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This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Bioactive Lipids in the Lipidomics Era (C2)


Organizer(s) Sarah Spiegel, Alfred H. Merrill and H. Alex Brown
February 20—25, 2007
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 20, 2006
Late Abstract Deadline: Nov 20, 2006
Scholarship Deadline: Oct 20, 2006
Early Registration Deadline: Dec 20, 2006

Supported by the Director's Fund

Summary of Meeting:
The identification of many receptors and targets of bioactive lipid mediators has led to research uncovering their roles in regulating many important normal and pathophysiological processes. It has become evident that the biological activities and functions of lipid signaling molecules are dependent on both their molecular structures and complex cell-specific interactions among the different pathways involved in their biosynthesis and metabolism. The growing complexity of these interactions and the thousands of cellular lipids, together with genomics and proteomics technology already in place, has emphasized the need for development of complementary lipidomics technology. The goal of this meeting is to bring investigators studying signaling and metabolism of bioactive lipids together with researchers who are now developing lipidomics methods for exhaustive characterization and systematic measurement by mass spectrometry of the lipidome, ie cellular lipids, their precursors and their metabolites. The program of this meeting has been designed to foster and synergize research in these areas.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 20

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Edward A. Dennis, University of California, San Diego, USA
LIPID MAPS and Eicosanoid Lipidomics


WEDNESDAY, FEBRUARY 21

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Lipidomics Across the MAP
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Dennis R. Voelker, National Jewish Health, USA

Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Lipid Rafts

Takao Shimizu, University of Tokyo, Japan
Profiling Lipid Mediators and Membrane Lipids in Various Disease Models

H. Alex Brown, Vanderbilt University, USA
Phospholipids and Signaling Networks

Michael J.O. Wakelam, Babraham Institute, UK
The Importance of Lipidomic Analysis in Signalling Research

Maria Fuller, SA Pathology, University of Adelaide, Australia
Short Talk: Lipid Composition of Microdomains is Altered in a Cell Model of Gaucher Disease

Alan N. Hunt, University of Southampton, UK
Short Talk: Dissecting the Topological Dynamics of the Lipidome

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—16:45
Coffee Available

Chamisa Lobby
16:45—19:00
Bioactive Lipids Functions
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA

Jerold J. Chun, The Scripps Research Institute, USA
New Roles for Lysophospholipid Signaling

Andrew J. Morris, University of Kentucky, USA
New Lipid Phosphatases and Unexpected Functions

Suzanne E. Barbour, Virginia Commonwealth University, USA
Platelet-Activating Factor Acetylhydrolase (PAFAH) in Aggressive Periodontitis and Cardiovascular Disease

Andrew D. Renault, MPI of Developmental Biology, Germany
Short Talk: Lipid Phosphate Phosphatases are Necessary for the Trans-Epithelial Migration of Germ Cells

Reinhard Sebastian Bauer, LIMES, Germany
Short Talk: Novel Functions for the Drosophila Dihydroceramide Synthase DLAG1 in Growth Regulation and Lipid Homeostasis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 22

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Bioactive Sphingolipids: New Frontiers
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lina M. Obeid, Stony Brook University Cancer Center, USA

Sarah Spiegel, Virginia Commonwealth University, USA
The Role of ABC Transporters in Sphingosine-1-Phosphate Secretion

Hugh Rosen, ActivX Biosciences, USA
S1P Receptor Immunopharmacology

Julie D. Saba, Children’s Hospital Oakland Research Institute, USA
S1P Lyase in Cell Fate and Intestinal Tumorigenesis

Richard L. Proia, National Institutes of Health, USA
Physiologic Functions of Lipids as Revealed by Knockout Mice

Petra Keul, University of Duisburg, Essen, Germany
Short Talk: The Sphingosine-1-Phosphate Analogue and Immunosuppressant FTY720 Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

M. Cameron Sullards, Georgia Institute of Technology, USA
Short Talk: Identification and Structure Determination of Sphingolipids From Sphingoid Bases to Sulfatides Using Q-Trap and Chip-Based Nanoelectrospray Ionization With Hybrid Q-TOF Tandem Mass Spectrometry

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—16:45
Coffee Available

Chamisa Lobby
16:45—19:00
Bioactive Lipids and Human Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jerold J. Chun, The Scripps Research Institute, USA

Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Lysophospholipids in Cancer

Lina M. Obeid, Stony Brook University Cancer Center, USA
Sphingosine Kinase and Cancer

Susan A. Henry, Cornell University, USA
Phospholipid Mediated Signaling in Yeast: New Roles for Phosphatidic Acid and Diacylglycerol

Robert V. Stahelin, Indiana University School of Medicine, USA
Short Talk: Disparate Membrane Targeting Mechanisms of Matrix Proteins From Retroviruses and Filoviruses

Greger Orädd, Umeå University, Sweden
Short Talk: NMR Studies of Oriented Domain-Forming Model Membranes

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 23

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lipid Partners and Microenviroments
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Yusuf A. Hannun, Stony Brook Cancer Center, USA

Gordon Tollin, University of Arizona, Tucson, USA
Plasmon-Waveguide Resonance Studies of Lateral Segregation of Lipids and Proteins Into Microdomains (Rafts): Effects of Microenvironment on GPCR Distribution and Function

Dennis R. Voelker, National Jewish Health, USA
Macromolecular Assemblies of Lipids and Proteins Regulate Non-Vesicular Phospholipid Traffic

William Dowhan, University of Texas Medical School, USA
Lipid Dependent Organization of Polytopic Membrane Proteins

John D. York, Vanderbilt University, USA
Inositol Polyphosphate Regulation of Nuclear Processes and Development

Banafshé Larijani, Cancer Research, London Research Institute, UK
Short Talk: Role of Phosphoinositide Signaling in Nuclear Envelope Assembly

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—16:45
Coffee Available

Chamisa Lobby
16:45—19:00
New Lipid Functions
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Wonhwa Cho, University of Illinois at Chicago, USA

Christian R.H. Raetz, Duke University Medical Center, USA
Structure and Inhibition of Enzymes that Assemble Endotoxins

Charles E. Chalfant, Virginia Commonwealth University, School of Medicine, USA
Ceramide 1-Phosphate, A Novel Activator of cPLA2

Courtney Frasch, National Jewish Medical and Research Center, USA
Short Talk: Lysophosphatidylserine (Lyso-PS), a Signaling Phospholipid, is Made by Activated Neutrophils in a NADPH-Dependent Manner

Josef Ecker, University of Regensburg, Germany
Short Talk: Isomer Specific Effects of Conjugated Linoleic Acid on Macrophage ABCG1 Transcription by a SREBP-1c Dependent Mechanism

Bogdan G. Gugiu, University of California, Los Angeles, USA
Short Talk: Receptors of Biotinylated Oxidized Phospholipids in Human Aortic Endothelial Cells

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2

SATURDAY, FEBRUARY 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lipidomics Technologies and Opportunities for New Paradigms
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Edward A. Dennis, University of California, San Diego, USA

Alfred H. Merrill, Jr., Georgia Institute of Technology, USA
SphinGOMAP

Robert C. Murphy, University of Colorado Denver, USA
Neutral Lipid Analysis by Mass Spectrometry

Vytas A. Bankaitis, Texas A&M University, USA
Functional Anatomy of the Sec14 Superfamily of Lipid Binding Proteins

Wonhwa Cho, University of Illinois at Chicago, USA
Lipid-Protein Interactions in Cell Signaling and Real-Time Monitoring of Lipid Mediators

Peter Sjövall, SP Swedish National Testing and Research Institute, Sweden
Short Talk: Imaging TOF-SIMS Analysis of Tissue Sections From Kidney Patients and Controls

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—12:00
Workshop on Lipidomics Technologies

Chamisa Ballroom 1
* H. Alex Brown, Vanderbilt University, USA

* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Computation and Visualization in Lipidomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Robert C. Murphy, University of Colorado Denver, USA

Yusuf A. Hannun, Stony Brook Cancer Center, USA
Sphingolipid Metabolism and Function in Yeast, Analysis and Simulation

Jens Nielsen, Chalmers University of Technology, Sweden
Systems Biology of Lipid Metabolism in Saccharomyces cerevisiae: Mapping of Global Regulatory Structures

Carissa L. Perez, Fred Hutchinson Cancer Research Center, USA
Short Talk: Metabolic Labeling Assays of Fatty Acid Synthesis and Turnover in C. elegans

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM080134-01




We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc.
Advion BioSciences, Inc.


Cayman Chemical Company, Inc.

Matreya LLC


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676