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This meeting took place in 2008



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Signaling Pathways in Cancer and Development (C6)


Organizer(s) Juan Carlos Izpis├║a Belmonte and Geoffrey M. Wahl
March 24—29, 2008
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 26, 2007
Late Abstract Deadline: Dec 26, 2007
Scholarship Deadline: Nov 26, 2007
Early Registration Deadline: Jan 25, 2008

Supported by the Director's Fund

Summary of Meeting:
Our views of how cancer arises are changing dramatically. While cancer was originally thought to be a cell autonomous process, we now realize that cancers comprise aberrant organs, in which cell:cell, and cell:matrix interactions are critical. Furthermore, it now seems likely that not all cells within a tumor mass are, in fact, tumorigenic. Rather, specialized cells, that resemble tissue stem cells in some of their properties, may be responsible for tumor formation. Finally, the signaling pathways involved in normal development and in cancer have long been known to be similar. Studies over the past several years have given insight into how these pathways work, and how they can be manipulated for therapeutic benefit. Given all these links between cancer formation and development, and the potential applications to new treatment strategies, this conference has been developed to link these two important, rapidly evolving, and exciting areas.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 24

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Hans C. Clevers, Hubrecht Institute, Netherlands
The Wnt Target Gene Lgr5, a Marker for Adult Stem Cells in Multiple Tissues


TUESDAY, MARCH 25

07:00—08:00
Breakfast

Sunshine/Rainbow/Twilight
08:00—11:00
Enabling Technologies and Treatment
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Generation of iPS Cells from Adult Human Fibroblasts

Angel Raya, Center of Regenerative Medicine, Spain
Generation of Patient-Specific iPS Cells

Marius Wernig, Stanford University, USA
Short Talk: Direct Reprogramming of Mouse Fibroblasts and Therapeutic Applicability

Christopher L. Murriel, OncoMed Pharmaceuticals, Inc., USA
Short Talk: The use of a Dual Function Single Lentiviral Vector System for Cre/Lox Mediated Gene Recombination and Inducible Gene Silencing in vivo

Gerald M. Pao, The Salk Institute, USA
Short Talk: Use of Lentiviral Vectors in Human Stem Cell Biology

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—18:50
Wnt Signaling in Development and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Elaine V. Fuchs, HHMI/Rockefeller University, USA
Wnt Signaling, Stem Cell Activation and Cancer in Skin

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling during Development and Tissue Regeneration

Randall T. Moon, University of Washington School of Medicine, USA
Wnt Signaling during Development and Cancer

18:50—19:30
Stem Cells: A Potential Common Link Between Development and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

19:30—20:30
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 1

Sunshine

WEDNESDAY, MARCH 26

07:00—08:00
Breakfast

Sunshine/Rainbow/Twilight
08:00—11:00
Adult Stem Cells
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Fiona M. Watt, King's College London School of Medicine, UK
Epidermal Stem Cells and Cancer

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Genetic Interaction between PGE2 and Wnt Signaling in Stem Cell Formation and Organ Regeneration

Connie J. Eaves, British Columbia Cancer Agency, Canada
Mammary Epithelial Stem Cells

Helen M. Blau, Stanford University, USA
Adult Stem Cell Behavior In Bioengineered Niches

Hao Chang, University of Texas M. D. Anderson Cancer Center, USA
Short Talk: Misregulated beta-catenin signaling causes Sertoli cell tumor development

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Proliferation, Aging and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Margaret T. Fuller, Stanford University, USA
Regulation of Proliferation and Differentiation in Adult Stem Cell Lineages

Leanne Jones, University of California, Los Angeles, USA
Aging-Related Changes to Stem Cells and the Stem Cell Niche

Brigid L. M. Hogan, Duke University Medical Center, USA
Stem/Progenitor Cells in Lung Development, Homeostasis, and Repair

Ignacio Flores, Spanish National Cancer Research Centre (CNIO), Spain
Telomerase Regulation and Stem Cell Behavior

Tatjana Piotrowski, Stowers Institute for Medical Research, USA
Short Talk: Interactions between beta-Catenin and Fgf Signaling Regulate Directional Migration of Groups of Cells

19:15—20:15
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 2

Sunshine

THURSDAY, MARCH 27

07:00—08:00
Breakfast

Sunshine/Rainbow/Twilight
08:00—10:50
Organogenesis and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Catriona H.M. Jamieson, University of California, San Diego, USA
The Molecular Evolution of Leukemia Stem Cells

Frank McKeon, The Jackson Laboratory for Genomic Medicine and Genome Institute of Singapore, USA
TAp63 and the Female Germline

Bruce A. Edgar, German Cancer Research Center, Germany
Homeostatic Growth Mediated by Intestinal Stem Cells in Adult Drosophila

Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA
The Hippo Signaling Pathway in Organ Size-Control and Cancer

Nicolas Di-Poi, University of Geneva, Switzerland
Short Talk: Distinct Roles for Hoxd Genes in Metanephric Kidney Development

10:50—11:30
Enabling Technologies and Treatment
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Title to be Determined

09:20—09:40
Coffee Break

Foyer
11:30—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Hedgehog Signaling in Development and Cancer
Meeting has ended...abstracts no longer viewable online.

Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling during Cancer Growth

* Matthew P. Scott, Stanford University, USA
Communicating with Hedgehogs

Norbert Perrimon, Harvard Medical School, USA
Genetic Analysis of Growth and Homeostasis

William Matsui, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, USA
Short Talk: Hedgehog Signaling, Self-Renewal and Cancer Stem Cells

Uda Ho, Queensland Institute of Medical Research, Australia
Short Talk: Hedgehog Signaling in Lung Development

19:15—20:15
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 3

Sunshine

FRIDAY, MARCH 28

07:00—08:00
Breakfast

Sunshine/Rainbow/Twilight
08:00—11:00
Stem Cell Renewal Mechanisms
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Austin Smith, University of Cambridge, UK
The Ground State of Pluripotency

Sheng Ding, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
A Chemical Approach to Pluripotency and Reprogramming

Kathrin Plath, University of California, Los Angeles, USA
In vitro Reprogramming of Human and Murine Somatic Cells to an Embryonic State

Konrad Hochedlinger, Massachusetts General Hospital, USA
Global Epigenetic Reprogramming by Defined Transcription Factors

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Ronin Is Essential for Embryogenesis and the Pluri-Potency of Mouse ES Cells and Acts Independently of Canonical Pathways

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Stem Cells: A Potential Common Link Between Development and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
The Loss of Nf1 Transiently Promotes Self-Renewal but not Tumorigenesis by Neural Crest Stem Cells

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of Pro-survival Bcl-2 Family Members in Tumour Development and Sustaining Tumour Growth

Maikel Peppelenbosch, Erasmus Medical Center, Netherlands

Louis Vermeulen, CEMM, Netherlands
Short Talk: Single Cell Cloning of Colon Cancer Stem Cells Reveals Multi-Lineage Differentiation Capacity

19:00—20:00
Social Hour with Lite Bites

Sunshine
20:00—23:00
Entertainment

Sunshine

SATURDAY, MARCH 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Genentech, Inc.
Merck & Co., Inc.
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676