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This meeting took place in 2008



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Wnt/beta-Catenin Signaling in Development and Disease (B8)


Organizer(s) Joanna L. Groden and Randall T. Moon
February 17—22, 2008
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 17, 2007
Late Abstract Deadline: Nov 15, 2007
Scholarship Deadline: Oct 17, 2007
Early Registration Deadline: Dec 17, 2007

Supported by the Director's Fund

Summary of Meeting:
Current research has shown that the Wnt signaling pathways are vital in the regulation of growth and differentiation in many diverse organisms and cell types. From their importance in the development of the fly wing and the specification of the vertebrate embryonic axis, their roles in cancer susceptibility to their functions in stem cell biology, to their roles in cell movement and planar cell polarity, these pathways control numerous key processes. This meeting will provide a platform to review the latest research on the functions and mechanisms of action of beta-catenin dependent and independent Wnt/Frizzled signaling pathways in a variety of organisms, tissue systems, and disease contexts. Finally, this meeting will continue to be a major platform for announcing advances in the discovery of small molecule modulators that might serve as leads for drug development.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 17

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Thomas A. Rando, Stanford University School of Medicine, USA
Control of Muscle Stem Cell Fate by Wnt Signaling


MONDAY, FEBRUARY 18

07:00—08:00
Breakfast

Crestone
08:00—11:00
Pathway Components I
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Bill Arthur, Rosetta Inpharmatics-Merck & Co., Inc., USA
Screening the Wnt Pathway Using RNAi

Mien-Chie Hung, University of Texas MD Anderson Cancer Center, USA
Strategies for Therapeutic Targeting GSK-3beta and Erk

* Inke S. Näthke, University of Dundee, UK
The APC Protein in Cell Adhesion, Migration, and Division

Kristi L. Neufeld, University of Kansas, USA
Nuclear and Cytoplasmic Localization of the APC Tumor Suppressor

Ken-Ichi Takemaru, Stony Brook University, USA
Short Talk: Nuclear-Cytoplasmic Shuttling of Chibby Regulates Subcellular Localization of beta-Catenin

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone
13:00—22:00
Poster Viewing

Crestone
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
Pathway Components II
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Michael Ben Major, University of Washington, USA

Christopher J. Phiel, University of Colorado Denver, USA
In Vivo Functions of GSK-3 Isoforms

Hsien-yu Wang, Stony Brook University, USA
Inositol Pentakisphosphate Mediates Wnt/beta-Catenin Signaling

Xinhua Lin, Cincinnati Children's Hospital Medical Center, USA
The Retromer Complex is Involved in Wnt Secretion by Controlling Retrograde Transport of Wntless from Endosomes to Trans Golgi Network

Aaron M. Zorn, Cincinnati Children's Hospital Medical Center, USA
Sox Proteins Regulate Beta-catenin/Tcf Activity

19:15—20:15
Social Hour with Lite Bites

Crestone
19:30—22:00
Poster Session 1

Crestone

TUESDAY, FEBRUARY 19

07:00—08:00
Breakfast

Crestone
08:00—11:00
Wnt Signaling in Development
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Janet Heasman, Cincinnati Children's Research Foundation, USA
The Role of the Wnt Antagonist Dickkopf-1 in Patterning the Axis of the Xenopus Laevis Embryo

Edward E. Morrisey, University of Pennsylvania, USA
Novel Roles for Wnt Signaling in Lung and Cardiac Development

Diane C. Slusarski, University of Iowa, USA
Wnt/Calcium Signaling in Zebrafish Morphogenesis: Cues for Laterality and Polarity

Christian P. Petersen, Northwestern University, USA
Short Talk: smed beta catenin-1 is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

Woo-Yang Kim, University of North Carolina, USA
Short Talk: Glycogen Synthase Kinase-3s are Required for Mouse Brain Development

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone
13:00—22:00
Poster Viewing

Crestone
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Wnt Signaling in Stem Cells and Regeneration
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Gary D. Hammer, University of Michigan, USA
Wnt/beta-Catenin Signaling in Adrenocortical Stem/Progenitor Cells: Implications for Adrenocortical Carcinoma

* Randall T. Moon, University of Washington School of Medicine, USA
WNT Signaling in Zebrafish Regeneration

Sarah E. Millar, University of Pennsylvania, USA
Title to be Determined

Nick Barker, Institute of Medical Biology, Singapore
Short Talk: LGR5 Marks Stem Cells in Multiple Adult Tissues

19:00—20:00
Social Hour with Lite Bites

Crestone
19:30—22:00
Poster Session 2

Crestone

WEDNESDAY, FEBRUARY 20

07:00—08:00
Breakfast

Crestone
08:00—11:00
Interactions of Wnt with Other Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Barry M. Gumbiner, University of Virginia School of Medicine, USA
Cadherin and Beta-Catenin Signaling Interactions

Stephen Carl Ekker, Mayo Clinic, USA
Wnt5 Signaling in Organogenesis and Human Craniofacial Development

Marek Mlodzik, Mount Sinai School of Medicine, USA
Wnt/Fz-Planar Cell Polarity (PCP) Signaling: Signaling Specificity, Regulation, and Interactions with Other Pathways

Lena Al-Harthi, Rush University, USA
Lithium Inhibits HIV Replication in Peripheral Blood Mononuclear Cells (PBMCs) by Activating the beta-catenin

Wolfram Goessling, Brigham and Women's Hospital-Harvard Medical School, USA
and

Trista E. North, Beth Israel Deaconess Medical Center, USA
Short Talk: Genetic Interaction between PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone
13:00—22:00
Poster Viewing

Crestone
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Wnt Regulation of Gene Expression
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Marian Waterman, University of California, Irvine, USA
LEF/TCF Control of Gene Expression

Katherine A. Jones, The Salk Institute, USA
Control of H3K4 Trimethylation at Wnt-induced genes

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
The Role of the Pygopus-BCL9 Complex in TCF-mediated Transcription

Timothy A. Blauwkamp, University of Michigan, USA
Short Talk: Novel TCF Binding Sites Specify Transcriptional Repression by Wnt Signaling

19:00—20:00
Social Hour with Lite Bites

Crestone
19:30—22:00
Poster Session 3

Crestone

THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

Crestone
08:00—11:00
Wnt Signaling in Cancer
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Joanna L. Groden, Ohio State University, USA

Sylvie Robine, Institut Curie, France
RAS Pathway Synergy with wnt Signaling in in vivo Models of Cancer

Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Naked1 and Naked2, Mammalian Orthologs of Naked Cuticle, are Differentially Regulated in Colorectal Cancer

Michael Ben Major, University of Washington, USA
Proteomic Dissection of the Wnt/beta-Catenin Signal Transduction Pathway

Matthias Ernst, Olivia Newton-John Cancer Research Institute, Australia
Short Talk: Enforced Expression of DNA Methyltransferase 3a Enhances Polyposis in ApcMin/+ Mice by Transcriptional Silencing of Sfrp5

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Pharmacological Modulation of Wnt Signaling
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Caterina A.M. La Porta, University of Milan, Italy
Cancer Stem Cells and Therapeutic Perspectives

Elena Brin, Ambrx, USA
Short Talk: Selective Apoptosis Induction in Wnt-Deregulated Cancer Cells

Thomas Andersson†, Swedish University of Agricultural Sciences, Sweden
Short Talk: Foxy-5, A WNT-5-Derived Hexapeptide

* Trevor Clive Dale, Cardiff University, UK
Cell Based Screening for Inhibitors of the Wnt Signaling Pathway

19:00—20:00
Social Hour with Lite Bites

Crestone
20:00—23:00
Entertainment

Crestone

FRIDAY, FEBRUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD057682-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. March of Dimes Foundation
The Company of Biologists Ltd
 

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