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This meeting took place in 2008



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RNAi, MicroRNA, and Non-Coding RNA (C8)


Organizer(s) Judy Lieberman and Phillip A. Sharp
March 25—30, 2008
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 27, 2007
Late Abstract Deadline: Dec 27, 2007
Scholarship Deadline: Nov 27, 2007
Early Registration Deadline: Jan 28, 2008

Sponsored by Alnylam Pharmaceuticals, Inc., Novartis Institutes for BioMedical Research, and Santaris Pharma A/S

Summary of Meeting:
RNA interference (RNAi) describes a variety of evolutionarily conserved mechanisms for regulating gene transcription and post-transcriptional events that are important for controlling development and cell proliferation, survival, differentiation and effector functions. RNAi also protects the genome from transposons and viruses. This meeting will explore recent developments in understanding the molecular mechanisms and cell biology of RNA-based post-transcriptional silencing and for maintaining regions of silenced chromatin. It will consider methods to uncover regulatory networks of endogenous microRNAs and their target genes and illustrative examples in a variety of organisms. Recent advances in harnessing RNA interference for genetic screening and therapeutic gene silencing will also be explored.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 25

15:00—19:30
Registration

Grand Foyer
18:30—19:30
Refreshments

Grand Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Judy Lieberman, Harvard University, USA
and

* Phillip A. Sharp, Massachusetts Institute of Technology, USA
Introductions

Craig C. Mello, University of Massachusetts Medical School, USA
Small RNA Pathways and Germline in C. elegans

Gregory J. Hannon, University of Cambridge, UK
Conserved Roles of Small RNAs in Genome Defense


WEDNESDAY, MARCH 26

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:00
MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNAs and their Targets

Carlo M. Croce, Ohio State University, USA
MicroRNA Genes and Cancer

Eric N. Olson, University of Texas Southwestern Medical Center, USA
microRNAs Control of Muscle Development and Disease

* V. Narry Kim, Seoul National University, South Korea
lin 28-Mediated Terminal Uridylation of pre-let-7

Joel G. Belasco, New York University School of Medicine, USA
Short Talk: Importance of Translational Repression and non-Nucleolytic Ago Isoforms for on-Target RNA Interference

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky Ballroom A, Foyer
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

Sea to Sky Ballroom A, Foyer
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:15
MicroRNAs and Their Targets (Plants and Invertebrates). Session Supported by Regulus Therapeutics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Victor R. Ambros, University of Massachusetts, USA

* Victor R. Ambros, University of Massachusetts, USA

Stephen M. Cohen, Institute of Molecular and Cell Biology, Singapore
MicroRNA Functions

Oliver Hobert, Columbia University, USA
The Regulatory Architecture of a miRNA-Controlled 3'UTR

Molly C. Hammell, Cold Spring Harbor Laboratory, USA
Short Talk: mirWIP: microRNA Target Prediction Based on miRNP Enriched Transcripts

Marcelo A. German, Dow AgroSciences, USA
Short Talk: Global Identification of miRNA-Target RNA Pairs by Parallel Analysis of RNA Ends (PARE)

Eric C. Lai, Sloan-Kettering Institute, USA
Short Talk: Biogenesis and Function of Hairpin RNAs

Alla Grishok, Columbia University Medical Center, USA
Short Talk: Targets of Endogenous RNAi Processes in C. elegans

19:15—20:15
Social Hour with Lite Bites

Sea to Sky Ballroom A, Foyer
19:30—22:00
Poster Session 1

Sea to Sky Ballroom A, Foyer

THURSDAY, MARCH 27

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
RNA Interference: Regulation of Transcription
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
Danesh Moazed, Harvard Medical School, USA
Role of Non-Coding RNAs in Heterochromatin Assembly

* Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
RNA-Directed DNA Methylation in Arabidopsis

Alexei A. Aravin, California Institute of Technology, USA
Small RNA Pathways in Mouse Germline

René F. Ketting, Institute for Molecular Biology, Germany
TRF-Like Terminal Transferases affect RNAi and Chromosome Segregation in C. elegans

Michel A.J. Georges, University of Liège, Belgium
Small RNAs and Imprinting

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky Ballroom A, Foyer
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Sea to Sky Ballroom A, Foyer
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Non-coding RNAs
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Investigations of the Functional Roles of the Pervasive Transcription Observed for Genomes

Gene W. Yeo, University of California, San Diego, USA
Short Talk: Analysis of Small RNAs in Stem Cell Development

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structural Biology of Riboswitch-Mediated Gene Regulation and Argonaute-Mediated Gene Silencing

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Identifying MicroRNAs and Their Targets

19:00—20:00
Social Hour with Lite Bites

Sea to Sky Ballroom A, Foyer
19:30—22:00
Poster Session 2

Sea to Sky Ballroom A, Foyer

FRIDAY, MARCH 28

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
07:00—08:00
Poster Setup

Sea to Sky Ballroom A, Foyer
08:00—11:00
RNA Interference: Newly Emerging Biology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Phillip D. Zamore, University of Massachusetts Medical School, USA
Germline and Somatic Small RNAs

Thomas Tuschl, HHMI/Rockefeller University, USA
miRNA Profiling and in Situ Hybridization to Examine Their Cell-Type Specific Expression Patterns

Haifan Lin, Yale University, USA
Epigenetic Function of Piwi and piRNAs

Phillip A. Sharp, Massachusetts Institute of Technology, USA
miRNA Silencing by Translational Inhibition and mRNA Degradation

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Short Talk: Mechanism of miRNA-Mediated Gene Silencing

09:20—09:40
Coffee Break

Grand Foyer
11:00—12:00
Lunch

Sea to Sky Ballroom A, Foyer
12:00—14:30
Poster Session 3

Sea to Sky Ballroom A, Foyer
14:30—16:30
Workshop 1: New Approaches to shRNA-Based Screening and Therapy

Sea to Sky Ballroom BC
David E. Root, Broad Institute, USA
Pooled shRNA Screens for Functional Fingerprinting

Edward Harlow, Constellation Pharmaceuticals, USA
shRNA Screens to Identify Targets for Cancer Drug Development

Michael T. Hemann, Massachusetts Institute of Technology, USA
In Vivo Screens to Identify Mechanisms of Drug Resistance

Mark A. Kay, Stanford University, USA
Functional Evidence for Restricting MicroRNA Targets to the 3' Untranslated Region of mRNAs

* John J. Rossi, Beckman Research Institute of the City of Hope, USA
Applying RNAi for the treatment of HIV infection

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
RNA Interference: Mechanisms and Cell Biology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Mechanism of Translational Inhibition by miRNAs

Carl D. Novina, Dana-Farber Cancer Institute, USA
Short Talk: MicroRNA-Targeted mRNAs Contain 40S, but not 60S Components

* Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Role of Dicer in miRNA Pathways and Beyond

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Mechanisms of Small RNA Processing

19:00
On Own for Dinner


SATURDAY, MARCH 29

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
07:00—08:00
Poster Setup

Sea to Sky Ballroom A, Foyer
08:00—11:00
RNAi-Based Screening
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
The Protein Coding Cofactors of miRNAs and siRNAs

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
RNAi Screen for Mammalian Biology and a Bit About Eri-1

Reuven Agami, Netherlands Cancer Institute, Netherlands
Dead End 1 Blocks microRNA Access to Target mRNA

Scott M. Hammond, University of North Carolina at Chapel Hill, USA
Regulation of microRNA Biogenesis by Lin-28

09:20—09:40
Coffee Break

Grand Foyer
11:00—12:00
Lunch

Sea to Sky Ballroom A, Foyer
12:00—14:30
Poster Session 4

Sea to Sky Ballroom A, Foyer
14:30—16:30
Workshop 2: Translating RNAi

Sea to Sky Ballroom BC
Lee Lim, Sirna/Merck, USA
Using Profiling to Study miRNAs

Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA
Cellular Delivery of siRNAs and Antagomirs Using Chemical Conjugation and Complexation Strategies

* C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Therapeutic Approaches for Modulating Gene Expression Utilizing Single Stranded Oligonucleotides

David L. Lewis, Arrowhead Research Corporation, USA
Dynamic PolyConjugates: A Rationally Designed, Modular Platform for Systemic siRNA Delivery

Fumitaka Takeshita, National Cancer Center Research Institute, Japan
Systemic microRNA Therapy for Cancer Metastasis

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
RNAi-Based Therapy
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
RNAi and Neurodegenerative Diseases

Judy Lieberman, Harvard University, USA
Silent Treatment for Cancer

Markus Stoffel, ETH Zürich, Switzerland
Molecular Mechanisms of Cellular Uptake of Cholesterol-Conjugated RNAs

Morten Lindow, Santaris Pharma, Denmark
Short Talk: LNA-Mediated microRNA Silencing in non-Human Primates

19:00—20:00
Social Hour with Lite Bites

Sea to Sky Ballroom A, Foyer
20:00—23:00
Entertainment

Sea to Sky Ballroom A, Foyer

SUNDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA132336-01




We gratefully acknowledge additional support for this conference from:

Alnylam Pharmaceuticals, Inc. Integrated DNA Technologies
Isis Pharmaceuticals, Inc. Merck & Co., Inc.
Novartis Institutes for BioMedical Research
QIAGEN, Inc.
Regulus Therapeutics Inc. Santaris Pharma A/S

Luminex Corporation


QIAGEN, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Isis Pharmaceuticals, Inc.


Mirus Bio LLC


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676