Snowbird Resort Floorplan

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This meeting took place in 2008


Here are the related meetings in 2018:
Frontiers in Islet Biology and Diabetes (B3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Islet and Beta Cell Development and Transplantation (Z4)


Organizer(s) Chris Wright, Helena Edlund, David M. Harlan and Ray MacDonald
April 6—11, 2008
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 6, 2007
Late Abstract Deadline: Jan 9, 2008
Scholarship Deadline: Dec 6, 2007
Early Registration Deadline: Feb 6, 2008

Supported by the Director's Fund


Summary of Meeting:
This meeting presents an integrated program on pancreatic islet developmental biology, islet transplantation, and immunity. It is designed to interdigitate with and to augment the companion parallel conference “Islet and Beta-Cell Biology”. The meeting will encompass pioneering science in several disciplines, including development, regeneration, stem cells, transcription factors, transplantation, cell biology, gene regulation, immunity, and diabetes. Islet transplantation as an emergent therapy for diabetes is severely hampered by an insufficient islet supply, gradually decreasing islet function post-transplantation, and by toxic immuno-suppression. Understanding the rules that guide pancreas development in vivo will promote methods to generate new islets from adult or embryonic stem cells, and yet our knowledge remains inadequate as it pertains to the mechanisms controlling normal islet development and function, or of the maintenance of the islet cell differentiated state, survival, and physiological function after transplantation. Similarly, the means elude us to safely, effectively, and reliably prevent recurrent immune attack on the transplanted islets. The meeting program focuses on these challenges by covering the most recent progress in these rapidly moving fields and discussing strategies to overcome major obstacles. The meeting builds upon the extremely strong foundation laid by the 2006 Keystone meeting on “Pancreatic Islets”, which very effectively brought together the fields of islet transplantation and basic pancreatic development. A most important aspect of the meeting will be the instructions given to the speakers to identify specific caveats and problems with the current state of research, to define short and long term goals for the field and, moreover, to orient their presentation in a manner that maximizes accessibility to attendees from the other research areas.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 6

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Chris Wright, Vanderbilt University Medical Center, USA

* Christopher B. Newgard, Duke University Medical Center, USA

Mark A. Magnuson, Vanderbilt School of Medicine, USA
Beta Cells, Technology Convergence and Team Science

Andrew Hattersley, Peninsula Medical School, UK
What can Genetics Teach us about the Beta-Cell?


MONDAY, APRIL 7

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Stem Cells and Optimization of Beta Cell Function to Transplantation (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Chris Wright, Vanderbilt University Medical Center, USA

* Christopher B. Newgard, Duke University Medical Center, USA

Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK
Ion Channels and Diabetes

Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Integration of Beta-Cell Transcription and Metabolic Regulation

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Using Functional Genomics to Identify Targets for Beta-Cell Expansion

Douglas A. Melton, Harvard University, USA
Making Beta Cells

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Understanding and Controlling Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* David M. Harlan, National Institutes of Health, NIDDK, USA

E. William St. Clair, Duke University Medical Center, USA
Targeting B Cells in Autoimmune Disease

Arlene H. Sharpe, Harvard Medical School, USA
PD-L1 for Maintenance of Self-Tolerance

Thomas Kay, St. Vincent's Institute of Medical Research, Australia
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice

Shira Y. Perl, National Institutes of Health, USA
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans


Following Session is for Islet and Beta Cell Biology (Z3)

17:00—19:00
Transcriptional Networks that Regulate Islet Function
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Pdx1 Partners and Targets in ß Cell Development

Roland W. Stein, Vanderbilt University Medical Center, USA
Transcriptional Control of Beta-Cell Function

Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Constructing a Functional Beta Cell, One Histone at a Time

Chutima Noi Talchai, Columbia University, USA
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Maybird/Wasatch

TUESDAY, APRIL 8

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Pancreas Development – Transcription \ Factors
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Harry Heimberg, Vrije Universiteit Brussel, Belgium

Ray MacDonald, University of Texas Southwestern Medical Center, USA
Transcriptional Control of Early Pancreatic Development

Lori Sussel, University of Colorado, USA
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation

Helena Edlund, Umeå University, Sweden
Signaling and Transcription Factors in the Pancreas

Chris Wright, Vanderbilt University Medical Center, USA
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation

Victoria E. Prince, University of Chicago, USA
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4


Following Session is for Islet and Beta Cell Biology (Z3)

08:00—11:15
Metabolic Control of Insulin Secretion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Marc Prentki, , Canada

Alan D. Attie, University of Wisconsin-Madison, USA
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance

Charles A. Stanley, Children's Hospital of Philadelphia, USA
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways

Guy A. Rutter, Imperial College London, UK
Genetic Associations and the Regulation Late Events in Insulin Exocytosis

Richard G. Kibbey, Yale University, USA
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion

Christopher B. Newgard, Duke University Medical Center, USA
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Stem Cells and Pancreatic Islets
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Douglas A. Melton, Harvard University, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction and Specification of Endoderm from Embryonic Stem Cells

Markus Grompe, Oregon Health & Science University, USA
Characterization and Behavior of Liver and Pancreas Stem Cells

Maike Sander, University of California, San Diego, USA
Transcriptional Regulators of Stem-Cellness

Jackie E. Lee, Living Cell Technologies Limited, New Zealand
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells


Following Session is for Islet and Beta Cell Biology (Z3)

17:00—19:00
Mediators of Beta Cell Stress
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* R. Paul Robertson, Pacific Northwest Research Institute, USA

Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA
Oxidative Stress, UCP2 and beta-Cell Function

Feroz R. Papa, University of California, San Francisco, USA
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress

Roger D. Cox, MRC Harwell, UK
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2

Andreas C. Wiederkehr, University of Geneva, Switzerland
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Maybird/Wasatch

WEDNESDAY, APRIL 9

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Model Systems for Assessing Beta Cell Replacements
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Ray MacDonald, University of Texas Southwestern Medical Center, USA

Klaus Ulrich Pechhold, University of Massachusetts, USA
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes

Alvin C. Powers, Vanderbilt University School of Medicine, USA
Imaging Approaches to Follow Beta Cells in Vivo

Yuval Dor, Hebrew University-Hadassah Medical School, Israel
Determinants of Pancreatic Beta Cell Regeneration

Holger Andreas Russ, University of California, San Francisco, USA
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing

Jake A. Kushner, Baylor College of Medicine, USA
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age

Emmanuel E. Baetge, Nestlé Institute of Health Sciences, Switzerland
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm


Following Session is for Islet and Beta Cell Biology (Z3)

08:00—11:15
The Molecular Machinery of Insulin Secretion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK

Sara C. Kozma, University of Cincinnati, USA
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue

Tadao Shibasaki, Kobe University Graduate School of Medicine, Japan
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells

Debbie C. Thurmond, Indiana University School of Medicine, USA
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c

Tye Deering, University of Texas Southwestern Medical Center, USA
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes

Hainan Chen, Icahn School of Medicine at Mount Sinai, USA
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf

Leslie Ann Caromile, University of Connecticut Health Center, USA
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion

Samuel B. Stephens, Duke University Medical Center, USA
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:15—13:00
Poster Setup

Superior/Superior Lobby/Maybird/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Pancreatic Development – Intercellular Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Maike Sander, University of California, San Diego, USA

Matthias Hebrok, University of California, San Francisco, USA
Wnt and Hedgehog Signaling

Steven D. Leach, Memorial Sloan Kettering, USA
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish

Palle Serup, University of Copenhagen, Denmark
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps

Ondine Cleaver, University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development


Following Session is for Islet and Beta Cell Biology (Z3)

17:00—19:00
Emerging Technologies for Beta-Cell Research
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Roland W. Stein, Vanderbilt University Medical Center, USA

Ali Mortazavi, California Institute of Technology, USA
Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq

Thomas Kodadek, The Scripps Research Institute, USA
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes

Per-Olof Berggren, Karolinska Institutet, Sweden
Insight into Pancreatic Beta Cell Function and Survival

Thue W. Schwartz, University of Copenhagen, Denmark
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Maybird/Wasatch

THURSDAY, APRIL 10

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Moving Towards Clinical Application
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Kevan C. Herold, Yale University, USA
Effects of Immune Modulation on Beta Cells

David M. Harlan, National Institutes of Health, NIDDK, USA
Status of Clinical Trials Testing Beta Cell Regeneration

* Christian P. Larsen, Emory University School of Medicine, USA
Costimulatory Pathway Based Clinical Trials

Patrik Brundin, Lund University, Sweden
Neural Cell Grafting for Clinical Brain Repair

Keren Francis, Technion - Israel Institute of Technology, Israel
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro

Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades


Following Session is for Islet and Beta Cell Biology (Z3)

08:00—11:15
Beta-Cell Mechanisms: Lessons from Other Systems
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK

Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Fuel Sensing in Islet Non-Beta Cells

Randy J. Seeley, University of Michigan, USA
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance

Johan M. Thevelein, Katholieke Universiteit Leuven and VIB, Belgium
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast

Fiona M. Gribble, University of Cambridge, UK
Fuel-Sensing in the L-Cell

Nils Wierup, Lund University, Sweden
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone

Kathryn Claiborn, , USA
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Islet Proliferation and Survival
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Helena Edlund, Umeå University, Sweden

Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist

Harry Heimberg, Vrije Universiteit Brussel, Belgium
Beta Cell Progenitors in Adult Mouse Pancreas

Seung K. Kim, Stanford University, USA
Control of Pancreas Cell Proliferation

Sonya G. Fonseca, Novartis, USA
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1


Following Session is for Islet and Beta Cell Biology (Z3)

17:00—19:00
Mechanisms of Beta-Cell Failure In Disease and Possible Drug Targets
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Paul K. Burn, Sanford Research & Sanford School of Medicine, USA

Nancy A. Thornberry, Kallyope, Inc., USA
GLP-1 and Next Generation Insulin Secretagogues

Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?

Jens Zehetner, ETH Zurich, Switzerland, Switzerland
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird/Wasatch
20:00—23:00
Entertainment

Ballroom 2-3

FRIDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-02




We gratefully acknowledge additional support for this conference from:

JDRF Merck & Co., Inc.

ViaCyte, Inc.

 

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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