Granlibakken Tahoe Floorplan

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This meeting took place in 2008



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Genetics and Biochemistry of Sleep (C5)


Organizer(s) Amita Sehgal, Jay C. Dunlap and Emmanuel Mignot
March 7—12, 2008
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 7, 2007
Late Abstract Deadline: Dec 5, 2007
Scholarship Deadline: Nov 7, 2007
Early Registration Deadline: Jan 21, 2008

Supported by the Director's Fund

Summary of Meeting:
Sleep is increasingly being recognized as an important area of research that is also relevant for our understanding of other physiological functions. Among recent advances are the identification of genes that contribute to sleep disorders (e.g., narcolepsy, advanced sleep phase syndrome), the development of animal, including invertebrate, model systems for sleep, the discovery of sleep-regulating genes and the demonstration of links between sleep and metabolism. In addition, the serious health consequences of disrupted sleep have been rigorously documented. Major questions now are how the timing and duration of sleep are controlled by the circadian and sleep-promoting homeostatic systems, and what essential functions are served by sleep. The program emphasizes the benefits of a cross-disciplinary approach to address the problems posed above. It also highlights the extent to which sleep impacts other aspects of physiology, and the progress towards understanding the molecular basis of sleep disorders.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 7

15:00—19:30
Registration

Pre Function
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Allan I. Pack, University of Pennsylvania School of Medicine, USA
Functional Genomic Approaches to the Study of Sleep


SATURDAY, MARCH 8

07:00—08:00
Breakfast

Granhall
08:00—11:20
Control of Sleep and Vigilance by Circadian and Non-Circadian Mechanisms
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Amita Sehgal, University of Pennsylvania Perelman School of Medicine, USA

David F. Dinges, University of Pennsylvania School of Medicine, USA
Trait-Like Differential Vulnerability to the Neurobehavioral Effects of Sleep Loss in Humans

Monique K. LeBourgeois, Brown University, USA
Short Talk: Salivary Dim Light Melatonin Onset (DLMO) and Reported Sleep in Preschool Children

Clifford B. Saper, Beth Israel Deaconess Medical Center, USA
Inducible Clocks: Living in an Unpredictable World

Jerry M. Siegel, University of California, Los Angeles, USA
Phylogeny of Sleep

Ravi Allada, Northwestern University, USA
Neural Circuits Controlling Sleep in Drosophila

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Molecular Mechanisms of the Circadian Clock
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Michael W. Young, Rockefeller University, USA
Regulation of Period Function and Stability by Doubletime

Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Genetic Analysis of Circadian Rhythms in Mammals

* Jay C. Dunlap, Dartmouth Medical School, USA
Molecular Mechanisms of the Clock in Neurospora

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay Room
20:00—21:00
Social Hour

Bay Room

SUNDAY, MARCH 9

07:00—08:00
Breakfast

Granhall
08:00—11:30
Circadian Physiology and Other Sleep-Relevant Physiological Phenomena
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Paolo Sassone-Corsi, University of California, Irvine, USA
Signaling to Chromatin and the Circadian Clock

Ueli Schibler, University of Geneva, Switzerland
Control of Circadian Gene Expression and Physiology by Central and Peripheral Clocks

Nicolas Cermakian, Douglas Mental Health University Institute, Canada
Short Talk: Entrainment of Clock Gene Expression in Peripheral Blood Mononuclear Cells Following Simulated Night Shift Work with Light/Darkness Intervention

* Irene Tobler, University of Zurich, Switzerland
Daily Torpor and Use-Dependent Aspects of Sleep

Cheng Chi Lee, University of Texas Health Science Center, USA
A Metabolic Rhythm Regulated by Constant Darkness

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
14:30—16:30
Workshop 1: Therapeutic Intervention to Treat Sleep Disturbances

Mountain
Philippe Mourrain, Stanford University, USA
Sleeping with the Fishes, a Concrete Story

Sonia Ancoli-Israel, University of California, San Diego, USA
Treatment of Sleep Disorders in Older Adults

* David P. White, Respironics, Inc./Harvard Medical School, USA
Phenotyping in Obstructive Sleep Apnea: Implications for Therapy and Genetic Studies

John Joseph Renger, Merck Research Laboratories, USA
Leveraging the Genetics of Sleep to Identify Novel Targets for the Treatment of Neurological Disease

Christine Dugovic, Johnson and Johnson Pharmaceutical Research and Development, USA
New Therapeutic Targets for Sleep-Wake Disorders

Norio K. Ishida, National Institute of Advanced Industrial Science and Technology (AIST), Japan
PPARalpha Ligand is a New Target for DSPS - From Circadian Clock to Seasonal Clock

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Neural Basis of Sleep
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Barbara E. Jones, McGill University, Canada
Neuronal and Chemical Substrates of Sleep-Wake States

* Luis de Lecea, Stanford University, USA
Neuropeptides and Sleep

Michael M. Rosbash, Brandeis University, USA
Pharmacological Approaches to the Study of Sleep in Drosophila

Thomas S. Kilduff, SRI International, USA
Short Talk: Gene Expression during Sleep Deprivation and Recovery Sleep: Global, Regional and Cellular Analyses

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay Room
20:00—21:00
Social Hour

Bay Room

MONDAY, MARCH 10

07:00—08:00
Breakfast

Granhall
08:00—11:30
Molecular Analysis of Sleep
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Chiara Cirelli, University of Wisconsin, Madison, USA
Genetic Screens for Sleep Mutants in Drosophila

* Fred W. Turek, Northwestern University, USA
Genetic Analysis of Sleep in Mammals

Sigrid C. Veasey, University of Pennsylvania School of Medicine, USA
Selective Loss of Catecholaminergic Wake-Active Neurons in a Murine Sleep Apnea Model

Paul Franken, University of Lausanne, Switzerland
Circadian Genes = Sleep Homeostatic Genes = Metabolic Genes?

09:20—09:40
Coffee Break

Pre Function
14:30—16:30
Workshop 2: New Approaches to the Study of Sleep

Mountain
Amanda Sorribes, Universidad Autónoma de Madrid, Spain
Statistics of Sleep-Wake Transitions: Drosophila vs Mammals

Kyunghee Koh, University of Pennsylvania, USA
Severe Reduction of Sleep in Sleepless Mutants

* David M. Raizen, University of Pennsylvania School of Medicine, USA
Lethargus is a C. Elegans Sleep-like State

Heather Anne Mitchell, Emory University, USA
Responses of Dopamine beta-Hydroxylase Knockout (Dbh -/-) Mice to Modafinil Support a Dual Noradrenergic-Dopaminergic Mechanism of Action

David A. Prober, Harvard University, USA
Hypocretin/Orexin Overexpression Induces an Insomnia-Like Phenotype in Zebrafish

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Relationship between Sleep and Metabolism
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Eve Van Cauter, University of Chicago, USA
Sleep Duration and Quality: Impact on Carbohydrate Metabolism and Appetite Regulation

Jason R. Gerstner, University of Wisconsin, USA
And

Jerry C.P. Yin, University of Wisconsin-Madison, USA
A Role for Fatty-Acid Binding Proteins in Sleep Homeostasis and Long-Term Memory in Drosophila

Masashi Yanagisawa, University of Tsukuba, Japan
Molecular Genetic Dissection of Sleep/Wake Regulation

19:00—20:00
Dinner

Granhall

TUESDAY, MARCH 11

07:00—08:00
Breakfast

Granhall
08:00—11:00
Genetic/Genomic Approaches to the Study of Human Sleep Disorders
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Emmanuel Mignot, Stanford University School of Medicine, USA
Molecular Studies in Narcolepsy and Hypersomnia

Ying-Hui Fu, University of California, San Francisco, USA
Genetic Analysis of Advanced Sleep Phase Syndrome

Mehdi Tafti, University of Lausanne, Switzerland
Genetics of Normal and Pathological Sleep in Humans

Juliane Winkelmann, Helmholtz Zentrum München, Germany
Genetics of Restless Legs Syndrome

09:20—09:40
Coffee Break

Pre Function
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Role of Sleep in Other Physiological Processes
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Giulio Tononi, University of Wisconsin, Madison, USA
Sleep and Synaptic Plasticity

Ted Abel, University of Pennsylvania, USA
The Role of Sleep in Hippocampal Memory Storage and Synaptic Plasticity

Julie A. Williams, University of Medicine and Dentistry of New Jersey, USA
Interaction between Sleep and the Immune Response in Drosophila

Mark R. Opp, University of Michigan, USA
Short Talk: Role of Cytokine-Neurotransmitter Interactions in Sickness-Induced Suppression of REMS

19:00—20:00
Social Hour

Bay Room
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

WEDNESDAY, MARCH 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS061372-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Johnson & Johnson Pharmaceutical Research & Development, L.L.C.


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