Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2008



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Tumor Suppressors and Stem Cell Biology (C3)


Organizer(s) Sean J. Morrison and Alejandro Sánchez Alvarado
February 24—29, 2008
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Oct 24, 2007
Late Abstract Deadline: Nov 26, 2007
Scholarship Deadline: Oct 24, 2007
Early Registration Deadline: Dec 26, 2007

Supported by the Director's Fund

Summary of Meeting:
Stem cells play key roles in the development, maintenance, and reproduction of all known multicellular organisms. Stem cells operate in a wide variety of biological contexts from homeostasis to regeneration and must be subject to complex and robust regulation. Recent evidence suggests that tumor suppressor mechanisms, originally discovered for their ability to inhibit tumorigenesis, also play widespread roles in the physiological regulation of stem cells. Tumor suppressors play critical roles in the regulation of tissue homeostasis, stem cell self-renewal, regeneration, and aging. This reveals mechanistic links between the regulation of stem cells, and the regulation of cancer cells that could potentially be exploited to target cancer and to enhance regeneration. The dual roles of these mechanisms in stem cell and cancer biology illuminate the evolved balance between the promotion of regeneration and the suppression of cancer.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 24

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Charles J. Sherr, St. Jude Children's Research Hospital, USA
Tumor Suppressors (RB, p53 INK4 genes, & ARF): On the Road to Immortality


MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Tumor Suppressors and the Evolution of Stem Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Andrea I. McClatchey, Massachusetts General Hospital, USA
Membrane Organization in Tissue Homeostasis and Tumorigenesis

Gad Shaulsky, Baylor College of Medicine, USA
Cell Competition, Stem Cells and the Evolution of Sociality

Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Asymmetric Stem Cell Division during Tissue Homeostasis and Aging

* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
Stem Cells and their Regulation in the Planarian Schmidtea Mediterranea

Bret Pearson, University of Utah, USA
Short Talk: Adult Stem Cells and Tumorigenesis in the Freshwater Planarian

Junlin Qi, University of Washington, Seattle, USA
Short Talk: microRNA-195 Regulates Human Embryonic Stem Cell Division

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Epigenetic Regulation of Stem Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Megan F. Cole, Massachusetts Institute of Technology, USA
Connecting Signaling to the Core Regulatory Circuitry of Embryonic Stem Cells

Patrick M.P. Viatour, Stanford University, USA
Short Talk: Hematopoietic Stem Cell Quiescence is maintained by Compound Contributions of the Retinoblastoma Gene Family

Valerie M. Renault, Stanford Medical School - Stanford University, USA
Short Talk: The Role of FoxO Transcription Factors in the Maintenance of Neural Stem Cells during Aging

Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The E3 Ligase Fbw7, a T-ALL Tumor Suppressor, is a Novel Regulator of Hematopoietic Stem Cell Self-Renewal

Emmanuelle Passegué, Columbia University, USA
Short Talk: Regulation of Hematopoietic Stem Cell Functions by JunB

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Tumor Suppressors and the Environmental Control of Stem Cells
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Ruth Lehmann, New York University School of Medicine, USA
The Niche and Germline Homeostasis

* David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cell Niche

Judith E. Kimble, University of Wisconsin, Madison, USA
Germline Stem Cells and their Niche in C. elegans

Linheng Li, Stowers Institute for Medical Research, USA
Stem Cells, Niches, and Zones

Maria Sol Flaherty, New York University School of Medicine, USA
Short Talk: A Novel BTB-Domain Protein Regulates Stem Cell Self-Renewal Downstream of JAK/STAT Signaling in the Drosophila Testis

Vivienne I. Rebel, University of Texas Health Science Center, USA
Short Talk: CBP+/- Mice Develop Myelodysplasia and Hhypersensitivity to gamma Radiation with Age

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Physiological Function of Tumor Suppressors
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in Vivo

Tian Xu, Yale University School of Medicine, USA
Immune Response of Blood Cells to Tumors in Drosophila

Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Mechanisms Regulating Stem Cell Fate

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Pacific Ballroom
07:00—08:00
Poster Setup

Pacific Ballroom
08:00—11:15
Stem Cell Self-Renewal
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Lineage Determination in the Hematopoietic System

Guy Sauvageau, IRIC/Université de Montréal, Canada
Bmi1 Integrates Multiple Pathways in Hematopoietic Stem Cell Regulation

Cheng-Yu Lee, University of Michigan, USA
Regulation of Neuroblast Self-Renewal in Drosophila

Fiona Doetsch, Columbia University, USA
MicroRNA Regulation of Adult Neural Stem Cells

Janel E. Le Belle, University of California, Los Angeles, USA
Short Talk: Deletion and Inactivation of the Tumor Suppressors TSC and PTEN Influence Neural Stem Cell Self-Renewal and Neurogenesis

Susumu Goyama, University of Tokyo, Japan
Short Talk: Evi-1 is a Critical Regulator for Hematopoietic Stem Cells and Leukemic Cells

09:20—09:40
Coffee Break

BC Foyer
11:15—12:15
Lunch

Pacific Ballroom
12:00—14:30
Poster Session 3

Pacific Ballroom
14:30—15:00
Coffee Available

Pacific Foyer
15:00—17:00
Stem Cells and Cancer
Meeting has ended...abstracts no longer viewable online.

Pacific Ballroom
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Title to be Determined

John E. Dick, Princess Margaret Cancer Centre, Canada
Modeling the Human Leukemogenic Process

* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal Versus Cancer Cell Proliferation

 
On Own for Dinner


THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Tumor Suppressors and Regeneration
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Peter W. Reddien, Whitehead Institute, USA
Identification of Regeneration and Stem Cell Regulatory Genes in Planaria

Amy J. Wagers, Harvard University, USA
Regulation and Function of Skeletal Muscle Stem Cells

Leanne Jones, University of California, Los Angeles, USA
Aging-Related Changes to Stem Cells and the Stem Cell Niche

* Irving L. Weissman, Stanford University, USA
Stem Cells and the Origin of Self/Non-Self Recognition

Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
Short Talk: The Role of the Rb Family in Retinal Development and Retinoblastoma

Christine Karlsson, Lund University, Sweden
Short Talk: Defining Regulators of Hematopoietic Stem Cell Self-Renewal using RNA Interference in High-throughput Genetic Screens

09:20—09:40
Coffee Break

BC Foyer
11:00
On Own for Lunch

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Stem Cells and Aging
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Norman E. Sharpless, University of North Carolina School of Medicine, USA
Tumor Suppressors and Aging

Heinrich Jasper, Buck Institute for Research on Aging, USA
Stress Signaling, Stem Cells and Aging

Thomas A. Rando, Stanford University School of Medicine, USA
Wnt Signaling Alters Stem Cell Fate in Aged Tissue

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

FRIDAY, FEBRUARY 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA132459-01




We gratefully acknowledge additional support for this conference from:

Merck & Co., Inc.

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