Copper Mountain Resort Floorplan

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This meeting took place in 2008



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Metabolic Pathways of Longevity (G1)


Organizer(s) Arlan G. Richardson, Eva L. Feldman and Nir Barzilai
March 30—April 4, 2008
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Nov 30, 2007
Late Abstract Deadline: Dec 31, 2007
Scholarship Deadline: Nov 30, 2007
Early Registration Deadline: Jan 29, 2008

Supported by the Director's Fund

Summary of Meeting:
This meeting brings together leading investigators in aging and diabetes to discuss how alterations in insulin/IGF-I signaling affect longevity, and the similarities between insulin resistance and aging. Data emerging from several areas suggest that insulin and insulin-like growth factor (IGF-I) could be key players in the regulation of longevity in organisms as diverse as invertebrates and humans. Caloric restriction, which retards aging, is shown to reduce plasma levels of insulin and IGF-I, and the disruption of the insulin/IGF-I receptor in nematodes and flies is shown to increase lifespan. However, mammals with genetic or acquired defects in the insulin signaling pathway are at risk for age-related diseases and increased mortality, e.g., insulin resistance and diabetes.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 30

15:00—19:30
Registration

Kokopelli's
18:30—19:30
Refreshments

Kokopelli's
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Arlan G. Richardson, University of Texas Health Science Center, USA

Nir Barzilai, Albert Einstein College of Medicine, USA
The Paradigm of Longevity across Models and its Paradoxes


MONDAY, MARCH 31

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
Longevity and Insulin/IGF-I Signaling in Invertebrates
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Brian K. Kennedy, Buck Institute for Research on Aging, USA

Radhika Muzumdar, Yeshiva University, USA
Talk Title to be Determined

Dominic J. Withers, Imperial College London, UK
The Role of Insulin Receptor Substrate (IRS) Adaptor Proteins in the Regulation of Longevity in Mice and Drosophila

Marc Tatar, Brown University, USA
Role of Insulin Signaling in Drosophila

Andrew G. Dillin, University of California, Berkeley, USA
PHA-4/Foxa is Essential and Specific for DR-mediated Longevity

Michael A. Riehle, University of Arizona, USA
Short Talk: Shutting Down Insulin Signaling: PTEN in the Mosquito Aedes Aegypti and its Effect on Reproduction and Lifespan

Mirela Matecic, University of Virginia, USA
Short Talk: Identification of Genetic and Metabolic Pathways that Regulate Yeast Chronological Lifespan

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Longevity and Insulin/IGF-I Signaling in Humans
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Nir Barzilai, Albert Einstein College of Medicine, USA

Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Genome Wide Association Study of Glucose Homeostasis and Cardiovascular Aging

Yousin Suh, Albert Einstein College of Medicine, USA
Functional Insulin-like Growth Factor-I Receptor Mutations in Centenarians

David R. Clemmons, University of North Carolina at Chapel Hill, USA
Modulation of Tissue Responsiveness to IGF-I by Hyperglycemic Stress

Gil Atzmon, Albert Einstein College Of Medicine, USA
Short Talk: The Growth Hormone Receptor exon-3 Deletion is a Marker for Exceptional Longevity

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
19:30—22:00
Poster Session 1

Bighorn C

TUESDAY, APRIL 1

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
Longevity and Insulin/IGF-I Signaling in Rodents
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Marc Tatar, Brown University, USA

Makoto Kuro-O, UT Southwestern Medical Center at Dallas, USA
The Anti-Aging Mechanism Mediated by Klotho Gene Family

Anne Brunet, Stanford University, USA
FOXO Transcription Factors: Central Sensors of Environmental Stimuli that Regulate Longevity

Feng Liu, University of Texas Health Science Center, USA
Neuronal Insulin/IGF-I Signaling and the Regulation of Mammalian Lifespan

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Signaling, Adipose Tissue and Mechanisms of Increased Lifespan

Johan Svensson, Sahlgrenska University Hospital, Sweden
Short Talk: Liver-Derived IGF-I Regulates Life Span in Mice

Joseph A. Baur, University of Pennsylvania, USA
Short Talk: Resveratrol in Health and Longevity

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
14:30—16:30
Workshop 1: Drug Discovery/Therapeutic Intervention

Bighorn B
* Nancy L. Nadon, National Institute on Aging, USA

Richard A. Miller, University of Michigan, USA
NIA Interventions Testing Program: Current Status and Future Plans

David E. Harrison, The Jackson Laboratory, USA
The Checkered History of Anti-Aging Interventions

Randy Strong, South Texas Veterans Health Care System, USA
Pharmacological Intervention in the mTOR Signaling Pathway during Aging: Technical Challenges and Solutions

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Richard A. Miller, University of Michigan, USA

Brian K. Kennedy, Buck Institute for Research on Aging, USA
Conserved Longevity Pathways and Dietary Restriction

Pankaj Kapahi, Buck Institute for Research on Aging, USA
Regulation of Nutrient Modulated Lifespan by TOR Pathway in Drosophila

Christopher J. Lynch, Pennsylvania State University, USA
Rodent Models of Altered mTOR and Plasma Leucine



Navdeep S. Mutti, DuPont-Pioneer, USA
Short Talk: Deciphering the Role of Insulin / Insulin-like (IIS) and TOR Signaling Cascade in Diphenic Caste Development in the Honey Bees, Apis Mellifera

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
19:30—22:00
Poster Session 2

Bighorn C

WEDNESDAY, APRIL 2

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
The Role of Nutrient Sensing in Aging II: Caloric Restriction
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Arlan G. Richardson, University of Texas Health Science Center, USA

David A. Sinclair, Harvard Medical School, USA
Evidence that Chromatin Reorganization is a Driver of Genomic Instability and Aging in Mammals

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Control of Metabolism through the PGC-1 Pathways

Cheryl A. Conover, Mayo Clinic College of Medicine, USA
Role of Reduced IGF Binding Protein Protease on Local IGF-I and Lifespan

Leanne M. Redman, Pennington Biomedical Research Center, USA
Calorie Restriction (CR) in Humans and the Phenotype of Aging

Michael Ristow, ETH Zürich, Switzerland
Short Talk: Extending Life Span by Increasing Oxidative Stress: The Concept of Mitohormesis

Johannes Bauer, Southern Methodist University, USA
Short Talk: dSir2 and Dmp53 Interact to Mediate Aspects of CR-Dependent Life Span Extension in D. melanogaster

09:20—09:40
Coffee Break

Kokopelli's
14:30—16:30
Workshop 2 : Modulation of Longevity by Nutritional Manipulations

Bighorn B
* James F. Nelson, University of Texas Health Science Center, USA

Fernanda Menezes Cerqueira, Universidade de São Paulo, Brazil
Mild Mitochondrial Uncoupling Increases Life Span and Improves Redox State in Mice: A New Caloric Restriction Mimetic

Shailender Singh Chauhan, Panjab University, India
Beneficial Effects of Dietary Restriction (DR) in Retarding Age Related Biochemical Complications - A Possible Remedy for Aging

Shailender Singh Chauhan, Panjab University, India
Beneficial Effects of Dietary Restriction (DR) in Retarding Age Related Biochemical Complications - A Possible Remedy for Aging

Chen-Yu Liao, Barshop Institute for Longevity and Aging Studies, USA
Does Fat Mass Play a Role in Life Extension by Caloric Restriction? --- Verification by QTL Mapping

Tadasuke Komori, Wakayama Medical University, Japan
Fasting-Induced Expression of Klotho in the Mouse Hypothalamus

Meng C. Wang, Baylor College of Medicine, USA
Regulation of Longevity by the Coordination of Fat Metabolism and Reproduction

Philip Turnbull, Receptos, USA
The Hunt for Small Molecule Direct Activators of SIRT-1

Vladimir I. Titorenko, Concordia University, Canada
A Modular Network Regulates Longevity in Yeast

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Metabolic Signaling and Aging
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Randy Strong, South Texas Veterans Health Care System, USA

Dean Jones, Emory University, USA
Redox Compartmentation and Signaling in Aging: Is there a Redox Code?

Martin G. Myers, Jr., University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Regulation of Metabolism and Life Span by Neuronal Insulin Signaling Cascades

Shin-ichi Oka, University of Medicine and Dentistry of New Jersey, USA
Short Talk: Cardiac Sirt1 Negatively Regulates PPARalpha and PGC-1alpha: Implication of Energy Metabolism and Heart Failure

19:00
On Own for Dinner


THURSDAY, APRIL 3

07:00—08:00
Breakfast

Kokopelli's
08:00—11:00
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Eva L. Feldman, University of Michigan, USA

Arlan G. Richardson, University of Texas Health Science Center, USA
Does Altered Insulin/IGF-1 Signaling Increase Life Span and Reduce Oxidative Stress?

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Genomic Analysis of Insulin Resistance

K. Sreekumaran Nair, Mayo Clinic, USA
Insulin Resistance, Mitochondrial Function and Aging

Gaelle Laurent, Curie Institute, France
Short Talk: Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin-Signaling

Mette Soerensen, University of Southern Denmark, Denmark
Short Talk: Genetic Determinants of Extreme Survival - Genetic Variation in Mn-Superoxide Dismutase and Glutathione Peroxidase 1 Genes

09:20—09:40
Coffee Break

Kokopelli's
16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Yousin Suh, Albert Einstein College of Medicine, USA

Holly Van Remmen, Oklahoma Medical Research Institute, USA
Potential Role of Mitochondria and Oxidative Stress in Muscle Loss

Eva L. Feldman, University of Michigan, USA
Mitochondrial Fusion and Fission Mediate Senescence

Enrique Cadenas, University of Southern California, USA
Energy Metabolism and Mitochondrial Function in Aging: Role of Protein Post-Translational Modifications

Natascia Ventura, University of Rome, Italy
Short Talk: p53 Rheostatically Modulates C. elegans Longevity Depending on the Level of Mitochondrial Stress

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
20:00—23:00
Entertainment

Kokopelli's

FRIDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG032146-01




We gratefully acknowledge additional support for this conference from:

Glenn Foundation for Medical Research Seahorse Bioscience, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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