Swissotel The Stamford Floorplan

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This meeting took place in 2008



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Stem Cells, Cancer and Aging (S3)


Organizer(s) Sir David P. Lane, Hans C. Clevers, Arnold J. Levine and Xin Lu
September 29—October 4, 2008
Swissotel The Stamford • Singapore, Singapore
Abstract Deadline: May 29, 2008
Late Abstract Deadline: Jun 30, 2008
Scholarship Deadline: Jun 12, 2008
Early Registration Deadline: Jul 29, 2008

In collaboration with Agency for Science, Technology and Research (A*STAR) and held in conjunction with the International Society of Differentiation. Sponsored by Lilly Singapore Centre for Drug Discovery.

Summary of Meeting:
Recent studies on the effect of polymorphisms in human tumor suppressor pathways on cancer incidence and longevity have confirmed long held views of the link between the key processes that control human aging and cancer incidence. One interpretation of these findings is that the stem cell is the key target for carcinogenesis. Further, the thresholds that regulate stem cell death in response to damage make the bargain between too-resilient stem cells, which result in long life but increased cancer risk, and too-sensitive stem cells, which ablate the occurrence of cancer but can shorten life span through stem cell exhaustion. Dramatic progress in the understanding of signaling pathways and points of intervention which will be debated in this meeting offers the enticing prospect of regulating these pathways to extend healthy lifespan and reduce cancer incidence in the human population.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, SEPTEMBER 29

15:00—19:00
Registration and Sign-Up for Biopolis Tours

Stamford Foyer

TUESDAY, SEPTEMBER 30

07:00—08:00
Breakfast

Canning
07:00—12:00
Poster Setup

Stamford Foyer
08:00—08:15
Welcoming Remarks

Stamford Ballroom
Lim Chuan Poh, A*STAR, Singapore

08:15—08:30
Opening Remarks

Stamford Ballroom
David P. Lane, Experimental Therapeutic Centre, Singapore

Hans C. Clevers, Hubrecht Institute, Netherlands

08:30—12:00
Models of Aging
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* David P. Lane, Experimental Therapeutic Centre, Singapore

Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair and the Connection between Cancer and Aging

Lawrence A. Donehower, Baylor College of Medicine, USA
Insights into Stem Cells and Aging Provided by A P53 Mutant Mouse

Heidi Scrable, Mayo Clinic, USA
p53 and IGF: An Ancient Connection

Mary Ellen Perry, DPCPSI, OD, National Institutes of Health, USA
p53 and Aging in Experimental Animals

09:40—10:00
Coffee Break

Stamford Foyer
12:00—13:00
Lunch

Canning
13:00—14:00
ISD Award Lecture: Anne McLaren Memorial Lecturer
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Hans C. Clevers, Hubrecht Institute, Netherlands

Magdalena Zernicka-Goetz, University of Cambridge, UK
Cell Fate, Plasticity and Pluripotency in the Early Mouse embryo

14:00—14:30
Coffee Available

Stamford Foyer
14:30—16:00
Regulating Tumor Suppression
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Hans C. Clevers, Hubrecht Institute, Netherlands

Gerard I. Evan, University of Cambridge, UK
Switchable Tumor Suppression Models to Control Cancer and Aging

Alea A. Mills, Cold Spring Harbor Laboratory, USA
p63 Deficiency and Aging

16:00—18:00
Poster Session 1

Stamford Foyer
17:00—18:00
Social Hour

Stamford Foyer

WEDNESDAY, OCTOBER 1

07:00—08:00
Breakfast

Canning
07:00—12:00
Poster Setup

Stamford Foyer
08:00—11:30
Signaling Pathways in Cancer and Development
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore

Hans C. Clevers, Hubrecht Institute, Netherlands
Identification of Stem Cells in Small Intestine and Colon by a Single Marker Gene LGR5

Yoshiaki Ito, Cancer Science Institute of Singapore, National University of Singapore, Singapore
RUNX3, a Novel Gate Keeper of Colon Carcinogenesis

Vinay B. Tergaonkar, Institute of Molecular and Cell Biology, Singapore
New Controls of the NF-kappa B Pathway

Michael Karin, University of California, San Diego, USA
Inflammatory Processes in Metastatic Progression

09:40—10:00
Coffee Break

Stamford Foyer
11:30—12:30
Lunch

Canning
12:30—14:30
Poster Session 2

Stamford Foyer
14:00—14:30
Coffee Available

Stamford Foyer
14:30—16:30
Counting Stem Cells
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Gerard I. Evan, University of Cambridge, UK

Connie J. Eaves, British Columbia Cancer Agency, Canada
Title to be Determined

Andrei V. Gudkov, Roswell Park Cancer Institute, USA
Saving Stem Cells to Survive Radiation

Hongyan Wang, Duke NUS-Graduate Medical School Singapore, Singapore
Short Talk: Brain Tumor Suppressors and Neural Stem Cell Self-Renewal in Drosophila


THURSDAY, OCTOBER 2

07:00—08:00
Breakfast

Canning
07:00—12:00
Poster Setup

Stamford Foyer
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore

Arnold J. Levine, Institute for Advanced Study, USA
Single Nucleotide Polymorphisms in the p53 Pathway

09:00—11:30
New Models to Find Novel Cancer and Aging Pathways
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Arnold J. Levine, Institute for Advanced Study, USA

Xin Lu, Ludwig Institute for Cancer Research, UK
ASPP2 Mediates Senescence and Inhibits Autophagy and Tumourgenicity Induced by H-RasV12

Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore
Harnessing Transposons for Cancer Gene Discovery

Edison T. Liu, The Jackson Laboratory, USA
Comprehensive Identification of Genomic Rearrangements in Human Cancer

09:00—09:20
Coffee Break

Stamford Foyer
11:30—12:30
Lunch

Canning
12:30—14:30
Poster Session 3

Stamford Foyer
14:00—14:30
Coffee Available

Stamford Foyer
14:30—16:30
New Targets and Therapeutic Approaches to Cancer and Aging
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
* Xin Lu, Ludwig Institute for Cancer Research, UK

Gregory L. Verdine, Harvard University, USA
Drugging “Undruggable” Targets in Cancer

David P. Lane, Experimental Therapeutic Centre, Singapore
Small Molecule Switches to Control p53 Activity

Axel Ullrich, Max Planck Institute of Biochemistry, Germany
The Singapore OncoGenome Project as Part of an Effort to Develop a Portfolio of Targeted Cancer Therapeutics


FRIDAY, OCTOBER 3

07:00—08:00
Breakfast

Canning
07:30—08:30
Transfer to Biopolis

08:30—10:30
Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.

Biopolis
* Xin Lu, Ludwig Institute for Cancer Research, UK

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Cancer Stem Cells in the Hematopoietic System

Colin L. Stewart, Institute of Medical Biology, Singapore
The Lamins and the Functional Architecture of the Nucleus in Disease and Aging

Daniel G. Tenen, Cancer Science Institute, Singapore
Transcription Factor C/EBP alpha Regulates Hematopoietic Stem Cell Proliferation and Maintenance during Aging

10:30—11:00
Coffee Break

Biopolis Foyer
11:00—12:00
ISD Award Lecture: Jean Brachet Memorial Lecturer
Meeting has ended...abstracts no longer viewable online.

Biopolis
* Hans C. Clevers, Hubrecht Institute, Netherlands

Giulio Cossu, Stem Cell Research Institute, Italy
Towards Cell Therapy for Muscular Dystrophies

12:00—13:00
Lunch Catered by Biopolis

Biopolis
12:30—14:00
Optional Tour of Biopolis

12:30—14:00
Transfer to Hotel

14:30—15:00
Coffee Available

Stamford Foyer
15:00—16:45
More Adult Stem Cells in the Self-Renewing Tissues
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
Davor Solter, Institute of Medical Biology, Singapore
Preformation Versus Epigenesis in Driving Mammalian Development

Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore
Potentiality of Mammary Epithelial Cells with a Basal Phenotype

16:45—17:00
Meeting Sum Up
Meeting has ended...abstracts no longer viewable online.

Stamford Ballroom
Xin Lu, Ludwig Institute for Cancer Research, UK

Arnold J. Levine, Institute for Advanced Study, USA

17:00—18:00
Social Hour

Stamford Foyer

SATURDAY, OCTOBER 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Agency for Science, Technology and Research (A*STAR) Cell Signaling Technology, Inc.
International Society of Differentiation Isis Pharmaceuticals, Inc.
Lilly Singapore Centre for Drug Discovery Singapore Tourism Board

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