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This meeting took place in 2008



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Molecular Basis for Chromatin Modifications and Epigenetic Phenomena (D3)


Organizer(s) Peter Fraser, Sepideh Khorasanizadeh and Asifa Akhtar
April 7—12, 2008
Snowmass Resort • Snowmass, Colorado USA
Abstract Deadline: Dec 7, 2007
Late Abstract Deadline: Jan 10, 2008
Scholarship Deadline: Dec 7, 2007
Early Registration Deadline: Feb 7, 2008

Supported by the Director's Fund

Summary of Meeting:
Many chromatin modifications and structures are surprisingly dynamic, yet are involved in initiating and heritably maintaining distinct gene expression patterns that direct and preserve cellular identities. The molecules that target and regulate these modifications and how they influence—and may be influenced by—higher-order chromatin structures, nuclear organization, and various nuclear processes, are areas of intense interest and excitement. This meeting will examine the latest discoveries surrounding the molecular basis of chromatin modifications and explore their connections to various biological processes and epigenetic phenomena such as dosage compensation, imprinting, heterochromatin formation and gene expression in differentiation, development and disease. The goal is to promote a more integrated picture of the molecular interrelationships between chromatin structure and function that exercise the hidden regulatory information in the genomes of complex organisms.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, APRIL 7

15:00—19:30
Registration

1st Floor Foyer
18:30—19:30
Refreshments

1st Floor Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Peter Fraser, Florida State University, USA
Introduction

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
INO80 Chromatin Remodeling Complex at Breaks, Forks and Promoters: A Multitude of Functions


TUESDAY, APRIL 8

07:00—08:00
Breakfast

Hoaglund/Erickson/ Carrol/Sinclair
08:00—11:15
Post-Translational Modifications of Histones
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany

Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Role of Histone Methylation in Germ Cell Development and Stem Cell Pluripotency

Kristian Helin, University of Copenhagen, Denmark
Epigenetic Control and the Development of Cancer

Zhibin Wang, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Combinatorial Patterns of Histone Acetylations and Methylations in the Human Genome

Craig L. Peterson, University of Massachusetts Medical School, USA
Histone Modifications and Chromatin Structure

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Short Talk: H2AZ is Enriched at Polycomb Group Protein Target Regions in ES Cells and is Required for Proper Execution of Developmental Programs

09:20—09:40
Coffee Break

Hoaglund/Erickson/ Carrol/Sinclair
11:00—13:00
Poster Setup

Hoaglund/Erickson/ Carrol/Sinclair
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

Hoaglund/Erickson/ Carrol/Sinclair
16:30—17:00
Coffee Available

Hoaglund/Erickson/ Carrol/Sinclair
17:00—19:00
Atomic Structures of Chromatin Protein Complexes
Meeting has ended...abstracts no longer viewable online.

Anderson Room
Vidya Subramanian, Massachusetts Institute of Technology, USA
Histone Chaperones: Structure, Function, and Regulation

Masami Horikoshi, University of Tokyo, Japan
Short Talk: From Histone Modification to Nuclesome Disassembly

Ji-Joon Song, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Structural Basis of Histone H4 Recognition by p55

Ji-Joon Song, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Structural Basis of Histone H4 Recognition by p55

* Sepideh Khorasanizadeh, Sanford Burnham Prebys Medical Discovery Institute, USA
Multiple Roles for Chromodomains in Epigenetic Regulation

Natalie Nady, Stanford University, USA
Short Talk: Reading the Histone Code by MBT Domains – Structural Insights into MEthyl Mark Recognition

19:00—20:00
Social Hour with Lite Bites

Hoaglund/Erickson/ Carrol/Sinclair
19:30—22:00
Poster Session 1

Hoaglund/Erickson/ Carrol/Sinclair

WEDNESDAY, APRIL 9

07:00—08:00
Breakfast

Hoaglund/Erickson/ Carrol/Sinclair
08:00—11:15
Chromatin Dynamics
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Histone Replacement Dynamics

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Slicing, Spreading and Copying Heterochromatin with RNAi

Sevinc Ercan, University of North Carolina, USA
Short Talk: Dynamic and Bimodal Binding of the C. elegans Dosage Compensation Complex

Andrea Schäfer, German Cancer Research Center, Germany
Short Talk: Molecular Mechanism of Active DNA Demethylation

Jessica K. Tyler, Weill Cornell Medicine, USA
Chaperoning Histones

Jonathan Widom, Northwestern University, USA
The Genomic Code for Nucleosome Positioning

Raul A. Urrutia, Mayo Clinic Rochester, USA
Subcodes within the Histone Code

09:20—09:40
Coffee Break

Hoaglund/Erickson/ Carrol/Sinclair
11:15—13:00
Poster Setup

Hoaglund/Erickson/ Carrol/Sinclair
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Hoaglund/Erickson/ Carrol/Sinclair
16:30—17:00
Coffee Available

Hoaglund/Erickson/ Carrol/Sinclair
17:00—19:00
Stem Cell Chromatin Dynamics
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Wolf Reik, Babraham Institute, UK

Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Bradley E. Bernstein, Massachusetts General Hospital, USA
Chromatin Landscapes of Pluripotent and Lineage-Committed Cells

Neil Brockdorff, University of Oxford, UK
Chromatin Regulation by H2A Ubiquitylation

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Short Talk: Genome-scale DNA Methylation Maps of Pluripotent and Differentiated Cells

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Short Talk: H2AZ is Enriched at Polycomb Group Protein Target Regions in ES Cells and is Required for Proper Execution of Developmental Programs

19:00—20:00
Social Hour with Lite Bites

Hoaglund/Erickson/ Carrol/Sinclair
19:30—22:00
Poster Session 2

Hoaglund/Erickson/ Carrol/Sinclair

THURSDAY, APRIL 10

07:00—08:00
Breakfast

Hoaglund/Erickson/ Carrol/Sinclair
07:00—08:00
Poster Setup

Hoaglund/Erickson/ Carrol/Sinclair
08:00—11:15
Epigenetics and Chromatin Modification Mechanisms
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Craig L. Peterson, University of Massachusetts Medical School, USA

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins

Francis Stewart, Technische Universitaet Dresden, Germany
The Histone Methyltransferase, Mll2, is only Essential in a Brief Window during Development and for the Germ Lineage

Rebecca A. Mosher, University of Arizona, USA
Short Talk: PolIVb Influences RNA-Directed DNA Methylation and Demethylation Independently of its Role in siRNA Biogenesis

Jürg Müller, Max Planck Institute of Biochemistry, Germany
Transcriptional Control by the Polycomb System

Kai Ge, NIDDK, National Institutes of Health, USA
Isolation of Histone H3K4 Methyltransferase Complexes that Associate with a Histone H3K27 Demethylase

Matthew Gamble, Albert Einstein College of Medicine, USA
Short Talk: The Histone Variant MacroH2A1 Occupies Large Chromatin Domains and Positively Regulates Genes on Autosomes

09:20—09:40
Coffee Break

Hoaglund/Erickson/ Carrol/Sinclair
11:15—12:15
Lunch

Hoaglund/Erickson/ Carrol/Sinclair
12:00—14:30
Poster Session 3

Hoaglund/Erickson/ Carrol/Sinclair
14:30—16:30
Workshop: Chromatin as a Drug Target

Anderson Room
* Janine Arts, Ortho Biotech Oncology Research and Development (J&J), Belgium

Scott A. Armstrong, Dana-Farber Cancer Institute, USA
H3K79 Methylation Abnormalities Define Murine and Human MLL-AF4 Leukemias

Tuncay Baubec, Friedrich Miescher Institute, Switzerland
Zebularine is a Potent Inhibitor of Plant DNA Methylation

Donghang Cheng, MD Anderson Cancer Center, USA
Arginine Methyltransferases as Novel Theraputic Targets for Breast Cancer

Vibhor Gupta, Jawaharlal Nehru University, India
Profiling the Epigenetic and Transcriptional Effects of Histone Deacetylase Inhibitors

Joan Oliva Vilana, LA Biomed, USA
Spontanous Formation of Tumors in Drug Primed DDC Mice: An Epigenetic Phenomena

Pedro Vladimir Pena, University of Colorado Health Sciences Center, USA
Molecular Mechanism of Histone H3K4Me3 Recognition by Plant Homeodomain of ING1 and the Effects of Cancer Specific Mutations

16:30—17:00
Coffee Available

Hoaglund/Erickson/ Carrol/Sinclair
17:00—19:00
Large Scale Epigenetic Control
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Anne C. Ferguson-Smith, University of Cambridge, UK

Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation and Chromatin Regulation

Edith Heard, Institut Curie, France
Nuclear and Chromatin Dynamics during X-Chromosome Inactivation

Wolf Reik, Babraham Institute, UK
Epigenetic Regulation of Lineage Commitment and Pluripotency in the Mammalian Embryo

Mareike Puschendorf, Friedrich Miescher Institute, Switzerland
Short Talk: PRC1 and Suv39h Specify Parental Asymmetry at Constitutive Heterochromatin in Early Mouse Embryos

19:00
On Own for Dinner


FRIDAY, APRIL 11

07:00—08:00
Breakfast

Hoaglund/Erickson/ Carrol/Sinclair
08:00—11:00
Nuclear and Chromosome Dynamics
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Edith Heard, Institut Curie, France

Peter Fraser, Florida State University, USA
3D Transcription Networks

Yijun Ruan, University of Connecticut, USA
A Whole Genome View of Long-Range Chromatin Interactions in Transcription Regulation

Michael R. Hübner, Cold Spring Harbor Laboratory, USA
Short Talk: Dynamic Analysis and Induction of Polycomb Bodies at a Specific Genetic Locus

Vicki L. Chandler, Minerva Schools at Keck Graduate Institute, USA
Interchromosomal Transfer of Epigenetic Information

Anton Krumm, University of Washington Medical Center, USA
Short Talk: Role of Cohesion in Interphase Chromatin

09:20—09:40
Coffee Break

Hoaglund/Erickson/ Carrol/Sinclair
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Hoaglund/Erickson/ Carrol/Sinclair
17:00—19:00
Epigenomics and Disease
Meeting has ended...abstracts no longer viewable online.

Anderson Room
* Peter Fraser, Florida State University, USA

Robert J. Sims, Constellation Pharmaceuticals, USA
Mechanisms of Epigenetic Signaling

Janine Arts, Ortho Biotech Oncology Research and Development (J&J), Belgium
Chromatin as a Drug Target

Anne C. Ferguson-Smith, University of Cambridge, UK
The Establishment and Maintenance of Genomic Methylation Imprints

Nathan R. Rose, University of Oxford, UK
Short Talk: Structural and Mechanistic Studies on the JMJD2 Histone Demethylases

19:00—20:00
Social Hour with Lite Bites

Hoaglund/Erickson/ Carrol/Sinclair
20:00—23:00
Entertainment

Hoaglund/Erickson/ Carrol/ Sinclair

SATURDAY, APRIL 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

CellCentric Ltd. Integrated DNA Technologies
March of Dimes Foundation
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

BioMed Central Ltd

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676