Fairmont Banff Springs Floorplan

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This meeting took place in 2008



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Molecular Control of Adipogenesis and Obesity (X3)


Organizer(s) Ormond A. MacDougald and Evan D. Rosen
February 19—24, 2008
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 22, 2007
Late Abstract Deadline: Nov 20, 2007
Scholarship Deadline: Oct 22, 2007
Early Registration Deadline: Dec 19, 2007

Supported by the Director's Fund


Summary of Meeting:
The worldwide epidemic in obesity has brought with it dramatic increases in the prevalence of co-morbid, chronic conditions including insulin resistance and type 2 diabetes. To further our understanding of the molecular control of adipogenesis and obesity, this meeting will focus on several rapidly developing and important areas. These include novel transcriptional regulators of adipogenesis, the adipocyte lipid droplet as an organelle, mechanisms of insulin-resistance, relationships between white adipocytes and alternative mesenchymal cell fates, and genetic contributions to energy balance in humans and model organisms. Cutting edge research in these areas will improve our understanding of mechanisms by which precursor cells develop into adipocytes, and how excess adipose tissue leads to diseases such as diabetes. Our goal is to attract researchers from around the world to participate in an interactive meeting on these physiological and pathological aspects of adipose tissue biology.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 19

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Michael W. Schwartz, University of Washington, USA
and

* Ormond A. MacDougald, University of Michigan, USA
Opening Remarks

Charles S. Zuker, HHMI, Columbia University, USA
The Emerging Biology of Taste Perception

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Genome Screens for Fat Storage Genes in C. elegans


WEDNESDAY, FEBRUARY 20

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:15
Interactions between Brain and Periphery I (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Stephen O'Rahilly, University of Cambridge, UK

Masato Kasuga, National Center for Global Health and Medicine, Japan
Role of IL-6/STAT3 in Insulin Action

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown Fat Determination by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors

Nadine Cybulski, Biozentrum, University of Basel, Switzerland
and

Pazit Polak, Biozentrum, University of Basel, Switzerland
Short Talk: mTOR Signaling in Adipose Tissue Controls Body Metabolism

Jeffrey M. Friedman, Rockefeller University, USA
Neuronal Integration of Humoral Signals Controlling Energy Balance

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS Proteins, Metabolism and Longevity

Su Gao, , USA
Short Talk: The Role of Malonyl-CoA and Long-chain Fatty Acyl-CoA in Mediating Leptin’s Anorectic Signaling in Specific Hypothalamic Nuclei

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15—13:00
Poster Setup

New Brunswick, Alberta, Cascade
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Hot Topics Workshop: CNS Control of Lipids and New Insights into Hindbrain Regulation of Energy Blance

Van Horne Ballroom C
Claudia Pascalle Coomans, Leiden University Medical Center, Netherlands
Brain Insulin Promotes Fat Storage in White Adipose Tissue

John M. Stafford, Vanderbilt University, USA
CNS Neuropeptide Y Signaling Modulates VLDL-TG Production

Roger Gutiérrez-Juárez, Albert Einstein College Of Medicine, USA
The Hypothalamic Sensing of Leucine Regulates Plasma Triglycerides

Allyn L. Mark, University of Iowa, USA
Leptin Signaling in the Nucleus Tractus Solitarii Increases Sympathetic Outflow to the Kidney

Qi Wu, Baylor College of Medicine, USA
Starvation after AgRP-neuron Ablation Is Mediated By the Hindbrain and is Independent of Melanocortin Signaling

* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Brainstem melanocortin Signaling in the Control of Food Intake and Energy Balance

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Lower Organisms as Models of Lipid Homeostasis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Hedgehog Signaling and Mesenchymal Cell Fate

Anders M. Näär, Harvard Medical School, USA
SREBP and Lipid Metabolism in C. elegans

Kaveh Ashrafi, University of California, San Francisco, USA
Energy Regulatory Circuits in C. elegans

Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
Short Talk: Genetic Screen for Regulators of Obesity and Aging Identifies the Nutrient Sensing TOR Pathway

17:00—19:00
Hypothalamic Integration of Adiposity Signals: Arcuate Nucleus
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Martin G. Myers, Jr., University of Michigan, USA

Gregory S. Barsh, Stanford University Medical Center, USA
Stat3 and PI3K Signaling in Arcuate Nucleus Neurons

Randy J. Seeley, University of Michigan, USA
Actions of GLP-1 in the CNS to Regulate Glucose Homeostasis and Food Intake

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Hypothalamic Integration of Hormonal Inputs

Sabrina Diano, Yale University School of Medicine, USA
Short Talk: Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Ghrelin’s Action on Arcuate Nucleus NPY/AgRP Neurons

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 1

New Brunswick, Alberta, Cascade

THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
07:00—08:00
Poster Setup

New Brunswick, Alberta, Cascade
08:00—11:15
Novel Transcriptional Pathways in Adipogenesis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Ormond A. MacDougald, University of Michigan, USA

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Beyond PPARgamma: Searching for Novel Transcriptional Pathways in Adipogenesis

Karsten Kristiansen, University of Copenhagen, Denmark
The Tumor Suppressors pRB and p53 as Regulators of Adipocyte Differentiation and Function

Jacqueline M. Stephens, Louisiana State University, USA
Short Talk: STAT5A is Adipogenic in vivo and Plays an Important Role in the Regulation of Lipid Metabolism and Insulin Resistance in Adipocytes

Stephen R. Farmer, Boston University School of Medicine, USA
Role of SIRT1 in Regulating PPARg Activity during the Formation and Function of Adipocytes

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Novel Mechanisms Regulating Adipogenesis

Deborah Clegg, Cedars-Sinai Medical Center, USA
Short Talk: Sexual Dimorphism of Adipose Tissues

08:00—11:15
Energy Balance: Beyond the Arcuate Nucleus
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Michael W. Schwartz, University of Washington, USA

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Direct CNS Targets of Leptin, Insulin, and Serotonin that Underlie Coordinated Body Weight and Glucose Homeostasis

Martin G. Myers, Jr., University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action

Harvey J. Grill, University of Pennsylvania, USA
Explaining the Intake Inhibition of Leptin: Amplification of the Satiating Effects of Gastrointestinal Signals in NTS Neurons

Diana L. Williams, Florida State University, USA
Integration of Adiposity- and Satiety-Related Signals

Michael Rosenbaum, Columbia University Medical College, USA
Short Talk: Effects of Weight Loss and Leptin on In vivo Regional Neuronal Responses to Visual Food Stimuli

William F. Colmers, University of Alberta, Canada
Short Talk: Developmental Switch in Neuropeptide Y and Melanocortin Effects in the Paraventricular Nucleus of the Hypothalamus

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15—12:00
Lunch

New Brunswick, Alberta, Cascade
12:00—14:30
Poster Session 2

New Brunswick, Alberta, Cascade
14:30—16:30
Workshop 1: Hot Topics

Van Horne Ballroom AB
Robert A. Koza, Maine Medical Center Research Institute, USA
Evaluation of Mesoderm Specific Transcript as an Epigenetic Target for Diet-Induced Obesity in Mice

* Jacob E. Friedman†, University of Colorado School of Medicine, USA

Christoph Buettner, Mount Sinai School of Medicine, USA
Leptin Controls Adipose Tissue Endocannabinoid Levels and Lipogenesis through Hypothalamic Pathways that are Independent of STAT3 Signaling

Alexander S. Banks, Harvard Medical School, USA
Energy Conservation Phenotypes in SirT1 Gain-of-Function Mice

Yasunori Aizawa, Tokyo Institute of Technology, Japan
Noncoding “Long” RNAs in the Signaling Networks behind hMSC Differentiation

Philippe Boucher, UMR CNRS 7213, University of Strasbourg, France
Control of Adipogenesis and Fatty Acid Metabolism by LRP1

Annette Schürmann, German Institute of Human Nutrition Potsdam-Rehbruekce, Germany
Adipose-Specific Deletion of the Ras-homologous GTPase Arfrp1 Leads to Suppression of Triglyceride Storage

Bradley K. Yoder, University of Alabama at Birmingham, USA
Ciliary Dysfunction and Altered Energy Homeostasis

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Adipocytes and Inflammation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Karen Reue, University of California, Los Angeles, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Tissue and Acute Phase Response

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Metabolic Benefits of Interventions Targeting Proinflammatory Pathways

Haiming Cao, NHLBI, National Institutes of Health, USA

Jun Wada, Okayama University Graduate School of Medicine, Japan
Short Talk: Effects of Vaspin on Inflammatory and Metabolic Responses in Obesity

17:00—19:00
Regulation of Energy Homeostasis Circuitry
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

Michael L.J. Ashford, University of Dundee, UK
Leptin Signaling Mechanisms in Arcuate Nucleus Neurons

Leona Plum, Columbia University Medical Center, USA
Hypothalamic Function of FoxO Proteins

Tamas L. Horvath, Yale School of Medicine, USA
Synaptic Plasticity of Hypothalamic Circuits Controlling Energy Balance

Qingchun Tong, University of Texas Medical School at Houston, USA
Short Talk: Roles of GABA Release from Agrp Neurons

19:00
On Own for Dinner


FRIDAY, FEBRUARY 22

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:30
Adipocytes from the Inside Out
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Stephen R. Farmer, Boston University School of Medicine, USA

Dawn L. Brasaemle, Rutgers University, USA
Molecular Aspects of Lipid Droplet Biology

Karen Reue, University of California, Los Angeles, USA
The Lipin Protein Family: Roles in Adipogenesis and Triglyceride Biosynthesis

Tae-Hwa Chun, University of Michigan, USA
Short Talk: Pericellular Collagenenolysis as a Rheostat of Obesity Progression

Jorge Plutzky, Brigham and Women's Hospital, USA
Retinoid Metabolism in Energy Balance

Joel M. Goodman, University of Texas Southwestern Medical School, USA
Lipid Droplet Assembly and Communication in Yeast

Carole Sztalryd, VAH and University of Maryland School of Medicine, USA
Short Talk: Interaction between Lipases and Lipid Droplet Coat Proteins

08:00—11:15
Food Hedonics: Engaging the Limbic Circuitry
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Dianne Figlewicz Lattemann, VA Puget Sound Health Care System, USA

Gary Aston-Jones, Medical University of South Carolina, USA
Role of Orexin Neurons in Conditioned Reward-Seeking and Addiction: Implications for Obesity

Gorica D. Petrovich, Boston College, USA
Learned Cue-Induced Eating: A Forebrain-Hypothalamic Network

Dianne Figlewicz Lattemann, VA Puget Sound Health Care System, USA
Regulation of Food Reward by Adiposity Signals

Jeffrey W. Grimm, Western Washington University, USA
Incubation of Sucrose Craving

Brian J. Oldfield, Monash University, Australia
Short Talk: A More Complete View of the Interaction between Homeostatic, Hedonistic and Cognitive Pathways Mediating Appetite

Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA
Short Talk: The Orexigenic Hormone Ghrelin Defends Against Depressive Symptoms of Chronic Stress

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:30—13:00
Poster Setup

New Brunswick, Alberta, Cascade
11:30
On Own for Lunch

13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
14:30—16:30
Workshop 2: Molecular Targets and New Therapeutics

Van Horne Ballroom
* Donald A. McClain, University of Utah School of Medicine, USA

Alain Baron, Elcelyx Thereapeutics Inc., USA
Integrated Neurohormonal Therapy of Obesity

Cristina M. Rondinone, MedImmune, Inc., USA
RNA Interference: Novel Targets, Unique siRNA Drugs to Treat Metabolic Disorders?

Tara B. Manion, Pfizer Inc, USA
Integration of Gut Hormones, Metabolism and Food Intake

Anne Reifel Miller, Lilly Research Laboratories, USA
The Unexpected Complexity of the AdipoR2-Deficient Mouse Phenotype

Bei B. Zhang, Pfizer Inc., USA
Targeting AMPK Activation for the Treatment of Diabetes and Related Metabolic Disorders

Brad Geddes, Elixir Pharmaceuticals, Inc., USA
Improved Insulin Sensitivity in Ghrelin Receptor Knockout Mice Assessed by Glycemic Clamp Analyses

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Interactions between Brain and Periphery II (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
Barry E. Levin, VA Medical Center, USA
Hypothalamic Integration of Nutrient-Related and Hormonal Inputs Controlling Energy Balance

* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
CNS Regulation of Energy Balance and Glucose Metabolism

Timothy J. Bartness, Georgia State University, USA
Neural Connections between Brain and Adipose Tissue

Liangyou Rui, University of Michigan, USA
Short Talk: Identification of Neuronal SH2B1 as a Key Regulator of Energy Balance and Body Weight

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 3

New Brunswick, Alberta, Cascade

SATURDAY, FEBRUARY 23

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:15
Adipocyte Plasticity and Fate Choices
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Dawn L. Brasaemle, Rutgers University, USA

Ormond A. MacDougald, University of Michigan, USA
Regulation of Adipocyte Differentiation and Metabolism

Sven Enerbäck, University of Gothenburg, Sweden
FOX Transcription Factors in White and Brown Adipose Tissue

Jan Nedergaard, Stockholm University, Sweden
Short Talk: UCP1 Ablation Induces Obesity and Obliterates Diet-Induced Adrenergic Thermogenesis

Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA
Kinases and Their Transcription Targets in Adipocyte Cell Fate

Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Bone Marrow-Derived Progenitor Cells Give Rise to a Unique Adipocyte Population in Adipose Tissue

Barbara Cannon, Stockholm University, Sweden
Short Talk: A Myogenic Gene Expression Signature Establishes that Brown and White Adipocytes Originate from Distinct Cell Lineages

08:00—11:15
Emerging Aspects of Energy Homeostasis Biology
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* David E. Cummings, University of Washington, USA

Gary J. Schwartz, Albert Einstein College of Medicine, USA
Distributed Neural Nutrient Sensing in the Control of Energy Homeostasis

Marilyn Ader, Cedars-Sinai Medical Center, USA
Effect of Antipsychotic Medications on the Risk of Obesity and Diabetes

Robert V. Farese Jr., Harvard School of Public Health, USA
Mechanisms of Cellular Lipid Storage

Robert F. Margolskee, Monell Chemical Senses Center, USA
Beyond Taste: The Roles of Taste Receptors and Gustducin in Gastrointestinal Chemosensation

Heike Münzberg, Pennington Biomedical Research Center, USA
Short Talk: LepRb Neurons in the DMH as Potential Integrators of Homeostatic Control

Ted D. Hoyda, Queen's University, Canada
Short Talk: The Electrophysiological Actions of Adiponectin in the Paraventricular Nucleus of the Hypothalamus

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Genetics of Obesity and Diabetes (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Daniel Porte Jr., University of California, San Diego, USA

Rudolph L. Leibel, Columbia University, USA
Genetic Modifiers of Obesity/Diabetes in Mice and Humans

Stephen O'Rahilly, University of Cambridge, UK
Lessons from Human Phenotypes of Obesity and Insulin Resistance

Joel N. Hirschhorn, Children's Hospital, Boston, USA
Genomewide Association Studies of Type 2 Diabetes, Obesity and Stature

David A. Buchner, Case Western Reserve University, USA
Short Talk: The Genetic Architecture of Diet-Induced Obesity

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
20:00—23:00
Entertainment

New Brunswick, Alberta, Cascade

SUNDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-02




We gratefully acknowledge additional support for this conference from:

ALPCO Diagnostics Isis Pharmaceuticals, Inc.
Merck & Co., Inc. Seahorse Bioscience, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Hoffmann-La Roche, Inc.


Lilly Research Laboratories


Merck Research Laboratories


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676