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This meeting took place in 2008



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Cell Death and Cellular Senescence (J8)


Organizer(s) Jacqueline A. Lees, Sally A. Kornbluth and Gerard I. Evan
February 7—12, 2008
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 8, 2007
Late Abstract Deadline: Nov 7, 2007
Scholarship Deadline: Oct 8, 2007
Early Registration Deadline: Dec 10, 2007

Supported by the Director's Fund


Summary of Meeting:
Cell death is known to play a critical role in both normal development and human disease. We have a good understanding of the proteins that constitute the apoptotic machinery as well as the signaling pathways that regulate this process. Many of these regulatory proteins can also induce cellular senescence, a state of irreversible cell arrest. After some initial speculation that cellular senescence might be primarily a phenomenon of cultured cells, there is now unequivocal evidence that cellular senescence occurs in vivo in response to both telomere erosion and oncogenic activation and, furthermore, that this plays a key role in tissue maintenance and tumor suppression. This meeting will explore the fundamental mechanisms that control cell death and cellular senescence and discuss how each of these processes impact both normal development and tumor suppression. To achieve this goal, the meeting assembles a broad spectrum of speakers whose interests span a variety of model organisms. The Keynote Speaker, Craig Thompson, will discuss the relationship between metabolic status and cell survival. This meeting will be held in conjunction with “Cell Death in the Immune System”. Joint sessions will include the core apoptotic machinery, cell death and cellular homeostasis, signaling and apoptosis, and autophagy, inflammation and apoptosis.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 7

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Douglas R. Green, St. Jude Children's Research Hospital, USA

* Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Anergy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress

Jürg Tschopp, University of Lausanne, Switzerland
Inflammatory Caspases


FRIDAY, FEBRUARY 8

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Cell Death and Cellular Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Sally A. Kornbluth, Duke University Medical Center, USA

Jacqueline A. Lees, Massachusetts Institute of Technology, USA
The Role of Bmi1 in Tumorigenesis

Gerard I. Evan, University of Cambridge, UK
Intrinsic Tumor Suppression

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Mechanism of Immunopathology Induced by TNFalpha or Fas Ligand

Vishva M. Dixit, Genentech, Inc., USA
Targeting the IAPs

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regulation of Apoptosis (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Michael Karin, University of California, San Diego, USA
NF-kB has Important Antiapoptotic Functions, a Negative Regulator of Caspase 1

Nika N. Danial, Dana-Farber Cancer Institute, USA
A Phospho-BAD BH3 Helix Selectively Activates Glucose Metabolism

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

SATURDAY, FEBRUARY 9

07:00—08:00
Breakfast

Colorado Ballroom
08:00—11:00
Apoptosis Pathways in Model Organisms
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Joan S. Brugge, Harvard Medical School, USA

Kristin White, Harvard Medical School, USA
Regulation of Neural Stem Cell Apoptosis in Drosophila

John M. Abrams, University of Texas Southwestern Medical Center, USA
The Drosophila p53 regulatory network

David W. Andrews, Sunnybrook Research Institute, Canada
Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Conserved Mitochondrial Regulators of Cell Death


Following Session is for Cell Death in the Immune System (J7)

08:00—11:00
Lymphocyte Activation, Tolerance, and Survival
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Thomas A. Ferguson, Washington University School of Medicine, USA

David Hildeman, Cincinnati Children's Hospital, USA
Roles of Bim and Bcl-2 in Control of T Cell Homeostasis

Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of Caspase 3 in T Lymphocyte Death, Anergy and Cross Presentation

Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
CTL Memory and T Cell Survival

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Life and Death in the Thymus

Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: TCR and Subset-Specific Regulation of Fas-Induced Cell Death

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Apoptosis Pathways in Vertebrates
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Laura D. Attardi, Stanford University School of Medicine, USA

Joan S. Brugge, Harvard Medical School, USA
Entosis: Suicide/Murder of Homeless Cells

Kay F. Macleod, University of Chicago, USA
Short Talk: Regulation of Mitochondrial Integrity and Non-Apoptotic Cell Death by BNIP3 and Tumor Progression

Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Cul7 a Novel Antiapoptotic Oncogene

Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
The Mdm2/Mdm4 Complex: A Rheostat for p53 Activity


Following Session is for Cell Death in the Immune System (J7)

17:00—19:00
Impact of Apoptotic Cells on the Immune System
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA

Shigekazu Nagata, IFReC, Osaka University, Japan
Phosphatidylserine Receptor for Engulfment of Apoptotic Cells

Thomas A. Ferguson, Washington University School of Medicine, USA
Immune Tolerance by Apoptotic Cells: The Role of Caspase-Induced Mitochondrial Disruption

Matthew L. Albert, Genentech, Inc., USA
Autophagic Death Facilitates Efficient Antigen Cross-Priming

Colin S. Duckett, University of Michigan, USA
Short Talk

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

SUNDAY, FEBRUARY 10

07:00—08:00
Breakfast

Colorado Ballroom
08:00—11:00
Signaling Pathways, Cell Death and Senescence
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks In Vivo

Jeffrey C. Rathmell, Vanderbilt University, USA
Metabolism and Cell Death

Aimee L. Edinger, University of California, Irvine, USA
Short Talk: Nutrient Transporter Down-Regulation Contributes to the Induction of Cell Death by Ceramide

Laura D. Attardi, Stanford University School of Medicine, USA
Dissecting P53 Function using Knock-in Mice


Following Session is for Cell Death in the Immune System (J7)

08:00—11:00
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada

David Wallach, Weizmann Institute of Science, Israel
What is the REAL Functional Significance of Death Signaling by Receptors of the TNF/NGF Family?

Joseph A. Trapani, Peter MacCallum Cancer Centre, Australia
Structure/Function Analysis of the Lymphocyte Toxins Perforin and Granzyme B

Marcus E. Peter, University of Chicago, USA
The Role of microRNAs in Tumor Progression

Judy Lieberman, Harvard University, USA
New Features of Granzyme A-Mediated Caspase-Independent Programmed Cell Death

Henning Walczak†, University College London, Cancer Institute, UK
Short Talk: Identification of the Apoptosis-Inducing Murine TRAIL-R as a Specific Suppressor of Metastasis Derived from Autochthonous Epithelial Tumors

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Telomeres and Senescence
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA

Steven E. Artandi, Stanford University, USA
Telomerase in Stem Cells and Cancer

Chunying Du, Stowers Institute for Medical Research, USA
Short Talk: Bruce, an Inhibitor of Spoptosis and Role in DNA Damage Resistance to Suppress Tumor Development

Murray O. Robinson, Molquant, Inc., USA
Human in Mouse Tissue Transgenic Breast Tomors: Dissecting Genetic Requirements for Tumorigenesis


Following Session is for Cell Death in the Immune System (J7)

17:00—19:00
Autophagy and Host Defense
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy, Innate Immunity, and Microbial Countermeasures

Savithramma P. Dinesh-Kumar, Yale University, USA
Life After Death: Role for Autophagy during Plant Innate Immunity

Christian Münz, University of Zurich, Switzerland
Viral Regulation of Autophagy for Antigen Presentation on MHC Class II Molecules

David J. Granville, University of British Columbia, Canada
Short Talk: To be Determined

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

Colorado Ballroom
08:00—11:00
Signaling and Apoptosis (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Gerard I. Evan, University of Cambridge, UK

Douglas R. Green, St. Jude Children's Research Hospital, USA
Matters of Life and Death; Mitochondria, ER and the Greasy Road to Apoptosis

Sally A. Kornbluth, Duke University Medical Center, USA
Apoptosome Regulation in Cancer a Point of Resistance to Chemotherapy

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspase Pathways

Huseyin Mehmet, Zafgen Inc, USA
Caspase-12 in Inflammation, Association with Sepsis and Neonatal Brain Injury

Xiaodong Wang, National Institute of Biological Sciences, China
Short Talk: CAS/PHAP/Hsp70 Promote Nucleotide Exchange on Apaf-1 and Block Cytochrome C Induced Apaf-1 Aggregation

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Autophagy, Inflammation and Apoptosis (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Christian Münz, University of Zurich, Switzerland

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Role of Autophagy Genes ATG5 and ATG16L1 in Immunity and Inflammation

Eileen P. White, Rutgers University, USA
Role of Autophagy in Cancer and Therapy

Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Organ-Specific Regulation of Cancer Development

You-Wen He, Duke University Medical Center, USA
Short Talk: Autophagy in T Lymphocytes

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
End of Meeting Reception and Entertainment Supported in part by Merck & Co., Inc.

Breckenridge Ballroom

TUESDAY, FEBRUARY 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA130252-01




We gratefully acknowledge additional support for this conference from:

Merck & Co., Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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