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This meeting took place in 2008



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Viral Immunity (A5)


Organizer(s) Jack R. Bennink, Marcia A. Blackman and Ann B. Hill
January 20—25, 2008
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 20, 2007
Late Abstract Deadline: Oct 23, 2007
Scholarship Deadline: Sep 20, 2007
Early Registration Deadline: Nov 20, 2007

Supported by the Director's Fund

Summary of Meeting:
The most exciting recent advances in viral immunity include the increased understanding of the role of innate immune mechanisms, interaction between innate and adaptive immunity, pathogen manipulation of host responses, and activation of immune responses and generation of immune memory. Despite these advances, basic mechanisms of anti-viral immunity are poorly characterized for many acute infections and less well understood for chronic infections. Efforts are also required to exploit recent research advances to improve vaccine design and therapeutic intervention. This meeting will include both innate and adaptive immunity and juxtapose animal models with human studies as it attempts to foster collaborative efforts between attending viral immunologists. Expert talks in plenary sessions will encompass the latest in critical areas of viral immunity. Workshops and additional presentations will cover provocative and cutting-edge results from attendees. The meeting objective is to accelerate progress in understanding and manipulating anti-viral immunity to improve human health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 20

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—19:45
Welcome and Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Jack R. Bennink, NIAID, National Institutes of Health, USA

* Marcia A. Blackman, Trudeau Institute, USA

* Ann B. Hill, Oregon Health & Science University, USA

19:45—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Gary J. Nabel, Sanofi, USA
Rational Vaccine Design: Where We Are and What We Still Need to Know


MONDAY, JANUARY 21

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:15
Innate Immunity to Viruses
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Raymond M. Welsh, University of Massachusetts Medical School, USA

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Regulation of Herpesvirus Latency by Niche-Specific Viral and Host Genes: The Good News about Herpes

Bryan R. Cullen, Duke University Medical Center, USA
Viruses, microRNAs and RNA Interference

Evelyn A. Kurt-Jones, University of Massachusetts Medical School, USA
Toll Like Receptors in Viral Immunity

Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia
NK Licensing of DCs for Initiation of Adaptive Immunity to Murine Cytomegalovirus

Nicole Baumgarth, University of California, Davis, USA
Short Talk: Infection-Induced Innate Signals Promote Rapid Effector B Cell Responses to Influenza

Deborah J. Lenschow, Washington University School of Medicine, USA
Short Talk: Protein Conjugation is Critical to the Antiviral Activity of ISG15

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Cellular and Humoral Effector Mechanisms
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Marcia A. Blackman, Trudeau Institute, USA

Jenny M. Woof, University of Dundee, UK
Anti-Viral Mucosal Immunoglobulins

Ted C. Pierson, NIAID, National Institutes of Health, USA
The Stoichiometry of Antibody-Mediated Neutralization of West Nile Virus: Implications for Vaccine Development and Immune Escape

Mark K. Slifka, Oregon National Primate Research Center, Oregon Health & Science University, USA
Duration of Antiviral T Cell and B Cell Responses and How Monkeypox Seeks to Evade Them

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Selective CD4 T Cell Help for Antibody Responses to Vaccinia, a Large Viral Pathogen: Deterministic Linkage of T and Ab Specificities

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 1

Crestone/Red Cloud

TUESDAY, JANUARY 22

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:15
Antigen Presentation and Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA

Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Intravital Imaging of Anti-Viral CD8+ T Cell Activation

Francis R. Carbone, University of Melbourne, Australia
Dendritic Cell Subset Involvement during Peripheral Infection

Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA
The Many Paths to MHC Class II-Restricted Presentation of the Influenza Glycoproteins

Stephen J. Turner, University of Melbourne, Australia
Acquiring the Capacity to Kill: Molecular Characterisation of Virus-Specific T Cell Function

Chris C. Norbury, Pennsylvania State University Medical School, USA
Short Talk: Viral Sequestration of Antigen Subverts Cross Priming

Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Killer T Cell Response to Influenza: Disparate Dendritic Cell Stimulation of Naïve and Memory Cells

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—12:15
Round Table Discussion on Mouse Norovirus and its Impact on Mouse Colonies and Immunological Studies: How Much Should We Worry?

Shavano/Torreys
* Ann B. Hill, Oregon Health & Science University, USA

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Janko Nikolich-Zugich, University of Arizona College of Medicine, USA

Kim Y. Green, NIAID, National Institutes of Health, USA

11:15—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
14:30—16:30
Workshop 1: Basic Studies of Innate and Adaptive Immunity

Shavano/Torreys
* Barry T. Rouse, University of Tennessee, USA

* Aron E. Lukacher, Penn State University College of Medicine, USA

14:30—15:30
1A: Innate Immunity

Shavano/Torreys
Catherine Ptaschinski, University of Michigan, USA
TLR9 Stimulation Modulates Gammaherpesvirus Latency

Teresa R. Johnson, Edward Via College of Osteopathic Medicine, USA
Respiratory Syncytial Virus (RSV) Infects and Matures Primary Dendritic Cells and DC-Sign/R Binds RSV Attachment Glycoprotein but is not Required for Infection

Lauren A. O'Donnell, Duquesne University, USA
Interferon-Gamma Signaling in Neurons: Classical Pathways or New Roads to Viral Clearance?

Julie McAuley, University of Melbourne, Australia
The 1918 Influenza A Virus PB1-F2 Protein Contributes to the Immunopathogenesis of Viral and Secondary Bacterial Pneumonia

15:30—16:30
1B: Cellular and Humoral Effector Mechanisms

Shavano/Torreys
Youn Soo Choi, Seoul National University College of Medicine, South Korea
Mechanisms of B-1 Cell Activation to Influenza virus Infection

Ryan A. Langlois, University of Minnesota, USA
Regulation of Acute Influenza Virus Immunity by Lymph Node Dendritic Cells

Daniela Anghelina, New York University, USA
Critical Role for Regulatory T Cells in Preventing Fatal Disease in Mice with Coronavirus-Induced Encephalitis

Magdalini Moutaftsi, Infectious Disease Research Institute, USA
Correlates of Protection Efficacy Induced by VACV-specific CD8+ T cell Epitopes in the Murine Intranasal Challenge Model

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Viral Immune Modulators
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Jonathan W. Yewdell, NIAID, National Institutes of Health, USA

Ann B. Hill, Oregon Health & Science University, USA
CMV and the Mammalian Immune System: 70 Million Years of Obsession and Deception

Klaus Früh, Oregon Health & Science University, USA
Novel Host Targets and Functions of Viral and Cellular Membrane Associated RING-CH (MARCH) Proteins

Grant McFadden, University of Florida, USA
Molecular Mechanisms of Poxvirus Immune Evasion and Tropism

Luis J. Sigal, Fox Chase Cancer Center, USA
Short Talk: The Poxvirus IFN-Alpha Binding Protein is Essential for Virulence and an Effective Target for Vaccination

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 2

Crestone/Red Cloud

WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:15
Immunity to Chronic and Persistent Viral Infection
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Ann B. Hill, Oregon Health & Science University, USA

Marcia A. Blackman, Trudeau Institute, USA
Establishment and Immune Control of gamma-Herpesvirus Latency

Christian Münz, University of Zurich, Switzerland
Human Natural Killer Cell Activation by Dendritic Cells during Viral Infection

Barbara Rehermann, NIDDK, National Institutes of Health, USA
Host Factors Involved in the Control of Viral Infections

Kim J. Hasenkrug, NIAID, National Institutes of Health, USA
Immunotherapy for Chronic Viral Infection

Mary Premenko-Lanier, Emory University, USA
Short Talk: Transient FTY720 Treatment Promotes Immune Mediated Clearance of Chronic LCMV

Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
Short Talk: CD8+ T Cell Dysfunction During Chronic Viral Infections

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Crestone/Red Cloud
13:00—22:00
Poster Viewing

Crestone/Red Cloud
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Inflammation, Immune Pathogenesis and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Anne B. Krug, Technical University Munich, Germany
Activation of TLR-Dependent and TLR-Independent Signaling Pathways by Viral Nucleic Acids

Stephen D. Miller, Northwestern University Medical School, USA
Virus-Induced CNS Autoimmunity: Lessons from Theiler's Virus Infection

Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Novel Avenues for the Immunotherapy of Persistent Viral Infections

David M. White, NCID/DVRD/Special Pathogens Branch, USA
Short Talk: Regulatory T-cell Responses to Lassa Fever Virus and Ebolavirus Infection of Dendritic Cells

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
19:30—22:00
Poster Session 3

Crestone/Red Cloud

THURSDAY, JANUARY 24

07:00—08:00
Breakfast

Crestone/Red Cloud
08:00—11:15
T Cell Memory
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* John T. Harty, University of Iowa, USA

David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Regulation of the CD8+ T Cell Recall Response to Respiratory Virus Infections

Raymond M. Welsh, University of Massachusetts Medical School, USA
Cross-Reactive Pathogenic Epitopes and Vaccine Design

Donna L. Farber, Columbia University Medical Center, USA
Memory CD4 T Cell-Mediated Protection and Immunopathology in Influenza Infection

Leo Lefrançois, University of Connecticut Health Center, USA
Memory T Cell Development in vivo

Joseph D. Miller, Centers for Disease Control, USA
Short Talk: Using the Smallpox Vaccines to Study Human Effector and Memory CD8 T Cell Responses to Acute Viral Infection

Janko Nikolich-Zugich, University of Arizona College of Medicine, USA
Short Talk: Immunological Basis of Age-Related Vulnerability to West Nile Virus

09:20—09:40
Coffee Break

Shavano Peak Foyer
14:30—16:30
Workshop 2: Anti-Viral Drug Discovery/Therapeutics

Shavano
* Barney S. Graham, NIAID, National Institutes of Health, USA

* Robert L. Coffman, Dynavax Technologies, USA

14:30—15:30
2A: Vaccines

Shavano
Shih-Wen Lin, National Cancer Institute, National Institutes of Health, USA
Recombinant Adeno-Associated Virus (AAV) Vectors Induce Functionally Impaired Transgene Product-Specific CD8+ T Cells

Julie Ledgerwood, NIAID, National Institutes of Health, USA
DNA Vaccines Developed for Emerging Infectious Diseases Induce Neutralizing Antibody and Cellular Immune Responses in Healthy Adults.

Corey D. Smith, Queensland Institute of Medical Research, Australia
Development of an EBV-Specific Polyepitope Based Vaccine for the Treatment of Hodgkin’s Lymphoma and Nasopharyngeal Carcinoma

Krystle N. Agans, Battelle Memorial Institute, USA
A New Adjuvanted Low-Dose Candidate Pandemic Influenza A(H5N1) Vaccine Protect Ferrets Against Homologous Clade 1 Viral Challenge and Induces Clade 2 Cross-Reactive Antibodies

15:30—16:30
2B: Therapeutics

Shavano
Sharvan Sehrawat, University of Tennessee, USA
FTY720 Treatment Effectively Induces Antigen-Specific Foxp3+ Regulatory T cells: An Additional Mechanism of Immunosuppression?

Elizabeth J. Ryan, University College Dublin, Ireland
GM-CSF may Modulate the Response to IFN-Alpha in Chronic Hepatitis C Virus (HCV) Infection

Aurelia A. Haller, GlobeImmune Inc., USA
Therapeutic and Prophylactic Viral Immunity in Animals and Humans

Florian Full, University Hospital Erlangen, Germany
Cytomegalovirus Specific T Cells Suitable for Adoptive Transfer: a new Approach Using CMV Specific Recombinant Immunoreceptors

14:30—16:30
Workshop 3: Antigen Presentation, Memory & Pathogenesis

Torreys
* Kevin L. Legge, University of Iowa Carver College of Medicine, USA

* Liisa K. Selin, University of Massachusetts Medical School, USA

14:30—15:30
3A: Antigen Presentation & Lymphocyte Activation

Torreys
Eric F. Tewalt, University of Virginia, USA
Poxvirus-Mediated Blockade of MHC Class I-, but not MHC Class II-Restricted Presentation of Peptides Derived from Exogenous Proteins

Laura K. Mackay, University of Melbourne, Australia
Antigen Processing and Presentation for CD8+ and CD4+ T Cell Recognition: Newly Synthesised Versus Stable Proteins

Taeg S. Kim, Bristol Myers Squibb, USA
An Airway Mucosal CD103+ dendritic Cell Subset is Specialized for Priming Influenza Virus-Specific Cytotoxic CD8+ T Cells

Jennifer Bassett, McMaster University, Canada
Long-Term, Low-Level Antigen Presentation Following Adenovirus Immunization Evokes a Sustained Effector/Effector Memory CD8+ T Cell Response that is Maintained by Radioresistant Antigen Presenting Cells

15:30—16:30
3B: Immunodominance, Memory and Pathogenesis

Torreys
Paul G. Thomas, St. Jude Children's Research Hospital, USA
CD8 T Cell Epitope Recognition: Broad Detection through a Narrow Window

Shawn D. Blackburn, Wistar Institute, USA
Selective Expansion of a Subset of Exhausted CD8 T cells with áPD-L1 Blockade.

Eric J. Yager, Albany Medical College, USA
Naïve Precursor T Cell Frequencies Impact Cellular Responses to Influenza Virus Infection in Aged Mice

Nuray Aslan, University of Massachusetts Medical School, USA
Expansion of Influenza M1-specific Memory cells Cross-Reactive with two Epstein-Barr virus (EBV) Lytic Epitopes Correlate with Severity of EBV-Induced Infectious Mononucleosis

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Vaccines and Therapeutic Interventions
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Jack R. Bennink, NIAID, National Institutes of Health, USA

Robert L. Coffman, Dynavax Technologies, USA
Development of a Hepatitis B Vaccine Using an Immunostimulatory Oligodeoxynucleotide Adjuvant

Suzanne L. Epstein, Center for Biologics Evaluation and Research, FDA, USA
Short Talk: Comparison of Cold-Adapted and DNA Prime-Adenovirus Boost Vaccines for Induction of Heterosubtypic Immunity to Influenza A Virus

John T. Harty, University of Iowa, USA
Regulating the CD8 T Cell Response to Infection and Vaccination

Cliona M. Rooney, Baylor College of Medicine, USA
Development of T Cell Immunotherapies for Post-Transplant Viral Infections

19:00—20:00
Social Hour with Lite Bites

Crestone/Red Cloud
20:00—23:00
Entertainment

Crestone/Red Cloud

FRIDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI075653-01




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676