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This meeting took place in 2008



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G Protein-Coupled Receptors: New Insights in Functional Regulation and Clinical Application (E2)


Organizer(s) Heidi E. Hamm, P. Jeffrey Conn, Jean-Philippe Pin and Olivier Civelli
May 18—23, 2008
INEC-Ireland's National Events Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Jan 18, 2008
Late Abstract Deadline: Feb 19, 2008
Scholarship Deadline: Jan 18, 2008
Early Registration Deadline: Mar 31, 2008

In collaboration with Science Foundation Ireland; Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development

Summary of Meeting:
The G-protein-coupled-receptor (GPCR) family accounts for almost 3% of the human genome and encompasses the largest number of receptors identified to date. Further, GPCRs have proven to be one of the primary targets for therapeutic drug intervention. Work in the field is rapidly progressing through the identification of structural aspects of activation, dimerization and its functional significance, ligand-directed signaling, de-orphanization of GPCRs and their signaling pathways, allosteric modulators of GPCR activation, as well as novel interacting protein complexes and their correlate signaling cascades. This Keystone Symposia meeting will focus on these important aspects of GPCRs as well as how they regulate functional systems such as sleep, stress and feeding. Finally, the effect of genetic disease on GPCR activation and signaling will be discussed.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 18

15:00—19:30
Registration

INEC Conference Centre Foyer
18:30—19:30
Refreshments

INEC Conference Centre Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
Brian K. Kobilka, Stanford University School of Medicine, USA
Structure and Dynamics of the Human beta 2 Adrenergic Receptor


MONDAY, MAY 19

07:00—08:00
Breakfast

INEC Conference Centre Foyer
08:00—11:15
GPCR Conformation
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Jean-Philippe Pin, Montpellier University, France

Krzysztof Palczewski, Case Western Reserve University, USA
Structure of Rhodopsin

Gebhard F. X. Schertler, Paul Scherrer Institut, Switzerland
Structure of the Beta 1 Adrenergic Receptor: Progress in Obtaining Recombinant G Protein Coupled Receptor Structures

Martin Caffrey, University of Limerick, Ireland
Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases

Jonathan A. Javitch, Columbia University, USA
Dopamine D2 Receptors Form Higher Order Oligomers at Physiological Expression Levels

Jean-Louis Banères, CNRS - UMR5247 IBMM, France
Heterodimer Regulation of GPCR Activation

09:20—09:40
Coffee Break

INEC Conference Centre Foyer
11:15—13:00
Poster Setup

INEC Conference Centre Foyer
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:15
Intracellular Signaling
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Jonathan A. Javitch, Columbia University, USA

Xia Zhang, University of Ottawa, Canada
Role of PTEN and 5-HT2c Receptor Coupling in Drug Abuse

Lan Ma, Fudan University, China
Beta-Arrestin and Synaptic Plasticity

Joan Heller Brown, University of California, San Diego, USA
GPCR Regulation of Cell Proliferation

Brigitte L. Kieffer, Douglas Institute, Canada
A New Approach to Study GPCR Trafficking in vivo

19:15—20:15
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 1

INEC Conference Centre Foyer

TUESDAY, MAY 20

07:00—08:00
Breakfast

INEC Conference Centre Foyer
08:00—11:00
Interacting Proteins
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Joan Heller Brown, University of California, San Diego, USA

John J.G. Tesmer, University of Michigan, USA
Structural Analysis of an Ancient Pathway Linking Gq-Coupled Receptors to RhoA

Emiliana Borrelli, University of California, Irvine, USA
Specificity of Dopamine Mediated Signaling Differentially Directed by the Two D2 Receptor Isoforms

Taroh Iiri, University of Tokyo, Japan
Talk Title to be Determined

Zoe Jade Barclay, University of Edinburgh, UK
Short Talk: Evidence for the Formation of a Functional Signaling Complex of the 5-HT2A Receptor with ARF1 and PLD1 and its Disruption in an H452Y Polymorphic Variant of the Receptor

Dominique Massotte, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France

09:20—09:40
Coffee Break

INEC Conference Centre Foyer
11:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
Deorphanized GPCRs
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Olivier Civelli, University of California, Irvine, USA

Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Welcome Remarks

Stefan Offermanns, Universität Heidelberg, Germany
Nicotinic Acid Receptor - Pharmacological and Physiological Functions

Rainer K. Reinscheid, University of California, Irvine, USA
Neuropeptide S Modulates Arousal and Stress Responses

Hans Bräuner-Osborne, University of Copenhagen, Denmark
Basic Amino Acid Receptor GPRC6A Uncovered

Deborah Greene Nguyen, Organovo, USA
Short Talk: Utilizing High-Throughput Profiling to Identify Modulators of Novel GPCRs

19:00—20:00
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 2

INEC Conference Centre Foyer

WEDNESDAY, MAY 21

07:00—08:00
Breakfast

INEC Conference Centre Foyer
07:00—08:00
Poster Setup

INEC Conference Centre Foyer
08:00—11:15
GPCRs in Physiology 1
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Stefan Offermanns, Universität Heidelberg, Germany

Kenji Kangawa, National Cardiovascular Center Research Institute, Japan
Ghrelin: Physiological Significance and Therapeutic Potential for Cardiovascular Diseases

Mark J. Zoller, Senomyx, Inc., USA
Using Sweet and Umami Taste Receptors to Discover Taste Enhancers

William Henry Colledge, University of Cambridge, UK
GPR54 and Kisspeptins

Shuh Narumiya, Kyoto University, Japan
Physiology and Clinical Application of the Prostanoid Receptors

Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandin Receptors in Cardiovascular Disease

09:20—09:40
Coffee Break

INEC Conference Centre Foyer
11:15—12:00
Lunch

INEC Conference Centre Foyer
12:00—14:30
Poster Session 3

INEC Conference Centre Foyer
14:30—16:30
Workshop: Can Industry and Academic Scientists Cooperate to Facilitate Drug Discovery?

INEC Main Auditorium
* P. Jeffrey Conn, Vanderbilt University School of Medicine, USA
A Model for Early Stage Drug Discovery in an Academic Setting

Roy G. Smith, The Scripps Research Institute, USA
Growth Hormone Secretagogue Receptor

Gerard J. Marek, Abbott Laboratories, USA
Academic-Industry Collaborations: An Industry Perspective

Hugh Rosen, ActivX Biosciences, USA
Chemical Probes not Drugs from Academia

Bruce Posner, University of Texas Southwestern Medical Center, USA
The Pfizer-TSRI Collaboration: Partnering for Success in Early Lead Discovery

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
GPCRs in Physiology 2
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Brigitte L. Kieffer, Douglas Institute, Canada

Wylie W. Vale, The Salk Institute, USA
Corticotropin Releasing Factor Family of Ligands and their Receptors and Binding Protein

Gilbert Vassart, Université Libre de Bruxelles, Belgium
Constitutive Activity of Wild Type GPCRs: Physiological and Evolutionary Significance

Masayasu Kojima, Kurume University, Japan
Phenotypic Analysis of Ghrelin Knockout Mouse

Jean-Pierre Vilardaga, University of Pittsburgh, USA
Short Talk: Conformational Cross-Talk between GPCR Heterodimers Controls Cell Signaling

19:00
On Own for Dinner


THURSDAY, MAY 22

07:00—08:00
Breakfast

INEC Conference Centre Foyer
08:00—11:00
GPCRs in Preclinical Drug Programs
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Heidi E. Hamm, , USA

Hugh Rosen, ActivX Biosciences, USA
Under the Influence: S1P Receptor Therapeutics

Timothy W. Lovenberg, Johnson & Johnson Pharmaceutical Research and Development LLC, USA
Relaxin 3 and Insulin 5 as Unique GPCR Agonists: Pharmacology and Preclinical Challenges

Andrew D. Howard, Merck Research Laboratories, USA
GPCRs in Metabolism

Colleen Marie Niswender, Vanderbilt University, USA
Allosteric Modulation of mGluR4 as a Novel Therapeutic Direction for the Treatment of Parkinson's Disease

Katsutoshi Sasaki, Kyowa Hakko Kirin Co., Ltd., Japan
Short Talk: Reverse Chemical Genetics Approach Using a GPR4 Antagonist to Find a Novel Drug Candidate for Respiratory Diseases

09:20—09:40
Coffee Break

INEC Conference Centre Foyer
11:00
On Own for Lunch

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
Novel GPCR Drugs in the Clinic
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
Vincent Mutel, INFLAM ALPS, Switzerland
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Clinical Efficacy in Gastroesophageal Reflux Disease, Migraine and Acute Anticipatory Anxiety

* Gerard J. Marek, Abbott Laboratories, USA
Use of mGluR Allosteric Modulators in Schizophrenia

Madhu Chintala, Schering Plough Research Institute, USA
PAR1 Antagonist

Javier González-Maeso, Mount Sinai School of Medicine, USA
Short Talk: Identification of a Serotonin/Glutamate Receptor Complex Implicated in Psychosis

19:00—20:00
Social Hour with Lite Bites

INEC Conference Centre Foyer
20:00—23:00
Entertainment

INEC Conference Centre Foyer

FRIDAY, MAY 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13MH083445-01




We gratefully acknowledge additional support for this conference from:

Fáilte Ireland Merck & Co., Inc.
Pfizer Global Research & Development Science Foundation Ireland

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Addex Pharmaceuticals SA


Merck & Co., Inc.


Senomyx, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676