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This meeting took place in 2007



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MicroRNA and Cancer (E1)


Organizer(s) Gregory J. Hannon, Carlo M. Croce and Scott Hammond
June 8—12, 2007
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Feb 8, 2007
Late Abstract Deadline: Mar 12, 2007
Scholarship Deadline: Feb 8, 2007
Early Registration Deadline: Apr 9, 2007

Supported by the Director's Fund

Summary of Meeting:
To date, most studies of the genetic mutations that contribute to tumor formation have focused on alterations in the sequence, gene structure, copy number and expression of protein coding genes. However, we find increasingly that the genome generates a diversity of non-coding RNAs, many of which have unknown functions. MicroRNAs act through the RNAi pathway to regulate the expression of protein coding genes, which they recognize through complementary base pairing. Accumulating data suggests causal roles for microRNAs in human cancer, including observations of microRNA genes at tumor-associated chromosomal lesions and direct demonstrations that altered expression of microRNAs can accelerate tumor development. Analysis of microRNA expression signatures may contribute to cancer diagnosis, and microRNAs themselves are potential targets for cancer therapy. This meeting will highlight emerging roles of microRNAs in tumorigenesis and place these in the context of microRNAs biochemistry and biology. Bringing together investigators from two distinct fields, namely RNA and cancer biology, will facilitate new ideas regarding the means by which microRNAs impact tumor initiation and progression.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JUNE 8

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer

SATURDAY, JUNE 9

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
Small RNA Biology
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Gregory J. Hannon, University of Cambridge, UK

Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Genome-Wide Maps of the Human Transcriptome Reveal an Interleaved Organization and Novel Short and Long Classes of RNAs

Amy E. Pasquinelli, University of California, San Diego, USA
Regulation of Gene Expression by MicroRNAs

Andrew Grimson, Whitehead Institute for Biomedical Research, USA
miRNA Targeting: Determinants Beyond Seed Pairing

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone/Red Cloud
13:00—20:00
Poster Viewing

Crestone/Red Cloud
14:30—15:00
Coffee Available

Shavano Peak Foyer
15:00—17:15
Measuring microRNA Expression
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Scott M. Hammond, University of North Carolina at Chapel Hill, USA

Hui Wang, Agilent Technologies, Inc., USA
Direct and Sensitive miRNA Profiling from Low-Input Total RNA

Martina U. Muckenthaler, Children's Hospital, University of Heidelberg, Germany
MiChip: A Microarray Platform for Expression Profiling of microRNAs Based on Locked-Nucleic Acid (LNA) Oligonucleotide Capture Probes

Keld Sorensen, Siemens Healthcare, USA
Short Talk: High Throughput microRNA Expression Profiling Using a Bead Based Multiplex System

Caifu Chen, Life Technologies, USA
MicroRNA Expression Profiling from Single Cells using Multiplex PreAmp TaqMan® MicroRNA Assays

Andy Bader, Mirna Therapeutics Inc., USA
Clinical Applications of miRNAs

17:15—18:15
Social Hour with Lite Bites

Crestone/Red Cloud
17:30—20:00
Poster Session 1

Crestone/Red Cloud

SUNDAY, JUNE 10

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
MicroRNAs and Cancer
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Scott M. Hammond, University of North Carolina at Chapel Hill, USA
MicroRNA Expression in Cancer

Lin He, University of California, Berkeley, USA
A microRNA Component of the p53 Tumor Suppressor Network

Carlo M. Croce, Ohio State University, USA
MicroRNAs as oncogenes and tumor suppressors

Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
Short Talk: let-7 Represses Hmga2 to Prevent Human Tumors

Katia Basso, Columbia University, USA
Short Talk: Identification of Normal and Neoplastic Human Mature B Cells “miRome”

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone/Red Cloud
13:00—20:00
Poster Viewing

Crestone/Red Cloud
14:30—15:00
Coffee Available

Shavano Peak Foyer
15:00—17:00
MicroRNAs and Cancer
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Carlo M. Croce, Ohio State University, USA

Reuven Agami, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Lecture: MicroRNAs as Oncogenes

Sakari Kauppinen, Aalborg University, Denmark
Antagonizing microRNAs for Therapeutics

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
Reprogramming of MicroRNA Expression by Oncogenes and Tumor Suppressors

Marcus E. Peter, University of Chicago, USA
Short Talk: Reduced Let-7 Expression is a Marker for CD95 Type I Cells Representing More Advanced and Less Differentiated Stages of Cancer

17:00—18:00
Social Hour with Lite Bites

Crestone/Red Cloud
17:30—20:00
Poster Session 2

Crestone/Red Cloud

MONDAY, JUNE 11

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
MicroRNAs in Development
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
MicroRNA Control in Lymphocytes

Antonio J. Giraldez, Yale University School of Medicine, USA
MicroRNAs in Vertebrate Development

Antony Rodriguez, Baylor College of Medicine, USA
Short Talk: miR-155/bic is Essential for Normal Immune Function in Mice

María José Bueno, Universidad Autónoma de Madrid, Spain
Short Talk: Genetic and Epigenetic Silencing of miR-203 Enhances ABL1 Oncogene Expresión in Hematopoietic Malignancies

Sarah Kathryn Fineberg, University of Iowa, USA
Short Talk: miR-34a Modulates Neural Progenitor Cell Differentiation

Rui Yi, University of Colorado Boulder, USA
Short Talk: Functional Study of a Skin Specific microRNA in Embryonic Skin Development

09:20—09:40
Coffee Break

Shavano Peak Foyer
14:30—15:00
Coffee Available

Shavano Peak Foyer
15:00—17:00
MicroRNAs in Cancer
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Carlo M. Croce, Ohio State University, USA

Andrea Ventura, Memorial Sloan Kettering Cancer Center, USA
On the Role of microRNAs in Mouse Development and Cancer

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
MicroRNAs in development and cancer

Bill Piu Wong, Stanford University, USA
Short Talk: miR-142 is a Novel Collaborating Oncogene in Haematological Malignancies

Christopher Y. Park, Memorial Sloan Kettering Cancer Center, USA
Short Talk: miRNA Expression Profiling of Human Acute Myeloid Leukemia Reveals a Leukemia Stem Cell Signature

18:00—19:00
Social Hour with Lite Bites

Gazebo
18:00—21:00
Entertainment

Gazebo

TUESDAY, JUNE 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


EMD Millipore

Exiqon A/S
febit inc. Integrated DNA Technologies

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Agilent Technologies


EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676