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This meeting took place in 2008



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Tolerance in Transplantation and Autoimmunity (A8)


Organizer(s) Jeffrey A. Bluestone, Abul K. Abbas, Laurence A. Turka and Diane J. Mathis
January 29—February 3, 2008
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 1, 2007
Late Abstract Deadline: Nov 1, 2007
Scholarship Deadline: Oct 1, 2007
Early Registration Deadline: Dec 3, 2007

Sponsored by Novo Nordisk A/S

Summary of Meeting:
The past 40 years has seen enormous progress in the treatment of organ transplantation and autoimmunity. However, with the modern era of immunosuppression, significant problems remain including strikingly higher rates of cardiovascular disease, opportunistic infection, and malignancy. The ability to induce immune tolerance would solve most of these problems. There has been enormous progress in our understanding of the basic processes of both central and peripheral tolerance. Moreover, the development of novel cell surface, soluble and cellular targets has created new therapeutics. The goals of this meeting will be to present cutting edge basic and clinical tolerance research related to transplantation and autoimmunity. Presentations will focus on both advances in basic understanding of immune tolerance, pre-clinical models of disease as well as far-reaching mechanistic studies devoted to the understanding of diseases and therapeutic interventions. The meeting stands out as bringing both basic science and clinical research experts together to explore the major biological pathways of tolerance at the molecular, cellular, pre-clinical and clinical levels. Thus, the meeting will promote critical interchanges between scientists who study these processes and educate students. The long-term objective is to increase our understanding of basic tenets underlying tolerance, to establish new collaborative research projects between basic and clinical researchers and to excite future scientists in this field of study.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 29

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Multiple Steps to Tolerance and Autoimmunity


WEDNESDAY, JANUARY 30

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
Central Tolerance
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Philippa C. Marrack, HHMI/National Jewish Health, USA
How the T Cell Repertoire becomes Peptide and MHC Specific

George S. Eisenbarth, University of Colorado Health Sciences Center, USA
Insulin: Tolerance and Intolerance in Type 1 Diabetes of Man and Mouse

Megan Sykes, Massachusetts General Hospital, USA
Clinical Application of Bone Marrow Transplantation in Organ Transplantation

Mark S. Anderson, University of California, San Francisco, USA
Mechanisms of a Novel Autoimmunity Syndrome caused by a Dominant Mutation in Aire

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
14:30—16:30
Workshop 1

Shavano/Torreys
* Bruce R. Blazar, University of Minnesota, USA
Role of Indoloeamine 2, 3 Dioxygenase and Regulating Alloresponses

Steven D. Levin, Alpine Immune Sciences, USA
Identification and Characterization of Vsig9 as an Inhibitory Member of the CD28 Family

Elizabeth C. Nowak, Dartmouth Medical School, USA
Specific DC Subsets and Co-Stimulatory/Inhibitory Molecules Regulate Conversion of Naïve CD4+ T Cells to Foxp3+ Regulatory T Cells

Greg M. Delgoffe, University of Pittsburgh, USA
Identification of mTOR as a Central Regulator in Adaptive Effector versus Regulatory T Cell Lineage Development

Girdhari Lal, National Centre for Cell Science, India
Epigenetic Regulation of Foxp3 Expression and Efficient Generation of Regulatory CD4+ T Cells from Peripheral Naïve CD4+CD25- T Cells

Allison L. Bayer, University of Miami School of Medicine, USA
IL-2R and IL-7R Signaling Normally Functions during Thymic Development of CD4+CD25+Foxp3+ Regulatory Cells

* Hugh Auchincloss, NIAID/NIH/HHS, USA

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Biochemical Pathways of Tolerance
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Thoughts on Treg and Th17 Differentiation and Function

* Diane Mathis, Harvard Medical School, USA
CD4, CD25, Foxp3 and Tregs Regulate Diabetes Progression in NOD Mice

Andrew C. Chan, Genentech, Inc., USA
Cellular Polarity in Tcell Biology

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 1

Crestone/Red Cloud

THURSDAY, JANUARY 31

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
Co-Stimulatory and Inhibitory Receptors and Cytokines
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Arlene H. Sharpe, Harvard Medical School, USA
PD-L1:PD-1 and PD-L1:B7-1 Interactions and T Cell Tolerance

Flavio G. Vincenti, University of California, San Francisco, USA
Costimulation Blockade with Belatacept in Renal Transplantation

* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
TIM Family of Genes: Role in T Cell Differentiation, Autoimmunity and Tolerance

Christian P. Larsen, Emory University School of Medicine, USA
Determinants of Transplantation Tolerance Induction

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
14:30—16:30
Workshop 2: Drug Discovery and Therapeutic Intervention

Shavano/Torreys
* Jeffrey L. Browning, Boston University School of Medicine, USA
BioGen/IDEC

Paul Anthony Blair, University College London, UK
Suppressive Effect of Regulatory B Cells in Experimental Lupus: Translation to Systemic Lupus Erythematosus

Joseph M. Dal Porto, Pfizer Center for Therapeutic Innovation, USA
Immunomodulation of B Cell Activation via Non-Depleting, Therapeutic Intervention of the CD19 Co-Receptor

Barbara Metzler, Novartis Institutes for BioMedical Research, Switzerland
Homeostatic Tuning of FoxP3+CD4 T Cell Populations under Continuous Exposure to FTY720

Andrew Miller, , USA
ITPKb is a Negative Regulator of B Cell Tolerance via Inhibition of Store-Operated Calcium Channels

Mark R. Rigby, Emory University, USA
Costimulation Antagonists Result in Abortive Activation of Antigen-Stimulated T Cells

Anne S. De Groot, EpiVax, Inc., USA
A Novel Model of IVIG Immunosuppression: Activation of Natural Regulatory T cells by IgG-Derived Peptides

* David W. Scott, Uniformed Services University of Health Sciences, USA
Peptide-IgG Transduced B Cells that Activated via TLR4 and TLR9 have Opposite Effects on Tolerance Induction

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Bioinformatics and Biomarkers in Tolerance
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Terry B. Strom, Beth Israel Deaconess Medical Center, USA
Gene Expression Profiling to Study Tolerance

Ken H. Buetow, National Cancer Institute, National Institutes of Health, USA
Enabling the Molecular Medicine Revolution through Network-Centric Biomedicine

David A. Hafler, Yale University School of Medicine, USA
Tolerance in Transplantation and Autoimmunity

Vicki L. Seyfert-Margolis, Food and Drug Administration, USA
Short Talk: New Biomarkers in Immune Tolerance

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 2

Crestone/Red Cloud

FRIDAY, FEBRUARY 1

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
Regulatory Cells to Control Immunity
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Immune Homeostasis in Autoimmunity

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Cell-Mediated Control of Immune Mediated Inflammation

Herman Waldmann, University of Oxford, UK
How is Infectious Tolerance Generated?

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
In Vitro Expansion and Therapy with Regulatory T Cells

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
14:30—16:30
Workshop 3

Shavano/Torreys
* Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
A Dominant Function for Interleukin 27 in Generating Interleukin 10-Producing Anti-Inflammatory T Cells

Benoit L. Salomon, University Pierre et Marie Curie, France
CD4+ T Cells Limit their Own-Pathogenicity by Activating Regulatory T Cells

Irene Puga, Institut Municipal d'Investigació Mèdica, Spain
Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

Francisco J. Quintana, Harvard Medical School, USA
Control of Foxp3 Expression and Treg Generation by AHR

Masahide Tone, University of Pennsylvania, USA
Smad3 and NFAT Cooperate to Induce FoxP3 Expression through its Enhancer

Gerald J. Prud'homme, St. Michael's Hospital, Canada
Neuropilin-1 is a Receptor for Latent and Active TGF-beta-1 and Contributes to Regulatory T Cell Activity

* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia
Role of Different Thymic Dendritic Cells in the Development of Thymic Tregs

Qizhi Tang, University of California, San Francisco, USA
Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
B Cells in Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Dissecting the Autoantibody Response

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Activation and Regulation of Autoreactive B Cells: T Cells, Tolls, and Tolerance

John C. Cambier, University of Colorado SOM, USA
Chronic Transduction of Biased Inhibitory Signals Maintains the Antigen Unresponsiveness of Anergic B Cells

E. William St. Clair, Duke University Medical Center, USA
Short Talk: B Cells as Therapeutic Targets for Human Autoimmunity

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 3

Crestone/Red Cloud

SATURDAY, FEBRUARY 2

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:00
Balancing Effector and Regulatory T Cells in Immunity and Disease
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Abul K. Abbas, University of California, San Francisco, USA
Development of Autoagressive and Protective T Cell Responses to a Systemic Antigen

Brigitta Stockinger, Francis Crick Institute, UK
Context Matters - Regulation of Th17 Responses

Kathryn J. Wood, University of Oxford, UK
Transplantation Tolerance in the Clinic

Andrew D. Wells, University of Pennsylvania, USA
Short Talk: Foxp3 and Ikaros: Partners in Regulatory T Cell Function

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: Interleukin-35: A Novel Cytokine that Mediates Regulatory T Cell Function

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Innate Immunity in Autoimmune Disease, Transplantation and Allergic Diseases
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Laurence A. Turka, Massachusetts General Hospital, USA
Expression and Function of MyD88 and TLRs on T Cells

Robert L. Coffman, Dynavax Technologies, USA
TLR Interventions in Allergy

Alberto Sanchez-Fueyo, Hospital Clinic Barcelona, Spain
Short Talk: Identification of Operationally Tolerant Liver Transplant Recipients

Wayne W. Hancock, Children's Hospital of Philadelphia, USA
Exploiting Epigenetic Mechanisms to Prevent and Cure Autoimmunity and Transplant Rejection

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
20:00—23:00
Entertainment

Crestone/Red Cloud

SUNDAY, FEBRUARY 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI075649-01




We gratefully acknowledge additional support for this conference from:

JDRF National Multiple Sclerosis Society
Novo Nordisk A/S
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676