Granlibakken Tahoe Floorplan

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This meeting took place in 2008



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Biomarker Discovery, Validation and Applications (B1)


Organizer(s) Mark S. Boguski and Jean-Jacques Garaud
February 3—8, 2008
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Oct 3, 2007
Late Abstract Deadline: Nov 1, 2007
Scholarship Deadline: Oct 3, 2007
Early Registration Deadline: Dec 3, 2007

Supported by the Director's Fund

Summary of Meeting:
Conceptually, biomarkers are emerging as a new organizing principle for translational research involving multidisciplinary and parallel activities in basic research, technology development and clinical application. The primary reason for this is that the concept encompasses a broad swath of potential roles in human disease including prevention, diagnosis, prognosis, patient stratification and the pharmacodynamic and pharmacokinetic properties of drugs as well as their efficacies and toxicities. This meeting attempts to bring together scientists, technologists and research physicians to focus attention on key challenges and highlight synergies among groups working in different but overlapping areas. The meeting will address major trends in the field from macromolecular analytics to clinical imaging and overall strategies for biomarker development and applications.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 3

15:00—19:30
Registration

Pre-Function
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
A Systems Approach to Drug Development and Implementation


MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Granhall
08:00—11:00
New Strategies for Biomarker Discovery and Use
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Michael Gillette, Broad Institute, USA
The Long and Winding Road: Discovery, Verification and Validation of Protein Biomarkers

* Mark S. Boguski, Harvard Medical School, USA
Proteomics, Systems Biology and Knowledge-Mining in Drug and Biomarker Discovery

Christoph W. Turck, Max Planck Institute of Psychiatry, Germany
The Quest for Mood Disorder Biomarkers

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Biomarker Qualification
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Michael L. Bittner, Tgen, USA
Genomic Classification: The Epistemological Wall

David F. Ransohoff, University of North Carolina at Chapel Hill, USA
Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer: Status in 2008

* Christie L. Hunter, AB SCIEX, USA
Novel Strategy Involving Peptide MRM-based Assays and Chemistry for Targeted Quantitation of Biomarkers in Plasma

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay Room
20:00—21:00
Social Hour

Bay Room

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Granhall
08:00—11:00
Imaging Biomarkers 1
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Proteomic Mapping of Vascular Biomarkers to Image Antibody Penetration into Single Organs and Solid Tumors

Maria Bobadilla, F. Hoffmann-La Roche Ltd., Switzerland
Systems Biology of the Pancreatic beta Cells: A Novel Paradigm for Biomarker Discovery in Type 2 Diabetes

Mitchell Albert, Harvard Medical School, USA
Pulmonary Imaging: From Structural to Functional with Hyperpolarized 3He MRI

* Perry F. Renshaw, University of Utah, USA
Imaging’s Role in Advancement in Psychiatric Disease Management and Therapy Development

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee Available

Pre Function
17:00—17:40
Genomic Strategies
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Perry F. Renshaw, University of Utah, USA

* Joseph R. Nevins, Duke University Medical Center, USA
Genomic Strategies for Personalized Cancer Therapy

17:40—19:00
Imaging Biomarkers 2
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Gary J. Kelloff, National Cancer Institute, National Institutes of Health, USA
OBQI: Project Overview and Objectives (Science and Medical Perspective)

Jonathan H. Gillard, University of Cambridge, UK
Tracking Inflammation in Atherosclerotic Plaques: Latest Clinical Results

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay Room
20:00—21:00
Social Hour

Bay Room

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Granhall
08:00—11:00
Multiplex Biomarkers and System Response Profiles
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Analysis of Disease Signatures in Gene Expression Profiles from Peripheral Blood Leukocytes

Joachim L. Schultze, LIMES Institute, University of Bonn, Germany
Applying Genome-Wide High Throughput Technologies to Clinical Biomarker Development

Shannon Neeley, Ut M. D. Anderson Cancer Center, USA

Jay W. Heinecke, University of Washington School of Medicine, USA
Mass Spectrometric Approaches for Identifying Inflammatory Pathways that Generate Dysfunctional HDL in Humans

09:20—09:40
Coffee Break

Pre Function
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
New Technologies
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Peter W. Laird, Van Andel Research Institute, USA
DNA Methylation Biomarkers as Cancer Biomarkers

* Ruth Birner-Gruenberger, Medical University of Graz, Austria
Activity-Based Proteomics: Enzymatic Activity Profiling in Complex Proteomes

Keith O. Elliston, Genstruct Inc., USA
Identifying Mechanistic Biomarkers using Causal Modeling Powered by Molecular Profiling

19:00—20:00
Social Hour

Granhall
19:30—20:30
Dinner

Granhall

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Granhall
08:00—11:00
Translational Medicine and the Critical Path 1
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
* Jean-Jacques Garaud, F. Hoffmann-La Roche Ltd, Switzerland
Efficacy Biomarkers in Early Clinical Development

Richard Levine, National Institutes of Child Health and Human Development, USA
An Excess of Circulating Anti-Angiogenic Factors: Final Common Pathway to the Maternal Hypertensive Syndrome of Preeclampsia

Rick Baehner, Genomic Health, Inc., USA
Development and Clinical Use of Oncotype DX TM, a Multigene Test that Facilitates Treatment Decisions in Early Breast Cancer

Paul Delmar, ,
Title to be Determined

09:20—09:40
Coffee Break

Pre Function
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Translational Medicine and the Critical Path 2
Meeting has ended...abstracts no longer viewable online.

Mountain / Lake
Maryellen de Mars, Critical Path Institute, USA
Genetic Markers and Diagnostics: Progress towards Personalized Warfarin Therapy

* Denis Hochstrasser, University Hospital of Geneva, Switzerland
Clinical Practice & Biomarker Proteomic Discovery

Frank D. Sistare, Merck Research Laboratories, USA
Biomarkers of Drug-induced Kidney Injury: Moving with Histopathology and Molecular Signatures Toward an Advanced Accessible Safety Biomarker Toolbox

19:00—20:00
Social Hour

Bay Room
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

FRIDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA132374-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Applied Biosystems


Merck & Co., Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676