Beaver Run Resort Floorplan

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This meeting took place in 2007



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The Transient Receptor Potential Ion Channel Superfamily (Q1)


Organizer(s) James W. Putney, Bernd Nilius and Craig Montell
September 18—23, 2007
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: May 18, 2007
Late Abstract Deadline: Jun 19, 2007
Scholarship Deadline: May 18, 2007
Early Registration Deadline: Jul 18, 2007

Supported by the Director's Fund

Summary of Meeting:
In recent years, knowledge of TRP channel biology has increased at a tremendous pace. These channels are now known to be regulated in two general ways: by physical perturbations (i.e., temperature, mechanical) or by classical signal transduction cascades (most commonly phospholipases). In addition, mutations in TRP channels are known to be the basis for a number of inherited diseases, including mucolipidosis and polycystic kidney disease. However, there is a great deal of controversy regarding the mechanisms of activation and regulation of many TRPs, especially those thought to be involved in the long elusive mechanism of store-operated channels. This symposium will highlight current knowledge of structure, function, regulation and pharmacology of the TRPs, especially with regard to current controversies. Additionally, the roles of TRPs in diseases will be addressed, including the potential for treating diseases through knowledge of their regulation, and through design of therapeutic agents to modify their behavior.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, SEPTEMBER 18

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
Craig Montell, Johns Hopkins University, USA
TRP Channels: Mediators of Sensory Signaling


WEDNESDAY, SEPTEMBER 19

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
TRPs: Temperature and Pain
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Owen P. Hamill, University of Texas Medical Branch, USA

Makoto Tominaga, National Institutes of Natural Sciences, Japan
Physiological Significance of the Thermosensitive TRP Channels

Ardem Patapoutian, The Scripps Research Institute, USA
Molecular Mechanisms of Temperature Sensation

Michael J. Caterina, Johns Hopkins School of Medicine, USA
A Novel Mechanism of Use - Dependent Changes in TRPV Channel Signaling

Paul Garrity, Brandeis University, USA
Feeling the Heat: Thermosensory Behavior in Drosophila

Vera Y. Moiseenkova-Bell, Baylor College of Medicine, USA
Short Talk: Cryo-Electron Microscopy of TRP Family Channels

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:00—16:30
Coffee Available

Foyer
16:30—18:30
TRPs: Taste and Mechanosensation
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Bernd Nilius, Katholieke Universiteit Leuven, Belgium

Emily Liman, University of Southern California, USA
TRPM5 and Taste Transduction

Diana Bautista, University of California, Berkeley, USA
Mammalian Mechanotransduction

Owen P. Hamill, University of Texas Medical Branch, USA
The Role of the Mechanosensitive Ca2+ Permeant Channel in Prostate Tumor Cell Migration

Julia F. Doerner, Ruhr University, Germany
Short Talk: Direct Activation of TRPA1 by Ca2+

18:30—19:30
Social Hour with Lite Bites

Peaks 1 - 3
19:00—21:30
Poster Session 1

Peaks 1 - 3

THURSDAY, SEPTEMBER 20

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Activation Mechanisms
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Shmuel Muallem, University of Texas Southwestern Medical Center, USA

Johannes Oberwinkler, Universitaet des Saarlandes, Germany
TRPM3, A Novel Ionotropic Steroid Receptor in the Endocrine System

Andrea Fleig, Queen's Medical Center, USA
Gating Mechanisms of TRPM2

Donald L. Gill, Temple University School of Medicine, USA
TRPC Channels – Transducers of Multiple Signals

Lutz Birnbaumer, NIEHS, National Institutes of Health, USA
Molecular Basis of Capacitative Calcium Entry (CCE): TRPCs, 1P3rs, STIMs, and Orai

Moshe Parnas, Hebrew University, Israel
Short Talk: Membrane Lipids Remove Divalent Open Channel Block in TRP and NMDA Channels

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:00
Workshop 1: Controversies Concerning Activation Mechanisms I: Direct Activation by Thermal and Mechanical Stimuli

Peaks 4 - 5
* Andrea Fleig, Queen's Medical Center, USA

Adriana Sumoza-Toledo, Columbus Children's Hospital, USA
Reactive Oxygen Species Induce Calcium Influx and Phagocyte Cell Death by a Mechanism Dependent on ADPR and PARP-1; Possible Functional Role for TRPM2 Cation Channel

Frank John Patrick Kühn, Institute of Physiology, Germany
Activation of TRPM8 Channel by Icilin and Menthol is Mediated on Different Sides of the Cell Membrane

Gerard Ahern, Georgetown University, USA
Voltage is a Partial Activator of Thermo-Sensitive TRP Channels

Céline E. Riera, Cedars-Sinai Medical Center, USA
Artificial Sweeteners and Metallic Tasting Salts Activate TRPV1 Receptors

16:00—16:30
Coffee Available

Foyer
16:30—18:30
TRPs and Protein-Protein Interaction
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Emily Liman, University of Southern California, USA

René J.M. Bindels, Radboud University Nijmegen Medical Centre, Netherlands
Regulation of Epithelial TRP Channels

Shmuel Muallem, University of Texas Southwestern Medical Center, USA
The TRPML Channels: Properties and Function

Rachelle Gaudet, Harvard University, USA
Unexpected Journey from Crystal Structure to New Model of TRPV1 Activity

Rui Xiao, Baylor College of Medicine, USA
Short Talk: Synergistic Activation of TRPC4 and TRPC5 by Receptor Signaling through Gq/11 and Gi/o Proteins

18:30—19:30
Social Hour with Lite Bites

Peaks 1 - 3
19:00—21:30
Poster Session 2

Peaks 1 - 3

FRIDAY, SEPTEMBER 21

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Reverse Genetic Approaches
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Craig Montell, Johns Hopkins University, USA

Bernd Nilius, Katholieke Universiteit Leuven, Belgium
Functional Roles of TRP Channels: Unexpected Views

Yasuo Mori, Kyoto University, Japan
Oxidative Stress-Activated Ca2+ Channel TRPM2 Mediates Inflammation via Chemokine Production

X.Z. Shawn Xu, University of Michigan, USA
TRP Channel Regulation of Proprioception and Drug Dependence in C. elegans

Thomas Gudermann, Ludwig-Maximilians-Universitaet, Germany
TRPC Channel Function in the Cardiopulmonary System

Melissa A. Fowler, University of Texas Southwestern Medical Center, USA
Short Talk: Corticolimbic Expression of TRPC1, TRPC4, and TRPC5 Channels in the Rodent Brain

09:20—09:40
Coffee Break

Foyer
11:00—11:30
Poster Setup

Peaks 1-3
23:30—12:30
Lunch

Foyer / Peaks 1 - 3
12:00—21:00
Poster Viewing

Peaks 1-3
12:00—14:30
Poster Session 3

Peaks 1 - 3
14:30—16:00
Workshop 2: Controversies Concerning Activation Mechanisms II: Activation by Signal Transduction Cascades

Peaks 4 - 5
* Donald L. Gill, Temple University School of Medicine, USA

Tibor Rohacs, UMDNJ - New Jersey Medical School, USA
Dual Regulation of TRPV1 by Phosphoinositides

Leonidas Tsiokas, Oklahoma University Health Science Center, USA
Assembly of TRPP2 and TRPC1 Forms a Novel G Protein Coupled Receptor-Activated Ion Channel

Sandeep C. Pingle, Georgetown University Medical Center, USA
TRP and Store-Operated Calcium Channels in Dendritic Cells

Sohag Saleh, St. George's University, London, UK
Diverse TRPC Heteromultimers Form Store- Operated Channels in Native Vascular Smooth Muscle Preparations

Nathaniel A. Jeske, University of Texas Health Science Center, USA
PKA Sensitization of TRPV1 is Dependent on A-Kinase Anchoring Protein

16:00—16:30
Coffee Available

Foyer
16:30—18:30
TRPs in the Nervous System
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Indu S. Ambudkar, NIDCR, National Institutes of Health, USA

Martha C. Nowycky, UMDNJ-New Jersey Medical School, USA
TRPC5 Channels: Function and Properties

Michael Tymianski, Toronto Western Research Institute (TWRI), Canada
Role of TRP Channels in Ischemic Brain Damage

Guo-li Ming, University of Pennsylvania, USA
TRPC in Neuronal Navigation: Development and Guidance

Seog Bae Oh, Seoul National University, South Korea
Short Talk: Membrane-Delimited Activation of Transient Receptor Potential Vanilloid 1 by mGluR5 in Nociceptors


SATURDAY, SEPTEMBER 22

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Store-Operated Channels
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Thomas Gudermann, Ludwig-Maximilians-Universitaet, Germany

James W. Putney, Jr., NIEHS, National Institutes of Health, USA
Store-Activation of CRAC and TRPC Channels

Indu S. Ambudkar, NIDCR, National Institutes of Health, USA
Function and Regulation of TRPC1 in Salivary Gland

Victoria M. Bolotina, Boston Medical Center, USA
Calcium Influx Factor

Patrick G. Hogan, La Jolla Institute of Allergy and Immunology, USA
Stim-Orai Signalling in T-Lymphocytes

Paul Rosenberg, Duke University, USA
Short Talk: STIM1/Orai1 Signaling Controls Store Operated Calcium Entry in Skeletal Muscle

09:20—09:40
Coffee Break

Foyer
16:00—16:30
Coffee Available

Foyer
16:30—18:30
TRPs and Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 4 - 5
* Michael Tymianski, Toronto Western Research Institute (TWRI), Canada

Michael Köttgen, Johns Hopkins University, USA
Calcium Signaling through TRPP2: from Polycystic Kidney Disease to Fly Sperm

Chris Benham, University of Hertfordshire, UK
TRPM2 Channels and Neurodegeneration: TRPV1 and Inflammatory Pain

Thierry Capiod, Inserm U800, France
Short Talk: Capacitative Calcium Entry and TRPC6 Expression Control Human Hepatoma Cells Proliferation

James W. Putney, Jr., NIEHS, National Institutes of Health, USA
Meeting Highlights

18:30—19:30
Social Hour with Lite Bites

Peaks 1 - 3
19:30—22:30
Entertainment

Peaks 1 - 3

SUNDAY, SEPTEMBER 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS059298-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


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Phone:+1 970-262-2690

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