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This meeting took place in 2008



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Translational Regulatory Mechanisms (A7)


Organizer(s) Nahum Sonenberg, Alan G. Hinnebusch and Joel D. Richter
January 28—February 2, 2008
Coeur d'Alene Resort • Coeur d'Alene, Idaho USA
Abstract Deadline: Sep 26, 2007
Late Abstract Deadline: Oct 31, 2007
Scholarship Deadline: Sep 26, 2007
Early Registration Deadline: Nov 28, 2007

Supported by the Director's Fund

Summary of Meeting:
There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 28

15:00—19:30
Registration

Conference Center Lobby
18:30—19:30
Refreshments

Bay 2
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Bay 3-4
Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Translational Control by miRNAs and RNA-Binding Proteins

Robert H. Singer, Albert Einstein College of Medicine, USA
Conserved Translational Mechanisms of Localized mRNA


TUESDAY, JANUARY 29

07:00—08:00
Breakfast

Bay 2
08:00—11:15
The Translational Apparatus: Prokaryotes versus Eukaryotes
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK
Structural Studies on Functional Complexes of the Ribosome

Ada Yonath, Weizmann Institute of Science, Israel
Ribosomal Regulaory Mechanism

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Getting the Message: Ribosome Recruitment by Viruses and Cells

* Rachel Green, Johns Hopkins University School of Medicine, USA
Mechanistic Studies of Ribosome Function and Potential Implications for Translational Control

Alan G. Hinnebusch, National Institutes of Health, USA
Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection

09:20—09:40
Coffee Break

Conference Center Lobby
11:15—13:00
Poster Setup

Bay 5-6
13:00—22:00
Poster Viewing

Bay 5-6
16:30—17:00
Coffee Available

Conference Center Lobby
17:00—19:30
New Insight into Translation Initiation
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Jon R. Lorsch, Johns Hopkins School of Medicine, USA
The Molecular Mechanics of Start Site Recognition by the Eukaryotic Translational Machinery

Tatyana V. Pestova, SUNY Downstate Medical Center, USA
Assembly of 48S Initiation Complexes on mRNAs with Highly Structured 5’-UTRs

Gerhard Wagner, Harvard Medical School, USA
Protein Interactions in Eukaryotic Translation Initiation and their Inhibition

Richard J. Jackson, University of Cambridge, UK
Reinitiation Mechanisms in Mammalian mRNA Translation

Assen Marintchev, Harvard Medical School, USA
Short Talk: Organization of the eIF4A/4G/4H Complex: from Model to Experiment

19:30—20:30
Social Hour with Lite Bites

Bay 5-6
19:30—22:00
Poster Session 1

Bay 5-6

WEDNESDAY, JANUARY 30

07:00—08:00
Breakfast

Bay 2
08:00—11:00
mRNA Transport and Localization
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Robert H. Singer, Albert Einstein College of Medicine, USA

Anne Ephrussi, European Molecular Biology Laboratory, Germany
oskar RNP Assembly for Coordinated Transport and Translation Control

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
The P-Body Component GW182 is Essential for miRNA-Mediated Gene Silencing

Jennifer Darnell, Rockefeller University, USA
Crosslinking-IP (CLIP) Identification of Novel Pre- and Post-Synaptic RNA Targets of the Fragile X Mental Retardation Protein, FMRP

Jason M. Casolari, Stanford University, USA
Short Talk: mRNA Localization and Organization in S. cerevisiae

John H. Carson, University of Connecticut Health Center, USA
Short Talk: Multiplexed Dendritic Targeting of LTP RNAs by the A2 Pathway

Alexander F. Palazzo, Harvard Medical School, USA
Short Talk: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA

09:20—09:40
Coffee Break

Conference Center Lobby
11:00—13:00
Poster Setup

Bay 5-6
13:00—22:00
Poster Viewing

Bay 5-6
16:30—17:00
Coffee Available

Conference Center Lobby
17:00—19:15
Translational Control of Development
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Matthias W. Hentze, European Molecular Biology Laboratory, Germany

Robert J. Schneider, New York University School of Medicine, USA
eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy

Joel D. Richter, University of Massachusetts Medical School, USA
Translational Control of Cellular Senescence by CPEB

Howard Lipshitz, University of Toronto, Canada
Control of mRNA Translation, Stability and Localization during Early Drosophila Development

Scott L. Noble, University of Colorado Denver Health Sciences Center, USA
Short Talk: P-body/Stress Granule-Like Particles are Regulated and Linked to Maternal mRNA Control during C. Elegans Development

Robin P. Wharton, Duke University Medical Center, USA
Short Talk: RNA Tethering to Explore Mechanisms of Regulation in the Early Drosophila Embryo

19:15—20:15
Social Hour with Lite Bites

Bay 5-6
19:30—22:00
Poster Session 2

Bay 5-6

THURSDAY, JANUARY 31

07:00—08:00
Breakfast

Bay 2
08:00—11:00
Translational Control in Learning and Memory
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Joel D. Richter, University of Massachusetts Medical School, USA

Eric Klann, New York University, USA
Synaptic Plasticity and Memory Phenotypes in Mice with Mutations for Translational Control Proteins

Nahum Sonenberg, McGill University, Canada
Control of Memory by eIF2

Melissa J. Moore, Moderna Therapeutics, USA
Interactions between eIF4A and its Accessory Factors eIF4B and eIF4H

Jean-Claude Lacaille, Université de Montréal, Canada
Short Talk: Staufen1 Regulation of Protein Synthesis-Dependent Long-Term Potentiation and Synaptic Function in Hippocampal Pyramidal Cells

Joseph Rayman, Columbia University, USA
Short Talk: Functional Studies of a Neuronal Aplysia TIA Ortholog

Douglas R. Cavener, Pennsylvania State University, USA
Short Talk: PERK is Required to Regulate Different Cellular Functions in the Endocrine and Exocrine Pancreas and Bone

09:20—09:40
Coffee Break

Conference Center Lobby
11:00—13:00
Poster Setup

Bay 5-6
13:00—22:00
Poster Viewing

Bay 5-6
16:30—17:00
Coffee Available

Conference Center Lobby
17:00—19:15
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bodies) I
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Allan Jacobson, University of Massachusetts Medical School, USA
NMD: mRNA Decay Solves a Translational Problem

Lynne E. Maquat, University of Rochester Medical Center, USA
Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay

Paul J. Anderson, Harvard Medical School, USA
A Genomic siRNA Screen Identifies Signaling Pathways Required for the Assembly of Stress Granules and P-Bodies

Oliver Mühlemann, University of Bern, Switzerland
Short Talk: Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3’ Untranslated Region

Yuichi Otsuka, Ohio State University, USA
Short Talk: 5’ Capping of Endonuclease-Generated mRNA Decay Intermediates by a Cytoplasmic Capping Enzyme Complex

19:15—20:15
Social Hour with Lite Bites

Bay 5-6
19:30—22:00
Poster Session 3

Bay 5-6

FRIDAY, FEBRUARY 1

07:00—08:00
Breakfast

Bay 2
08:00—11:15
Translational Control and Disease Models
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Nahum Sonenberg, McGill University, Canada

David Ron, University of Cambridge, UK
Regulation of Intermediary Metabolism by Endoplasmic Reticulum Stress-Induced Phosphorylation of Translation Initiation Factor 2-alpha

Peter Sarnow, Stanford University School of Medicine, USA
Subversion of a Liver-Specific microRNA by Hepatitus C Virus

Ian J. Mohr, New York University School of Medicine, USA
Assembly of Translation Initiation Factor Complexes in Virus-Infected Cells

Thomas E. Dever, National Institutes of Health, USA
Regulation of the eIF2 Kinase PKR

Suzanne Komili, Harvard Medical School, USA
Short Talk: Functional Specificity among Duplicated Ribosomal Protein Genes Regulates Gene Expression in Yeast

Mauro Costa-Mattioli, Baylor College of Medicine, USA
Short Talk: Translational Control of the Innate Immune Response

09:20—09:40
Coffee Break

Conference Center Lobby
16:30—17:00
Coffee Available

Conference Center Lobby
17:00—19:30
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bodies) II
Meeting has ended...abstracts no longer viewable online.

Bays 3-4
* Paul J. Anderson, Harvard Medical School, USA

John Blenis, Weill Cornell Medical College, USA
Regulation of Protein Synthesis by mTOR Signaling

Joel G. Belasco, New York University School of Medicine, USA
Translational Repression, mRNA Decay, and RNA Interference

Zissimos Mourelatos, University of Pennsylvania School of Medicine, USA
Mammalian microRNAs and piRNAs

Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Large Scale Identification of Translational and Transcriptional miRNA Targets

Herve Le Hir, CNRS-Centre de Genetique Moleculaire, France
Short Talk: The NMD Factors Upf2 and Upf3 Recruit Upf1 to the Exon-Junction Complex and Stimulate its RNA Helicase Activity

19:30—20:30
Social Hour with Lite Bites

Bay 5-6
20:00—23:00
Entertainment

Bay 5-6

SATURDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13HD056600-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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