Eldorado Hotel & Spa Floorplan

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This meeting took place in 2008



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Complex Traits: Biologic and Therapeutic Insights (C4)


Organizer(s) Trudy F.C. Mackay, Lon Cardon and David R. Cox
February 29—March 5, 2008
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Oct 30, 2007
Late Abstract Deadline: Nov 29, 2007
Scholarship Deadline: Oct 30, 2007
Early Registration Deadline: Dec 31, 2007

Supported by the Director's Fund

Summary of Meeting:
Most phenotypic variation in populations, including variation in susceptibility to common human diseases, is attributable to segregating alleles of multiple genes, whose expression is dependent on the environment. Rapidly increasing knowledge about variation in genome sequence and gene expression will facilitate understanding the relationships of genotype to complex phenotypes and the evolutionary mechanisms shaping variation for complex traits, in humans and model organisms. Major questions to be solved regarding the genetic architecture of complex traits include the following: (1) the relative prevalence of common and rare variants; (2) whether causal variation is typically regulatory or structural; (3) how many segregating alleles affect any given trait and their pleiotropic effects on other traits; and (4) the extent to which allelic effects depend on other segregating alleles and the environment. This meeting aims to address these questions by bringing together investigators from population and quantitative genetics, genomics, and with expertise in model systems and humans.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 29

15:00—19:30
Registration

Zia Concourse
18:30—19:30
Refreshments

Sunset Room
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University, USA

Michael Lynch, Indiana University, USA
Spontaneous Mutation, Complex Traits and Evolution


SATURDAY, MARCH 1

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
The Spectrum of Genetic Variation
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Charles H. Langley, University of California, Davis, USA
Polymorphism and Divergence across the Drosophila melanogaster Genome

Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
Whole-Genome Variation and its Impact on Reproductive Isolation in Arabidopsis thaliana

Eleazar Eskin, University of Calfornia, Los Angeles, USA
A Sequence-Based Variation Map of 8.27 million SNPs in Inbred Mouse Strains

* Peter Donnelly, University of Oxford, UK
Human Genetic Variation and Disease Susceptibility

Richard M. Durbin, Wellcome Trust Sanger Institute, UK
Short Talk: Whole Genome Sequence Variation in 70 Saccharomyces Strains

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Genetic Variation and Evolution
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Adam Eyre-Walker, University of Sussex, UK
Inferring the Effects of Mutations from DNA Sequence Data

Daniel L. Hartl, Harvard University, USA
Therapeutic Insights from Yeast: Plasticity, Pleiotropy, and Mutability in the Transcriptome

* Sarah A. Tishkoff, University of Pennsylvania, USA
Genotypic and Phenotypic Variation in Africa

James P. Noonan, Yale University School of Medicine, USA
Short Talk: Functional Insights into the Role of Gene Regulatory Change in Human Evolution

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

SUNDAY, MARCH 2

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
The Genetic Architecture of Gene Expression
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Ritsert C. Jansen, University of Groningen, Netherlands
Statistical Challenges for Genetical Genomics

* Leonid Kruglyak, Princeton University, USA
Genetic Architecture of Gene Expression in Yeast

Eric Schadt, Mount Sinai School of Medicine, USA
Mapping the Genetic Architecture of Gene Expression in Mouse and Human Populations

Vivian Cheung, University of Michigan, USA
Genetics of Natural Variation in Human Gene Expression

Jan Veldink, University Medical Center Utrecht, Netherlands
Short Talk: Differential Expression of Gene Networks in Peripheral Blood of Sporadic Amyotrophic Lateral Sclerosis (ALS) Patients Reveals Molecular Heterogeneity of the Disease

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
13:30—14:30
Editor's Roundtable

Anasazi Ballroom
14:30—16:30
Workshop: Short Talks Selected from Abstracts

Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University, USA

Michael N. Weedon, Peninsula Medical School, UK
Genome Wide Association Analysis Identifies 20 loci that Influence Adult Height

Laurens Basten Snoek, Wageningen University and Research Centre, Netherlands
The Genetic Architecture of Life-History Variation

Cristen J. Willer, University of Michigan, USA
Genome-Wide Association Scans Identify Novel Loci That Influence Lipid Levels and Risk of Coronary Artery Disease

Michael Olivier, Medical College of Wisconsin, USA
Complete Dissection of a QTL Identifies Five Novel Genes Responsible for Altered Lipid Levels in the Metabolic Syndrome

Hyun Seok Kim, University of Texas Southwestern Medical Center, USA
A Systematic Screen for Genes Contributing to Quantitative Traits in Yeast using Quantitative non-Complementation

Yi Jia, Iowa State University, USA
Genetic Control of the Transcription of Natural Antisense Transcripts (NATs) in Maize

Yurii Aulchenko, Novosibirsk State University, Russia
Comparison of Methods for Genome-Wide Quantitative Trait Association Analysis in Related Individuals

Ana-Teresa Maia, CRUK-Cambridge Research Institute, UK
New Approach to Study Susceptibility to Breast Cancer: Allelic Variation of Gene Expression Analysis

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
The Genetic Architecture of Complex Traits: Lessons from Model Organisms
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University, USA
Genetic Analysis of Complex Traits in Drosophila

Ronald W. Davis, Stanford University, USA
Chemical and Complex Genetics in Yeast

Beverly Paigen, The Jackson Laboratory, USA
Genetic Dissection of Mouse Complex Traits

Bart M.G. Smits, University of Wisconsin - Madison, USA
Short Talk: Characterization of Mcs5a, a non-Coding Breast Cancer Susceptibility Locus

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

MONDAY, MARCH 3

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Human Complex Traits: Progress and Prospects
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
P Eline Slagboom, , Netherlands
Genetic and Biomarker Studies for Human Longevity

* Carole Ober, University of Chicago, USA
Genome-Wide Association Studies in a Founder Population

Gilles Thomas, NCI - National Institutes of Health, USA
Genome-Wide Association Studies in Breast and Prostate Cancer: Cancer Genetic Markers of Susceptibility (CGEMS).

Adnan Derti, Harvard Medical School, USA
Short Talk: Assessing Excess Epistasis Among Functionally Related Human Genes

09:20—09:40
Coffee Break

Zia Concourse
16:30—17:00
Coffee Available

Zia Concourse
17:00—18:40
Whole Genome Association Studies
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* David R. Cox, Perlegen Sciences, Inc., USA
Common Human DNA Variation and Complex Human Traits: Success Stories

Teri Manolio, National Institutes of Health, USA
Collaboration and Data Sharing in the Genetic Association Information Network

Richard Spielman, University of Pennsylvania, USA
Short Talk: Monozygotic Twins Reveal Germ-line Contribution to Allelic Expression Differences

Minerva M. Carrasquillo, Mayo Clinic, USA
Short Talk: Genome-Wide Association Scan for Late Onset Alzheimer’s Disease (LOAD)

18:40—19:15
Roundtable: Whole Genome Scans in Non-Academic Medicine

Anasazi Ballroom
* David R. Cox, Perlegen Sciences, Inc., USA

Kári Stefánsson, deCode Genetics, Iceland
Prospects for Whole Genome Analysis for Individualized Medicine in the Real World

19:00
On Own for Dinner


TUESDAY, MARCH 4

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Behavioral Genetics and Genomics
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Robert R.H. Anholt, North Carolina State University, USA
Genetic Architecture of Complex Behavior in Drosophila

Emmanuel Mignot, Stanford University School of Medicine, USA
Molecular Studies in Narcolepsy and Hypersomnia

Kári Stefánsson, deCode Genetics, Iceland
Genetic of Common Diseases

Hans A. Hofmann, University of Texas at Austin, USA
Genes, Hormones and Brains: A Genomic Analysis of Social Behavior

Susan T. Harbison, North Carolina State University, USA
Short Talk: Identification of Co-Regulated Genetic Networks Contributing to Naturally Occurring Genetic Variation in Drosophila Sleep

09:20—09:40
Coffee Break

Zia Concourse
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Epigenetics and Genomic Rearrangement
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* James R. Lupski, Baylor College of Medicine, USA
Genomic Rearrangements and Gene Copy Number Variation as a Cause for Complex Traits

Andrew Chess, Massachusetts General Hospital, USA
Epigenetic Mechanisms of Gene Regulationand Their Impact on Complex Traits

Iuliana Ionita, Harvard University, USA
Short Talk: On the Analysis of Copy-Number Variations (CNVs) in Genome-Wide Association Studies: A Translation of the Family-Based Association Test (FBAT) Approach

Dana C. Crawford, Case Western Reserve University, USA
Short Talk: APOA1/C3/A4/A5 Gene Cluster SNPs and their Interaction with Dietary Intake are Associated with Triglyceride Levels in the Third National Health and Nutrition Examination Survey

Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
Short Talk: On the Complexity of the Growth Phenotype

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

WEDNESDAY, MARCH 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HG004585-01




We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676