Fairmont Banff Springs Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2008



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

NF-kappaB (B6)


Organizer(s) Vishva M. Dixit, Shao-Cong Sun and Sankar Ghosh
February 12—17, 2008
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 12, 2007
Late Abstract Deadline: Nov 12, 2007
Scholarship Deadline: Oct 12, 2007
Early Registration Deadline: Dec 12, 2007

Supported by the Director's Fund

Summary of Meeting:
Research focused on NF-kappaB has continued to grow exponentially in recent years, fueled in part by the progress in accruing basic knowledge on this pathway, which in turn has provided the stimulus for applied research. Continued growth in this field is also the result of discoveries that reveal the ever-increasing importance of NF-kappaB in many cell types in both normal health and disease. NF-kappaB has become an integral part of diverse research disciplines, including immunology, signal transduction, chromatin regulation, autoimmune diseases, diabetes, osteoporosis and cancer, just to name a few. NF-kappaB is of great interest to clinical research and remains a prime target for therapeutic intervention in many diseases. The 2008 Keystone meeting on NF-kappaB will come at a particularly exciting time, when a number of unexpected new regulatory pathways and functions of this transcription factor family are emerging. For example extensive regulation of NF-kappaB at the chromatin level occurs in addition to the primary regulation, which is relief of inhibition by IkappaB proteins that normally keep NF-kappaB inactive in the cytoplasm. Regulation at the chromatin level is accomplished via signal-induced modifications of NF-kappaB itself or of interacting partners. An additional area of great activity has been the discovery of regulatory ubiquitination events in multiple steps of the NF-kappaB pathway, and we anticipate that the meeting will provide significant new insight in this area. In recent years evidence for the importance and extent of inappropriate activation of NF-kappaB in tumorigenesis has continued to emerge. The link between inflammation (via NF-kappaB) and tumorigenesis has led to tremendous interest in this area and we anticipate that significant new information will be presented at this meeting. New data will be presented on the roles of NF-kappaB in multiple myeloma, squamous head and neck cancers, breast cancer and diffuse large B cell lymphomas. Clinical trials are underway to evaluate NF-kappaB as a therapeutic target in these and other malignancies, and results from such trials are expected at this meeting.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 12

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom Foyer AB
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
NF-kappaB: A Phylogenetic Perspective


WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

New Brunswick, Alberta
08:00—11:00
Regulation of the NF-kappaB Pathway
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Alain Israël, Institut Pasteur, France
Structure-Function Analysis of NEMO

Inder M. Verma, The Salk Institute, USA
Novel Roles of the IKK Complex

* Sankar Ghosh, Columbia University, USA
PDK1 Integrates CD28+ CD3 Signaling to NFkB

Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Negative Regulation of NF-kB by CYLD

Gutian Xiao, University of Pittsburgh Medical Center, USA
Short Talk: Novel Mechanisms of p100 Processing and NF-kappaB Regulation

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

New Brunswick, Alberta
14:30—16:30
Workshop 1: NF-kappaB Signaling

Van Horne Ballroom AB
* Alexander Hoffmann, University of California, Los Angeles, USA

Olga V. Savinova, Sanford Research/University of South Dakota, USA
Molecular Organization of Endogenous p105 and p100 Complexes and their Role in LPS Signalling

Tom Huxford, San Diego State University, USA
IkappaBzeta Specifically Binds NF-kappaB p50 Homodimer and Forms a Ternary Complex on kappaB DNA

Ralf B. Marienfeld, Unviersity of Ulm, Germany
The Phosphorylation of Serine 68 in the IKK-Binding Domain of NEMO Interferes with the Structure of the IKK-Complex and the TNF-alpha-Induced NF-kappaB Activity

Melanie Herscovitch, Boston University, USA
Role of Cysteine Residues in NEMO Structure and Function

Sergei Makarov, Attagene, Inc., USA
Homogenous Reporter System Enables Quantitative Functional Assessment of Multiple Transcription Factors

Casey W. Wright, University of Texas Medical Branch, USA
ARNT Modulates CD30-Mediated NF-kappaB Transactivation Through Regulation of RelB

Kam C. Yeung, University of Toledo Health Science Campus, USA
RKIP is a Scaffold Protein of the IkappaB Kinase Complex

Benjamin A.A. Barre, University of Bristol, UK
A Cell Cycle Regulatory Network Controlling NF-kappaB Subunit Activity and Function

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Signaling to NF-kappaB
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Vishva M. Dixit, Genentech, Inc., USA
Role of cIAP1/2 in the Non-Canonical NF-kB Survival Pathway

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Signaling by Ubiquitin and Viruses to NFkB

Xin Lin, University of Texas MD Anderson Cancer Center, USA
NF-kappaB Signaling Regulated by CARMA Family Members

Steven C. Ley, Francis Crick Institute, UK
Short Talk: NF-kappaB1 p105: A Third Way to NF-kappaB Activation

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta
19:30—22:00
Poster Session 1

New Brunswick, Alberta

THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

New Brunswick, Alberta
07:00—08:00
Poster Setup

New Brunswick, Alberta
08:00—11:15
Regulation of NF-kappaB and Chromatin
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA

Gioacchino Natoli, IEO, European Institute of Oncology, Italy
NF-kB Inflammation and the Epigenome: A Tale of Reciprocal Influences

Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
New Insights into Molecular Underpinnings of HIV Latency

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Crystal Structure of TRAF6 Reveals the Molecular Mechanism for Poly-Ubiquitin Synthesis

Stephen T. Smale, University of California, Los Angeles, USA
Differential Gene Activation by NF-kappaB Family Members in a Chromatin Environment

Edward W. Harhaj, University of Miami School of Medicine, USA
Short Talk: TAX1BP1 and Itch are Essential Subunits of an A20 Ubiquitin Editing Complex

Neil D. Perkins, University of Newcastle, UK
Short Talk: Regulation of RelA(p65) Functionality

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15—12:00
Lunch

New Brunswick, Alberta
12:00—14:30
Poster Session 2

New Brunswick, Alberta
14:30—16:30
Workshop 2: NF-kappaB in Inflammatory Diseases and Cancer

Van Horne Ballroom AB
* Genhong Cheng, University of California, Los Angeles, USA

Adam S. Adler, Genentech, Inc., USA
Motif Module Map Reveals Enforcement of Aging by Continual NF-kappaB Activity

Jeremy S. Tilstra, University of Pittsburgh, USA
NF-kappaB Inhibitor, PTD-NBD, Delays the Onset of Age-Associated Functional Decline in a Model of Advanced Aging

Ruaidhrí John Carmody, University College Cork, Ireland
Bcl-3 Inhibits Inflammatory Gene Expression By Blocking NF-kappaB p50 Ubiquitination

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
NF-kappaB Activation in Enterocytes Regulates Survival and Sensitivity to Chemotherapy in a Model of Sporadic Intestinal Tumorigenesis

Bernd Baumann, University of Ulm, Germany
Constitutive IKK2 Activation in Acinar Cells is Sufficient to Induce Acute Pancreatitis in vivo

Michael Hinz, Max Delbrück Center for Molecular Medicine, Germany
Inhibition of Hsp90-Cdc37 Interferes with Signal-Responsiveness of IkappaB Kinases and Provides a Therapeutic Option for NF-kappaB Dependent Diseases

Deborah Veis Novack, Washington University, USA
The Alternative NF-kappaB Pathway via NIK and RelB Mediates Tumor-Induced Osteolysis

Diana Legarda-Addison, Mount Sinai School of Medicine, USA
NF-kappaB-Independent Role of NEMO/IKKgamma in Regulating TNF-Induced Apoptosis

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Genetic Analysis of NF-kappaB Function
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Manolis Pasparakis, University of Cologne, Germany
Genetic Analysis of the IKK Complex Using Conditional Knock-Outs

Alexander Hoffmann, University of California, Los Angeles, USA
Homeostatic Mechanisms Determine the Responsiveness of the IkappaB-NF-kappaB Signaling Module

* Ranjan Sen, National Institute of Aging, National Institutes of Health, USA
Regulation of NF-kappaB Function in Lymphocytes

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Short Talk: Multiple Developmental Defects in Mice Lacking the IkappaBalpha N-Terminal Nuclear Export Sequence

19:00
On Own for Dinner


FRIDAY, FEBRUARY 15

07:00—08:00
Breakfast

New Brunswick, Alberta
08:00—11:00
NF-kappaB Signaling in the Innate Immune System
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Diversity in the NF-kappaB System Revealed by Analysis of Toll-Like Receptor Signaling Pathways

Michelle A. Kelliher, University of Massachusetts Medical School, USA
Rip Proteins in Innate Immune Signaling

Genhong Cheng, University of California, Los Angeles, USA
TRAF3, a Critical Negative Regulator of Both Classical and Alternative NF-kappaB Activation

Michael Naumann, Institute of Experimental Internal Medicine, Germany
Short Talk: COP9 Signalosome Controls the Turnover of IkappaB-Molecules

Martin E. Dorf, Harvard Medical School, USA
Short Talk: PKC Phosphorylation of TRAF2 Mediates Recruitment of IKKa/b and K63-linked Polyubiquitination

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

New Brunswick, Alberta
16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
NF-kappaB and the Adaptive Immune System
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Regulation of NF-kappaB in Immunologic Contexts

Steve D. Gerondakis, Monash University, Australia
Negative Regulation of CD8 Memory T-Cell Development and Homeostasis

Daniel Krappmann, Helmholtz Zentrum München, Germany
Short Talk: Malt1 Ubiquitination Triggers NF-kappaB Signaling upon T cell Activation

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta
19:30—22:00
Poster Session 3

New Brunswick, Alberta

SATURDAY, FEBRUARY 16

07:00—08:00
Breakfast

New Brunswick, Alberta
08:00—11:00
NF-kappaB, Inflammation and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Michael Karin, University of California, San Diego, USA
IKK-NF-kappaB Signaling and the Control of Caspase Activation and Cell Survival

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
The Role of NFkB in Liver Physiology and Cancer: Lessons from Different Animal Models

Louis M. Staudt, National Cancer Institute, NIH, USA
Genomic Aberrations that Activate NF-kappaB Constitutively in Lymphoid Malignancies

Thomas D. Gilmore, Boston University, USA
A Human Model System for Re1-Induced B-Cell Lymphomagenesis

Carter Van Waes, NIDCD, National Institutes of Health, USA
Short Talk: The NF-kappaB Proteome and Transcriptome as Biomarkers and Targets for Therapy in Human Head and Neck Squamous Cell Carcinomas

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00
On Own for Lunch

14:30—16:30
Workshop 3: NF-kappaB in the Immune Response

Van Horne Ballroom AB
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA

Michael J. May, University of Pennsylvania, USA
The IKK Complex Recruits Homer-3 to the Immunological Synapse

Fabrice Agou, Institut Pasteur, France
Solution Structure of NEMO Zinc Finger and Impact of an Anhidrotic Ectodermal Dysplasia with Immunodeficiency-Related Point Mutation

Christian Kaltschmidt, Bielefeld University, Germany
NF-kappaB is Transported to the Nucleus via Cytoplasmic Dynein/Dynactin Motor Complexes in Hippocampal Neurons

Raquel Sitcheran, Texas A&M Health Science Center, USA
Glutamate Signalling to NFkB Glial Cells of the CNS

Lin-Feng Chen, University of Illinois at Urbana-Champaign, USA
Brd4 Coactivates NF-kappaB-mediated Inflammatory Response via Specific Binding to Acetylated RelA

Ilaria Tassi, Alector, USA
Dendritic Cells Require PLCgamma2 to Sense Pathogen Associated Molecular Patterns through TLR and Non-TLR Receptors

Miguel E. Moreno-Garcia, Seattle Children's Research Institute, USA
CARMA1 Nucleates Activation-Induced Degradation of the CARMA/Bcl10/Malt Signalosome to Limit NF-kappaB Activation in Lymphocytes

Nadine Hövelmeyer, University of Mainz, Germany
Regulation of B Cell Homeostasis and Activation by the Tumor Suppressor Gene Cyld

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
NF-kappaB: Benchside to Clinic
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Anning Lin, Shanghai Institute of Biochemistry and Cell Biology, China
Wiring the Intracellular Signaling Circuitry by NF-kappaB

Rudi Beyaert, Ghent University - VIB, Belgium
Short Talk: ABINs and TAX1BP1 are Ubiquitin-Binding Proteins that Negatively Regulate NF-kappaB Activation by Targeting A20 to Specific Signaling Proteins

* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
Targeting NF-kappaB Activity in Cancer Cells

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta
20:00—23:00
Entertainment

New Brunswick, Alberta

SUNDAY, FEBRUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI077107-01




We gratefully acknowledge additional support for this conference from:


GlaxoSmithKline Research & Development, Ltd.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676