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This meeting took place in 2008



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Structural Genomics and its Applications to Chemistry, Biology and Medicine (J2)


Organizer(s) Ian A. Wilson, Janet M. Thornton and Kurt Wüthrich
January 6—11, 2008
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 11, 2007
Late Abstract Deadline: Oct 15, 2007
Scholarship Deadline: Sep 11, 2007
Early Registration Deadline: Nov 6, 2007

Supported by the Director's Fund


Summary of Meeting:
Structural genomics has already significantly advanced high throughput (HT) technologies, including automation and robotics, for cloning, expression, purification and determination of protein structures by crystallography and NMR. These methodologies are now being applied to the field of proteomics to accelerate our understanding of the ever expanding protein universe (fold and function) as a result of the explosion in gene sequencing and to tackle challenging targets, such as membrane proteins, macromolecular complexes and eukaryotic targets. This meeting will focus on current approaches in structural genomics and on how structural genomics tools can be applied to topical problems in structural, molecular, cell and chemical biology not only within large consortia, but also for single investigator laboratories and smaller scale projects. In this way, the enormous complexity presented by even single proteomes – such as human, mouse, as well as human pathogens – can be tackled so as to significantly impact chemical, biological and biomedical research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 6

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner/Storm Peak
* Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany

* Ian A. Wilson, The Scripps Research Institute, USA

Michael G. Rossmann, Purdue University, USA
Hybrid Structural Approaches: The Study of Viruses

Jeffrey I. Gordon, Washington University School of Medicine, USA
The Human Microbiome: Exploring the Microbial Side of Ourselves


MONDAY, JANUARY 7

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:15
Advances in Protein Production and Crystallization
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Aled M. Edwards, University of Toronto, Canada

Lance Stewart, Institute for Protein Design at University of Washington, USA
Synthetic Gene Design for Structural Proteomics

Yaeta Endo, Ehime University, Japan
Advances in the Cell-Free Protein Production for Protein Biology

Neil Isaacs, University of Glasgow, UK
Methods of Membrane Protein Production

Andrzej Joachimiak, Argonne National Laboratory, USA
Lessons Learned from High-throughput Protein Production

Ian A. Wilson, The Scripps Research Institute, USA
Can We Predict Which Proteins Will Crystallize


Following Session is for Frontiers of Structural Biology (J1)

08:00—11:00
Macromolecular Interactions
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Juli Feigon, University of California, Los Angeles, USA

Charalampos Kalodimos, Rutgers University, USA
Structural Basis for the Assembly of Large Protein Machineries Determined by NMR: The Sec Translocase Machinery

Keiichi Namba, Osaka University, Japan
Molecular Mechanisms of Self-Assembly and its Regulation of the Bacterial Flagellum

Erik R. P. Zuiderweg, University of Michigan, USA
The Allosteric States of Hsp70 Chaperones Visualized by NMR

Juha P. Himanen, Sloan-Kettering Institute, USA
Short Talk: Structural Studies on Eph Receptor-ephrin Recognition and Signaling

Mark D. Allen, Medical Research Council, UK
Short Talk: FtsK: gamma Domain and KOPS Recognition

Chun Tang, NIDDK, National Institutes of Health, USA
Short Talk: Visualizing Transient Low-Population Intermediates by Paramagnetic Relaxation Enhancement

09:20—09:40
Coffee Break

Foyer
11:15—12:00
Open Meeting of the Protein Structure Initiative (PSI)
Meeting has ended...abstracts no longer viewable online.

Sunshine
* John C. Norvell, NIGMS, National Institutes of Health, USA

12:00—13:00
Poster Setup

Rainbow/Twilight/Sunset/Skyline
13:00—22:00
Poster Viewing

Rainbow/Twilight/Sunset/Skyline
14:00—16:30
Workshop 1: Applications of Structural Genomics for Structural Biology

Sunshine
* Lance Stewart, Institute for Protein Design at University of Washington, USA

John Walchli, deCODE Biostructures, Inc., USA
Gene Composer: A Construct and Codon Engineering Tool for Synthetic Structural Biology

Martin Hammarström, Karolinska Institute, Sweden
The Use of Systematic N- and C-terminal Deletions to Promote Production and Structural Studies of Recombinant Proteins

Asli Ertekin, University of Massachusetts Medical School, USA
Using Mass Spectrometry-based Amide Hydrogen/Deuterium Exchange in Optimizing Protein Constructs for NMR Structure Determination

David C. Wood, Pfizer, St. Louis, USA
Parallel Protein Expression, Purification and Analysis for Structural Biology

David Cooper, Pfizer, USA
The SER Salvage Strategy

Heath E. Klock, Genomics Institute of the Novartis Research Foundation, USA
Salvage Pathways for Problematic Targets: Lessons Learned from Structural Genomics

Matthew D. Zimmerman, University of Virginia, USA
Efficient Experimental Design and Quantitative Analysis of Crystallization Experiments with the Xtaldb Expert System

Edward H. Snell, Hauptman Woodward Medical Research Institute, USA
Order from Chaos - the Design and Interpretation of High Throughput Crystallization Screens to Guide Optimization

Shohei Koide, New York University Langone Medical Center, USA
Protein Engineering Pipeline for Chaperone-Assisted Crystallography

Markus G. Grütter, University of Zurich, Switzerland
Technological Advances for Supramolecular Assemblies

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Pushing the Limits of Structural Biology I: Membrane Proteins (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner/Storm Peak
* Robert M. Stroud, University of California, San Francisco, USA

Wayne A. Hendrickson, Columbia University, USA
Ligand Stimulated Transitions in Nicotinic Acetylcholine Receptor á9

Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland
Solution NMR Spectroscopy in Membrane Protein Structural Genomics

Raymond C. Stevens, University of Southern California, USA
High Resolution Crystal Structures of the Human b2-Adrenergic Receptor and Implications in GPCR Biology and Drug Discovery

Tony Kossiakoff, University of Chicago, USA
Short Talk: Structures of Open and Closed Forms of Full-Length KcsA Channel Using Chaperone-Assisted Crystallography: Application to Solving the Structure of the Closed and Open Forms of KcsA

19:00—20:00
Social Hour

Rainbow/Twilight/Sunset/Skyline
19:30—22:00
Poster Session 1: Protein Prediction, Structure Determination and Methods

Rainbow/Twilight/Sunset/Skyline

TUESDAY, JANUARY 8

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
Advances in X-ray and NMR Structure Determination. Session Supported in part by Bruker BioSpin Corp. and Bruker AXS Inc.
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland

Masatsune Kainosho, Nagoya University, Japan
Stereo-Array Isotope Labeling (SAIL) for NMR

Michael Nilges, Institut Pasteur, France
New Calculation Protocols for Analyzing NOE Data: Solid State NMR, Synmetric Multimers and Inconsistent Data

Victor S. Lamzin, BIOXHIT, Germany
A Highly Integrated Platform for Structural Biology and Advances in Ligand Fitting

John A. Tainer, The Scripps Research Institute, USA
Short Talk: X-ray Solution Scattering (SAXS) Combined with Crystallography and Computation: Defining Accurate Dynamic Macromolecular Assemblies in Solution

David Baker, University of Washington, USA
Structure Determination and Refinement from Limited Experimental Data Using Rosetta


Following Session is for Frontiers of Structural Biology (J1)

08:00—11:00
Macromolecular Dynamics: Experiment and Theory
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Gerhard Wagner, Harvard Medical School, USA

Klaus J. Schulten, University of Illinois at Urbana-Champaign, USA
The Computational Microscope: Multiscale Modeling of Cellular Systems

Michele Vendruscolo, University of Cambridge, UK
Simultaneous Determination of Protein Structure and Dynamics

Dorothee Kern, Brandeis University, HHMI, USA
A Hierarchy of Space and Time in Protein Dynamics - Linkage to Catalysis and Signaling

Peter E. Wright, The Scripps Research Institute, USA
The Dynamic Energy Landscape of DHFR Catalysis

A. Joshua Wand, University of Pennsylvania, USA
Short Talk: Using Dynamics as a Proxy for Entropy: Applications of NMR Relaxation to Studies of the Origin of High Affinity Association by Calmodulin

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Sunset/Skyline
13:00—22:00
Poster Viewing

Rainbow/Twilight/Sunset/Skyline
14:00—16:30
Workshop 2: Advances in Methodologies/Tools for Structural Genomics and Structural Biology
Focusing on hardware, software, devices and databases.

Sunshine
* Andrzej Joachimiak, Argonne National Laboratory, USA

Cory J. Gerdts, Protein BioSolutions, USA
The Microfluidic Protein Crystallization System (MPCS)

Andy May, Chan Zuckerberg Biohub, USA
Diffraction-Capable Microfluidic Crystallization Chips for Screening and Structure Determination

Stephen R. Wasserman, SGX Pharmaceuticals, Inc, USA
The Integration of Rapid Synchrotron-based X-ray Crystallography into Structural Genomics and Drug Development: The SGX-CAT Beamline at the Advanced Photon Source

Wuxian Shi, Brookhaven National Laboratory, USA
Metalloproteomics - High Throughput Metal Analysis of Proteins

Wladek Minor, University of Virginia, USA
HKL-3000 - Towards the Future of Protein Crystallography

Dušan Turk, Jozef Stefan Institute, Slovenia
MAIN Entering 2008: Real Space Model Fitting – As Good As It Gets

George N. Phillips, Jr., University of Wisconsin, CESG, USA
Map Interpretation and Ensemble Refinements

Ashley M. Deacon, Stanford Synchrotron Radiation Laboratory, USA
Maintaining High Quality Structure Depositions at JCSG

Thomas Andrew Binkowski, Argonne National Laboratory, USA
Comparison and Analysis of Protein Functional Surfaces

Subramanian Sri Krishna, Sanford-Burnham Medical Research Institute, USA
TOPSAN: A Community-driven Protein Knowledgebase for Structural Genomics

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Ligands as Probes for Function
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Stephen K. Burley, Rutgers University, USA

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Metabolomics and its Role in Enzyme Function Assignment

Janet M. Thornton, European Bioinformatics Institute, UK
Diversity of Ligands within Protein Families

Aled M. Edwards, University of Toronto, Canada
Screening for Function

Chang-Yub Kim, Los Alamos National Laboratory, USA
Short Talk: Development of a High-Throughput Ligand Screening Technique and Application to Structural Genomics

Maurizio Pellecchia, University of California, Riverside, USA
Short Talk: Targeting Apoptosis by Chemical Design: NMR Guided Reverse Chemical Genetics and Drug Discovery


Following Session is for Frontiers of Structural Biology (J1)

17:00—19:15
Membrane Protein Structure
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner/Storm Peak
* Alasdair C. Steven, NIAMS, National Institutes of Health, USA

Carola Hunte, University of Leeds, UK
Cytochrome c Binding to the Cytochrome bc1 Complex: An Interaction Critical for Electron Transfer

James Jeiwen Chou, Harvard Medical School, USA
Structure and Mechanism of the M2 Proton Channel of Influenza A Virus

William I. Weis, Stanford University, USA
Two Crystal Structures of the b2-Adrenergic Receptor

Lukas K. Tamm, University of Virginia, USA
Short Talk: Solution NMR Structure of the 33 kDa Outer Membrane Protein G

Daniel Martinez Molina, Karolinska Institutet, Sweden
Short Talk: Structure and Mechanism of Human Leukotriene C4 Synthase

19:15—20:15
Social Hour with Lite Bites

Rainbow/Twilight/Sunset/Skyline
19:30—22:00
Poster Session 2: Macromolecular Structure and Function

Rainbow/Twilight/Sunset/Skyline

WEDNESDAY, JANUARY 9

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
Exploiting the Expanding Protein Universe
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Andrej Sali, University of California, San Francisco, USA

Jo Handelsman, Yale University, USA
Structure and Function of Microbial Communities

Robert M. Stroud, University of California, San Francisco, USA
Membrane Proteomics

John Moult, University of Maryland Biotechnology Institute, USA
Expanding Structure Coverage of the Protein Universe with Comparative Modeling

Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
Short Talk: Harnessing Knowledge from Structural Genomics: the PSI Knowledgebase

Gaetano Thomas Montelione, Rutgers University, USA
Short Talk: Structural Genomics Provides Novel Hypotheses for Biology


Following Session is for Frontiers of Structural Biology (J1)

08:00—11:00
Protein – Nucleic Acid Interactions
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA

Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Molecular Recognition in Splicing Regulation

Juli Feigon, University of California, Los Angeles, USA
Structure and Function of Human Telomerase and H/ACA RNA

Eric Enemark, Cold Spring Harbor Laboratory, USA
Mechanism of DNA Translocation in a Replicative Hexameric Helicase

Elena Conti, Max Planck Institute of Biochemistry, Germany
The Exon Junction Complex and mRNA Qualitry Control

Marianna Teplova, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Recognition of the pre-mRNA GC and GCU Elements by Tandem Zinc Finger Domains of Muscleblind Protein MBNL1

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:30
Pushing the Limits of Structural Biology II: Advances in Methodologies for Structure Determination (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner/Storm Peak
* Wayne A. Hendrickson, Columbia University, USA

Hartmut Oschkinat, FMP Berlin, Germany
Solid State NMR Methods for Protein Structure Determination

Gerhard Wagner, Harvard Medical School, USA
Protein Complexes that Regulate Polypeptide Synthesis

Carolyn A. Larabell, University of California, San Francisco, USA
X-ray Tomography of Whole Cells at 50 nm Resolution

Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Mapping Molecular Landscapes Inside Cells by Cryoelectron Tomography

Andreas Hoenger, University of Colorado, Boulder, USA
Short Talk: PEET (Particle Estimation for Electron Tomography: A New Software Package for 3D Alignment and Averaging of Volume

19:30—20:30
Social Hour with Lite Bites

Rainbow/Twilight/Sunset/Skyline
20:00—22:00
Workshop on World-Wide Structural Genomic and Structural Proteomic Centers
Structural genomic, structural proteomic and protein production centers and consortia present their platforms to highlight new methods, technologies, databases, and computational tools that have enabled advances in protein production and structure determination for all classes of targets from bacterial to challenging macromolecules , such as membrane proteins, eukaryotic proteins and protein-protein complexes. An emphasis will be placed on what can now be utilized by the entire community, including single investigator laboratories to increase success and throughput and lower costs.

Sunshine

THURSDAY, JANUARY 10

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:15
Proteomics and Protein Assemblies/Networks
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Janet M. Thornton, European Bioinformatics Institute, UK

Andrej Sali, University of California, San Francisco, USA
Modeling the Structures of Macromolecular Assemblies

David Eisenberg, University of California, Los Angeles, USA
Protein Assemblies in Health and Disease

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
On the Characterization of Protein Complexes and Protein Interaction Networks

Adam Godzik, Sanford-Burnham Medical Research Institute, USA
Metabolic Reconstruction of Thermatoga Maritima

Alexander B. Sigalov, SignaBlok, Inc., USA
Short Talk: Homointeractions between Intrinsically Disordered Proteins: Unusual Structural Features and a Role in Immune Signaling

Akira Nozawa, Ehime University, Japan
Short Talk: A Cell-free System-based Method for Comprehensive Analysis of DNA Binding to Human Hormone Nuclear Receptors by Fluorescence Correlation Spectroscopy


Following Session is for Frontiers of Structural Biology (J1)

08:00—11:00
Large Macromolecular Complexes
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Elena Conti, Max Planck Institute of Biochemistry, Germany

Nenad Ban, ETH Zürich, Switzerland
Springs, Tethers and Switchblades: Mechanistic Insights into the Functioning of Large Macromolecular Assemblies Involed in Protein and Fatty Acid Synthesis

Carol V. Robinson, University of Oxford, UK
Mass Spectrometry and the Determination of Complex Architecture

Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK
Structure of the 70A Ribosome

Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
RNA Structure and Activities of the Eukaryotic RNA Exosome

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Exploiting Structure for Function
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Gaetano Thomas Montelione, Rutgers University, USA

Stephen K. Burley, Rutgers University, USA
Structural Genomics of Protein Phosphatases

Stefan Knapp, University of Oxford, UK
The Protein Kinase Family

Christine A. Orengo, University College London, UK
Short Talk: Structural Genomics to Explore the Evolution of Protein Function

Peter Kuhn, The Scripps Research Institute, USA
Proteomic Analysis of nsp3, a Multifunctional 1922 Amino Acid Polypeptide in SARS CoV


Following Session is for Frontiers of Structural Biology (J1)

17:00—19:00
Virus Structure and Assembly
Meeting has ended...abstracts no longer viewable online.

Mt. Werner/Storm Peak
* Michael G. Rossmann, Purdue University, USA

David I. Stuart, Oxford University, UK
The Virosphere - Insights from the Analysis of Complex Viruses

Alasdair C. Steven, NIAMS, National Institutes of Health, USA
Beyond Determinism: Coming to Terms with Variability in Virus Structures

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Studies of Large RNAs Involved in Retroviral Genome Packaging

20:00—21:00
Social Hour with Lite Bites

Foyer
21:00—23:00
Entertainment

Sunshine

FRIDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM081951-01




We gratefully acknowledge additional support for this conference from:

Bruker BioSpin Corp. deCODE chemistry & biostructures
Emerald BioSystems, Inc. Structural Genomics Consortium
Varian, Inc.
ISOTEC, a member of the Sigma-Aldrich Group

New Era Enterprises, Inc.

 

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Phone:+1 970-262-2690

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