Fairmont Empress Victoria Floorplan

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This meeting took place in 2008



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Cell Biology of Virus Entry, Replication and Pathogenesis (D6)


Organizer(s) Robert W. Doms, Beth Levine, Herbert (Skip) W. Virgin IV, and Robert A. Lamb
April 13—18, 2008
Fairmont Empress Victoria • Victoria, British Columbia Canada
Abstract Deadline: Dec 13, 2007
Late Abstract Deadline: Jan 14, 2008
Scholarship Deadline: Dec 13, 2007
Early Registration Deadline: Feb 13, 2008

Supported by the Director's Fund

Summary of Meeting:
Advances in structural biology have provided great insight into virus entry and assembly. The increasing use of whole genome screens, such as RNAi screens, has greatly accelerated the discovery of host factors needed for virus replication. Mechanisms underlying innate immunity and how viruses evade immune responses continue to be identified and provide fascinating insights into viral pathogenesis. Putting everything together to understand viral pathogenesis remains a central goal in this field. This meeting brings together experts on all facets of viral life cycles to develop insights into how viruses cause disease, and how this may be prevented.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 13

15:00—19:30
Registration

Victoria Conference Center-Level 2
18:30—19:30
Refreshments

Victoria Conference Center- Level 2
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Salon A
Bernard Moss, National Institutes of Health, USA
Through the Looking Glass: Stratagems of a Cytoplasmic DNA Virus


MONDAY, APRIL 14

07:00—08:00
Breakfast

Palm Court / Crystal Ballroom
08:00—11:15
Viral Structure and Entry
Meeting has ended...abstracts no longer viewable online.

Salon A
* Robert A. Lamb, Northwestern University, USA

Stephen C. Harrison, Harvard Medical School, USA
Molecular Mechanisms of Non-Enveloped Viral Entry

Margaret Kielian, Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms and Inhibition of Class II Fusion Proteins.

Yves Gaudin, CNRS, France
Structural Studies on the Vesicular Stomatitis Glycoprotein G: Membrane Fusion Revisited

Ari Helenius, ETH Zurich, Switzerland
New Pathways of Virus Entry

Jeffrey E. Lee, The Scripps Research Institute, USA
Short Talk: Crystal Structure of the Trimeric, Prefusion Ebola Virus Glycoprotein in Complex with an Antibody from a Human Survivor

Karin Stiasny, Medical University of Vienna, Austria
Short Talk: Dissection of the Flavivirus Membrane Fusion Pathway

09:20—09:40
Coffee Break

Victoria Conference Center-Level 2
11:15—13:00
Poster Setup

Salon B
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Salon B
14:30—16:30
Workshop 1: Viral Structure and Entry

Salon A
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Nicky E. Martin, University of Oxford, UK
Novel Role for beta 1 Integrin Revealed by Studies of Ebola Virus Entry: Regulation of Cathepsin Activity

Mei Lin Z. Bissonnette, Northwestern University, USA
Residues in the Outer Leaflet of the Transmembrane Domain of the Parainfluenza Virus 5 Fusion Protein are Critical for Membrane Fusion

Rahel Byland, University Children Hospital Zurich, Switzerland
Epstein-Barr Virus Binding to Epithelial Cells Triggers Signalling Cascades Crucial for Virus Entry

Henrik Garoff, Karolinska Institute, Sweden
Turning of the Receptor Binding Domains Opens up the Env of Moloney Murine Leukemia Virus for Membrane Fusion

Michael J. Root, Thomas Jefferson University, USA
Asymmetry in HIV-1 Inactivation Following Inhibitor Binding to gp41

Peter J.M. Rottier, Utrecht University, Netherlands
Refolding of the Spike Fusion Protein during Coronavirus Entry Involves Progression through Distinct Conformational Stages

Judith M. White, University of Virginia Health Sciences Center, USA
Novel Role for beta 1 Integrin Revealed by Studies of Integrins in Ebola Virus Entry: Regulation of Cathepsin L Activity

Kristen M. Guglielmi, Vanderbilt University, USA
Structural and Mutational Analysis of Reovirus Attachment Protein sigma 1 Binding to Junctional Adhesion Molecule-A

16:30—17:00
Coffee Available

Victoria Conference Center-Level 2
17:00—19:00
Viral Entry
Meeting has ended...abstracts no longer viewable online.

Salon A
* James M. Cunningham, Brigham and Women's Hospital, USA
Cysteine Cathepsins are Host Factors for Filovirus Infection

Carolyn B. Coyne, University of Pittsburgh, USA
Breaking Barriers: How Enteroviruses Enter Polarized Cell Monolayers

Michael Farzan, The Scripps Research Institute, USA
Receptors, Entry Proteins, and Viral Zoonoses

Michael S. Kay, University of Utah School of Medicine, USA
Short Talk: Potent D-peptide Inhibitors of HIV-1 Entry

19:00—20:00
Social Hour with Lite Bites

Salon B
19:30—22:00
Poster Session 1

Salon B

TUESDAY, APRIL 15

07:00—08:00
Breakfast

Palm Court / Crystal Ballroom
08:00—11:15
Viral Movement and Trafficking
Meeting has ended...abstracts no longer viewable online.

Salon A
Urs F. Greber, University of Zürich, Switzerland
Entry and Cytoplasmic Transport of Human Adenoviruses

* Lynn W. Enquist, Princeton University, USA
Trans-Neuronal Spread of Alpha Herpesvirus Infection

Michael Way, Cancer Research UK, UK
Rho-mDia Signalling Regulates Microtubule Dynamics and Cortical Actin during Vaccinia Virus Infection

Walther Mothes, Yale University School of Medicine, USA
Cell-to-Cell Transmission of Viruses

Benjamin K. Chen, Mount Sinai School of Medicine, USA
Short Talk: Live Imaging of the HIV Virological Synapse

Sarah Cohen, University of British Columbia, Canada
Short Talk: Nuclear Import of Parvovirus

09:20—09:40
Coffee Break

Victoria Conference Center-Level 2
11:15—13:00
Poster Setup

Salon B
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Salon B
16:30—17:00
Coffee Available

Victoria Conference Center-Level 2
17:00—19:00
Cellular Genes and Virus Infection
Meeting has ended...abstracts no longer viewable online.

Salon A
* Michael H. Malim, King's College London, UK
APOBEC Proteins and Intrinsic Resistance to HIV Infection

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Identification of Host Factors Involved in Viral Replication

Jonathan P. Stoye, National Institute for Medical Research, UK
Studies of Restriction Factor-Retrovirus Interactions

Sonia Jiménez-Baranda, National Center of Biotechnology, Spain
Short Talk: Filamin A (ABP280) Coordinates Actin Cytoskeleton Remodeling Required for HIV-1 Infection

19:00—20:00
Social Hour with Lite Bites

Salon B
19:30—22:00
Poster Session 2

Salon B

WEDNESDAY, APRIL 16

07:00—08:00
Breakfast

Palm Court / Crystal Ballroom
07:00—08:00
Poster Setup

Salon B
08:00—11:15
Viral Assembly and Release
Meeting has ended...abstracts no longer viewable online.

Salon A
* Jaisri R. Lingappa, University of Washington, USA
Targeting Viral-Host Interactions during Assembly: From Cell-Free Systems to Novel Antiviral Drugs

Paul D. Bieniasz, Aaron Diamond AIDS Research Center, USA
Retrovirus Assembly and Release

Wesley I. Sundquist, University of Utah School of Medicine, USA
Virus Assembly and Host Cell Pathways

Robert A. Lamb, Northwestern University, USA
Requirements for Influenza Virus-like Particle Assembly and Budding

Nathan Zauberman, Weizmann Institute of Science, Israel
Short Talk: Distinct DNA Exit and Packaging Portals in the Virus Acanthamoeba Polyphaga Mimivirus

Berend Jan Bosch, Utrecht University, Netherlands
Short Talk: On the Structure of Coronaviruses: Cryotomography of House Hepatitis Virus

09:20—09:40
Coffee Break

Victoria Conference Center-Level 2
11:15—12:15
Lunch

Salon B
12:00—14:30
Poster Session 3

Salon B
14:30—16:30
Workshop 2: Viral Pathogenesis and Immunity

Salon A
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Thomas E. Morrison, University of North Carolina, Chapel Hill, USA
A Critical Role for the Host Complement System in Ross River Virus-Induced Inflammatory Disease

Michelle M. Arnold, National Institutes of Health, USA
Suppression of the Innate Immune Response by NSP1 during Rotavirus Infection

Javier Guillermo Magadán, NICHD, National Institutes of Health, USA
The HIV-1 Vpu Accessory Protein Hijacks the p97-Ufd1-Npl4 Endoplasmic Reticulum-Associated Degradation Pathway to Mediate Down-Regulation of CD4 Receptor Molecules

Beatriz M.A. Fontoura, University of Texas Southwestern Medical Center, USA
Identification of Small Molecules that Antagonize the Inhibition of Gene Expression by NS1 Protein of Influenza A Virus and Attenuate Viral-mediated Cell Death

Annukka Aida Rose Antar, Johns Hopkins School of Medicine, USA
Junctional Adhesion Molecule-A is Required for Efficient Hematogenous Dissemination of Reovirus

Grzegorz Sarek, Institute of Biomedicine, Biomedicum Helsinki, Finland
Nucleophosmin is a Novel Regulator of KSHV Replication via Functional Interactions with Viral Cyclin and LANA

Tyler M. Sharp, Baylor College of Medicine, USA
Norwalk Virus Nonstructural Protein p22 Recruits COPII Vesicles via a Novel ER Exit Signal to Induce Golgi Disassembly

16:30—17:00
Coffee Available

Victoria Conference Center-Level 2
17:00—19:00
Viral Replication
Meeting has ended...abstracts no longer viewable online.

Salon A
Donald E. Ganem, Novartis Institutes for BioMedical Research, USA
MicroRNAs and the Biology of KSHV

Peter Sarnow, Stanford University School of Medicine, USA
Control of Hepatitis C Virus RNA Replication by microRNAs

* Paula Traktman, Medical College of Wisconsin, USA
Poxviruses - What Does it Take to Replicate DNA in the Cytoplasm?

Samson A. Chow, University of California, Los Angeles, USA
Short Talk: Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

19:00
On Own for Dinner


THURSDAY, APRIL 17

07:00—08:00
Breakfast

Palm Court / Crystal Ballroom
08:00—11:00
Viral Disease and Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Salon A
Ted C. Pierson, NIAID, National Institutes of Health, USA
The Stoichiometry of Antibody-Mediated Neutralization of West Nile Virus Infection: Factors that Govern Antibody Potency

Michael S. Diamond, Washington University School of Medicine, USA
The Critical Role of C1q in Modulating Antibody Neutralization and Enhancement of West Nile Virus Infection

* Susan R. Ross, University of Pennsylvania, USA
Mouse Mammary Tumor Virus's Interaction with the Innate Immune System

Grant McFadden, University of Florida, USA
Molecular Mechanisms of Poxvirus Immune Evasion and Tropism

09:20—09:40
Coffee Break

Victoria Conference Center-Level 2
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Victoria Conference Center-Level 2
17:00—19:00
Immune Evasion and Subversion of Host Defense
Meeting has ended...abstracts no longer viewable online.

Salon A
* Beth Levine, University of Texas Southwestern Medical Center, USA

Laurent Coscoy, University of California, Berkeley, USA
Immune Subversion by KSHV

Jae U. Jung, Keck School of Medicine of University of Southern California, USA
Induction and Evasion of the Type I Interferon Response by Viruses

Matthew L. Albert, Genentech, Inc., USA
The Immune Pathogenesis of Chikungunya Infection

Gary Thomas, Oregon Health & Science University, USA
Short Talk: HIV-1 Nef Binds PACS-2 to Assembly a Multi-Kinase Cascade that Triggers MHC-I Downregulation

19:00—20:00
Social Hour with Lite Bites

Palm Court / Crystal Ballroom
20:00—23:00
Entertainment

Palm Court / Crystal Ballroom

FRIDAY, APRIL 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI078578-01




National Institutes of Health

Grant No. 5U13AI60000-05




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund

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