Snowbird Resort Floorplan

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This meeting took place in 2008


Here are the related meetings in 2018:
Frontiers in Islet Biology and Diabetes (B3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Islet and Beta Cell Biology (Z3)


Organizer(s) Christopher B. Newgard, Frances M. Ashcroft and Roland W. Stein
April 6—11, 2008
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 6, 2007
Late Abstract Deadline: Jan 9, 2008
Scholarship Deadline: Dec 6, 2007
Early Registration Deadline: Feb 6, 2008

Supported by the Director's Fund


Summary of Meeting:
Despite many decades of research, important aspects of the molecular, biochemical and metabolic mechanisms that control the function of the islets of Langerhans have remained unresolved, due in part to the sequestration of these cells in the bowels of the exocrine pancreas. Nevertheless the key role of the islets in the pathogenesis of both major forms of diabetes has maintained the resolve of islet investigators at a high level, and has led to recent full-scale application of the tools of genetics, transcriptomics, genetic engineering, metabolomics, and informatics for understanding of normal islets and their loss of function in diabetes. Major progress has occurred in understanding of transcriptional networks that control islet function, growth and survival, and revealed that several factors thought of previously only as regulators of beta-cell development (e.g. Nkx6.1, Nkx2.2, Foxa1, Foxa2, MafA) are also key modulators of adult beta-cell function and growth. In addition, merger of genetic and metabolic analysis tools have allowed major inroads into identification of mitochondrially-derived mediators of insulin secretion that complement the classical KATP-channel dependent pathway. Finally, genetic studies have identified new diabetes candidate genes (e.g., the transcription factor Tcf712) that appear to play important roles in the islets—this field is just emerging and will likely be a cresting wave at the time of this proposed meeting. Major remaining problems are to test hypotheses about key genes and pathways emerging from application of "omics" technologies to islet research, and the identification of attractive targets for improving islet function and survival in both major forms of diabetes. The key meeting goals are: • To provide a forum for investigators of the field to hear of the latest insights from application of state-of-the-art technologies to the islet field. • To allow islet biologists to hear new findings from the areas of transcription factor biology, metabolism, intracellular trafficking and signaling, and drug target identification leading to synthesis of new and integrated ideas. • To provide stimulation and inspiration for young scientists who are training in the field via the opportunity to interact freely with senior scientists and present their own work in invited abstract talks and posters.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 6

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Chris Wright, Vanderbilt University Medical Center, USA

* Christopher B. Newgard, Duke University Medical Center, USA

Mark A. Magnuson, Vanderbilt School of Medicine, USA
Beta Cells, Technology Convergence and Team Science

Andrew Hattersley, Peninsula Medical School, UK
What can Genetics Teach us about the Beta-Cell?


MONDAY, APRIL 7

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Stem Cells and Optimization of Beta Cell Function to Transplantation (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Chris Wright, Vanderbilt University Medical Center, USA

* Christopher B. Newgard, Duke University Medical Center, USA

Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK
Ion Channels and Diabetes

Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Integration of Beta-Cell Transcription and Metabolic Regulation

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Using Functional Genomics to Identify Targets for Beta-Cell Expansion

Douglas A. Melton, Harvard University, USA
Making Beta Cells

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Transcriptional Networks that Regulate Islet Function
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Pdx1 Partners and Targets in ß Cell Development

Roland W. Stein, Vanderbilt University Medical Center, USA
Transcriptional Control of Beta-Cell Function

Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Constructing a Functional Beta Cell, One Histone at a Time

Chutima Noi Talchai, Columbia University, USA
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1

17:00—19:00
Understanding and Controlling Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* David M. Harlan, National Institutes of Health, NIDDK, USA

E. William St. Clair, Duke University Medical Center, USA
Targeting B Cells in Autoimmune Disease

Arlene H. Sharpe, Harvard Medical School, USA
PD-L1 for Maintenance of Self-Tolerance

Thomas Kay, St. Vincent's Institute of Medical Research, Australia
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice

Shira Y. Perl, National Institutes of Health, USA
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Maybird/Wasatch

TUESDAY, APRIL 8

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Metabolic Control of Insulin Secretion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Marc Prentki, , Canada

Alan D. Attie, University of Wisconsin-Madison, USA
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance

Charles A. Stanley, Children's Hospital of Philadelphia, USA
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways

Guy A. Rutter, Imperial College London, UK
Genetic Associations and the Regulation Late Events in Insulin Exocytosis

Richard G. Kibbey, Yale University, USA
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion

Christopher B. Newgard, Duke University Medical Center, USA
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion

08:00—11:00
Pancreas Development – Transcription \ Factors
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Harry Heimberg, Vrije Universiteit Brussel, Belgium

Ray MacDonald, University of Texas Southwestern Medical Center, USA
Transcriptional Control of Early Pancreatic Development

Lori Sussel, University of Colorado, USA
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation

Helena Edlund, Umeå University, Sweden
Signaling and Transcription Factors in the Pancreas

Chris Wright, Vanderbilt University Medical Center, USA
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation

Victoria E. Prince, University of Chicago, USA
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:15—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Mediators of Beta Cell Stress
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* R. Paul Robertson, Pacific Northwest Research Institute, USA

Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA
Oxidative Stress, UCP2 and beta-Cell Function

Feroz R. Papa, University of California, San Francisco, USA
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress

Roger D. Cox, MRC Harwell, UK
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2

Andreas C. Wiederkehr, University of Geneva, Switzerland
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell

17:00—19:00
Stem Cells and Pancreatic Islets
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Douglas A. Melton, Harvard University, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction and Specification of Endoderm from Embryonic Stem Cells

Markus Grompe, Oregon Health & Science University, USA
Characterization and Behavior of Liver and Pancreas Stem Cells

Maike Sander, University of California, San Diego, USA
Transcriptional Regulators of Stem-Cellness

Jackie E. Lee, Living Cell Technologies Limited, New Zealand
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Maybird/Wasatch

WEDNESDAY, APRIL 9

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
The Molecular Machinery of Insulin Secretion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK

Sara C. Kozma, University of Cincinnati, USA
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue

Tadao Shibasaki, Kobe University Graduate School of Medicine, Japan
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells

Debbie C. Thurmond, Indiana University School of Medicine, USA
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c

Tye Deering, University of Texas Southwestern Medical Center, USA
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes

Hainan Chen, Icahn School of Medicine at Mount Sinai, USA
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf

Leslie Ann Caromile, University of Connecticut Health Center, USA
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion

Samuel B. Stephens, Duke University Medical Center, USA
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide

08:00—11:15
Model Systems for Assessing Beta Cell Replacements
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Ray MacDonald, University of Texas Southwestern Medical Center, USA

Klaus Ulrich Pechhold, University of Massachusetts, USA
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes

Alvin C. Powers, Vanderbilt University School of Medicine, USA
Imaging Approaches to Follow Beta Cells in Vivo

Yuval Dor, Hebrew University-Hadassah Medical School, Israel
Determinants of Pancreatic Beta Cell Regeneration

Holger Andreas Russ, University of California, San Francisco, USA
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing

Jake A. Kushner, Baylor College of Medicine, USA
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age

Emmanuel E. Baetge, Nestlé Institute of Health Sciences, Switzerland
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:15—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Emerging Technologies for Beta-Cell Research
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Roland W. Stein, Vanderbilt University Medical Center, USA

Ali Mortazavi, California Institute of Technology, USA
Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq

Thomas Kodadek, The Scripps Research Institute, USA
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes

Per-Olof Berggren, Karolinska Institutet, Sweden
Insight into Pancreatic Beta Cell Function and Survival

Thue W. Schwartz, University of Copenhagen, Denmark
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man

17:00—19:00
Pancreatic Development – Intercellular Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Maike Sander, University of California, San Diego, USA

Matthias Hebrok, University of California, San Francisco, USA
Wnt and Hedgehog Signaling

Steven D. Leach, Memorial Sloan Kettering, USA
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish

Palle Serup, University of Copenhagen, Denmark
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps

Ondine Cleaver, University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Maybird/Wasatch

THURSDAY, APRIL 10

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Beta-Cell Mechanisms: Lessons from Other Systems
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK

Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Fuel Sensing in Islet Non-Beta Cells

Randy J. Seeley, University of Michigan, USA
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance

Johan M. Thevelein, Katholieke Universiteit Leuven and VIB, Belgium
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast

Fiona M. Gribble, University of Cambridge, UK
Fuel-Sensing in the L-Cell

Nils Wierup, Lund University, Sweden
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone

Kathryn Claiborn, , USA
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass

08:00—11:15
Moving Towards Clinical Application
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Kevan C. Herold, Yale University, USA
Effects of Immune Modulation on Beta Cells

David M. Harlan, National Institutes of Health, NIDDK, USA
Status of Clinical Trials Testing Beta Cell Regeneration

* Christian P. Larsen, Emory University School of Medicine, USA
Costimulatory Pathway Based Clinical Trials

Patrik Brundin, Lund University, Sweden
Neural Cell Grafting for Clinical Brain Repair

Keren Francis, Technion - Israel Institute of Technology, Israel
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro

Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Mechanisms of Beta-Cell Failure In Disease and Possible Drug Targets
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Paul K. Burn, Sanford Research & Sanford School of Medicine, USA

Nancy A. Thornberry, Kallyope, Inc., USA
GLP-1 and Next Generation Insulin Secretagogues

Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?

Jens Zehetner, ETH Zurich, Switzerland, Switzerland
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis

17:00—19:00
Islet Proliferation and Survival
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Helena Edlund, Umeå University, Sweden

Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist

Harry Heimberg, Vrije Universiteit Brussel, Belgium
Beta Cell Progenitors in Adult Mouse Pancreas

Seung K. Kim, Stanford University, USA
Control of Pancreas Cell Proliferation

Sonya G. Fonseca, Novartis, USA
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1

19:00—20:00
Social Hour with Lite Bites

Ballroom 1-2
20:00—23:00
Entertainment

Ballroom 1-2

FRIDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-02




We gratefully acknowledge additional support for this conference from:

JDRF

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