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This meeting took place in 2007



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Frontiers of NMR in Molecular Biology X (A3)


Organizer(s) Juli Feigon, Brian D. Sykes and Mitsuhiko Ikura
January 6—11, 2007
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 13, 2006
Late Abstract Deadline: Oct 10, 2006
Scholarship Deadline: Sep 13, 2006
Early Registration Deadline: Nov 6, 2006

Supported by the Director's Fund

Summary of Meeting:
Frontiers of NMR in Molecular Biology has evolved to be the premier meeting in macromolecular NMR. It brings together leaders in the field in methods development, data processing and analysis, and structural biology using solution and solid state NMR. This meeting will reflect the development and unique applications of NMR spectroscopy for studying biologically important macromolecules and their interactions. This includes analysis of structures along the pathway from free to bound; conformational dynamics that affect catalysis, function, and folding; screening of protein and RNA binding ligands for drug development; studies of misfolded proteins that can cause disease; nucleic acid folding and function; and methods for determining membrane protein structure and activity. This field has an enormous impact on the pharmaceutical industry, as well as on medical sciences, by providing methods for investigating proteins and nucleic acids that cause disease when mutated or that can be targeted by drugs for disease prevention. Challenges of more efficient structure determination, representation and analysis of dynamic data, and structural studies of macromolecular assemblies and complexes will be addressed.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 6

14:00—18:00
Registration

Ballroom Lobby
17:00—18:00
Refreshments

Ballroom Mezzanine and Lobby
18:00—18:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland
NMR, Protein Structure and Protein Folding

19:00—21:00
Drug Discovery and Ligand Interactions
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* John P. Marino, National Institute of Standards and Technology, USA

Philip J. Hajduk, Abbott Laboratories, USA
Protein-Ligand Interactions: Lessons from a Decade of NMR-Based Screening

Kevin H. Gardner, CUNY Advanced Science Research Center, USA
PAS Domains: A Versatile Way to Build a Biological Switch

Angela M. Gronenborn, University of Pittsburgh, USA
The Structural Basis for HIV-Inactivation by CV-N


SUNDAY, JANUARY 7

07:00—08:00
Breakfast

Superior/Superior Lobby/Maybird
08:00—11:15
Nucleic Acid Structure and Function
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Juli Feigon, University of California, Los Angeles, USA
The Wonderful World of RNA

Samuel E. Butcher, University of Wisconsin-Madison, USA
Structural Investigation of U2-U6 Spliceosomal RNAs

Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Structural Analysis of Multi-Domain Proteins and Complexes Involved in Splicing Regulation

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
NMR Studies of Retroviral Genome Packaging and Large RNAs

Hashim M. Al-Hashimi, Duke University, USA
RNA Dynamics and Structural Adaptation

Jens Wöhnert, University of Texas Health Science Center, USA
Short Talk: Ligand Induced Folding of the Guanine Binding Riboswitch RNA and its Domains

09:20—09:40
Coffee Break

Ballroom Mezzanine and Lobby
11:00—13:00
Poster Setup

Ballroom Mezzanine
13:00—22:00
Poster Viewing

Ballroom Mezzanine
14:30—16:30
Workshop A: NMR and Drug Discovery

Ballrooom 2-3
* Angela M. Gronenborn, University of Pittsburgh, USA

Brian J. Stockman, Pfizer Inc., USA
An NMR-based Functional Assay for NAD Synthetase

Markus Schade, Combinature Biopharm AG, Germany
Fragment-Based Lead Discovery by NMR: Novel Modulators for the Protein-Protein-Interaction Target PDZ Domain

Michelle A. Markus, Wyeth Pharmaceuticals, USA
Protein NMR at Wyeth: Screening Libraries of Compounds to Provide Novel Starting Points for Structure-Based Drug Design

Gregg Siegal, ZoBio, Netherlands
TINS: New Opportunities for Fragment Based Drug Discovery

Robert T. Clubb, University of California, Los Angeles, USA
Structure and Dynamic Studies of Staphylococcus aureus Sortase A Complex by NMR

Kalle Gehring, McGill University, Canada
Structural Studies of E3 Ubiquitin-Ligase Activation Mediated by the UBA Domains of Cbl-b and c-Cbl

Jie Zheng, St. Jude Children's Research Hospital, USA
NMR-Assisted Discovery of Wnt Signaling Inhibitors

Michael J. Overdui, University of Birmingham, UK
NMR Based Docking of Membrane Binding Domains to Micelle Structures

16:30—17:00
Coffee Available

Ballroom Mezzanine and Lobby
17:00—19:00
New Methods in Computation and High-Throughput
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Gaetano Thomas Montelione, Rutgers University, USA

Carol B. Post, Purdue University, USA
Conformational Analysis of Viral Capsid Proteins

Michael Nilges, Institut Pasteur, France
Detection of Errors in NMR Structures by Quantitative Treatment of NOE-Derived Distanes

John L. Markley, University of Wisconsin-Madison, USA
Probabilistic Approaches to NMR Data Collection and Analysis

David A. Case, Rutgers University, USA
Short Talk: Connecting NMR Relaxation Parameters to MD Simulations: A New Look at an Old Problem

19:00—20:00
Social Hour with Lite Bites

Ballroom Mezzanine
19:30—22:00
Poster Session 1

Ballroom Mezzanine

MONDAY, JANUARY 8

07:00—08:00
Breakfast

Superior/Superior Lobby/Maybird
08:00—11:15
New Methods in NMR
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Ann E. McDermott, Columbia University, USA

Ad Bax, NIDDK, National Institutes of Health, USA
Weak Alignment Offers New Opportunities in NMR of Biomolecules

Teresa Carlomagno, Universität Hannover, Germany
Around RNA: Novel Methods for NMR Spectroscopy on RNA and Structural Studies of a Large Spliceosomal RNP Complex.

Gerhard Wagner, Harvard Medical School, USA
NMR Methods for Studies of Protein Interactions and their Application to Problems of Protein Biosynthesis

A. Joshua Wand, University of Pennsylvania, USA
Proteins Under Pressure In Small Places: Adventures in NMR Spectroscopy of Encapsulated Proteins Dissolved in Low Viscosity Fluids.

Erik R. P. Zuiderweg, University of Michigan, USA
Short Talk: A Paradigm to Determine Large Protein Dynamics by NMR

Philipp Selenko, Leibniz-Institut für Molekulare Pharmakologie (FMP-Berlin), Germany
Short Talk: In-Situ Observation of Protein Phosphorylation by In-Cell NMR Spectroscopy

09:20—09:40
Coffee Break

Ballroom Mezzanine and Lobby
11:15—22:00
Poster Session 1 Informal Viewing

Ballroom Mezzanine
14:30—16:30
Workshop B: Protein and Nucleic Acids Production, Labeling, and Folding

Ballrooom 2-3
* Masatsune Kainosho, Nagoya University, Japan
Perspectives of the SAIL Method for Protein NMR Spectroscopy

Lenka Skrisovska, Institute of Molecular Biology and Biophysics, Switzerland
NMR Study of Interdomain Interactions of PTB, hnRNP L and Npl3 Using Segmental Isotope Labeling

Tapas K. Mal, University Health Network, Canada
NMR Studies on the Interaction of Inositol 1,4,5-trisphosphate (IP3) with its Receptor (IP3R) in Solution

Geoffrey A. Mueller, NIEHS, National Institutes of Health, USA
NMR Assignment of Polymerasebeta Labeled with 2H, 13C, and 15N in Complex with Substrate DNA

Jean-Pierre Simorre, Centre National de la Recherche Scientifique, France
Identification by Systematic Expression Screening and NMR Structure of an Independently Folded C-Terminal Domain of Influenza Polymerase Subunit PB2

16:30—17:00
Coffee Available

Ballroom Mezzanine and Lobby
17:00—19:00
Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* R. Andrew Byrd, NCI, National Institutes of Health, USA

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein

Brian D. Sykes, University of Alberta, Canada
in vito Structure and Dynamics to in situ Physiology to in vivo Pathophysiology: Lessons from Striated Muscle Calcium Regulatory Proteins

Mitsuhiko Ikura, University of Toronto, Canada
NMR Investigation on Protein-Protein Interactions in Transcription and Signal Transduction

Paul C. Driscoll, MRC-National Institute for Medical Research, UK
Short Talk: Solution Structure of the Bacterial Type IV Secretion System VirB9/VirB7 Interaction Complex from pKM101

19:00—20:00
Social Hour with Lite Bites

Ballroom Mezzanine
19:30—22:00
Poster Session 1 Continued


TUESDAY, JANUARY 9

07:00—08:00
Breakfast

Superior/Superior Lobby/Maybird
08:00—11:15
Solid State NMR of Macromolecules
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Brian D. Sykes, University of Alberta, Canada

Judith Herzfeld, Brandeis University, USA
The Origins of Vectoriality in the Ion-Motive Photocycle of Bacteriorhodopsin: Insights from Solid State NMR

Ann E. McDermott, Columbia University, USA
Solid State NMR Studies of Protein Dynamics

Hartmut Oschkinat, FMP Berlin, Germany
Structure Determination of Proteins by Magic-Angle Spinning Solid-State NMR

Mei Hong, Massachusetts Institute of Technology, USA
Oligomeric Structure, Orientation, and Dynamics of Membrane Proteins from MAS NMR

Manuel Etzkorn, Max-Planck-Institute for Biophysical Chemistry, Germany
Short Talk: Studying Structure and Complex Formation of a 7-Transmembrane Protein Receptor by Solid-State NMR

Gianluigi Veglia, University of Minnesota, USA
Short Talk: Investigation of Intramembrane Protein-Protein Interactions by NMR

09:20—09:40
Coffee Break

Ballroom Mezzanine and Lobby
11:15—13:00
Poster Setup

Ballroom Mezzanine
13:00—22:00
Poster Viewing

Ballroom Mezzanine
14:30—16:30
Workshop C: The Future of Publicly-Accessible Databases for NMR Spectroscopy

Ballrooom 2-3
* Robert Kaptein, University of Utrecht, Netherlands

* John L. Markley, University of Wisconsin-Madison, USA
PDB-BMRB Workshop on NMR Data Deposition and Validation

* Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
NMR and the PDB

Gaetano Thomas Montelione, Rutgers University, USA
Protein Structure Validation Software (PSVS) Suite and NMR RPF Scores

Eldon L. Ulrich, University of Wisconsin-Madison, USA
BMRB ADIT-NMR Provides Combined BMRB and PDB Deposition Capability

16:30—17:00
Coffee Available

Ballroom Mezzanine and Lobby
17:00—19:00
Macromolecules in Motion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Erik R. P. Zuiderweg, University of Michigan, USA

David E. Wemmer, University of California, Berkeley, USA
NMR Studies of Regulatory Proteins: Roles of Conformational Changes and Flexibility

Arthur G. Palmer, III, Columbia University, USA
Protein Motions in Catalysis, Binding, and Folding

David Fushman, University of Maryland, USA
Structure and Conformational Dynamics of Polyubiquitin Chains

Patrick Loria, Yale University, USA
Short Talk: Characterization of the Transition State for Functional Enzyme Motions

19:00—20:00
Social Hour with Lite Bites

Ballroom Mezzanine
19:30—22:00
Poster Session 2

Ballroom Mezzanine

WEDNESDAY, JANUARY 10

07:00—08:00
Breakfast

Superior/Superior Lobby/Maybird
08:00—11:15
Proteins Acting on Nucleic Acids
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Mitsuhiko Ikura, University of Toronto, Canada

G. Marius Clore, NIDDK, National Institutes of Health, USA
Detection and Visualization of Low-Population Encounter Complexes in Protein-Protein and Protein-DNA Association by Paramagnetic Relaxation Enhancement

Frédéric H.T. Allain, ETH Zurich, Switzerland
NMR of Protein-RNA Complexes: Shape and Sequence-Specific Recognition

Rolf Boelens, Utrecht University, Department of Chemistry, Netherlands
NMR Studies on Structure and Dynamics in DNA Repair

Deborah S. Wuttke, University of Colorado, USA
Structural Studies of Telomere-Associated Proteins

Tatiana G. Kutateladze, University of Colorado School of Medicine, USA
Short Talk: A Novel Function of PHD Fingers

James G. Omichinski, University of Montreal, Canada
Short Talk: NMR Structural Studies of the Interaction Between the p62/Tfb1 Subunit of TFIIH and the á Subunit of TFIIE

09:20—09:40
Coffee Break

Ballroom Mezzanine and Lobby
11:15—22:00
Poster Session 2 Viewing

Ballroom Mezzanine
14:30—16:30
Poster Session 2 Continued

Ballroom Mezzanine
16:30—17:00
Coffee Available

Ballroom Mezzanine and Lobby
17:00—19:00
Protein Folding and Misfolding
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David E. Wemmer, University of California, Berkeley, USA

Mark Girvin, Albert Einstein College Of Medicine, USA
Folding of Membrane Proteins in Detergents and Bicelles for NMR Studies

Peter E. Wright, The Scripps Research Institute, USA
Function, Flexibility, and Folding of Intrinsically Disordered Proteins.

Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution NMR Spectroscopy

John Christodoulou, University College London, UK
Short Talk: Probing Intact and Functional Ribosomes by NMR

19:00—20:00
Social Hour with Lite Bites

Ballroom Mezzanine
20:00—22:00
Entertainment

Ballroom 2-3

THURSDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 GM079039-01




We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Bruker BioSpin Corp.
Cambridge Isotope Laboratories Educational donation provided by Amgen
Varian, Inc.
Affymetrix, Inc.

ISOTEC, a member of the Sigma-Aldrich Group

New Era Enterprises, Inc.


Spectra Gases, Inc. Stable Isotopes Group

 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Abbott Laboratories


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676