Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2008



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Towards Identifying the Pathophysiology of Autistic Syndromes (C2)


Organizer(s) Joseph Piven and Pat Levitt
February 24—28, 2008
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 24, 2007
Late Abstract Deadline: Nov 26, 2007
Scholarship Deadline: Oct 24, 2007
Early Registration Deadline: Dec 26, 2007

Supported by the Director's Fund

Summary of Meeting:
Autism is a common and highly heritable, neurodevelopmental disorder defined by the co-occurrence of three characteristic, behavioral features: (1) deficits in social interactions, (2) abnormalities in verbal and non-verbal communication, and (3) highly restricted interests and repetitive behaviors. The developmental etiology and specific pathogenetic mechanisms underlying autism are unknown, but the pathophysiology that underlies a small subset of etiologically-defined, rarer neurodevelopmental disorders, thought to be associated with autism and autistic behaviors—e.g., Fragile X Syndrome, tuberous sclerosis, Smith-Lemli-Opitz Syndrome and Rett Syndrome—have been well-described, yet there is disproportionately little research on these conditions as models for understanding autism. Accumulating data suggest that an underlying pathophysiology in the development of brain connectivity may be the point of convergence across all of these disorders. This conference brings together a unique group of clinical and basic scientists to examine what is known about the genetic and neurobiological underpinnings of this subset of disorders as a starting point for identifying the pathophysiological basis of autism.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 24

15:00—19:30
Registration

Promenade
18:30—19:30
Refreshments

Promenade
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Patrick Bolton, King's College, London, UK
Overview of the Medical Condition Associated with the Autistic Phenotype (Rett, FXS, SLO, TSC)


MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Autism Overview
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Pat Levitt, Keck School of Medicine, USA

Geraldine Dawson, Duke University Medical Center, USA
The Syndrome of Autism: Early Patterns of Behavioral Symptoms, Brain Dysfunction, and Clinical Course

Daniel H. Geschwind, University of California, Los Angeles, USA
Tackling Genetic Complexity in Autism

David Amaral, University of California, Davis, USA
Neurobiological Studies in Autism

Mark H. Lewis, University of Florida, USA
The Pathophysiology of Repetitive Behavior

Joseph Piven, University of North Carolina at Chapel Hill, USA
Brain-Behavior Relationships in Early Development of Autism

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Ortiz
13:00—22:00
Poster Viewing

Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Neurocutaneous Disorders
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Daniel H. Geschwind, University of California, Los Angeles, USA

Alcino J. Silva, University of California, Los Angeles, USA
Memory and How it Fails: Unraveling Mechanisms and Finding Cures for Cognitive Disorders

Kevin Ess, Vanderbilt University, USA
Neurobiology of Tuberous Sclerosis Complex

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
The P13 Kinase Pathway and Mouse Models of Autism

19:00—20:00
Social Hour with Lite Bites

Ortiz
19:30—22:00
Poster Session 1

Ortiz

TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Fragile X Syndrome
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Joseph Piven, University of North Carolina at Chapel Hill, USA

Declan G. Murphy, King's College London, UK
An Overview of Brain and Behavioral Phenotypes in FXS

David L. Nelson, Baylor College of Medicine, USA
Modeling Modifiers in Fragile X Syndrome

William T. Greenough, University of Illinois at Urbana-Champaign, USA
Neurobiology of FXS

Gul Dolen, Johns Hopkins University, USA
Correction of Fragile X in Mice

Jacqueline J. Blundell, University of Texas Southwestern Medical Center, USA
Short Talk: A Potential Mouse Model of Non-syndromic Autism: Disease-Linked Point Mutation in Neuroligin-3 Produces Autism-Like Behavior in Mice

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Ortiz
13:00—22:00
Poster Viewing

Ortiz
14:30—16:30
Workshop: Epigenetics

Mesa A-B
* David L. Nelson, Baylor College of Medicine, USA

Yi Eve Sun, University of California, Los Angeles, USA
Title to be Determined

Arthur L. Beaudet, Baylor College of Medicine, USA
Distinct Genetic and Epigenetic Approaches to the Etiology of Autism Independent of Genetic Linkage and Association

Jonathan Sebat, University of California, San Diego, USA
Analysis of Genome Copy Number Variation in Autism Spectrum Disorders

Marylyn D. Ritchie, Pennsylvania State University, USA
Epistasis Modeling

16:30—17:00
Coffee Available

Promenade
17:00—17:50
Rett Syndrome
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Declan G. Murphy, King's College London, UK

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Deciphering the Neurobiology of Rett Syndrome

Sarika U. Peters, Baylor College of Medicine, USA
Short Talk: An Emerging Behavioral Phenotype in Female Carriers with MECP2 Duplications: Implications for the Broad Autism Phenotype

17:50—19:00
Smith Lemli Opitz Syndrome
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Forbes D. Porter, National Institutes of Health and Human Development, USA
Smith-Lemli-Opitz Syndrome: Mouse Models, Pathophysiology, and Treatment

Elaine Tierney, Kennedy Krieger Institute, USA
Smith-Lemli-Opitz Syndrome: Clinical Trials, Autism Interface

19:00—20:00
Social Hour with Lite Bites

Ortiz
19:30—22:00
Poster Session 2

Ortiz

WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Signaling Systems
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Michael E. Greenberg, Harvard Medical School, USA

Randy Blakely, Florida Atlantic University, USA
Rare Opportunities for Progress in Autism: Serotonin and Serotonin Transporters from Mouse to Man

Pat Levitt, Keck School of Medicine, USA
Convergent Evidence of C-Met Tyrosine Kinase Receptor Involvement In Forebrain Development and Autism Spectrum Disorder

Takao K. Hensch, Harvard University, USA
Excitatory-Inhibitory Balance in Neuronal Circuit Development

Lisa M. Boulanger, Princeton University, USA
Regulation of Glutamatergic Synaptic Transmission and Synaptic Plasticity by MHC Class I

Toru Takumi, Hiroshima University, Japan
Short Talk: The Mouse Model for Human 15q11-13 Duplication Displays Autistic Behaviour

09:20—09:40
Coffee Break

Promenade
16:30—17:00
Coffee Available

Promenade
17:00—18:15
Mechanism of Synapse Development
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Takao K. Hensch, Harvard University, USA

Michael E. Greenberg, Harvard Medical School, USA
Activity-Dependent Synapse Formation and Elimination, Role of MEF2

Beth Stevens, Children's Hospital Boston, USA
How are CNS Synapses Eliminated?

18:15—19:00
Discussion Panel: Toward Identifying the Pathophysiology of Autism

Mesa A-B
19:00—20:00
Social Hour with Lite Bites

Ortiz
20:00—23:00
Entertainment

Ortiz

THURSDAY, FEBRUARY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13MH082458-01




We gratefully acknowledge additional support for this conference from:

International Rett Syndrome Foundation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Organization for Autism Research

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676