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This meeting took place in 2008



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Eicosanoids and Other Mediators of Chronic Inflammation (A1)


Organizer(s) Roy J. Soberman, Garret A. FitzGerald and Bart N. Lambrecht
January 7—12, 2008
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 12, 2007
Late Abstract Deadline: Oct 15, 2007
Scholarship Deadline: Sep 12, 2007
Early Registration Deadline: Nov 7, 2007

Supported by the Director's Fund

Summary of Meeting:
Eicosanoids and interacting molecules regulate chronic inflammatory diseases by recruitment and activation of cells. To achieve the design of optimal therapeutic strategies for chronic inflammatory diseases, it is critical to understand how different pathways integrate with eicosanoids. To achieve this goal the meeting will focus on clinical areas where chronic inflammation is superimposed on pathobiology modulated by genetic and environmental susceptibilities: atherosclerosis, rheumatoid arthritis, pulmonary fibrosis, and allergic pulmonary inflammation. It will address unanswered questions as to specific signal transduction pathways and related biology of eicosanoid receptors and the structure of key biosynthetic enzymes. The meeting will examine how eicosanoids integrate with other mediators of chronic inflammation at the molecular, cellular, and organism level to regulate disease processes that include fibrosis, atherosclerosis, and allergic inflammation. The meeting will also focus on how eicosanoids regulate the function of macrophages and dendritic cells to control chronic inflammation. Basic, translational, clinical, and therapeutic findings will be highlighted. Upon completion of this meeting, participants should be able: • To explain current knowledge of the molecular mechanisms regulating the synthesis and response to eicosanoids. • To identify the roles of eicosanoids in chronic inflammatory diseases. • To identify mechanisms and gene networks which initiate and perpetuate chronic inflammation and their role relative to that of eicosanoids. • To understand molecular mechanisms of signaling pathways that integrate with eicosanoid receptors.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 7

15:00—19:30
Registration

Lower Atrium
18:30—19:30
Refreshments

Lower Atrium
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Gallatin
Raymond N. DuBois, Arizona State University, USA
PGE2 Signaling in Growth, Inflammation, and Cancer


TUESDAY, JANUARY 8

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandin Inhibition and Cardiovascular Biology

Emer Smyth, University of Pennsylvania School of Medicine, USA
Dimerization of Prostanoid Receptors

Colin D. Funk, Queen's University, Canada
Eicosanoid Function and Signaling in the Cardiovascular System of Genetically Modified Mice

William L. Smith, University of Michigan, USA
Function of the Homodimeric Structure of Cyclooxygenases

Douglas Kenneth Miller, Miller Associates, LLC, USA
Short Talk: Genetic Variations in 5-LO, FLAP and Leukotriene Pathway Genes are Associated with Coronary Artery Disease Risk

Douglas Kenneth Miller, Miller Associates, LLC, USA
Short Talk: Genetic Variations in 5-LO, FLAP and Leukotriene Pathway Genes are Associated with Coronary Artery Disease Risk

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson / Madison
13:00—22:00
Poster Viewing

Jefferson / Madison
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Genetics and Genomics of Eicosanoids
Meeting has ended...abstracts no longer viewable online.

Gallatin
Eric Schadt, Mount Sinai School of Medicine, USA
An Integrative Genomics Approach to Identify a Key Inflammation Sub-Network as a Key Driver of Metabolic Syndrome Traits

Desmond Joseph Fitzgerald, University College Dublin - UCD Research Building, Ireland
Genomics and Proteomics of Platelets in Vascular Inflammation

John A. Oates, Vanderbilt University School of Medicine, USA
Genetic Defect of cPLA2 and NSAID Toxicity

* Edward A. Dennis, University of California, San Diego, USA
Short Talk: Metabolomics of Eicosanoids from Macrophages to Tissues

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
19:30—22:00
Poster Session 1

Jefferson / Madison

WEDNESDAY, JANUARY 9

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Signaling Networks that Intersect with Eicosanoids
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Roy J. Soberman, Harvard Medical School, USA

Takao Shimizu, University of Tokyo, Japan
Biochemical and Pathophysiological roles of Two Types of Leukotriene B4 Receptors (BLT1 and BLT2)

Christopher K. Glass, University of California, San Diego, USA
Transcripton Factors that Control Macrophage Function in Inflammation

Shuh Narumiya, Kyoto University, Japan
Prostanoid Receptors in Signaling Network of Chronic Inflammation

Christina C. Leslie, National Jewish Health, USA
Activation of Group IVA cPLA2 and Eicosanoid Production by Fungal and Bacterial Pathogens in Mcrophages

Astrid M.L. Bengtsson, Lund University, Sweden
Short Talk: Pro-Inflammatory Mediator Leukotriene D4 Induces AP-1 but not NF-kappaB Signaling in Intestinal Epithelial Cells

Grzegorz Woszczek, King's College London, UK
Short Talk: IL-10 Inhibits Cysteinyl Leukotrienes Induced Activation of Human Monocytes and Monocyte-Derived Dendritic Cells

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Jefferson / Madison
13:00—22:00
Poster Viewing

Jefferson / Madison
14:30—16:30
Workshop 1 : Mechanisms of Chronic Inflammation

Gallatin
* Jilly F. Evans, PharmAkea Therapeutics, USA

Vineet Gupta, University of Miami, Miller School of Medicine, USA
Insights into Platelet Biology using Platelet Protein-Protein Interaction Networks

William L. Smith, University of Michigan, USA
Two Pathways for COX-2 Protein Degradation

Kelly Doyle, University of Utah, USA
Oxidation of 2-cys-Perxoiredoxins by Lipid Peroxide Metabolites of Lipoxygenases and Cyclooxygenase-2

Dan A. Dixon, University of South Carolina, USA
MicroRNA-Mediated Regulation of COX-2 Expression

Anita Sjölander, Lund University, Sweden
Beta-Catenin Increases Mitochondria Activity in Response to LTD4 Stimulation

Weisong Zhou, Vanderbilt University Medical Center, USA
The Protective Effect of PGI2 Overexpression in the Lung on Bleomycin-Induced Mortality and Pulmonary Cell Apoptosis

Akiko Maekawa, Brigham and Women's Hospital, USA
GPR17 Counterregulates the CysLT1 Receptor Response

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Eicosanoids, Chronic Inflammation and Malignant Transformation
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Christina C. Leslie, National Jewish Health, USA

Monica M. Bertagnolli, Brigham and Women's Hospital, USA
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Colon Cancer

Cornelia M. Ulrich, Fred Hutchinson Cancer Research Center, USA
Pharmacogenetics and COX-Inhibitors -- Can we Tailor Cancer Prevention?

Masataka Majima, Kitasato University School of Medicine, Japan
Roles of TP Signaling in Enhancement of Angiogenesis during Acute Ischemia and Proliferative Inflammation

Michael Backlund, Vanderbilt University, USA
Short Talk: Tumor Necrosis Factor-alpha Induction of NF-kB and E-Box Transcriptional Repressors Results in Diminution of 15-Hydroxyprostaglandin Dehydrogenase Expression in Colorectal Cancer Cells

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
19:30—22:00
Poster Session 2

Jefferson / Madison

THURSDAY, JANUARY 10

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:00
Cellular and Molecular Organization of the 5-Lipoxygenase Pathway
Meeting has ended...abstracts no longer viewable online.

Gallatin
* K. Frank Austen, Harvard Medical School, USA

Yoshihide Kanaoka, Harvard Medical School, USA
Structural Basis for Cysteinyl Leukotriene Biosynthesis: X Ray Crystal Structure of the Human LTC4 Synthase

Ingeborg Schmidt-Krey, Georgia Institute of Technology, USA
Structural Biology of LTC4 Synthase

Jilly F. Evans, PharmAkea Therapeutics, USA
The Crystal Structure of 5-Lipoxygenase-Activating Protein (FLAP)

Roy J. Soberman, Harvard Medical School, USA
Identification and Assembly of Distinct Leukotriene Biosynthetic Membrane Complexes

Christopher L. Rector, University of Colorado Health Sciences Center, USA
Short Talk: Determining LTA4 Stabilization in Human Neutrophils by the S100A8/A9 Complex

Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Leukotriene E4 Activates Peroxisome Proliferator Activated Receptor gamma and Potently Induces Prostaglandin D2 Generation by Human Mast Cells

09:20—09:40
Coffee Break

Lower Atrium
14:30—16:30
Workshop 2 : Eicosanoids in Immune Regulation

Gallatin
* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA

* Roy J. Soberman, Harvard Medical School, USA

Yasuyuki Kihara, University of Tokyo, Japan
Metabolism of Lipid Mediators in Experimental Allergic Encephalomyelitis

Chiara Carnini, Brigham and Women's Hospital, USA
Cysteinyl Leukotrienes in Pulmonary Fibrosis: Modulation of the Functions of Fibrocytes and Fibroblasts

Jui-Hung (Jimmy) Yen, Indiana University School of Medicine, USA
PGE2-Induced Metalloproteinase-9 Promotes Dendritic Cell Migration in vitro and in vivo

Kip M. Connor, Children's Hospital Boston/Harvard Medical School, USA
Dietary omega-3 Polyunsaturated Fatty Acids and their Bioactive Metabolites Protect against Pathologic Retinal Neovascularization through Modulation of Microglial Derived Cytokines

William R. Ferrell, University of Glasgow, UK
PAR2 in the Pathogenesis of Rheumatoid Arthritis

Victoria A. Blaho, Weill Cornell Medical College, USA
Blockade of the Leukotriene B4 Receptor BLT1 Increases the Severity and Duration of Arthritis in a Murine Model of Lyme Disease

Jana Stankova, Université de Sherbrooke, Canada
Human Natural Killer Cells Express the Leukotriene B4 Receptor, BLT1

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Chemical Biological Dissection of the Function of Eicosanoids and Related Molecules
Meeting has ended...abstracts no longer viewable online.

Gallatin
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Probing the Action of Fatty Acid Amides via Fatty Acid Amide Hydrolase

Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation and Inflammation

* Robert C. Murphy, University of Colorado Denver, USA
Eicosanoids and the Response to Oxidative Stress

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison
20:00—23:00
Entertainment

Jefferson / Madison

FRIDAY, JANUARY 11

07:00—08:00
Breakfast

Jefferson / Madison
08:00—11:15
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cells in the Initiation and Maintenance of Chronic Inflammation

Chun Geun Lee, Yale University School of Medicine, USA
A Critical Role for YKL-40 in the Regulation of Th2 Immunity

Francois Trottein, Institut Pasteur de Lille, France
Prostaglandin D2 in Dendritic Cell/Innate Immune Cell Interplay

Charlotte Weller, Wellcome Trust, UK
Mast Cell Trafficking: Identification of Chemotactic Factors

Sybille van den Brule, Université catholique de Louvain, Belgium
Short Talk: Implication of PGD2/DP in the Protective Effect of IL-9 against Lung Fibrosis

Hans-Erik Claesson, Biolipox AB, Sweden
Short Talk: Eoxins - Novel Proinflammatory Arachidonic Acid Metabolites Produced via the 15-Lipoxygenase-1 Pathway in Human Eosinophils and Mast Cells

09:20—09:40
Coffee Break

Lower Atrium
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Eicosanoid-Based Therapies for Chronic Inflammatory Disease
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Paola Patrignani, G. D'Annunzio University, Italy
Biochemistry of Long-term NSAID Therapy

Emanuela Ricciotti, University of Pennsylvania, USA
Short Talk: An Unbiased Approach to Identifying Off-Target Effects of Selective Cyclooxygenase-2 Inhibitors

Jonathan H. Gillard, University of Cambridge, UK
Imaging Macrophages in Carotid Atheroma

William Kerwin, University of Washington School of Medicine, USA
Quantifying the Effects of Inflammation in Carotid Atherosclerotic Plaque by MRI

19:00—20:00
Social Hour with Lite Bites

Jefferson / Madison

SATURDAY, JANUARY 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI075835-01




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