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This meeting took place in 2007



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Jaks, Stats and Immunity (A1)


Organizer(s) Thomas A.F. Decker, Christian W. Schindler and David E. Levy
January 5—10, 2007
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 13, 2006
Late Abstract Deadline: Oct 9, 2006
Scholarship Deadline: Sep 13, 2006
Early Registration Deadline: Nov 6, 2006

Sponsored by Pharmacopeia

Summary of Meeting:
The JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathways play an important role in a wide variety of biological processes. Most cytokines and many growth factors exert their biological functions via JAK/STAT signaling. The significance of JAK/STAT signaling is further underscored by the fact that aberrant JAK/STAT signaling is associated with human diseases such as immune disorders and tumorigenesis. Tyrosine phosphorylation of JAKs and STATs is a well established activator in these pathways, but STAT activity is also modulated by serine phosphorylation and, possibly, by methylation and acetylation as well. The identities and roles of the additional signal transduction pathways that might contribute to these modifications and other regulatory interactions are the subject of much current investigation. This meeting will focus on the following key aspects of current research in JAK/STAT signaling, particularly with regard to its role in immune function: recent advances in understanding the regulation of JAK activity, STAT nuclear translocation, the role of non-tyrosine- phosphorylated STATS, and negative regulation of the pathway; dissection and analysis of pathways that interact with JAKS and STATS in immune responses; links between the JAK/STAT pathway and innate immune receptors (e.g. Toll-like receptors) through type I interferon synthesis which, in turn, suggest critical roles of JAK/STAT target genes in the regulation of innate and adaptive immune response; and the role of JAK/STAT pathways in cancer will also play an important role.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 5

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
James E. Darnell, Rockefeller University, USA
JAKs-STATs: 15 Years of Whirlwind Activity


SATURDAY, JANUARY 6

07:00—08:00
Breakfast

3 Saddles/ Bear River
08:00—11:15
Regulation of Cytokine Receptor Signaling
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Robert D. Schreiber, Washington University School of Medicine, USA

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
MAVS – a Mitochondrial Antiviral Signaling Protein

Fred Schaper, School of Medicine RWTH-University Aachen, Germany
Regulation of Interleukin-6 Type Cytokine Signaling

Kenya Honda, School of Medicine, Keio University, Japan
IRFs in TLR Signaling

Akihiko Yoshimura, Keio University, Japan
SOCS1 and SOCS3 are Critical Regulators of Cytokine Signaling; Implication for Helper T Cell Differentiation and Tumor Development

Sandra E. Nicholson, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: SOCS Proteins – A Structure/Function Perspective

Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Short Talk: A Novel STAT1-Independent, c-Jun-Dependent Signal Transduction Pathway Necessary for the Transcriptional Activation of IFNgamma-Response Genes

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine Peak/ Twilight/ Rainbow
13:00—22:00
Poster Viewing

Sunshine Peak/ Twilight/ Rainbow
16:30—16:45
Coffee Available

Foyer
16:45—19:00
Jaks, Stats and Cancer
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* James E. Darnell, Rockefeller University, USA

Valeria Poli, University of Turin, Italy
in vivo Oncogenic Properties of Constitutively Active STAT3

Robert D. Schreiber, Washington University School of Medicine, USA
Stats and Cancer Immunoediting

Veronika Sexl, University of Veterinary Medicine, Austria
JAKs and STATs: For the Better or Worse in Leukemia Development

Giorgio G. Inghirami, Weill Cornell Medical College, USA
Short Talk: Dissection of Critical Pathways for Anaplastic Lymphoma Kinase Transformation

Olga A. Timofeeva, Georgetown University, USA
Short Talk: STAT3 N-Domain Targeting Reveals Novel STAT3 Functions in Breast Cancer Cells

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak/ Twilight/ Rainbow

SUNDAY, JANUARY 7

07:00—08:00
Breakfast

3 Saddles/ Bear River
08:00—11:15
Regulation of Stats: From Activation to Gene Expression
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* David E. Levy, New York University School of Medicine, USA

Nancy C. Reich, Stony Brook University, USA
Regulation of Stat Nuclear Translocation

Olli J. Silvennoinen, University of Tampere, Finland
Regulation of JAK/STAT Signaling – Assembly of the STAT6 Enhanceosome

Uwe Vinkemeier, University of Nottingham Medical School, UK
The Role of STAT1 Nucleocytoplasmic Shuttling in Interferon-gamma Signaling

J. Jillian Zhang, Cornell Medical School, USA
Short Talk: Stat1-Dependent Synergistic Activation of T-bet for IgG2a Production During Early Stage of B Cell Activation

Pravin B. Sehgal, New York Medical College, USA
Short Talk: Cytokine-Induced Targeting of STAT3-EGFP to Cytoplasmic Vesicles in Hep3B Cells: Live-Cell Imaging Studies

Toshio Kitamura, University of Tokyo, Institute of Medical Science, Japan
Short Talk: Rac1 and MgcRacGAP are Required for Nuclear Transport of the Tyrosine Phosphorylated Form of STAT3 and STAT5

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine Peak/ Twilight/ Rainbow
13:00—22:00
Poster Viewing

Sunshine Peak/ Twilight/ Rainbow
14:30—16:30
Workshop 1: Immunoregulation Involving Jak-Stat Signaling

Mt. Werner/Storm Peak
* Nancy C. Reich, Stony Brook University, USA

Florian Grebien, CeMM - Research Center for Molecular Medicine, Austria
Persistent STAT5 Activation Supports Functional Erythropoiesis in the Absence of Jak2 and EpoR

Bumsuk Hahm, University of Missouri-Columbia, USA
STAT2 is a Molecular Switch Regulating Dendritic Cell Development Mediated by Virus-Induced Type I Interferons

Markus Johannes Hofer, University of Sydney, Australia
PD-1/B7-H1 Dysregulation in Lethal Lymphocytic Choriomeningitis (LCMV) Virus Infection in STAT1 KO Mice

Sally Ann Litherland, Florida Hospital Cancer Institute, USA
Nonobese Diabetic (NOD) Congenic Mouse Analysis Defines an Idd4.3 Sequence Crucial to GM-CSF Regulation of STAT5 Binding and Associated Epigenetic Changes at the Csf2 and Ptgs2 Regulatory Sequences in Autoimmune Myeloid Cells

Mirko Trilling, Heinrich-Heine University, Germany
The Cytomegalovirus pM27 Protein Disrupts Interferon Jak-Stat-Signalling by Encoding Stat2 Specific Ubiquitin E3 Ligase Activity

Andrew Cherniack, Broad Institute, USA
TYK2 is Essential for IL-12 and IL-23 Dependent Cytokine Production and for Development of Organ Specific Autoimmunity

16:30—16:45
Coffee Available

Foyer
16:45—19:00
Stats and Interacting Pathways in Differentiation and Homeostasis of the Immune System and in Immune Disorders
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Akihiko Yoshimura, Keio University, Japan

Mark H. Kaplan, Indiana University School of Medicine, USA
STAT Regulation of T Helper Cell Differentiation and Function

Thomas A. Wynn, Pfizer, USA
Negative Regulation of IL-13 Signaling by IL-13Ra2

John J. O'Shea, NIAMS, National Institutes of Health, USA
Stat5 Signaling in Lymphocytes

Hauke Schmidt, Georg August University of Goettingen, Germany
Short Talk: Engagement of IFNAR on Myeloid Cells Determines the Course of Autoimmunity in the Central Nervous System

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 2

Sunshine Peak/ Twilight/ Rainbow

MONDAY, JANUARY 8

07:00—08:00
Breakfast

3 Saddles/ Bear River
08:00—11:00
Global Analysis of Immune and Cytokine Receptor Signaling
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Genhong Cheng, University of California, Los Angeles, USA

Martin P. Zeidler, University of Sheffield, UK
Identification of JAK/STAT Pathway Regulators using Drosophila and Human Cell Based Screens

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
CATERPILLER/NOC/NLR: Immune Genes Conserved From Plants to Humans

Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Pathway Proteomics in Immunity and Leukemia

Friedemann Horn, Universitat Leipzig, Germany
Short Talk: Transcriptional Control of Non-Coding RNA Genes by Stat3 Emerges as a Major Contribution to its Oncogenicity

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak/ Twilight/ Rainbow
13:00—22:00
Poster Viewing

Sunshine Peak/ Twilight/ Rainbow
14:30—16:30
Workshop 2: New Developments in Jaks and Stats

Mt. Werner/Storm Peak
* John J. O'Shea, NIAMS, National Institutes of Health, USA

Stephen Brown, University of Manchester, UK
The Drosophila Renal Tube as a Model for Human Jak/Stat Dependent Renal Diseases

Hana Krizova, National Cancer Institute, National Institutes of Health, USA
Structural Studies of the N-Terminal Domain of STAT Proteins

Walid Khaled, University of Cambridge, UK
Type-2 Cytokines and Stat6 Regulate Mammary Gland Development

Jeffrey G. Williams, University of Dundee, School of Biological Sciences, UK
A Novel Mode of STAT Regulation: Activation of the Dictyostelium STATc Protein

Cong Yan, Indiana University School of Medicine, USA
Overexpression of Stat3C in Lung Epithelial Cells Causes Lung Inflammation and Tumorigenesis

Jinbo Yang, Lerner Research Institute, Cleveland Clinic Foundation, USA
Unphosphorylated STAT3, Increased by gp130-Linked Cytokines, Activates Transcription by Binding to NFkappaB

16:30—16:45
Coffee Available

Foyer
16:45—19:30
The -Interferon-Stat Axis in Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Mark H. Kaplan, Indiana University School of Medicine, USA

David E. Levy, New York University School of Medicine, USA
Gene Expression in the Interferon Antiviral Response

Tom Maniatis, Columbia University, USA
The Function of IKK epsilon in IFN-mediated Antiviral Immunity

Genhong Cheng, University of California, Los Angeles, USA
Contribution of the Interferon/JAK/Stat Pathway to the Specificity of TRL - Mediated Gene PRograms

Christian W. Schindler, Columbia University, USA
Interferon Dependent Innate Responses to Microbial Pathogens

John J. Krolewski, University of California, Irvine, USA
Short Talk: Regulated Intramembrane Proteolysis Signaling by an Interferon Receptor Subunit

19:30—20:30
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak/ Twilight/ Rainbow

TUESDAY, JANUARY 9

07:00—08:00
Breakfast

3 Saddles/ Bear River
08:00—11:00
Recognition and Signaling in Viral and Bacterial Infection
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Tom Maniatis, Columbia University, USA

Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria
Synthesis and Role of Type I Interferon in Bacteria Infection

Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Triggering Antiviral Responses by the Cytoplasmic RNA Helicase RIG-I

Mathias Müller, Veterinary University of Vienna, Austria
The Janus Face of Tyk2 in Pathogen Challenges

Curt M. Horvath, Northwestern University, USA
How to Target STAT Proteins and Other Important Lessons from the Study of Virus-Host Interactions

Yoshiyuki Minegishi, University of Tokushima, Japan
Short Talk: Human Tyk2 Deficiency Reveals Requisite Roles of Tyk2 in Multiple Cytokine Signals Involved in Innate and Acquired Immunity

09:20—09:40
Coffee Break

Foyer
16:30—16:45
Coffee Available

Foyer
16:45—19:00
Regulation of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria

Susetta Finotto, University of Mainz, Germany
The gp130 Cytokine Family Signal Transduction, between CD4+T Regulatory Cell Expansion and CD4+T Effector Programmed Cell Death

Marco Colonna, Washington University School of Medicine, USA
TRL - Dependent gamma Independent Pathways of Type I INF

Michael A. Farrar, University of Minnesota, USA
Short Talk: Distinct Cytokines Govern IL-2Rbeta-Dependent Regulatory T Cell Development, Homeostasis and Function

Jason S. Stumhofer, University of Arkansas for Medical Sciences, USA
Short Talk: Dissection of the gp130-Mediated STAT Signaling Pathways for the Type I Cytokines IL-6 and IL-27

Lucas J. Thompson, Agonox, Inc, USA
Short Talk: Innate Inflammatory Signals Following Infection with Different Pathogens Dictate the Dependence of Responding CD8 T Cells on IFN-I Signals

19:00—20:00
Social Hour with Lite Bites

Foyer
20:00—23:00
Entertainment

Sunshine

WEDNESDAY, JANUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI071686-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Educational donation provided by Amgen
Pharmacopeia
 

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