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This meeting took place in 2008



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Diabetes Mellitus, Insulin Action and Resistance (A6)


Organizer(s) Mary-Elizabeth Patti and David E. Moller
January 22—27, 2008
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 24, 2007
Late Abstract Deadline: Oct 25, 2007
Scholarship Deadline: Sep 24, 2007
Early Registration Deadline: Nov 26, 2007

Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development

Summary of Meeting:
The incidence of type 2 diabetes is increasing worldwide at an alarming rate – mandating intensive efforts to improve our understanding of diabetes pathophysiology, improve options for therapy, and most importantly, to initiate strategies for disease prevention in high-risk groups. This meeting will focus on recent advances in our understanding of the molecular pathogenesis of insulin resistance, diabetes, and related syndromes, with particular emphasis on (1) multi-system nature of diabetes pathophysiology, (2) genetic basis of insulin resistance and diabetes risk, (3) potential links between epigenetic modulation of gene expression and diabetes risk related to “environmental” mechanisms, (4) pathways linking obesity, inflammation, and diabetes risk, and (5) new molecular mechanisms of insulin resistance. Moreover, the meeting will highlight novel pharmacologic targets for diabetes therapy. A key goal of the meeting will also be to facilitate collaborative interactions between basic scientists and translational clinical scientists focused on prevention and treatment of insulin resistance and diabetes.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 22

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA
and

* David E. Moller, Eli Lilly and Company, USA
Introductory Remarks

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Resistance, Obesity and Type 2 Diabetes: Which is the Chicken and Which is the Egg?

Leif C. Groop, Lund University, Sweden
Searching for the Genetic Causes of Type 2 Diabetes


WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Insulin Resistance and Diabetes Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

Ele Ferrannini, University of Pisa, Italy
Overview: Relative Role of Insulin Resistance vs. Beta Cell Dysfunction in Diabetes Pathogenesis

Hannele Yki-Järvinen, University of Helsinki, Finland
Role of Fatty Liver in the Pathogenesis of Metabolic Syndrome and Type 2 Diabetes

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Cellular Mechanisms of Insulin Resistance and the Role of Skeletal Muscle Insulin Resistance in the Pathogenesis of the Metabolic Syndrome

Gökhan S. Hotamisligil, Harvard University, USA
Inflammation and ER Stress in Metabolic Disease

Michael Ristow, ETH Zürich, Switzerland
Short Talk: Impaired Oxidative Phosphorylation Induces Oxidative Stress, Decreases Life Span and Promotes Type 2 Diabetes and Obesity

J. Andrew Pospisilik, Max Planck Institute for Immunobiology and Epigenetics, Germany
Short Talk: Targeted Deletion of AIF Reduces OxPhos and Prevents Diabetes and Obesity

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
12:00—13:30
Meet the Professor Lunch: NIH Grant Application Process and Endo-Related Study Sessions
Box Lunches available for purchase. Advance sign-up will be required.

Colorado Ballroom
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Introduction

* Philip F. Smith, NIDDK, National Institutes of Health, USA

13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Genetics and Syndromes Related to Type 2 Diabetes
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Leif C. Groop, Lund University, Sweden

Philippe Froguel, Imperial College of London, UK
Human Polygenic Severe Obesity Genes, What's New? What's Interesting?

Leslie J. Baier, National Institutes of Health, USA
The Search for Type 2 Diabetes and Obesity Susceptibility Genes in Pima Indians

Andrea Dunaif, Icahn School of Medicine at Mount Sinai, USA
PCOS and Type 2 Diabetes – Insights from Genetic Studies

Jeremy B.M. Jowett, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: A Systems Biology Approach to Determining the Biological Consequences of Genetic Variation in Humans: The PPAR gamma Pro12Ala Variant

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

THURSDAY, JANUARY 24

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Adipose and Inflammatory Links to Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Michael P. Czech, University of Massachusetts Medical School, USA

Isaac Kohane, Harvard Medical School, USA
Getting Better and More Numbers for Discovery Research in the Genomic Era

Lily Q. Dong, University of Texas Health Science Center, USA
Short Talk: “Ying-Yang” Regulation of Adiponectin Signaling by APPL Isoforms

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Lipogenic Pathways: Links to Diabetes Risk

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Potent Roles of the Immune System in Obesity Induced T2DM and CVB

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Transcriptional Networks Leading From Obesity to Insulin Resistance

David A. Bernlohr, University of Minnesota, USA
Short Talk: Role of Adipose Protein Carbonylation in Insulin Resistance; The HNE Pathway

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
12:00—13:30
Meet the Professor Lunch: Clinical DM for PhDs

Colorado Ballroom
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Introduction

* Martin J. Abrahamson, Harvard Medical School, USA

13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Epigenetic and Metabolic Determinants of Insulin Resistance and Diabetes Risk
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Miguel Constância, University of Cambridge, UK
Epigenetics: Basic Mechanisms and Potential Links to Developmental Origins of Adult Disease

Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA
Short Talk: Maternal High Fat Diet Causes Fetal Lipotoxicity

Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Genetic and Environmental Pathways to Human Diabetes Risk

Don Ayer, University of Utah, USA
Short Talk: Glucose Sensing and Regulation of Glucose-Dependent Transcription

Assam El-Osta, Baker IDI Heart Research Institute, Australia
Short Talk: Transient Hyperglycemia Induces Persistent Transcriptional Activity; Insights into Epigenetic Change and Glycemic Memory

19:15—20:15
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

FRIDAY, JANUARY 25

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Searching for New Therapeutic Targets
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* David E. Moller, Eli Lilly and Company, USA

Alan D. Attie, University of Wisconsin-Madison, USA
Multidimensional Approaches to DM Gene Discovery

Michael P. Czech, University of Massachusetts Medical School, USA
Systems Biology Approaches to Metabolic Disease

Alexei Kharitonenkov, Novo Nordisk, USA
Metabolic Actions of FGF-21

D. Grahame Hardie, University of Dundee, UK
AMP-Activated Protein Kinase as a Drug Target in Type 2 Diabetes and Metabolic Syndrome

Carsten Schmitz-Peiffer, Garvan Institute of Medical Research, Australia
Short Talk: Inhibition of PKCepsilon is a Potential Therapy for Type 2 Diabetes by Reconstituting Glucose-Stimulated Insulin Secretion and Reducing Insulin Clearance

Joe S. Grimsby, MedImmune, USA
Short Talk: Antidiabetic Effects of Glucokinase Activators: From Benchside to Bedside

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Drug Discovery Workshop

Colorado Ballroom
* David E. Moller, Eli Lilly and Company, USA

* Jin-Long Chen, NGM Biopharmaceuticals, Inc., USA

Ranabir Sinha Roy, Merck & Co. Inc., USA
DPP-4 Inhibitors and Next-Generation Insulin Secretagogues

Bryan Goodwin, , USA
Orphan Nuclear Receptors and Beyond in the Treatment of Metabolic Disease

Cord Dohrmann, Evotec AG, Germany
Identifying Drug Targets Regulating Metabolism in Drosophila

Brian Zambrowicz, Regeneron, USA
Using Mouse Genetics to Understand Gene Function and Identify Targets for Drug Discovery

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Novel Pathways in Diabetes and Metabolic Syndrome
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Separating “Good” from “Bad” Adipose

Juleen R. Zierath, Karolinska Institutet, Sweden
Down-Regulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Sirtuins and Transcriptional Control in Hepatic Metabolism

Maziyar Saberi, NGM Biopharmaceuticals, USA
Short Talk: Novel Liver-Specific TORC2 siRNA Corrects Hyperglycemia in Rodent Models of Type 2 Diabetes

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

SATURDAY, JANUARY 26

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
New Molecular Mechanisms of Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
RBP4 and Insulin Resistance

Deborah M. Muoio, Duke University Medical Center, USA
Lipid-Induced Mitochondrial Stress and Insulin Resistance in Skeletal Muscle

Joyce J. Repa, University of Texas Southwestern Medical Center, USA
The Oxysterol Nuclear Receptors and Glucose Homeostasis

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
A Cofactor Network that Controls PGC-1alpha Activity and Energy Homeostasis

Alexander S. Banks, Harvard Medical School, USA
Short Talk: Metabolic Mimicry of Calorie Restriction by SirT1 Gain-of-Function in Mice

Matthias Mann, Max Planck Institute of Biochemistry, Germany
Short Talk: Mapping the Mitochondrial Proteome – Implications for Insulin Action and Diabetes

Mark A. Febbraio, Garvan Institute of Medical Research, Australia
Short Talk: Activating HSP72 Protects against Obesity-Induced Insulin Resistance

09:20—09:40
Coffee Break

Foyer
12:00—13:30
Meet the Professor Lunch: Perspectives of Science in Drug Discovery and Careers in Industry
Box Lunches available for purchase. Advance sign-up will be required.

Colorado Ballroom
* David E. Moller, Eli Lilly and Company, USA
Introduction

* Rebecca A. Taub, VIA Pharmaceuticals, Inc, USA

* Thomas (Gus) A. Gustafson, Janssen Pharmaceuticals, USA

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Transcriptional Interface between Lipid and Glucose Metabolism
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Anna Krook, Karolinska Institutet, Sweden

Marc R. Montminy, The Salk Institute for Biological Studies, USA
The TORC Family of CREB Coactivators: Regulators of Energy Balance

Markus Stoffel, ETH Zürich, Switzerland
Cross-Talk between Insulin Signaling and FOXA2 in the Liver and Lateral Hypothalamus

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown Fat Determination by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors

Jiandie Lin, University of Michigan Medical School, USA
Short Talk: Decoding the PGC-1 Transcriptional Network through Genome-Wide Coactivation Analyses

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

SUNDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-02




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Educational grant from Lilly USA, LLC
Merck & Co., Inc. Pfizer Global Research & Development
Seahorse Bioscience, Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational grant from Lilly USA, LLC


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