Eldorado Hotel & Spa Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2008



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

TGF-ß Family in Homeostasis and Disease (B2)


Organizer(s) Joan Massagué, Liliana Attisano and Alexander F. Schier
February 3—8, 2008
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Oct 3, 2007
Late Abstract Deadline: Nov 2, 2007
Scholarship Deadline: Oct 2, 2007
Early Registration Deadline: Dec 4, 2007

Supported by the Director's Fund

Summary of Meeting:
As a set of cytokines with a powerful signal transduction system and the ability to regulate a large number of critical genes and functions, the TGF-ß family controls cell fate and behavior in every stage of embryonic development and every tissue in the adult. Recently identified components and connections of this pathway provide new insights into how cells read TGF-ß signals under normal conditions and mishandle these signals in various diseases. By focusing on these topics, this meeting will provide an update on the TGF-ß system, its role in physiology and pathogenesis, and its promise as a drug target in cancer and other disorders.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 3

15:00—19:30
Registration

North End of Concourse
18:30—19:30
Refreshments

Sunset Room
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Joan Massagué, Memorial Sloan Kettering Cancer Center, USA

Edward M. De Robertis, Howard Hughes Medical Institute and University of California, USA
Integrating D-V and A-P Signals by BMP and Wnt via Smad1/Mad phosphorylations in Xenopus and Drosophila Embryos


MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Lobby Lounge
08:00—11:15
Signaling System I
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
High Throughput Mapping Interactomes in Mammalian Systems

Elizabeth J. Robertson, University of Oxford, UK
High Throughput Mapping Interactomes in Mammalian Systems

* Alexander F. Schier, Harvard University, USA
Regulation of TGF-beta Signaling by microRNAs

Andrew P. Hinck, University of Texas Health Science Center, USA
Cooperative Assembly of TGF-beta and BMP Signaling Complexes is Mediated by Disparate Mechanisms and Distinct Modes of Receptor Binding

Lan Xu, University of Massachusetts Medical School, USA
Short Talk: Whole-genome RNAi Screening Identifies Msk as a Nuclear Import Factor for Activated Smads

Katerina Pardali, AstraZeneca, Sweden
Short Talk: Monitoring the Dynamics of Smad Complex Formation Using Proximity Ligation

09:20—09:40
Coffee Break

Devargas Concourse
11:15—13:00
Poster Setup

Sunset Room
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

Devargas Concourse
17:00—19:00
Signaling System II
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Xin-Hua Feng, Baylor College of Medicine, USA
Phospho-Control of SMAD Signaling

Caroline S. Hill, Francis Crick Institute, UK
The Role of the E3 Ubiquitin Ligase, Arkadia in TGF-beta Signaling

* Liliana Attisano, University of Toronto, Canada
A Genome-Wide Approach to Identify Smad/Foxh1 Targets during Early Mouse Development

Gareth Inman, Beatson Institute for Cancer Research, UK
Short Talk: Carm1 is a Smad Cofactor that Links TGF-beta Signaling to Gene Activation, Motility and Growth Arrest

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Lobby Lounge
07:00—08:00
Poster Setup

Sunset Room
08:00—11:15
Cancer I
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGF-beta Primes Breast Tumors for Lung Metastasis through Angiopoietin-Like 4

* Lalage M. Wakefield, NCI, National Institutes of Health, USA
Death by a Thousand Cuts: Suppression of Metastasis by Anti-TGF-beta Antibody Therapy

Jonathan M. Yingling, Idera Pharmaceuticals, Inc., USA
TGF-beta Inhibitors

Akiyoshi Komuro, University of Tokyo, Japan
Short Talk: Deletion of TGF-beta Signaling in Diffuse-Type Gastric Cancer Cells Promotes Tumor Progression in vivo via Alteration of Tumor Microenvironment

Veronica R. Placencio, Vanderbilt University, USA
Short Talk: Stromal TGF-ß Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity

09:20—09:40
Coffee Break

Devargas Concourse
11:15—12:15
Lunch

Lobby Lounge
12:00—14:30
Poster Session 2

Sunset Room
16:30—17:00
Coffee Available

Devargas Concourse
17:00—19:00
Signaling System III
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Lilach Gilboa, Weizmann Institute of Science, Israel
How to Organize an Organ: Gonadogenesis and Germ Line Stem Cell Establishment in Drosophila melanogaster

* Elaine V. Fuchs, HHMI/Rockefeller University, USA
Stem Cell Quiescence and Tissue Homeostasis in the Skin

Michael B. O'Connor, University of Minnesota, Twin Cities, USA
Modulating BMP Mophogen Activity in the Drosophila Embryo and the Pupal Wing

David Wotton, University of Virginia, USA
Short Talk: Tgif Function is Required for Gastrulation

19:00
On Own for Dinner


WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Lobby Lounge
08:00—11:00
Connective Tissue
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
Marfan Syndrome: From Molecules to Medicines

Bart Loeys, Ghent University Hospital, Belgium
TGFbeta and Connective Tissue Disorders: An Intimate Interplay

Edward B. Leof, Mayo Clinic, USA
Regulation of Cell Type-Specific TGF-beta Signaling by the Coordinate Action of Erbin and the NF2 Tumor Suppressor Merlin

Kelsa Teeters, University of Hawaii, USA
Short Talk: Dysregulation of the Immune Response Associated with Allergen Challenge in Caveolin-1 Deficient Mice

Marene Landström, Rudbeck Laboratory, Sweden
Short Talk: The TGF-beta Type I Receptor Engages TRAF6 and Lys63-Dependent Ubiquitination of TAK1 to Activate a Specific Smad-Independent Pathway

Gerard C. Blobe, Duke University, USA
Short Talk: Role of the Tumor Suppressor TbetaRIII in Regulating Directional Migration during Epithelial and Cancer Cell Migration

09:20—09:40
Coffee Break

Devargas Concourse
11:00—13:00
Poster Setup

Sunset Room
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

Devargas Concourse
17:00—19:00
Immunity and Inflammation
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Regulatory T Cells, TGF-beta and Immune Suppression

Christoph Becker, Friedrich Alexander University of Erlangen-Nürnberg, Germany
TGF-beta Dependent T Cell Differentiation in Colitis

Rachael Watson, University of Florida, USA
Short Talk: A Model of Arthrofibrosis Using Intra-articular Gene Delivery of TGF-beta1

Hiroaki Ikushima, University of Tokyo, Japan
Short Talk: An Id-Like Molecule, HHM, is a Synexpression Group-Restricted Regulator of TGF-beta Signaling through Modulation of the Interaction of Smads with Transcription Factors

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Lobby Lounge
08:00—11:15
Cancer II
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Nabeel Bardeesy, Massachusetts General Hospital, USA
TGFbeta Signaling in Pancreatic Cancer

Joan Seoane, Vall d'Hebron Institute of Oncology (V.H.I.O.), Spain
The Oncogenic Role of TGF-beta in Glioma

Theresa A. Guise, Indiana University, USA
Transforming Growth Factor Beta (TGFbeta): Role in Bone Metastases due to Breast Cancer, Prostate Cancer and Melanoma

* Kunxin Luo, University of California, Berkeley, USA
SnoN, TGF-beta Signaling and Regulation of Cell Growth

Sophia Bornstein, Oregon Health & Science University, USA
Short Talk: Deletion of Smad4 Leads to Head and Neck Squamous Cell Carcinoma Formation through Increased Genomic Instability and Inflammation

Piotr Jachimczak, RealTVac, Germany
Short Talk: Inhibition of TGF-beta2 with Antisense Oligonucleotide AP 12009 in Recurrent or Refractory High-Grade Glioma: Results of a Phase IIb study

09:20—09:40
Coffee Break

Devargas Concourse
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Devargas Concourse
17:00—18:30
Musculoskeletal
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Rik Derynck, University of California, San Francisco, USA
Non-Smad Signaling in the TGF-beta Response

* Xiao-Fan Wang, Duke University Medical Center, USA
Extracellular Matrix Protein TGFBI/ßIg-h3 Promotes Metastasis of Colon Cancer by Enhancing Cell Extravasation

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

FRIDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA130244-01




We gratefully acknowledge additional support for this conference from:


Anita Roberts Memorial Fund
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676