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This meeting took place in 2007



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Systems Biology and Regulatory Networks (X5)


Organizer(s) Michael Snyder and Erin K. O'Shea
March 22—27, 2007
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 22, 2006
Late Abstract Deadline: Dec 21, 2006
Scholarship Deadline: Nov 22, 2006
Early Registration Deadline: Jan 23, 2007

Supported by the Director's Fund


Summary of Meeting:
The past several years has witnessed a revolution in the manner in which biological problems are analyzed. Large-scale systematic methods have been applied to analyze complex cellular and developmental processes and regulatory networks that control them. The goals of this meeting are to bring together leading investigators in the areas of genomics, proteomics and systems biology to discuss the elucidation of complex biological processes and the transcription and posttranscriptional networks that control them.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 22

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Sunshine
* John R. Yates III, The Scripps Research Institute, USA

Donald F. Hunt, University of Virginia, USA
Innovative Technology for the Study of Cell Signaling

* Steven P. Gygi, Harvard Medical School, USA

Lucy Shapiro, Stanford University, USA
Spatial and Temporal Components of the Bacterial Cell Cycle Genetic Circuitry


FRIDAY, MARCH 23

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:15
Transcriptional Regulatory Networks
Meeting has ended...abstracts no longer viewable online.

Sunshine
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Regulatory Circuitry of Human Embryonic Stem Cells

Aviv Regev, Massachusetts Institute of Technology/Broad Institute, USA
Natural History and Evolutionary Principles of Gene Duplication in Fungi

Alexander D. Johnson, University of California, San Francisco, USA
Evolution of Transcriptional Curcuits

* Gloria M. Coruzzi, New York University, USA
A Systems Approach to Nitrogen Networks and the “VirtualPlant”

Mark D. Biggin, Lawrence Berkeley National Laboratory, USA
Short Talk: Berkeley Drosophlia Transcription Network Project

Andrea Califano, Columbia University, USA
Short Talk: Genome-Wide Discovery of Post-Translational Modulators of Transcriptional Interactions in Human B Lymphocytes


Following Session is for Cell Signaling and Proteomics (X6)

08:00—11:00
Frontiers and Challenges in Signaling I
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Michael J. Weber, University of Virginia, USA

Anne Brunet, Stanford University, USA
Signaling Networks in Aging and Longevity

Tony Hunter, The Salk Institute for Biological Studies, USA
Kinomics: Challenges for the Future

Lewis C. Cantley, Weill Cornell Medicine, USA
The Role of Phosphorylation in Signaling

Joris Benschop, University Medical Center Utrecht, Netherlands
Short Talk: Post-Translational Regulation of the Yeast Mediator Complex

Karl R. Clauser, Broad Institute of Massachusetts Institute of Technology, Harvard, USA
Short Talk: Phosphoproteomic Screen Defines Polo-Box Domain Mitotic Interactome and Identifies the Cytokinesis Regulator Rho-Associated Kinase-2 as a Plk1 Substrate

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Storm Peak/Rainbow/Twilight
13:00—22:00
Poster Viewing

Storm Peak/Rainbow/Twilight
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Posttranslational Networks (Joint)
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Sunshine
Michael P. Snyder, Stanford University School of Medicine, USA
Regulatory Networks in Eucaryotes

Steven P. Gygi, Harvard Medical School, USA
Measuring Changes In Protein Phosphorylation State On A Proteome Scale

* Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Interaction Domains in Cellular Regulation

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 1

Storm Peak/Rainbow/Twilight

SATURDAY, MARCH 24

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:15
Complex Systems I
Meeting has ended...abstracts no longer viewable online.

Sunshine
John R. Carlson, Yale University, USA
Analysis of the Drosophila Olfactory System

* Susan K. Dutcher, Washington University School of Medicine, USA
Comparative Genomic Analysis of Chlamydomonas Flagella and Insight into Human Disease

Phillippe Cluzel, University of Chicago, USA
Inferring Cellular Response from Behavioral Variability in a Simple Signal Transduction Network

Stuart K. Kim, Stanford University Medical Center, USA
Genome-Wide Views of Aging Gene Networks

Christopher J. Bakal, Institute of Cancer Research, UK
Short Talk: Genetically Identical Cells can Adopt a Wide Variety of Shapes

Rodney J. Rothstein, Columbia University Medical Center, USA
Short Talk: Taking a Global Approach to Explore how Cells Respond to DNA Damage


Following Session is for Cell Signaling and Proteomics (X6)

08:00—11:00
Frontiers and Challenges in Signaling II
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Lewis C. Cantley, Weill Cornell Medicine, USA

Tania A. Baker, Massachusetts Institute of Technology, USA
Recognition Logic of the AAA+ Protein Unfolding ATPases

Michael J. Weber, University of Virginia, USA
Cell Signaling by the Erk Pathway

James A. Wells, University of California, San Francisco, USA
Degradomics: The Proteolysis of Cell Death

Marcus Smolka, Weill Institute for Cell and Molecular Biology , Cornell University, USA
Short Talk: Mapping the DNA Damage Signaling Network by a Global and Quantitative Phosphorylation Analysis

Joshua E. Elias, Harvard Medical School, USA
Short Talk: Progress Towards Global Measurements of Protein Degradation in Cultured Steady-State Cells by Quantitative Mass Spectrometry

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Storm Peak/Rainbow/Twilight
13:00—22:00
Poster Viewing

Storm Peak/Rainbow/Twilight
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Complex Systems II
Meeting has ended...abstracts no longer viewable online.

Sunshine
Erin K. O'Shea, Harvard University, USA
Signal Processing by Promoters

Jack F. Greenblatt, University of Toronto, Canada
Protein and Genetic Interaction Networks for Pathway Elucidation

* Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Transcriptional Landscape of the Human Genome: Same Genomic Locus-Multiple Functional Transcripts

Yijun Ruan, University of Connecticut, USA
Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag (CIA-PET) to Study Transcription Regulation in Cancer Cells


Following Session is for Cell Signaling and Proteomics (X6)

17:00—19:00
Phosphorylation Profiling I
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Steven P. Gygi, Harvard Medical School, USA

Joshua J. Coon, University of Wisconsin, USA
Tracking Kinase Signaling Cascades in Human Embryonic Stem Cells

Peipei Ping, University of California, Los Angeles, USA
Regulation of Cardiac 20S Proteasome Complexes by Associating Partners

Cristian I. Ruse, The Scripps Research Institute, USA
Barium Precipitation for Phosphopeptide Profiling

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 2

Storm Peak/Rainbow/Twilight

SUNDAY, MARCH 25

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:15
Posttranscriptional Regulatory Networks
Meeting has ended...abstracts no longer viewable online.

Sunshine
David P. Bartel, HHMI, MIT and Whitehead Institute, USA
Global Analysis of microRNAs

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Conserved microRNAs with New Roles

* Gisela T. Storz, National Institutes of Health, USA
Wide Ranging Functions of Small RNAs in Bacteria

Alexander F. Schier, Harvard University, USA
MicroRNAs in Vertebrate Embryogenesis

Kimberly C. Tu, University of Utah, USA
Short Talk: Multiple Small RNAs Act Additively to Integrate Sensory Information and Control Quorum Sensing in Vibrio Harveyi

Manolis Kellis, Massachusetts Institute of Technology / Broad Institute, USA
Short Talk: Regulatory Networks in 12 Drosophila genomes


Following Session is for Cell Signaling and Proteomics (X6)

08:00—11:00
Frontiers and Challenges in Signaling III
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Peipei Ping, University of California, Los Angeles, USA

J. Wade Harper, Harvard Medical School, USA
Control of Signaling Systems through the Ubiquitin Proteasome Pathway

Thibault Mayor, University of British Columbia, Canada
Profiling of Ubiquitylated Proteins using Quantitative Mass Spectrometry to Reveal Proteasome Substrates and Rpn10 Receptor Repertoire

H. Alex Brown, Vanderbilt University, USA
Lipid Signaling Networks

Dorothea Fiedler, Princeton University, USA
Short Talk: An E-MAP of Kinase and Phosphatase Signaling in Saccharomyces cerevisiae

Adam Friedman, Harvard Medical School, USA
Short Talk: Functional Genomic Screens for Novel Regulators of Receptor Tyrosine Kinase and ERK Signaling Specificity

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Storm Peak/Rainbow/Twilight
13:00—22:00
Poster Viewing

Storm Peak/Rainbow/Twilight
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cascades Controlling Developmental Fates (Joint)
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Sunshine
Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology - Balancing the Fat Equation

Ulrike Gaul, Rockefeller University, USA
Decoding Transcription Control in Drosophila Segmentation

* Roger Brent, Molecular Sciences Institute, USA
Physiology and Genetic Regulation of Cellular Signal Transmission

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 3

Storm Peak/Rainbow/Twilight

MONDAY, MARCH 26

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
Systems Analysis of Disease
Meeting has ended...abstracts no longer viewable online.

Sunshine
Vamsi K. Mootha, Massachusetts General Hospital, USA
Systems Analysis of Human Mitochondrial Disorders

Brenda J. Andrews, University of Toronto, Canada
Systematic Yeast Genetics to Explore Biological Pathways and Kinase Targets

Maureen E. Hillenmeyer, Stanford University, USA
Short Talk: The Chemical Genomic Portrait of the Cell Reveals a Phenotype for all Yeast Cells

* Garry P. Nolan, Stanford University, USA
Mechanistic Insights from the Single Cell: Inference Engines for Signaling with Clinical Samlpes

Andrea H. Bild, University of Utah, USA
Short Talk: Unique Patterns of Pathway Deregulation and Chemotherapeutic Responses in Breast Cancer Subtypes

Thomas G. Graeber, University of California, Los Angeles, USA
Short Talk: Phosphoproteome Analysis of Drug-Resistant BCR-ABL Mutants Reveals Mutant-Specific Global Signaling Patterns and BCR-ABL ATP Binding Loop Phosphorylation Pattern-Based Determinants of Oncogenicity


Following Session is for Cell Signaling and Proteomics (X6)

08:00—11:00
Microarray Technology for Signaling
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Ole N. Jensen, University of Southern Denmark, Denmark

Speaker to be Announced

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Topology and Dynamics of Protein Interaction Networks

Lawrence E. Goldfinger, University of California, San Diego, USA
Short Talk: Discovering Novel Ras Effectors in Cell Migration

Neil E. Olszewski, University of Minnesota, USA
Short Talk: Determining the Function of O-GlcNAc Modification in Signaling Pathways of Plants

Rune Linding, University of Copenhagen, Denmark
Short Talk: Systematic Discovery of In Vivo Phosphorylation Networks

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Integrative Networks
Meeting has ended...abstracts no longer viewable online.

Sunshine
Aimee Dudley, Institute for Systems Biology, USA
Analysis of Individual Expression Variation Reveals a Post Transcriptional Network

* Audrey P. Gasch, University of Wisconsin-Madison, USA
Integrative Signaling Networks in the Regulation of Stress-Dependent Geomic Expression in Yeast

Edward M. Marcotte, University of Texas at Austin, USA
Steps toward Directed Identification of Disease Genes: Rational Prediction of Loss of Function Phenotypes

Leroy E. Hood, Institute for Systems Biology, USA
A Systems Approach to Disease: Predictive and Preventive Medicine


Following Session is for Cell Signaling and Proteomics (X6)

17:00—19:00
Phosphorylation Profiling II
Meeting has ended...abstracts no longer viewable online.

Mt. Werner
* Joshua J. Coon, University of Wisconsin, USA

Benjamin A. Garcia, University of Pennsylvania, USA
Top Down Protein Analysis to Identify PTMs

Ole N. Jensen, University of Southern Denmark, Denmark
Analyzing Signaling in Membrane Proteins

Forest M. White, Massachusetts Institute of Technology, USA
Quantitative Analysis of ErbB Cellular Signaling Networks

20:00—21:00
Social Hour with Lite Bites

Storm Peak/Sunshine/Mt. Werner
20:00—23:00
Entertainment

Storm Peak/Sunshine/Mt. Werner

TUESDAY, MARCH 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Ariadne Genomics GeneGo, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676