Alpbach Congress Centrum Floorplan

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This meeting took place in 2008



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Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3)


Organizer(s) Michael F. Good and Nick M. Anstey
June 8—13, 2008
Alpbach Congress Centrum • Alpbach, Austria
Abstract Deadline: Feb 8, 2008
Late Abstract Deadline: Mar 11, 2008
Scholarship Deadline: Feb 8, 2008
Early Registration Deadline: Apr 8, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Our increased knowledge in basic immunology is having dramatic repercussions on our understanding of the immune responses to the malaria parasite and how these contribute to parasite resistance and to immunopathogenesis. Consequently, we are refining our classical approach to malaria vaccine development which has been based centrally on production of recombinant proteins of the merozoite or sporozoite surface. While these still represent the major pathway, we can now evaluate our approaches in terms of adjuvants, vectors and prime boost approaches to optimize immune responses and chances of success. Simultaneously, we are re-evaluating approaches based on whole parasites (sporozoites, red cell stages) using attenuated and inactivated organisms. The meeting will bring together world leaders in the three inter-related sub themes and update all attendees on the complex interactions between induction of immune responses and the consequences, both positive (i.e. immunity) and negative (immune dysregulation and disease). We will hear the latest reports on clinical trials for both the leading subunit and whole organismal vaccines in a venue which will see scientists from both developed countries and malaria-endemic countries sharing ideas and planning strategic research collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JUNE 8

15:00—19:30
Registration

Otto Molden Foyer
18:30—19:30
Welcome

Otto Molden Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Michael F. Good, Griffith University, Australia

Stephen L. Hoffman, Sanaria, USA
The Role of an Attenuated Sporozoite Vaccine in a Changing Malaria World


MONDAY, JUNE 9

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:45
Immunology I
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Mary M. Stevenson, McGill University, Canada
Dissecting the Innate Immune Response to Malaria in a Mouse Model

Jean Langhorne, Francis Crick Institute, UK
Antigen Presentation, Inflammatory Monocytes and CD4 T Cell Responses in a Blood-Stage Malaria Infection

* Eleanor M. Riley, Roslin Institute, UK
Innate Immunity to Malaria

Isabella A. Quakyi, University of Ghana, Ghana
Acquired Immunity and Biomarkers of Functional Relevance in Plasmodium falciparum Malaria

Greta Weiss, NIAID, National Institutes of Health, USA
Short Talk: The Impact of P. falciparum Infection on the Development and Maintenance of Memory B Cells

Tonia Woodberry, Menzies School of Health Research, Australia
Short Talk: Human T Cell Recognition of the Novel Vaccine Target Plasmodium HGXPRT following Natural Parasite Exposure

Diane Wallace Taylor, University of Hawaii, USA
Short Talk: Are Antimalarial Immune Responses Altered in Pregnant Women?

Shazia Khanam, Tata Institute of Fundamental Research, India
Short Talk: Murine Malarial Infections Affect Thymic T Cell Development

09:20—09:40
Coffee Break

Otto Molden Foyer
11:45—13:00
Poster Setup

Otto Molden Foyer
11:45
On Own for Lunch

13:00—22:00
Poster Viewing

Otto Molden Foyer
16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:00
Worms and Malaria
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunological Consequences of Malaria and Helminth Coinfection

Christian R. Engwerda, Queensland Institute of Medical Research, Australia
The Pathogenesis of Experimental Cerebral Malaria during Schistosoma mansoni Infection

Pierre Druilhe, Institut Pasteur, France
Worms Worsen Malaria: Understanding Human-P. falciparum Immune Interactions Uncovers the Immunological Role of Worms

19:00—20:00
Social Hour with Lite Bites

Otto Molden Foyer
19:30—22:00
Poster Session 1

Otto Molden Foyer

TUESDAY, JUNE 10

07:00—08:00
Breakfast

Your Lodging Location
07:00—08:00
Poster Setup

Otto Molden Foyer
08:00—11:30
Immunology II
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* James W. Kazura, Case Western Reserve University, USA
Natural Evolution of Adaptive Immunity to MSP1 during Childhood in Holoendemic Malaria: Relation to Resistance to Blood Stage Plasmodium falciparum in vivo

* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Generation and Maintenance of B Cell Immunological Memory in Response to Plasmodium falciparum

William R. Heath, University of Melbourne, Australia
Murine Blood-Stage Plasmodium berghei Infection Induces Pathogen-Specific CD8+ Cytotoxic T cell Immunity

Hajime Hisaeda, Kyushu University, Japan
Short Talk: Malaria Parasites Require Toll-Like Receptor 9 Signaling for Immune Evasion by Activating Regulatory T Cells

Maria Sophia Mackroth, Case Western Reserve University, USA
Short Talk: Human Cord Blood CD4+CD25hi Regulatory T Cells Suppress Prenatally Acquired T Cell Response to Plasmodium falciparum Antigens

Gabriela Minigo, Menzies School of Health Research, Australia
Short Talk: Mechanisms of Induction of Unconventional CD25- Regulatory T Cells and Conventional Treg and Association with Parasitemia in Malaria Infection

Michael Walther, Medical Research Council Laboratories, Fajara, Gambia
Short Talk: Immunoregulation in Uncomplicated and Severe P. falciparum Malaria

John T. Harty, University of Iowa, USA
Short Talk: Numerical Requirements for Long-Term CD8+ T Cell Immunity to P. berghei Sporozoite Challenge

09:20—09:40
Coffee Break

Otto Molden Foyer
11:30—12:30
Lunch

Otto Molden Foyer
12:30—14:30
Poster Session 2

Otto Molden Foyer
14:30—16:30
Pathogenesis I
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Kamija Samuel Phiri, College of Medicine, University of Malawi, Malawi
Pathogenesis of Severe Anaemia in Malawian Children Living in a Malaria Endemic Area

* Louis Schofield, James Cook University, Australia
Immunological Mechanisms Controlling Erythropoietic Suppression and Severe Anaemia in Experimental Malaria Infections

Douglas Golenbock, University of Massachusetts Medical School, USA
The Basis of Fever and Proinflammatory Cytokinemia in Acute Malaria

Constance A. Finney, University of Toronto, Canada
Short Talk: TLR Involvement during Experimental Malaria: Implications at both Ends of the Clinical Spectrum of Human Disease

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:00
Pathogenesis II - Cerebral Malaria
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Dan Milner, Harvard School of Public Health, USA
Pediatric Cerebral Malaria: Insights from the Ongoing Autopsy Study in Blantyre, Malawi

Isabelle Medana, Oxford University, UK
The Pathology and Pathophysiology of Cerebral Malaria in Adults

* Georges E. R. Grau, University of Sydney, Australia
Cerebral Malaria: Malarial Antigen Transfer by Microparticles or Trogocytosis as Effectors of Microvascular Endothelial Lesions

Gregory S. Park, University of Minnesota, USA
Short Talk: von Willebrand Factor, but not sVCAM-1 or sICAM-1, Effectively Discriminates between Cerebral and Uncomplicated Malaria in Ugandan Children

19:00
On Own for Dinner


WEDNESDAY, JUNE 11

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:30
Pathogenesis III
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Nicholas Beare, Royal Liverpool University Hospital, UK
Retinal Microvasculature and the Pathophysiology of Cerebral Malaria

* Nick M. Anstey, Menzies School of Health Research, Australia
Impaired Nitric Oxide Bioavailability and Endothelial Dysfunction in Severe Malaria: A Target for Adjunctive Therapy?

* Patrick E. Duffy, NIAID, National Institutes for Health, USA
Maternal and Fetal Factors Predict Malaria Outcomes during Infancy

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Immunogenetics of Disease Susceptibility

Gabriele S.V. Campanella, Massachusetts General Hospital, USA
Short Talk: Chemokine Receptor CXCR3 and its Ligands CXCL9 and CXCL10 are Required for the Development of Murine Cerebral Malaria

Brendan J. McMorran, University of Tasmania, Australia
Short Talk: Platelets have a Protective Role in Erythrocytic Stage Malaria Infection

Katsuyuki Yui, Nagasaki University, Japan
Short Talk: Malaria-Specific and Non-Specific Activation of CD8+ T-Cells during Blood Stage of Plasmodium berghei Infection

09:20—09:40
Coffee Break

Otto Molden Foyer
11:30—13:00
Poster Setup

Otto Molden Foyer
11:30
On Own for Lunch

13:00—22:00
Poster Viewing

Otto Molden Foyer
14:30—16:30
Workshop: Presentations by Travel Scholarship Awardees

Erwin Schrödinger Hall
Ana Maria Pamplona Santos, Instituto de Medicina Molecular, Portugal
Heme Oxygenase-1 and Carbon Monoxide Suppress the Pathogenesis of Experimental Cerebral Malaria

Patti Kiser, Colorado State University, USA
IL-10-Producing CD4+T-Cells Mitigate Malaria-Associated Anemia

Bernd Lepenies, Max Planck Institute of Colloids and Interfaces, Germany
Ligation of B and T Lymphocyte Attenuator (BTLA) Protects Mice from Cerebral Malaria during P. berghei ANKA Infection

* Ian A. Cockburn, Australian National University, Australia
Long-Term Antigen Presentation Following Exposure to Plasmodium Sporozoites may Induce T Cell Dysfunction

Olivia Finney, Seattle Childrens Research Institute, USA
Regulatory T Cells are Upregulated after Natural Exposure to Plasmodium falciparum

Indu Malhotra, Case Western Reserve University, USA
Effect of Prenatal Exposure to Malaria on the Susceptibility to Infection during Childhood

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:15
Vaccines I
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Vectored Malaria Vaccines

* Thomas L. Richie, Sanaria Inc., USA
Developing a Multi-Stage, Multi-Antigen Adenovirus-Vectored Vaccine against P. falciparum Malaria

Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium
The RTS,S. Malaria Vaccine Candidate: From Phase II to Phase III

Alessandro Sette, La Jolla Institute for Allergy & Immunology, USA
Short Talk: Meta-Analysis of Immune Epitope Data for Plasmodium Species: Overview and Applications for Malarial Immunobiology and Vaccine-Related Issues

Sope Omowale Olugbile, Institut de Biochimie, Switzerland
Short Talk: Novel Polyepitope Malaria Vaccine Candidate

19:15—20:15
Social Hour with Lite Bites

Otto Molden Foyer
19:30—22:00
Poster Session 3

Otto Molden Foyer

THURSDAY, JUNE 12

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:30
Vaccines II
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Louis H. Miller, National Institutes of Health, USA
Why a Malaria Vaccine is Possible

Brendan S. Crabb, Burnet Institute, Australia
New Insights into Merozoite Invasion and Post-Invasion Events

Denise L. Doolan, James Cook University, Australia
Plasmodium falciparum Immunomics and Vaccine Development

* Sanjai Kumar, Food And Drug Administration, USA
Considerations for Whole Parasite Based Malaria Vaccines

Arturo Reyes-Sandoval, University of Oxford, UK
Short Talk: A Phase I Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidate AdCh63 ME-TRAP, Alone and with MVA ME-TRAP, using a Prime-Boost Delivery Schedule

Edmond Joseph Remarque, Biomedical Primate Research Centre, Netherlands
Short Talk: Diversity-Covering Immunization with Plasmodium falciparum AMA1 (PfAMA1) Induces Broader Allelic Recognition and Growth Inhibition Responses in Rabbits and Rhesus

Toshihiro Horii, Research Institute for Microbial Diseases, Japan
Short Talk: Learning from Interfacing Studies on SE36: A Candidate Malaria Vaccine that Targets the Achilles’ Heel Antigen of Plasmodium falciparum

09:20—09:40
Coffee Break

Otto Molden Foyer
11:30
On Own for Lunch

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:15
Whole Parasite Vaccines
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Stephen L. Hoffman, Sanaria, USA
Progress Toward Development of a Metabolically Active, Non Replicating Plasmodium falciparum Sporozoite Vaccine

Stefan Kappe, Seattle BioMed, USA
Genetically Engineered Malaria Parasite Vaccines

Michael F. Good, Griffith University, Australia
Could a Whole Parasite Vaccine be Effective Against the Blood Stages?

Meta Roestenberg, Radboud University Medical Center Nijmegen, Netherlands
Short Talk: Sterile Protection against P. falciparum Challenge in Human Volunteers after Repeated Exposure to Sporozoites under Chloroquine Prophylaxis

Kavita Singh, National Institutes of Health, USA
Short Talk: Structures of the Plasmodium falciparum VAR2CSA DBL3x Domain and its Complex with Chondroitin Sulfate A that is Implicated in Pregnancy-Associated Malaria

19:15—19:30
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Nick M. Anstey, Menzies School of Health Research, Australia

19:30—20:30
Social Hour with Lite Bites

Otto Molden Foyer
20:00—23:00
Entertainment

Otto Molden Foyer

FRIDAY, JUNE 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI078721-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Sanaria Inc.


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