Granlibakken Tahoe Floorplan

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This meeting took place in 2007



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Drugs Against Protozoan Parasites (B1)


Organizer(s) Daniel E. Goldberg, R. Kip Guy and Stephen A. Ward
January 28—February 1, 2007
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Sep 28, 2006
Late Abstract Deadline: Oct 27, 2006
Scholarship Deadline: Sep 28, 2006
Early Registration Deadline: Nov 28, 2006

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
This is a period of rapid progress for the field of anti-protozoal drug development. Genomic efforts have led to the identification of a myriad of new drug targets. Studies on the mechanisms of drug action and drug resistance have yielded new insights into how to improve on old agents. Promising development efforts span the spectrum from lead identification to clinical trials to registration. Key problems include target selection, drug development in an academia-centered environment, and performing trials in endemic areas. This meeting will bring together biologists and chemists with diverse backgrounds and scientists in academia and industry to work together towards solutions to these problems of global importance.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 28

15:00—19:30
Registration

Prefunction
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Peter A. Winstanley, University of Liverpool, UK
Tropical Drug Discovery - From Scientific Idea to Registered Product


MONDAY, JANUARY 29

07:00—08:00
Breakfast

Granhall
08:00—11:00
Targets
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* James H. McKerrow, University of California, San Diego, USA

Julio A. Urbina, Venezuelan Institute for Science Research, USA
Inhibitors of T. cruzi Lipid Biosynthesis as Specific Chemotherapeutic Agents for Chagas Disease

Sylke Müller, University of Glasgow, UK
Antioxidant and Redox Systems of Plasmodium – Targets for Drug Design?

R. Luise Krauth-Siegel, University of Heidelberg, Germany
Enzymes of the Trypanothione Metabolism as Antitrypanosomal Drug Targets

Raymond Hui, University of Toronto, Canada
Short Talk: From Osteoporosis to Cryptosporidiosis: Inhibition of Cryptosporidium parvum Farnesyl Pyrophosphate Synthase by Bisphosphonates

Silvia N. J. Moreno, University of Georgia, USA
Short Talk: A Bifunctional Enzyme in the Isoprenoid Pathway of Toxoplasma gondii is the Target for Bisphosphonates

Rana Nagarkatti, FDA, USA
Short Talk: Targeting the Newly Characterized Plasmodium Protein HDP that Synthesizes Hemozoin; Identification of Novel Inhibitors by High Throughput Screening

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee Available

Prefunction
17:00—19:00
Functional Genomics/Proteomics
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Ian Street, Walter and Eliza Hall Institute of Medical Research, Australia

Joseph DeRisi, University of California, San Francisco, USA
Global Transcription Analysis for Drug Development

Maria Manuel Dias da Mota, Instituto Gulbenkian Ciência, Portugal
Identification of Host Factors Relevant for Malaria Infection

Marilyn Parsons, Seattle Biomedical Research Institute, USA
Drilling Down on the Kinome of Trypanosomatids

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay Room
20:00—21:00
Social Hour

Bay Room

TUESDAY, JANUARY 30

07:00—08:00
Breakfast

Granhall
08:00—11:15
Compounds
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Els Torreele, Drugs for Neglected Diseases (DNDi), Switzerland

Norbert De Kimpe, Ghent University, Belgium
Anti-Leishmanial Natural Products from a Medicinal Plant

Kelly Chibale, University of Cape Town, South Africa
Privileged Structures and Multi-Component Reaction Strategies in Antiprotozoal Drug Discovery

H. Ulrich Göringer, Darmstadt University of Technology, Germany
RNA Aptamers as Anti-Trypanosomal Agents

Dennis E. Kyle, University of South Florida, USA
Artemisinin Resistance and Recrudescence Mechanisms

Karl A. Werbovetz, Ohio State University, USA
Short Talk: Linear and Near-linear Diamidines with Potent Antileishmanial Activity

Wayne M. Best, Murdoch University, Australia
Short Talk: A Novel and Highly Potent Class of Compounds for the Treatment of Trypanosomiasis

09:20—09:40
Coffee Break

Prefunction
11:15—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee Available

Prefunction
17:00—19:00
Screening
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Marilyn Parsons, Seattle Biomedical Research Institute, USA

Ian Street, Walter and Eliza Hall Institute of Medical Research, Australia
High Throughput Screening Based Drug Discovery: The Search for New and Effective Treatments for Tropical Diseases

James C. Sacchettini, Texas A & M University, USA
Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

Jun O. Liu, Johns Hopkins University School of Medicine, USA
Methionine Aminopeptidases as Antimalarial Drug Targets

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay Room
20:00—21:00
Social Hour

Bay Room

WEDNESDAY, JANUARY 31

07:00—08:00
Breakfast

Granhall
08:00—11:00
Lead Optimization
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Kelly Chibale, University of Cape Town, South Africa

Jay D. Keasling, University of California, Berkeley, USA
Engineering Microorganisms for Production of Artemisinin

Domingo Gargallo-Viola, GlaxoSmithKline, Spain
Animal Models for Antimalarial Development

James H. McKerrow, University of California, San Diego, USA
Developing Drugs for Parasitic Diseases in an Academic Incubator

Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline Animalarials Targeting the Parasites Achilles Heel

09:20—09:40
Coffee Break

Prefunction
16:30—17:00
Coffee Available

Prefunction
17:00—19:00
Drug Development
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Dennis E. Kyle, University of South Florida, USA

Richard R. Tidwell, University of North Carolina at Chapel Hill, USA
Development of Diamidines for Anti-protozoal Chemotherapy

Henri Vial, Universite Montpellier II, France
Development of Choline Inhibitors for Antimalarial Chemotherapy

Els Torreele, Drugs for Neglected Diseases (DNDi), Switzerland
Rediscovering Nitro-Imidazoles as Promising Drug Candidates for Human African trypanosomiasis (HAT)

19:00—20:00
Social Hour

Granhall
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

THURSDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI071682-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


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