Copper Mountain Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Macrophage: Homeostasis, Immunoregulation and Disease (D2)


Organizer(s) Christopher L. Karp, Stefanie N. Vogel and Siamon Gordon
April 11—16, 2007
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Dec 11, 2006
Late Abstract Deadline: Jan 15, 2007
Scholarship Deadline: Dec 11, 2006
Early Registration Deadline: Feb 12, 2007

Supported by the Director's Fund

Summary of Meeting:
Macrophage-like cells are present in essentially all metazoans. Although often dismissed merely as scavengers, recent genetic, molecular, cellular, and in vivo insights into macrophage biology have focused mechanistic attention on their prodigiously varied roles: as sensors, effectors and regulators of innate immunity; as links between innate and adaptive immunity; as cells central to tissue development and homeostasis; as targets of diverse pathogens; and as cells integral to the pathogenesis of a variety of infectious and non-infectious diseases. Investigation into this profusion of roles has revealed startling conservation of underlying molecular themes and mechanisms, a growing understanding that forms the basis for the organization of this meeting. A special focus of the meeting will be on areas of macrophage biology that are usually neglected, including macrophage differentiation and heterogeneity, and their trophic and developmental roles. The meeting is intended to provide a state-of-the-art overview of macrophage biology, to highlight the translational implications of this work, to provide scientific "cross-fertilization" across different model systems, topics and levels of investigation, and to help define the most important questions to be addressed next in the field.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 11

15:00—19:30
Registration

Kokopelli's
18:30—19:30
Refreshments

Kokopelli's
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Siamon Gordon, University of Oxford, UK
Macrophage Differentiation and Heterogeneity


THURSDAY, APRIL 12

07:00—08:00
Breakfast

Ptarmigan
08:00—11:00
Pattern Recognition Receptors and Signaling: Activation
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Christopher L. Karp, Bill & Melinda Gates Foundation, USA

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Toll-Like Receptor Signaling

Jessica K. Bell, Virginia Commonwealth University, USA
Structural biology of Toll-like receptors

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
ERRa and PGC1D: A Gateway to IFNg Signaling and Innate Immunity

Luisa Martinez-Pomares, University of Nottingham, UK
The Role of Mannose Receptor in Immunity and Disease

Susan B. Carpenter, University of California, Santa Cruz, USA
Short Talk: A Novel Leucine Rich Repeat Containing Protein Involved in theTLR4 Signaling Pathway

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
14:30—16:30
Workshop 1: Receptors, Signaling and Effector Mechanisms

Bighorn B
* Siamon Gordon, University of Oxford, UK

Timo K. van den Berg, Sanquin Blood Supply, Netherlands
CD163 is a Macrophage Sensor for Bacteria

W. K. Eddie Ip, Massachusetts General Hosp. & Harvard Medical School, USA
Mannose-Binding Lectin Acts with Toll-like Receptors 2 and 6 in the Phagosome to Enhance Inflammatory Responses to Staphylococcus aureus

Kathryn J. Moore, New York University Medical Center, USA
CD36 Cooperates with a Novel TLR Heterodimer to Initiate Signaling to Oxidized Lipids

Subhankar Mukhopadhyay, Sir William Dunn School of Pathology, UK
CD200-CD200R: Negatively Regulates TLR Function

Abul K. Azad, Ohio State University, USA
DC-SIGN Cytoplasmic Motifs Regulate Phagocytosis And Phagosome-Lysosome Fusion Events Mediated By M. Tuberculosis Mannose-Capped Lipoarabinomannan in Myeloid Cells

Ellen M. van Beek, Vrije Universiteit Medical Center, Netherlands
Negative Regulation of the Phagocyte NADPH Oxidase by Signal Regulatory Protein Alpha

Fatoumata B. Sow, Novartis, USA
Hepcidin is Synergistically Induced in Mouse Macrophages by Mycobacteria And IFN-Gamma, and is Present in the Mycobacterial Phagosome

Toby Lawrence, INSERM, France

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Pattern Recognition Receptors and Signaling: Inhibition
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Stefanie N. Vogel, University of Maryland, USA

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
The CATERPILLER (CLR) Gene Family and Innate Immune Response

Christopher L. Karp, Bill & Melinda Gates Foundation, USA
Restraining TLR4 Signaling and Some Other Matters

David M. Mosser, University of Maryland, USA
Signal Transduction Leading to Macrophage IL-10 Production

Jessica A. Hamerman, Benaroya Research Institute, USA
Short Talk: Inhibition of Toll-Like Receptor Responses in Macrophages by TREM-2 and DAP12

19:00—20:00
Social Hour with Lite Bites

Bighorn C
19:30—22:00
Poster Session 1

Bighorn C

FRIDAY, APRIL 13

07:00—08:00
Breakfast

Ptarmigan
08:00—11:00
Macrophages as Immunoregulatory and Antigen Presenting Cells
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Michel Desjardins, University of Montreal, Canada
Phagocytosis and antigen cross-presentation

Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa
Alternatively Activated Macrophages: Lessons from Myeloid-specific Interleukin-4 Receptor Deficient Mice

Peter J. Murray, St. Jude Children's Research Hospital, USA
Functions of Arginase 1 in Macrophage Immune Responses

* Alan Sher, NIAID, National Institutes of Health, USA
LRG47 (Irgm1) Regulates Macrophage and Hematopoietic Responses to Infection

Tim Denning, Emory University, USA
Short Talk: A Unique Population of IL-10 Producing Lamina Propria Macrophages which Promote Intestinal Tolerance

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
14:30—16:30
Workshop 2: Macrophage Development, Differentiation, Trophic Functions

Bighorn B
* Lynda M. Stuart, Bill & Melinda Gates Foundation, USA

Amy L. Sullivan, University of California, San Diego, USA
The Transcriptional Coactivator, Megakaryoblastic Leukemia 1 (MKL1), is Regulated by the Proteasome during Monocyte Differentiation to Macrophages

Michael H. Sieweke, Centre d'Immunologic Marseille-Luming, France
Dissociation of Cell Cycle Withdrawl and Terminal Differentiation in Macrophage Development

Peter Laslo, Howard Hughes Medical Institute, University of Chicago, USA
Gene Regulatory Network Orchestrating Macrophage Cell Fate

Tracy Fischer, Temple University School of Medicine, USA
CD163 and CD16 Co-Expression by Circulating Monocytes/Macrophages in HIV: Potential Biomarkers for HIV Infection and AIDS Progression

Kaifeng Lisa Lin, University of North Carolina, Chapel Hill, USA
CCR2+ Monocytes-Derived CD11c+ Exudate Macrophages and DCs Induce the Immune Pathology of Influenza Virus Infection

Patrick W. Faloon, Broad Institute, USA
An in vivo Chemical Genetics Assay of Microglial Activation Using Zebrafish

Will Wood, University of Bristol, UK
Distinct Mechanisms Regulate Macrophage Chemotaxis during Wound Healing and Development in Drosophila

Chris J. Hall, University of Auckland, New Zealand
Real-Time Imaging of Inflammatory Events within Transgenic Zebrafish

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Macrophage-Antimicrobial Effector Mechanisms
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Sergio Grinstein, Hospital for Sick Children, Canada
Membrane Remodeling during Phagocytosis and Phagosome Maturation

Edgar Pick, Tel Aviv University, Israel
Structure-Function Analysis of NADPH Oxidase Assembly - Identification of p67phox - gp91phox Interaction Regions by "Peptide Walking"

* Jennifer L. Stow, University of Queensland, Australia
Cytokine Secretion and Phagocytosis

Andrzej Jankowski, Ryerson University, Canada
Short Talk: Magnesium Dependent Phosphatidic Acid Phosphohydrolase (PAP-1) is a Direct Regulator of Phagocytosis

19:00—20:00
Social Hour with Lite Bites

Bighorn C
19:30—22:00
Poster Session 2

Bighorn C

SATURDAY, APRIL 14

07:00—08:00
Breakfast

Ptarmigan
08:00—11:00
Macrophages in Development and Homeostasis
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Siamon Gordon, University of Oxford, UK

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Differentiation and Functions of Monocytes

Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Wnts, Macrophages and Scheduled Vascular Regression

Paul Martin, University of Bristol, UK
Genetic and Live Imaging Studies of Wound Healing and Inflammation

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophage – A Cellular Toolbox Used by Tumors to Promote Progression and Metastasis

Julia Kzhyshkowska, University of Heidelberg, Medical Centre Mannheim, Germany
Short Talk: Homeostatic Scavenger Receptor Stabilin-1 Links Endocytosis and Intracellular Sorting in Alternatively Activated Macrophages

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
14:30—16:30
Workshop 3: Macrophages and Disease Pathogenesis

Bighorn B
* David Greaves, University of Oxford, UK

Amin F. Majdalawieh, American University of Sharjah, United Arab Emirates
Adipocyte Enhancer-Binding Protein-1 (AEBP1) is a Critical Regulator of Macrophage Cholesterol Homeostasis and Macrophage Inflammatory Responsiveness

Katherine J. Strissel, Human Nutrition Research Center on Aging, Tufts University, USA
Macrophage-Mediated Adipose Tissue Repair and Remodeling in Obesity: Role in Adipose Tissue Inflammation and Systemic Insulin Resistance

Chad Steele, University of Alabama at Birmingham, USA
Impaired Pulmonary Innate Defense Against Aspergillus Fumigatus in Mice Deficient in the beta-Glucan Receptor Dectin-1

Sofia Dahlberg, Karolinska Institutet, Sweden
TLR9 Acts at an Early Stage in Host Defence Against Pneumococcal Infection

Scott C. Bryer, University of Illinois, Chicago, USA
Urokinase-TYPE Plasminogen Activator Mediates Macrophage CHEMOTAXIS Required for Efficient Skeletal Muscle Regeneration

Jeffery S. Tessem, Duke University Medical Center, USA
Macrophage Mediated Protection of Islets and Prevention of Diabetes during Pancreatitis

Gordon J. Gaschler, McMaster University, Canada
Cigarette Smoke Exposure Attenuates Activation of Mouse Alveolar Macrophages in Response to Nontypeable Haemophilus Influenzae

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Cryopyrin (Nlrp3) Inflammasome

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Macrophages in the Pathogenesis of Non-Infectious Diseases 1
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Alveolar Macrophage: Center Stage in Pulmonary Homeostasis

Harald Neumann, University Bonn, Germany
Microglial TREM and Inflammatory Neurodegeneration

Erica L. Granger, Pennsylvania State College of Medicine, USA
Short Talk: Identification of a Novel Subset of Activated Microglia in Diabetic Retinopathy

Christopher K. Glass, University of California, San Diego, USA
Macrophages, Nuclear Receptors and Inflammation

19:00—20:00
Social Hour with Lite Bites

Bighorn C
19:30—22:00
Poster Session 3

Bighorn C

SUNDAY, APRIL 15

07:00—08:00
Breakfast

Ptarmigan
08:00—11:00
Macrophage-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Stefanie N. Vogel, University of Maryland, USA
Role of TLR2 in the Response to Francisella tularensis In Vivo and In Vitro

Janice E. Clements, Johns Hopkins University, USA
The Innate Immune Response in the CNS: Induction of Transcriptional Latency of HIV/SIV in Macrophages

Michele S. Swanson, University of Michigan Medical School, USA
Autophagy and Pyroptosis, Partners in Innate Immunity

* Thomas A. Wynn, Pfizer, USA
Regulation of NOS2/ARG-1 Activity during Infection

Pascale Gueirard, Institut Pasteur, France
Short Talk: Shuttling Process: Macrophages Phagocytose Apoptotic Neutrophils Housing Leishmania Parasites within Endoplasmic Reticulum Derived Compartments

09:20—09:40
Coffee Break

Kokopelli's
16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Macrophages in the Pathogenesis of Non-Infectious Diseases 2
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Noah Saederup, Gladstone Institute of Cardiovascular Disease, USA
Chemokines, Monocyte Trafficking and Atherosclerosis

* Richard M. Ransohoff, Biogen, USA
Chemokine Receptors, Macrophages and Microglia: Compartmentalizing Neuroinflammation

Leonie A. Boven, Erasmus Medical Centre, Netherlands
Short Talk: Regulatory Foamy Macrophages in MS: Role of Liver X Receptors

Agnès Vignery, Yale School of Medicine, USA
Macrophage Fusion In Homeostasis And Disease

19:00—20:00
Social Hour with Lite Bites

Bighorn C
20:00—23:00
Entertainment

Bighorn C

MONDAY, APRIL 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI074291-01




We gratefully acknowledge additional support for this conference from:

National Multiple Sclerosis Society UCB Celltech

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676