transgenic Mice Lack Cd4+Foxp3+ Regulatory T Cells And Develop Lethal Multi-Organ Inflammation But Not Lymphoproliferative Syndrome

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

MONDAY, FEBRUARY 5

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Regulatory T Cells and Autoimmunity/Tumor Immunity
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Expanded Regulatory T Cells for the Treatment of Autoimmunity

Kenneth S. Tung, University of Virginia, USA
Regulatory T Cells Excel in Preventing but not Deterring Ongoing Autoimmune Disease

Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Enhancement of Regulatory T Cell Function in Man

Weiping Zou, University of Michigan, USA
B7-H4, IL-10 and Regulatory T Cells in Human Tumor Immunity

Omar Duramad, University of Texas, MD Anderson Cancer Center, USA
Short Talk: Origin and Dynamics of Tumor-Associated Foxp3+ Regulatory T Cells

09:20—09:40
Coffee Break

BC Foyer
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Immune Regulation of Transplantation
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Bruce R. Blazar, University of Minnesota, USA
Rapid Expansion of Functional Human CD4+25+ T Regulatory Cells (Tregs) Using Cell-Based Artificial Antigen Presenting Cells (aAPCs)

* Herman Waldmann, University of Oxford, UK
Explaining Infectious Tolerance

David C. Gondek, Harvard Medical School, USA
Granzyme B is Pivotal in T-Regulatory Contact-Mediated Immunosuppression in Transplantation Tolerance

Petra Hoffmann, University Hospital Regensburg, Germany
Short Talk: Only the CD45RA+ Subpopulation of CD4+CD25high T Cells Gives Rise to Homogeneous Regulatory T Cell Lines

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

TUESDAY, FEBRUARY 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 U13 AI60000-01




National Institutes of Health

Grant No. 1R13AI072874-01




We gratefully acknowledge additional support for this conference from:

JDRF National Multiple Sclerosis Society
UCB Celltech
 

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