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This meeting took place in 2008



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Basis for Biological Membrane Organization (A2)


Organizer(s) Kai Simons, Ira Mellman and Petra Schwille
January 12—17, 2008
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 12, 2007
Late Abstract Deadline: Oct 15, 2007
Scholarship Deadline: Sep 12, 2007
Early Registration Deadline: Nov 12, 2007

Supported by the Director's Fund

Summary of Meeting:
The organization of cell membranes is a hot topic and the field is characterized by controversies regarding how proteins and lipids interact and how membranes become compartmentalized to form platforms that function in signaling, trafficking and cell polarization. Lipids and membranes are central to understanding the pathogenesis of important diseases such as atherosclerosis, Alzheimer’s Disease, AIDS, and influenza. Major questions revolve around how lipids interact with other lipids and, most importantly, how proteins and lipids interact. The goal of this meeting is to bring together scientists from biochemistry, structural biology, lipidomics, molecular cell biology and biomedicine to discuss major issues in the field. The multidisciplinary character of the meeting will promote discussion and the program is designed to stimulate exchange among investigators who would not otherwise interact.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 12

15:00—19:30
Registration

Lower Atrium
18:30—19:30
Refreshments

Lower Atrium
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Michael S. Brown, University of Texas Southwestern Medical Center, USA
The SREBP Pathway for Membrane Cholesterol Homeostasis


SUNDAY, JANUARY 13

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK
Structural Biology of Cell Membrane Bending

Margaret Kielian, Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms and Lipid Interactions of Class II Fusion Proteins.

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Membrane Targeting by the HIV-1 Gag Protein

Shinya Yoshikawa, University of Hyogo, Japan
Lipid-Protein Interactions in Cytochrome c Oxidase

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson / Madison
13:00—22:00
Poster Viewing

Jefferson / Madison
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Membrane Dynamics
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Pietro V. De Camilli, Yale University School of Medicine, USA
Role of Dynamin in Membrane Fission

Patricia Bassereau, Institut Curie, France
Membrane Nanotubes and Intracellular Traffic

Cameron Scott, University of Geneva, Switzerland
Short Talk: Lumenal Ion Composition and Endosomal Membrane Dynamics

Enrico Gratton, University of Illinois at Urbana Champaign, USA
Short Talk: Detecting Membrane Transient Zones Using Scanning Fluctuation Correlation Spectroscopy

19:15—20:15
Social Hour with Lite Bites

Jefferson / Madison
19:30—22:00
Poster Session 1

Jefferson / Madison

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Membrane Phases
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Gerald Feigenson, Cornell University, USA
Phase Diagrams as Models for Plasma Membranes

Sarah Keller, University of Washington, USA
Domain Formation in Asymmetric Model Bilayers

Tobias Baumgart, University of Pennsylvania, USA
Of Domains and Boundaries: Phase Behavior and Partitioning in Biomembrane Models

Satyajit Mayor, National Centre for Biological Sciences, India
Active Membrane Organization in Living Cells

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson / Madison
13:00—22:00
Poster Viewing

Jefferson / Madison
14:30—16:30
Workshop 1: Molecular Basis for Domains within Membranes

Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Peter Mayinger, Oregon Health and Science University, USA
Lipid Phosphatases Establish Spatially and Functionally Distinct Regions within the Golgi

Robin Klemm, Harvard Medical School, USA
A Role for Lipid Rafts in Protein Sorting and Vesicle Formation at the trans Golgi Network

Jen Liou, UT Southwestern Medical Center, USA
Dynamic Contact Formation of the Endoplasmic Reticulum and the Plasma Membrane during Store-Operated Ca2+ Entry

Ritva Tikkanen, University Clinic of Frankfurt, Germany
Lymphocyte Raft Protein Reggie-2/Flotillin-1 Directly Interacts with HIV-1 Gag Protein and Plays a Role in Virus Assembly and Release

Angela Wandinger-Ness, University of New Mexico, USA
Sorting Out The Ciliary Transport Puzzle: Small GTPases and Renal Cystic Disease

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Membrane Cytoskeleton
Meeting has ended...abstracts no longer viewable online.

Gallatin
Ira Mellman, Genentech, Inc., USA

* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Pekka Lappalainen, University of Helsinki, Finland
Regulation of the Actin Cytoskeleton and Plasma Membrane Dynamics by MIM/ABBA Family Proteins

Anthony P. Bretscher, Cornell University, USA
Regulation of the Cell Cortex by ERM and their Association Proteins

Tatyana Svitkina, University of Pennsylvania, USA
Membranes on the Move

Chiara Zurzolo, Institut Pasteur, France
Short Talk: Prions Hi-Jack TNTs for Intracellular Transfer

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
19:30—22:00
Poster Session 2

Jefferson / Madison

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Membrane Signaling
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Ira Mellman, Genentech, Inc., USA

Gillian Griffiths, Cambridge Institute for Medical Research, UK
Secretory Lysosome

Mark M. Davis, Stanford University, USA
T-Cell Receptor Signaling

Jay T. Groves, University of California, Berkeley, USA
Membrane Spatial Organization and the Mechanics of T Cell Receptor Signaling

Katharina Gaus, University of New South Wales, Australia
Functional Implications of Membrane Condensation for T Cell Activation

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson / Madison
13:00—22:00
Poster Viewing

Jefferson / Madison
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Lipids and Fusion
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Andrej Shevchenko, Max Planck Institute, Germany
Toward Comprehensive Profiling of Membrane Lipidomes

Peter K. Kasson, University of Virginia, USA
Short Talk: Simulating Vesicle Fusion: Effects of Membrane Composition, Curvature, and Lipid Ordering

Leonid V. Chernomordik, National Institute of Child Health and Human Development, USA
Protein-Lipid Interplay in Membrane Fusion

Martin W. Hetzer, The Salk Institute, USA
Short Talk: Nuclear Envelope Formation by Chromatin-Mediated Reorganization of the Endoplasmic Reticulum

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
19:30—22:00
Poster Session 3

Jefferson / Madison

WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Membrane Morphogenesis
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Tom A. Rapoport, Harvard University Medical School, USA
How the ER Gets into Shape

Walther Mothes, Yale University School of Medicine, USA
Cell-to-Cell Transmission of Retroviruses via Filopodial Bridges

Daniel M. Davis, Imperial College London, UK
Membrane Nanotubes in Human T Cell Biology

Peter K. Jackson, Stanford University, USA
Biogenesis and Function of the Primary Cilium

Ruth Kroschewski†, Swiss Federal Institute of Technology, Switzerland
Short Talk:

09:20—09:40
Coffee Break

Lower Atrium
14:30—16:30
Workshop 2: New Technologies for Addressing Challenges in Studies of Biological Membranes

Gallatin
* Ira Mellman, Genentech, Inc., USA

Tristan S. Ursell, California Institute of Technology, USA
Dynamic Morphologies and Coalescence of Lipid Domains

Inhee Chung, Genentech Incorporated, USA
Reversible Dimerization of Single Epidermal Growth Factor Receptor and its Spatial Heterogeneity in Live A431 Cell

Suliana Manley, National Institutes of Health, USA
Live Cell Photoactivated Localization Microscopy (PALM) for the Spatio-Temporal Mapping of Single Molecule Diffusion in the Plasma Membrane

Dimitrios Stamou, University of Copenhagen, Denmark
How BAR Domains and Amphipathic Helixes Recognize Membrane Curvature: A High-Throughput Single Vesicle Study

Xavier Michalet, University of California, Los Angeles, USA
Single-Molecule Tracking of GPI-Anchored Protein Using Quantum Dots Shows Dynamic Partitioning In and Out of GM1 and Cholesterol-Rich Domains in the Plasma Membrane of Live Cells

Salvatore Chiantia, MPI-CBG, Germany
Role of Ceramide Domains in Membrane Protein Organization Investigated by Simultaneous FCS and AFM

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Membrane Sorting and Vesicle Formation
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Ira Mellman, Genentech, Inc., USA

Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Genome-Wide Survey of Endocytosis by Quantitative Multi-Parametric Image Analysis

Ari Helenius, ETH Zurich, Switzerland
Endocytic Pathways of Virus Entry

Sandra L. Schmid, University of Texas Southwestern Medical Center, USA
Role of Dynamin in Clathrin-Mediated Endocytosis

Jason A. Mears, Case Western Reserve University, USA
Short Talk: Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
20:00—23:00
Entertainment

Jefferson / Madison

THURSDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM081929-01




We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676