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This meeting took place in 2008



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Cancer Genomics and Epigenomics (C1)


Organizer(s) Andrew P. Feinberg, Greg J. Hannon and Rolf Ohlsson
February 19—24, 2008
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 19, 2007
Late Abstract Deadline: Nov 19, 2007
Scholarship Deadline: Oct 19, 2007
Early Registration Deadline: Dec 19, 2007

Supported by the Director's Fund

Summary of Meeting:
In the “post-genome” era, in which the human DNA sequence is available, as are those of many animal models, cancer genetics is being transformed both by the access to this sequence and by the technology that the genome project facilitated. It is now clear that many genetic changes occur in tumors, including mutations and copy number changes, as well as an even larger number of epigenetic alterations, such as altered DNA methylation, chromatin modification, and loss of genomic imprinting. High-throughput genomic and epigenomic approaches are now available, but are also being developed to assess the scope of these genomic/epigenomic changes. There is also a deeper evolution of our understanding that the genome and epigenome may be intrinsically disrupted in tumors, for example by palindrome formation and whole-band methylation. These advances raise several major questions, including: • Which genetic and epigenetic changes play a causal role in tumor initiation and progression? • What is the genetic and epigenetic basis of cancer predisposition? • Is there large scale disruption of the cancer genome and epigenome and how does this arise? • And how can we exploit advances in cancer genomics and epigenomics? • What are the cutting edge technologies that will advance the sensitivity of detection of subpopulations such as cancer stem cells? This symposium will explore the technological developments, large scale alterations, and gene-specific changes emerging in the genome-wide approach to cancer, as well as the implications of these discoveries for cancer prevention and therapy.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 19

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA

Janet D. Rowley, University of Chicago, USA
The Hidden Side of Leukemia Gene Expression


WEDNESDAY, FEBRUARY 20

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
High Throughput Genome, Epigenome, and Cell Biology Approaches (Technology)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Stephan Beck, University College London, UK
High-Throughput Approaches for DNA Methylation Profiling

John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences and University of Washington, USA
High Throughput Chromatin Analysis

* Rolf Ohlsson, Karolinska Institute, Sweden
Chromosomal Networks: New Perspectives of Cancer Epigenomics

Jeffrey A. Jeddeloh, Roche NimbleGen, USA
Short Talk: Sequence Capture: A Microarray Strategy for Genomic Selection Coupled to High-Throughput Sequencing Facilitates Genetic and Epigenetic Characterization upon Individual Alleles

Christoph Bock, Austrian Academy of Sciences, Austria
Short Talk: Powerful and User-Friendly Bioinformatic Methods for Cancer Epigenomics

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
High Throughput Sequencing of the Tumor Genome
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Richard Myers, Stanford University School of Medicine, USA

Matthew L. Meyerson, Dana-Farber Cancer Institute, USA
Genomic Alterations in Human Cancers

Aleksandar Milosavljevic, Baylor College of Medicine, USA
Short-Read Sequencing Applications

Heidi Greulich, Dana-Farber Cancer Institute, USA
Cancer Genome Sequencing

18:45—19:00
Open Discussion of Sequencing Methods
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Chromosome Abnormalities
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Donna G. Albertson, University of California, San Francisco, USA
Causes and Consequences of Genomic Instability in Cancer

Michael H. Wigler, Cold Spring Harbor Laboratory, USA
Variation in Gene Copy Number and Methylation in Human Cancer

Scott J. Diede, Fred Hutchinson Cancer Research Center, USA
DNA Palindrome Formation is Nonrandomly Distributed and Associated with Gene Amplification in Cancer

Shinya Toyokuni, Kyoto University Graduate School of Medicine, Japan
Short Talk: Chronic Oxidative Stress as a Cause of Genomic Amplification

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Integrative Genomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Edison T. Liu, The Jackson Laboratory, USA
Systems Integration in Genomic Medicine

* Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Lessons Learned from Pervasive Transcription: Possible Reasons and Mechanisms

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 22

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:30
Chromatin
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Peter Fraser, Florida State University, USA
Transcription and Genome Organization

* Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
Large Scale Chromosomal Interactions at the c-Myc Locus Regulated by SATB1

Bradley E. Bernstein, Massachusetts General Hospital, USA
Sequencing the Mammalian Epigenome

Agate Noer, University of Oslo, Norway
Short Talk: Modifications of Histone H3 Associated with Senescence and Differentiation of Human Adipose Stem Cells

Melissa J. Fullwood, Cancer Science Institute, Singapore
Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag Sequencing

Anderly C. Chueh, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Defining Neocentromere Identity: Role of L1 Retroelements in the Epigenetic Formation of Ectopic Centromere Chromatin

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
RNA and Functional Screening
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gregory J. Hannon, University of Cambridge, UK
Focal Re-Seqencing: A Comparison of Capture Platforms

Yaniv Erlich, Cold Spring Harbor Laboratory, USA
Short Talk: Improving Solexa Base Calling

René Bernards, Netherlands Cancer Institute, Netherlands
Biomarkers of Resistance to Cancer Therapy Discovered Through Functional Genetic Screens.

Lili Milani, University of Tartu, Estonia
Short Talk: Allele-Specific Analysis of Gene Expression in Childhood Acute Leukemia by Genome Wide SNP Genotyping

Sohail F. Tavazoie, Rockefeller University, USA
Short Talk: Endogenous Human MicroRNAs that Suppress Breast Cancer Metastasis

Milan G. Chheda, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: High Throughput RNAi Screen to Identify Genes Required for Stem Cell Phenotype of Glioblastoma Tumor Initiating Cells

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2

SATURDAY, FEBRUARY 23

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:30
Epigenomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetics and Epigenomics of Cancer Etiology

Tim H.-M. Huang, Ohio State University, USA
Finding and Defining Causes of Epigenetic Gene Silencing in Cancer

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Epigenetically Defined Heterogeneity in Normal and Neoplastic Breast Epithelium

Susan J. Clark, Garvan Institute of Medical Research, Australia
DNA Methylation Clusters

Alayne L. Brown, Stanford University, USA
Short Talk: Genome-Wide DNA Methylation Profiling of DNMT-Mutant Cells

Peter L. Molloy, CSIRO, Australia
Short Talk: Hypomethylation of Different Repeat Families in Colorectal Cancer

Kevin L. Gunderson, Illumina, Inc., USA
Short Talk: Infinium® Methylation Profiling of over 27,000 CpG Sites from CCDS Gene Promoters

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Translational Genomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Siavash K. Kurdistani, University of California, Los Angeles, USA
Epigenetic Reprogramming for Oncogenic Transformation

* Tomas Ekström, Karolinska Institutet, Sweden
Human Cytomegalovirus and its Association with Epigenetic Alterations

Jesse S. Boehm, Broad Institute, USA
Short Talk: Integrating Functional and Structural Cancer Genomics to Identify Drug Targets

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA132471-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Affymetrix, Inc.


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