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This meeting took place in 2007



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Immunological Intervention in Human Disease (A2)


Organizer(s) Jacques F. Banchereau, Federica Sallusto and Robert L. Coffman
January 6—11, 2007
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 13, 2006
Late Abstract Deadline: Oct 9, 2006
Scholarship Deadline: Oct 9, 2006
Early Registration Deadline: Nov 6, 2006

Sponsored by the Dana Foundation

Summary of Meeting:
Decades of intense cellular and molecular studies have permitted the identification of many components of the immune system. Studies of the mouse immune system, most particularly through the use of animals with targeted gene inactivation, have permitted remarkable progress in linking these components to specific functions in immunity. In spite of this progress, the study of the human immune system has in general lagged behind that of the mouse. Improvements in technologies, however, now permit a detailed analysis of the altered immune system in human diseases including cancer, allergy, autoimmunity, and infectious diseases. The meeting will emphasize 1) the importance of directly assessing the human immune response and 2) that not all of what we learn in the mouse can be directly translated to humans. To foster interactions between immunologists and pathologists from very different backgrounds, the meeting program includes a wide variety of experts investigating different human diseases that involve alterations of the immune system. Consequently, this meeting is highly likely to contribute to the education of a new generation of immunotherapists.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 6

15:00—19:30
Registration

Lower Atrium
18:30—19:30
Refreshments

Lower Atrium
19:30—20:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells in Medicine


SUNDAY, JANUARY 7

07:00—08:00
Breakfast

Jefferson
08:00—11:30
Human Immune Effectors and Pathways - I
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Dendritic Cell Subsets

Miriam Merad, Mount Sinai School of Medicine, USA
Short Talk: Harnessing Tissue Dendritic Cell Homeostasis for the Treatment of Graft Versus Host Disease

Lewis L. Lanier, University of California, San Francisco, USA
NK Receptors and their Control of Innate Immunity

Niklas K. Björkström, Karolinska Institute, Sweden
Short Talk: Fcgamma×RIII+ Effector CD8 T Cells with NK Cell-Like Functions Expand in Response to Chronic Viral Infections

Albert S. Bendelac, University of Chicago, USA
Adjuvant Effects of NKT Ligands

Vicki S. Stronge, STEMCELL Technologies Inc, Canada
Short Talk: Structural Insights into Glycolipid Loading by CD1d

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Exploring and Exploiting Human B Cell Memory

09:20—09:40
Coffee Break

Lower Atrium
11:30—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
14:00—16:30
Workshop 1: Assessing Human Immunity

Madison/Gallatin
Roshini S. Abraham, Mayo Clinic, USA
Assessment of Thymic Reconstitution in the Clinical Laboratory Using TRECs as a Marker

Florence Allantaz Frager, Baylor Institute for Immunology Research, USA
Blood Leukocyte Microarray Analysis to Diagnose Systemic Onset Juvenile Idiopathic Arthritis and to follow response to IL-1 Blockade

Jonathan C. Choy, Simon Fraser University, Canada
Induction of iNOS in Bystander Human T Cells Increases Allogeneic Responses in the Vasculature

David R. Karp, University of Texas Southwestern Medical Center, USA
Analysis of Partial and Complete SLE Phenotypes Using Autoantigen Proteome Arrays

Rimpei Morita, Baylor Research Institute, USA
Follicular Helper T cells: Development and Function

Johan K. Sandberg, Karolinska Institute, Sweden
Impact of HCV/HIV-1 co-infection and Treatment with Pegylated IFNalpha and Ribavirin on NK Cells and the Innate CD1d-Restricted NKT Cells

Blythe Duke Sather, Juno Therapeutics, USA
Wiskott Aldrich Syndrome Protein is Required for Regulatory T Cell Homeostasis

16:30—16:45
Coffee Available

Lower Atrium
16:45—19:00
Human Immune Effectors and Pathways - II
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
T Cell Subsets in Disease

Christine M. Rohowsky-Kochan, University of Medicine and Dentistry of New Jersey, USA
Short Talk: IL-6 and IL-23 are Critical Factors in the Generation of Human Th17-Secreting T Cells

Rene de Waal Malefyt, Merck Research Labs, USA
Short Talk: IL-23-Derived Human Th17 Cells Produce IL-17A, IL-17F, IL-22, IL-26, CCL20 and Enhance Epithelial Immunity

Yong-Jun Liu, Sanofi, USA
Plasmacytoid Dendritic Cells

Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans

19:00—20:00
Social Hour with Lite Bites

Jefferson
19:30—22:00
Poster Session 1

Jefferson

MONDAY, JANUARY 8

07:00—08:00
Breakfast

Jefferson
08:00—11:30
Immune Regulation and Autoimmunity - I
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Jeffrey V. Ravetch, Rockefeller University, USA
Inhibitory and Stimulatory Fcgamma Receptors

Silvia Gregori, San Raffaele Telethon Institute for Gene Therapy, Italy
Novel Approaches to Expand/Induce Regulatory T Cells

Catherine M. Hawrylowicz, King's College London, UK
Short Talk: TLR9 is Expressed by Human Drug-Induced IL-10 Secreting Treg and Ligation Modulates Function

Jeffrey A. Bluestone, University of California, San Francisco, USA
Human Regulatory T Cells

Brian M. J. Foxwell, Imperial College, UK
A Role for TRL Signaling in Driving Inflammation in RA

Mark Larché, McMaster University, Canada
Peptide-Based Therapeutic Vaccines for Allergic and Autoimmune Diseases

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
14:00—16:30
Workshop 2: Improving Human Vaccines

Madison/Gallatin
Anthony Byers, Sanofi Pasteur, USA
Vaccine Testing Potential of an in vitro Human Tissue Model

David M. Calderhead, Argos Therapeutics, USA
Development of Superior DC Co-Transfected with RNAs Encoding Antigen and CD40L that Induce Clinically Relevant CD4 Independent CD8 CTL

Mark DeBenedette, Argos Therapeutics, USA
PME-CD40L DC Prime the Expansion of CD28+/CD45RA- Long Lived Effector Memory CTL Having Clinical Relevance for Dendritic Cell Based Immunotherapies

Albert B. Deisseroth, Sidney Kimmel Cancer Center, USA
Vector Vaccine for Cancer and Infectious Diseases

Larry R. Pease, Mayo Clinic, USA
Modulation of Immune Polarity and Activation of Antigen-Specific CTL with a Human IgM Antibody that Cross-Links B7-DC

Georg Stary, Harvard Medical School, USA
TLR7/8-Activated Inflammatory Denditic CEells as Anti-Cancer Effector Cells

Chun I. Yu, Baylor Research Institute, USA
Humice to test efficacy of vaccines against Influenza virus

* Robert A. Seder, NIAID, National Institutes of Health, USA
TLR Ligands Influence the Quality of T Cell Responses

16:30—16:45
Coffee Available

Lower Atrium
17:00—19:00
Immune Regulation and Autoimmunity - II
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasome: A Danger Signal Sensing Complex Involved in Autoinflammatory Diseases

* Virginia Pascual, Cornell University, USA
IFNa and IL1 in Human Autoimmunity

Michel Gilliet, University Hospital of Lausanne, Switzerland
Short Talk: Innate Activation of Plasmacytoid DC by an Endogenous Peptide

Cornelia M. Weyand, Emory University School of Medicine, USA
Toll-like Receptors in Large Vessel Vasculitis

19:00—20:00
Social Hour with Lite Bites

Jefferson
19:30—22:00
Poster Session 2

Jefferson

TUESDAY, JANUARY 9

07:00—08:00
Breakfast

Jefferson
08:00—11:15
Innovations in Cancer I
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
Louis M. Staudt, National Cancer Institute, NIH, USA
Gene Expression Signatures of the Immune Response to Guide the Diagnosis, Prognosis and Treatment of Cancer

Andrew C. Chan, Genentech, Inc., USA
Targeting B Cells in Cancer and Autoimmunity

Bretton C. Summers, Genentech, USA
Short Talk: CXCR7 (RDC1) Directly Regulates Breast and Lung Cancer

* Laurence Zitvogel, Institut Gustave Roussy, France
Molecular Determinants of the Immunogenicity of Cell Death: Designing Tumor Vaccines with Apoptosis Inducers

Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Circulating Tumor-Associated Antigen Specific Regulatory CD4+ T Cells in Patients with Metastatic Melanoma

Philip D. Greenberg, University of Washington, USA
Adoptive T Cell Therapy of Cancer and Viral Diseases

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Jefferson
13:00—22:00
Poster Viewing

Jefferson
16:30—16:45
Coffee Available

Lower Atrium
16:45—19:00
Innovations in Cancer II
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Targeting MUC1 to Prevent Cancer

Dean L. Mann, University of Maryland Medical School, USA
Short Talk: Studies on the Safety of Intra-Tumoral Injuction of Autologous Dendritic Cell and Activated T Cells Combined With Conventional Therapies in Patients with Advanced Cancers

Madhav V. Dhodapkar, Yale School of Medicine, USA
Probing Immune Response to Human Premalignancy

Ronald Levy, Stanford University, USA
Lymphoma Vaccines

19:00—20:00
Social Hour with Lite Bites

Jefferson
19:30—22:00
Poster Session 3

Jefferson

WEDNESDAY, JANUARY 10

07:00—08:00
Breakfast

Jefferson
08:00—11:00
Innovations in Human Infections
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* Richard A. Koup, NIAID, National Institutes of Health, USA
Prime-Boost Vaccination Against HIV Infection

Rafick-Pierre Sékaly, Case Western Reserve University, USA
Reconstituting the HIV Specific Immune Response

Erika Adriana Eksioglu, H. Lee Moffitt Cancer Center, USA
Short Talk: Dendritic Cell Response to Hepatitis C Virus

Jay K. Kolls, Tulane School of Medicin, USA
IL-17 Family Members

Susanne I. S. Nylén-Spoomaker, NIAID, National Institutes of Health, USA
Short Talk: Human Visceral Leishmaniasis is Associated with IL-10 Producing T Cells that are Distinct from CD4+CD25+ (Foxp3) Regulatory T Cells

Kevin J. Tracey, Feinstein Institute for Medical Research, USA
The Inflammatory Reflex

09:20—09:40
Coffee Break

Lower Atrium
14:00—16:30
Workshop 3: Improving Autoimmunity and Allergy

Madison/Gallatin
* Robert L. Coffman, Dynavax Technologies, USA
Development of TLR7/9 Antaganoists for SLE

Ilan Bank, Tel Aviv University, Israel
alpha1beta1 Integrin+ and Regulatory Foxp3+ T Cells Constitute Two Functionally Distinct Human CD4+ T Cell Subsets Oppositely Modulated by TNFalpha Blockade

Alma-Martina Cepika, Baylor Institute for Immunology Research, USA
Toll-Like Receptors and Regulatory T Cells in Systemic Lupus Erythematosus

Grayson B. Lipford, Janus Biotherapeutics, Inc., USA
A Selective Toll-like Receptor 7/8/9 Antagonist for the Oral Treatment of Systemic Lupus Erythematosus

Nicola M. G. Smith, University of Oxford, UK
Defining an Effector T Cell Population in a Surrogate Model for RA

Horst von Bernuth, University V René Descartes, France
Human MyD88 Deficiency : A Novel Primary Immunodeficiency

Matthew J. Walters, ChemoCentryx, USA
Pharmacological Inhibition of Gut Homing CCR9 T-cells Alters Disease Severity in Murine Models of Inflammatory Bowel Disease

Kazuyuki Yoshizaki, Osaka University, Japan
Immunological Intervention in Rheumatoid Arthritis by the Blocking of Interleukin 6 a Single Cytokine

Chunfeng Qu, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, China
Maturation and Cross-Presentation by Human Monocyte-Derived Cells After Uptake of Apoptotic Flu-Infected or Poly-IC-Loaded Autologous Cells

16:30—16:45
Coffee Available

Lower Atrium
16:45—19:30
Humanized Mouse Models
Meeting has ended...abstracts no longer viewable online.

Madison/Gallatin
* A. Karolina Palucka, Tha Jackson Laboratory for Genomic Medicine, USA
Understanding the Interplay of the Human Immune System with Cancer in Immunodeficient Mice

Sean M. Stevens, Regeneron Pharmaceuticals Inc., USA
VelocImmune: Mice with Genetically Humanized Immune Systems, Constructed via VelociGene Technology

Markus G. Manz, University Hospital Zürich, Switzerland
Human Adaptive Immune System Rag2-/-gammac-/-Mice: Opportunities and Limitations

Frank Oliver Nestle, Sanofi, USA
Short Talk: Insights From a Humanized Mouse Model of Psoriasis Define a Novel Epithelial Homing Effector T Cell Population

Hergen Spits, University of Amsterdam, Netherlands
Construction of Human Immune System in Mice

19:30—20:30
Social Hour with Lite Bites

Jefferson/Madison
20:00—23:00
Entertainment

Jefferson/Madison

THURSDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI071685-01




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund Dana Foundation
JDRF UCB Celltech

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Regeneron Pharmaceuticals, Inc.


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