Snowbird Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2008


Here are the related meetings in 2018:
Lymphocytes and their Roles in Cancer (R1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Lymphocyte Activation and Signaling (B3)


Organizer(s) André Veillette and Michel C. Nussenzweig
February 3—8, 2008
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Oct 3, 2007
Late Abstract Deadline: Nov 2, 2007
Scholarship Deadline: Oct 3, 2007
Early Registration Deadline: Dec 4, 2007

Supported by the Director's Fund

Summary of Meeting:
The differentiation and activation of immune cells, including lymphocytes, is tightly controlled by a wide array of signaling molecules. These include receptors sensing external stimuli; kinases and phosphatases controlling the initiation of intracellular biochemical signals; adaptor molecules linking receptors to intracellular effectors; and transcription factors and other genomic modifiers regulating gene expression and structure. Over the past fifteen years, there has been a marked increase in our understanding of the roles and the regulation of these various molecules in a normal immune response. Recently, several of these components have been linked to human diseases such as auto-immunity, immunodeficiencies and lymphoid malignancies. In this symposium, we bring together distinguished researchers working at the cutting edge of immune cell signaling. These scientists will report on their most recent findings and provide a clear picture of where the field is going. The impact of their research findings on a better understanding and, possibly, better treatments of human diseases will be discussed. In particular, this meeting will highlight how immune cells can sense external stimuli and, through intracellular signal transduction cascades, mediate proper biological responses. It will also emphasize the impact of this knowledge on significant clinical problems such as auto-immunity, immunodeficiencies, tumor immunity, transplantation and infectious diseases.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 3

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Frederick W. Alt, Boston Children's Hospital, USA
Molecular Mechanisms Controlling Antigen Receptor Genes


MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Transcriptional Regulation of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Steven L. Reiner, Columbia University, USA
Specifying the T Cell Fates Required for Immunity

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Transcriptional Programs in T Cell Activation

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Calcium-Regulation Transcription in Lymphocyte Activation

Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of RORgammat in Development and Homeostasis of the Immune System

MacLean C. Sellars, IGBMC, France
Short Talk: Ikaros Controls Immunoglobulin Class Switch Recombination

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:00—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
14:30—16:30
Workshop 1: Transcriptional and Post-Transcriptional Control of Lymphocyte Activation and Differentiation

Ballroom 2-3
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA

Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Regulation of the Immunoglobulin Gene Diversification Enzyme AID

Velizar Stefanov Shivarov, Kyoto University Graduate School of Medicine, Japan
ssDNA Deamination Activity of AID is not Required for Class Switch Recombination

Heike Schmidlin, Academic Medical Center, University of Amsterdam, Netherlands
The Ets Factor Spi-B Inhibits Human Plasma Cell Differentiation

Hiroaki Kaku, Western Michigan University Homer Stryker M.D. School of Medicine, USA
FAIM, a New Germinal Center Gene, Is Involved in CD40-Mediated B Cell Activation

Frank Xiao-Feng Qin, University of Texas MD Anderson Cancer Center, USA
Antagonistic Cross-Regulation between Th1/Th2 Effector and Foxp3+ Regulatory T Cell Differentiation Pathways

Lisa C. Osborne, University of Pennsylvania, USA
Impaired T Cell Function and CD8 Memory Maintenance in a Novel IL-7Ralpha Knock-in Mouse

Andy L. Johnson, Cell Press, USA
Anarchin: A Novel Gene Necessary for T Cell Development

16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
DNA Modifications in Lymphocyte Activation and Transformation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Switching on Chromosome Translocations

* Gerald R. Crabtree, Stanford University, USA
Mapping and Modeling a Genetic Circuit of Lymphocyte Signaling

Alexander Tarakhovsky, Rockefeller University, USA
Histone Mimicry by a Histone Methyltransferase

John David Colgan, University of Iowa, USA
Short Talk: The Justy Mutation Identifies a Novel and Essential Regulator of Mouse B Cell Development

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch/Maybird

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Immunoreceptor Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Arthur Weiss, University of California, San Francisco, USA
Structural Insights into ZAP-70 Regulation and TCR Signaling

Lawrence E. Samelson, National Institutes of Health, USA
Signaling at the T Cell Antigen Receptor

* Michael Reth, Albert-Ludwigs University Freiburg, Germany
Amplification of Syk Activity at the B Cell Antigen Receptor

Andrey S. Shaw, Washington University School of Medicine, USA
Immunological Synapse and Polarity in T Lymphocytes

Nicholas R. J. Gascoigne, National University of Singapore, Singapore
Short Talk: The Role of Endogenous pMHC and CD8 in T Cell Antigen Recognition

Leslie E. Silberstein, Children's Hospital Boston, USA
Short Talk: Role of Focal Adhesion Kinase (FAK) in progenitor B Cell Proliferation and Localization in the Bone Marrow Microenvironment

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Imaging Lymphocyte Activation and Differentation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Ellen A. Robey, University of California, Berkeley, USA
Imaging the Dynamic Behavior of T Cells and Thymocytes in Tissues

Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic Intravital Visualization of Multi-Cellular Immune Communication in Lymph Nodes and Tissues

Facundo D. Batista, Ragon Institute of MGH, MIT and Harvard, USA
Initiation of B Cell Activation and Adaptive Immune Response

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Conduits Mediate Antigen Transport To Follicular Dendritic Cells

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch/Maybird

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Immune Modulation and Inhibition
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease

Andre Veillette, Institut de Recherches Cliniques de Montreal, Canada
SAP Family Adaptors in Immune Regulation

Sylvain Latour, Hopital Necker Enfants-Malades, France
Molecular Basis of X-Linked Lymphoproliferative Disease

Jun O. Liu, Johns Hopkins University School of Medicine, USA
Signaling by Carabin and other Calcium-Regulated Molecules in T Cells

Paula M. Oliver, University of Pennsylvania, USA
Short Talk: Nedd4-Family Ubiquitination Networks and how they Regulate T Cell Function

Wojciech A. Swat, Washington University School of Medicine, USA
Short Talk: Control of T Cell Activation by an ITAM-Signaling Pathway in Dendritic Cells

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
14:30—16:30
Workshop 2 : Lymphocyte Activation and Co-Stimulation

Ballroom 2-3
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA

Jerome Delon, Universite Paris Descartes, France
Atypical PKCs Regulate T Lymphocyte Polarity and Scanning Behavior

Jung-Hua Yeh, Genentech, Inc, USA
Maintenance of a late Phase of T Cell Cytoskeletal Polarity is Important for Normal T Cell Functions

Yeyan Ke, Columbia University, USA
A Novel Negative Regulatory Role of FAK in T Cell Activation and Function

Jane Oliaro, Peter MacCallum Cancer Centre, Australia
T Cells Undergo Asymmetric Cell Division – a New Mechanism to Dictate T Cell Fate

Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
Conditional mTOR Null Mice Reveal its Central Role in Directing Adaptive Effector Versus Regulatory T Cell Differentiation by Integrating Costimulatory and Cytokine Signals

Cindy Ma, Garvan Institute of Medical Research, Australia
Investigating the Mechanisms Adopted by CD4+CXCR5+ T Follicular Helper (TFH) Cells to Provide B Cell Help

Andrew J. Gross, University of California, San Francisco, USA
Developmental Acquisition of the Lyn–CD22–SHP-1 Inhibitory Pathway Promotes B Cell Tolerance

16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Cytoplasmic Effectors of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Adapters in T Cell Activation

* Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Role of Ras/Erk Pathway in B Lymphocyte Development and Activation

Michael Karin, University of California, San Diego, USA
NF-kappaB and JNK Signaling in Lymphocyte and Myeloid Cells - Dangerous Liaisons and Interesting Twists

Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: Role of Rac GTPases and their Exchange Factors in Lymphocyte Development and Activation

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Wasatch/Maybird

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Lymphocyte Regulation and Homing
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Cell-Mediated Control of Immune Mediated Inflammation

Xin Lin, University of Texas MD Anderson Cancer Center, USA
The Role of CARMA1 in TCR-Induced NF-kappaB and JNK Activation

* Margot Thome, University of Lausanne, Switzerland
Identification of NF-kappaB-Independent Functions of Bcl10 in Lymphocyte Activation

Fiona M. Powrie, University of Oxford, UK
Regulatory T Cells and Lymphocyte Homeostasis

Jeffrey C. Rathmell, Vanderbilt University, USA
Short Talk: Glucose Uptake in Lymphocyte Survival and Disease

09:20—09:40
Coffee Break

Ballroom Lobby & Mezzanine
16:30—17:00
Coffee Available

Ballroom Lobby & Mezzanine
17:00—19:00
Signaling in Lymphocyte Diseases and their Treatment
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Genevieve de Saint-Basile, INSERM U768, France
Inherited Defects of Lymphocyte Cytotoxic Activity

Yoshiyuki Minegishi, University of Tokushima, Japan
Signaling Defects in Hyper-IgE Syndromes

Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genetic Mechanisms that Mediate the Loss of Immune Tolerance in Lupus-Prone Mice

20:00—21:00
Social Hour with Lite Bites

Ballroom 1-2
21:00—23:00
Entertainment

Ballroom 1-2

FRIDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI075650-01




National Institutes of Health

Grant No. 5U13AI60000-05




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676