Big Sky Resort Floorplan

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This meeting took place in 2007


Here are the related meetings in 2018:
Ubiquitin Signaling (A8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Ubiquitin and Signaling (B4)


Organizer(s) Brenda A. Schulman, Tony Hunter, Mark W. Hochstrasser and Claudio A.P. Joazeiro
February 4—9, 2007
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Oct 4, 2006
Late Abstract Deadline: Nov 2, 2006
Scholarship Deadline: Oct 4, 2006
Early Registration Deadline: Dec 4, 2006

Supported by the Director's Fund

Summary of Meeting:
Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and deconjugation, and of nonproteasomal signaling functions for ubiquitin and ubiquitin-related proteins. The first Keystone meeting on Ubiquitin and Signaling, in February 2005, was highly successful, based on both strong attendance and feedback from the participants. The significance and timely nature of the ubiquitination problem is highlighted by the 2004 Nobel Prize in Chemistry honoring pioneers in the field. We anticipate a further explosion in our understanding of ubiquitination over the next few years, and propose a meeting that captures this momentum. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in numerous diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins, presenting the challenge to determine their functions and mechanistic links to the ubiquitin system. In addition, the ubiquitin system is now widely recognized as a target for pharmacological intervention in various diseases. The goal of the meeting is to bring together experts from different areas of ubiquitin research as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 4

15:00—19:30
Registration

Lower Atrium
19:00—20:00
Refreshments

Lower Atrium
20:00—21:00
Keynote Address: The Cecile Pickart Memorial Lecture
Meeting has ended...abstracts no longer viewable online.

Gallatin
Alfred L. Goldberg, Harvard Medical School, USA
What We've Learned and What We Haven't Learned About Protein Degradation


MONDAY, FEBRUARY 5

07:00—08:00
Breakfast

Jefferson/ Lake/ Canyon Rooms
08:00—11:15
Regulation by E3 Ubiquitin Ligases
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA

Michael Karin, University of California, San Diego, USA
Crosstalk Between Inflammation Cells and Carcinomas

J. Wade Harper, Harvard Medical School, USA
Genetic Discovery in the Ubiquitin Proteasome Pathway

Claudio A. P. Joazeiro, The Scripps Research Institute, USA
Functional Genomic Analyses of Ubiquitin Ligases

Mark A. Estelle, University of California, San Diego, USA
The F-box Protein TIR1 is a Receptor for the Plant Hormone Auxin

Bruce E. Clurman, Fred Hutchinson Cancer Research Center, USA
Fbw7 at the Crossroads of Cell Division, Growth, and Differentiation

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson/ Lake/ Canyon Rooms
13:00—22:00
Poster Viewing

Jefferson/ Lake/ Canyon Rooms
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Signal Transduction by Ubiquitin Conjugation and Deconjugation
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* J. Wade Harper, Harvard Medical School, USA

Vishva M. Dixit, Genentech, Inc., USA
ATM Mediated Auto-Degradation of the E3 Ubiquitin Ligase COP1 After DNA Damage

René Bernards, Netherlands Cancer Institute, Netherlands
RNAi Screens to Identify Functions of DUBs

Christian D. Schlieker, Whitehead Institute for Biomedical Research, USA
Short Talk: Structure of a Herpesvirus-Encoded Deubiquitinating Enzyme Reveals a New Class of Ubiquitin-Specific Proteases

Paul J. Lehner, Cambridge Institute for Medical Research, UK
Short Talk: Lysine-63 Linked Ubiquitination is Required for Efficient Internalization and Endolysosomal Degradation of Critical Immunoreceptors

19:00—20:00
Social Hour with Lite Bites

Gallatin/Lake/Canyon Rooms
19:30—22:00
Poster Session 1

Jefferson/ Lake/ Canyon Rooms

TUESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Jefferson/ Lake/ Canyon Rooms
08:00—11:00
Ubiquitin-Like Protein Pathways
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Daniel J. Finley, Harvard University, USA

Ronald T. Hay, University of Dundee, UK
Role of SUMO Modification in the Control of Gene Expression

Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
SUMO: Insights into Ubiquitin and Ubiquitin-Like Protein Conjugation

Frauke Melchior, Universität Heidelberg, Germany
Functions and Regulation of SUMOylation

Jorge A. Iñiguez-Lluhi, University of Michigan, USA
Short Talk: SUMO Modification Regulates Inactivation of the voltage-Gated Potassium Channel KV1.5

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural Insights into Ubiquitin-like Protein Activation

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson/ Lake/ Canyon Rooms
13:00—22:00
Poster Viewing

Jefferson/ Lake/ Canyon Rooms
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Regulation of and by the Proteasome and Signalosome
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Alfred L. Goldberg, Harvard Medical School, USA

Xing Wang Deng, Yale University, USA
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3-based E3 ligases

Ning Zheng, University of Washington, USA
Mechanism of Auxin Perception by the TIR1 F-box Protein

Daniel J. Finley, Harvard University, USA
Regulation of Proteasome Function

Rina Rosenzweig, Israel Institute of Technology, Israel
Short Talk: A Mason's Approach to the 19S Proteasome Regulator

19:00—20:00
Social Hour with Lite Bites

Gallatin/Lake/Canyon Rooms
19:30—22:00
Poster Session 2

Jefferson/ Lake/ Canyon Rooms

WEDNESDAY, FEBRUARY 7

07:00—08:00
Breakfast

Jefferson/ Lake/ Canyon Rooms
08:00—11:00
Ubiquitin and Subcellular Compartments
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Frauke Melchior, Universität Heidelberg, Germany

Simona Polo, FIRC Institute of Molecular Oncology, Italy
Molecular Mechanisms of Coupled Monoubiquitination

Thomas Sommer, Max Delbrück Center for Molecular Medicine, Germany
Protein Quality Control by the HRD-Ligase Complex

Mary Ann Osley, University of New Mexico School of Medicine, USA
Interplay between H2B Ubiquitylation and Histone Chaperones during Transcription Elongation

Sylvie Urbé, University of Liverpool, UK
Control of Growth Factor Receptor Dynamics by Reversible Ubiquitination

Vincent Chau, Pennsylvania State University College of Medicine, USA
Short Talk: The Crystal Structure of a RING-Ubc7 Fusion Reveals a Mechanism for the Activation of a Ubiquitin-Conjugating Enzyme

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson/ Lake/ Canyon Rooms
13:00—22:00
Poster Viewing

Jefferson/ Lake/ Canyon Rooms
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Novel Functions of Ubiquitin
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Simona Polo, FIRC Institute of Molecular Oncology, Italy

Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Ubiquitination and Degradation of the Cholesterol Biosynthetic Enzyme, HMG CoA Reductase

Mark W. Hochstrasser, Yale University, USA
Regulation of Ubiquitin Enzymes at the Endoplasmic Reticulum and Nuclear Envelope

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Cell-Polarity Control of Protein Degradation in Intestinal Epithelial Cells

Peter Kaiser, University of California, Irvine, USA
Short Talk: Proteolysis-Independent Regulation by Poly-Ubiquitination

19:00—20:00
Social Hour with Lite Bites

Gallatin/Lake/Canyon Rooms
19:30—22:00
Poster Session 3

Jefferson/ Lake/ Canyon Rooms

THURSDAY, FEBRUARY 8

07:00—08:00
Breakfast

Jefferson/ Lake/ Canyon Rooms
08:00—11:15
The Ubiquitin System: Disease and Drug Targets
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* Thomas Sommer, Max Delbrück Center for Molecular Medicine, Germany

Tony Hunter, The Salk Institute for Biological Studies, USA
Crosstalk Between Phosphorylation and Sumoylation Pathways and Ubiquitination

Gentry N. Patrick, University of California, San Diego, USA
UPS and Mammalian CNS Synapses

Ron R. Kopito, Stanford University, USA
Protein Aggregation and Neurodegeneration

Laurent Coscoy, University of California, Berkeley, USA
Ubiquitination on Non-lysine Residues

Agata Smogorzewska, Rockefeller University, USA
Short Talk: Cloning and Characterization of FANCI, a Novel Component of the Fanconi Anemia Pathway

Frédéric Colland, Hybrigenics, France
Short Talk: Identification and Characterization of Small Molecule Inhibitors of Ubiquitin-Specific Protease 8, a Newly Validated Cancer Target

09:20—09:40
Coffee Break

Lower Atrium
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Proteomics and Other Technology Trends
Meeting has ended...abstracts no longer viewable online.

Gallatin/ Madison
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Pharmacodynamic Imaging with Degron-Containing Luciferase Fusion Proteins

Steven P. Gygi, Harvard Medical School, USA
Mass Spectrometry Based Methods for Analysis of Site Specific Ubiquitination

Dieter A. Wolf, Harvard School of Public Health, USA
Systematic Screening for Ubiquitylation Substrates

Benjamin Nicholson, Progenra, USA
Short Talk: Mining the Deubiquitinase Space with a Novel Reporter Assay

19:00—20:00
Social Hour with Lite Bites

Jefferson/ Madison
20:00—23:00
Entertainment

Jefferson/ Madison

FRIDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Boston Biochem, an R&D Systems Company Educational donation provided by Amgen
ENZO LIFE SCIENCES INTERNATIONAL, INC. Invitrogen Corporation
Merck Research Laboratories
Proteome Resources LLC

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676