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This meeting took place in 2008



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Nuclear Receptors: Steroid Sisters (Z2)


Organizer(s) Nancy Lynn Weigel, Dean P. Edwards and W. Lee Kraus
March 30—April 4, 2008
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Dec 3, 2007
Late Abstract Deadline: Jan 2, 2008
Scholarship Deadline: Dec 3, 2007
Early Registration Deadline: Jan 30, 2008

Supported by the Director's Fund


Summary of Meeting:
Steroid receptors are hormone-regulated transcription factors that control a diverse array of physiological processes. Recent studies have (1) revealed new mechanisms by which steroid receptors modulate transcription and activate cell signaling pathways, (2) identified molecules with diverse functions that regulate steroid receptor action, and (3) elucidated roles for steroid receptors in both normal physiological processes and disease states, including cancer. Identification of the specific factors and molecular mechanisms that contribute to the tissue-specific actions and aberrant pathological effects of steroid receptors is critical for developing therapeutic agents. The objective of the meeting is to facilitate interactions between leaders in the field, younger scientists, and trainees to address these questions. Topics covered in this meeting include: (1) receptor structure and function; (2) genome-wide actions; (3) coactivators and corepressors; (4) chromatin remodeling; (5) interactions with cell signaling pathways; (6) novel biological roles for steroid receptors; and (7) steroid hormone actions in cancer.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 30

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom BC
* Peter Tontonoz, University of California, Los Angeles, USA

* Nancy Lynn Weigel, Baylor College of Medicine, USA

Eric N. Olson, University of Texas Southwestern Medical Center, USA
A MicroRNA Network that Governs Growth and Thyroid Hormone Responsiveness of the Heart


MONDAY, MARCH 31

07:00—08:00
Breakfast

Lower Level
08:00—11:15
Steroid Receptor and Coregulator Structure and Function
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA

Donald P. McDonnell, Duke University School of Medicine, USA
Nuclear Receptor-Coactivator Interactions as Targets for New Drug Discovery

Dean P. Edwards, Baylor College of Medicine, USA
The Role and Mechanisms of Progesterone Receptor Cross Talk with Signal Transduction Pathways

J. Wesley Pike, University of Wisconsin-Madison, USA
Regulation of Target Genes by The Vitamin D Receptor: Paradigms for Distal Enhancer Control

Peter E. Wright, The Scripps Research Institute, USA
Role of Protein Folding in Coactivator Function

Martin L. Privalsky, University of California, Davis, USA
Short Talk: Selective Impairment of Thyroid Hormone Receptor (TR)beta2 in Resistance to Thyroid Hormone Syndrome: Mutations Associated with Pituitary Resistance Disrupt Cooperative Contacts that Normally Enhance Coactivator Recruitment

Sebastiaan H. Meijsing, Max Planck Institute for Molecular Genetics, Germany
Short Talk: The Binding Site Code: The effect of DNA Binding Site Sequence Variation on Transcriptional Regulation by the Glucocorticoid Receptor


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

08:00—11:15
Differentiation and Development
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Regulation of Nutrient Metabolism by Lipid-Sensing Nuclear Receptors

Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany
Nuclear Receptor Regulation of microRNAs in the C. elegans Heterochronic Circuit

Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Metabolism by Drosophila Nuclear Receptors

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
The Nuclear Receptors, PPARgamma, VDR and RAR Link Lipid Metabolism And Immune Function In Developing Human Dendritic Cells

Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA
HNF4 Gene Regulation and Physiology in C. elegans

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
14:30—16:30
Workshop 1 - Hot Topics: Cancer/Signaling

Sea to Sky Ballroom C
* Donald P. McDonnell, Duke University School of Medicine, USA

Joyce Slingerland, UM Sylvester Comprehensive Cancer Center, USA
Src Promotes Estrogen Dependent ERa Proteolysis in Human Breast Cancer

Jerome C. Nwachukwu, New York University School of Medicine, USA
Roles of the Androgen Receptor Cofactor, ART-27 in Prostate Cancer

Sudipan Karmakar, Food & Drug Administration, USA
Depletion of SMRT Expression Inhibits the Proliferation of MCF-7 Breast Cancer Cell and Expression of Estrogen Receptor-alpha Target Genes

Jae-Kyung Myung, British Columbia Cancer Agency, Canada
Large Scale Analysis of the Phosphoproteome in Response to Rapid Signaling by Androgen

Muriel Le Romancer, INSERM, France
Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

14:30—16:30
Workshop 1 - Hot Topics

Sea to Sky Ballroom B
* Wen Xie, University of Pittsburgh, USA

Hong Soon Kang†, NIEHS, National Institutes of Health, USA
Physiological Functions of Retinoid-Related Orphan Receptor alpha (RORalpha) in Adipose Tissue

Pamela R. Moll, University of Toronto, Canada
Ligand Identification Using Live Zebrafish

Juliette Rambaud, Institut de Recherches Cliniques de Montreal, Canada
TIF1beta is a Coactivator of NGFI-B (Nur77), Nurr1 and NOR1

Chun-Li Zhang, University of Texas Southwestern Medical Center, USA
Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells and Animal Behavior

Michael L. Goodson, University of California, Davis, USA
Corepressor Isoform Diversity, Receptor Selectivity and Adipogenesis

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Steroid Receptor Signaling and Dynamics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Dean P. Edwards, Baylor College of Medicine, USA

Gordon L. Hager, NCI, National Institutes of Health, USA
Glucocorticoid Receptor Dynamics and Global Chromatin Structure

Boris J. Cheskis, Wyeth Research, USA
The Role of MNAR in Steroid Receptor Signaling

Stephen R. Hammes, University of Rochester Medical Center, USA
Extranuclear Steroid Signaling in the Ovary

Carol A. Lange, University of Minnesota, USA
Short Talk: Progesterone Receptor Rapid Signaling Mediates Ser345 Phosphorylation and Tethering to Sp1 Transcription Factors


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

17:00—19:00
Nuclear Receptor Structure/Function
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Fraydoon Rastinejad, Sanford Burnham Prebys Medical Discovery Institute, USA

Eric A. Ortlund, Emory University, USA
Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

H. Eric Xu, Van Andel Research Institute, USA
Structural Insights into Ligand-Dependent and -Independent Regulation of Nuclear Receptors

John W. R. Schwabe, University of Leicester, UK
From Novel Paradigms for Regulation of PPARgamma ƒnto Structures of the SMRT Repression Complex

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/ Mountain View/ Sky Ballroom A
19:30—22:00
Poster Session 1

Foyer/Mountain View/Sea to Sky Ballroom A

TUESDAY, APRIL 1

07:00—08:00
Breakfast

Lower Level
07:00—08:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
08:00—11:15
Steroid Receptors and Chromatin
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Myles Brown, Dana-Farber Cancer Institute, USA

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Transcriptional Regulation by Estrogen Receptors in the Chromatin Environment of the Nucleus

Trevor K. Archer, NIEHS, National Institutes of Health, USA
Regulating Nuclear Receptors with Chromatin

Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Targeting SWI/SNF in Prostate Cancer: Implications for AR Signaling and Regulated Proliferation

Robert G. Roeder, Rockefeller University, USA
Nuclear Receptors, Coactivators, and Chromatin

Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: A GRIP1-Associated SET Domain Methyl Transferase in Glucocorticoid Receptor Target Gene Expression

Didier Picard, University of Geneva, Switzerland
Short Talk: Mechanism of Activation of Unliganded ERalpha by cAMP and its Consequences for Target Gene Selection and Regulation


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

08:00—11:15
Drug Development
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Timothy M. Willson, GlaxoSmithKline, USA

Dennis L. Sprecher, GlaxoSmithKline, USA
PPARdelta: The Human Experience

Sunil Nagpal, Wyeth Research, USA

Konstantin Petrukhin, Columbia University, USA
NR2E3 Activators for the Treatment of Ophthalmic Diseases

Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy
Clinical Translation of FXR Agonists for the Treatment of Liver and Metabolic Disorders

Thomas P. Burris, Saint Louis University School of Medicine, USA
Short Talk: Identification of Heme as the Ligand for the Orphan Nuclear Receptors REV-ERBalpha and REV-ERBbeta

Henry M. Krause, University of Toronto, Canada
Structural Basis of Gas Regulation of REV-ERB Activity

09:20—09:40
Coffee Break

Foyer
11:15—12:00
Lunch

Grand Foyer/Sea to Sky Ballroom A
12:00—14:30
Poster Session 2

Foyer/Mountain View/Sea to Sky Ballroom A
14:30—16:30
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Receptor Function

Sea to Sky Ballroom C
* J. Wesley Pike, University of Wisconsin-Madison, USA

Ian M. Adcock, Imperial College London, UK
Glucocorticoid-Mediated Suppression of NF-kappaB-Stimulated TGFbeta1 Expression Requires the Methylase Suv39H1

Shilpa Chooniedass-Kothari, University of Manitoba, Canada
The Steroid Receptor RNA Activator Protein (SRAP) Acts as a Transcriptional Repressor

Peter J. Leedman, Western Australian Institute for Medical Research, Australia
PACT, TRBP, PKR and Dicer: Novel SRA-binding Coregulators that Modulate Nuclear Receptor Signaling

Deepa Chotai, Imperial College, UK
The Repression of Androgen Receptor Activity by Prohibitin

Beatrice D. Darimont, Merck Research Laboratories, USA
Recognition of the Glucocorticoid Receptor by Hsp90


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

14:30—16:30
Workshop 2 - Hot Topics

Sea to Sky Ballroom B
* Carlie J. M. de Vries, University of Amsterdam, Netherlands

Eric Schoenmakers, University of Cambridge, UK
A Mutation in the Human PPARgamma Ligand Binding Domain in Severe Insulin Resistance

Lillian J. Eichner, The Salk Institute, USA
miRNA Regulation of the ERR/PGC-1 Pathway

Thijs Pols, University of Amsterdam, Netherlands
Nur77 Modulates Hepatic Lipid Metabolism through Suppression of SREBP1c Activity

David W. Granger, GlaxoSmithKline, UK
Characterisation of a Novel Nuclear Receptor-like Protein

J. H. M. Stroeve, TNO Quality of Life, Netherlands
The Intestinal FXR-Mediated Fgf-15 Pathway Contributes to the Control of Hepatic Bile Acid Synthesis and Bile Formation in Chow Fed Mice but its Contribution is Overruled during Bile Acid Feeding and Bile Acid Sequestration

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B, C
* W. Lee Kraus, University of Texas Southwestern Medical Center, USA

Henk G. Stunnenberg, Radboud University, Netherlands
ChIP-seq Analyses of ER and GR Uncovers an Elaborate Ligand Dependent Interaction Network, the Interactome

Myles Brown, Dana-Farber Cancer Institute, USA
Defining the Nuclear Receptor Cistrome

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Integration of Nuclear and Extranuclear Signaling in Global Gene Regulation By Estrogen Receptors

Edwin Cheung, University of Macau, Macau
Short Talk: Global Analysis of Estrogen Receptor-Mediated Chromatin Interactions

19:00
On Own for Dinner


WEDNESDAY, APRIL 2

07:00—08:00
Breakfast

Lower Level
08:00—11:15
Steroid Receptors and Cancer
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA

Nancy Lynn Weigel, Baylor College of Medicine, USA
Androgen Receptor Action in Prostate Cancer

Patricia V. Elizalde, Instituto de Biología y Medicina Experimental, Argentina
Progesterone Receptor Signaling in Breast Cancer

Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
Steroid Hormones and Hormone Dependent Breast Cancer Metastasis

Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA
Estrogen Receptor and Coregulators in Breast Cancer

Suzanne AW Fuqua, Baylor College of Medicine, USA
Short Talk: A Model of Estrogen Receptor (ER) alpha-Positive Breast Cancer Metastasis

Nicola J. Clegg, Genentech Research & Early Development, USA
Short Talk: Androgen Receptor Antagonists with a Novel Mechanism of Action


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

08:00—11:15
Orphan Receptors In Metabolism
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Peter Tontonoz, University of California, Los Angeles, USA

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Fasting by the PPARalpha-FGF21 Pathway

Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
LRH-1 Actions Along the Enterohepatic Axis

Wen Xie, University of Pittsburgh, USA
PXR, CAR and LXR in Xeno- and Endobiotic Metabolism

Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Pancreatic Beta Cells

Kaoru Saijo, University of California, Berkeley, USA
Short Talk: A Nurr1/CoREST Transrepression Pathway Antagonizes Neurotoxicity of Activated Microglia

Steven J. Bensinger, University of California, Los Angeles, USA
Short Talk: An LXR-Dependent Sterol Signaling Pathway Couples Proliferation to Metabolism in the Acquired Immune Response

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
14:30—16:30
Workshop 3 - Hot Topics: Chromatin/Transcription

Sea to Sky Ballroom C
* Trevor K. Archer, NIEHS, National Institutes of Health, USA

Nina Heldring, Cornell University, USA
Molecular Mechanisms of Estrogen Receptor-Mediated Transcription Through the Activating Protein-1-Dependent "Tethering" Pathway

Mathieu Lupien, University Health Network, Canada
FoxA1 Translates Epigenetic Signatures into Enhancer Driven Lineage-Specific Transcription

Steven K. Nordeen, University of Colorado Health Sciences Center, USA
Progesterone Receptor Binds to an Estrogen Response Element, and Antagonizes Estrogen Receptor-Mediated Gene Induction. The Role of DNA as a Functional Ligand

Raj Kumar, Commonwealth Medical College, USA
Effects of Site-Specific Phosphorylation on the Structure and Functions of the Glucocorticoid Receptor AF1 Domain

Yang Sui Brooks, Medical College of Georgia, USA
Alternative Splicing of Nuclear Receptor Coactivator CoAA in Stem Cells

Martin E. van Royen, Erasmus Medical Center, Netherlands
Spatiotemporal Organization of AR intra- and Intermolecular Domain Interactions in Living Cells

Hong-Wu Chen, University of California, Davis, USA
Novel AAA+ ATPase Chromatin Coregulators are Key Integrators of Hormone Signaling and Cell Proliferation Control


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

14:30—16:30
Workshop 3 - Hot Topics

Sea to Sky Ballroom B
* Joyce J. Repa, University of Texas Southwestern Medical Center, USA

Tomas Jakobsson, Karolinska Institutet, Sweden
RAP250 is a Coactivator in the TGF-beta Signaling Pathway that Interacts with SMAD2 and SMAD3

Arjen Koppen, University Medical Centre Utrecht, Netherlands
Micro Array Assay for Real-Time Analysis of Coregulator-Nuclear Receptor Interactions

Federica Gilardi, University of Lausanne, Switzerland
Impact of Histone Deacetylases Modulating Nuclear Receptor Activity on Lipid Metabolism

Federica Gilardi, University of Lausanne, Switzerland
Impact of Histone Deacetylases Modulating Nuclear Receptor Activity on Lipid Metabolism

Ouliana Ziouzenkova, Ohio State University, USA
Proteomic Studies on Retinaldehyde Functions in Adipose Tissue

Elizabeth M. Simpson, University of British Columbia, Canada
Initial Association of NR2E1 with Bipolar Disorder and Identification of Candidate Mutations in Bipolar Disorder, Schizophrenia, and Aggression through Resequencing

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Nuclear Receptor and Coregulator Structure and Function (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B, C
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Bert W. O'Malley, Baylor College of Medicine, USA
Roles of Nuclear Receptor Coactivators in Physiology and Disease.

Orla M. Conneely, Baylor College of Medicine, USA
Orphan Receptors in Cell Growth and Tumorigenesis

Holly A. Ingraham, University of California, San Francisco, USA
Modulating Target Gene Recognition via Sumoylation of SF- 1 (NR5A1) as Revealed by Biochemical and Mouse Mutant

Fraydoon Rastinejad, Sanford Burnham Prebys Medical Discovery Institute, USA
Structural Organization of the Intact PPARƒ×-RXR Complex

19:15—20:15
Social Hour with Lite Bites

Grand Foyer/ Mountain View/ Sky Ballroom A
19:30—22:00
Poster Session 3

Foyer/Mountain View/Sea to Sky Ballroom A

THURSDAY, APRIL 3

07:00—08:00
Breakfast

Lower Level
08:00—11:15
Steroid Receptor Biology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Adriana Maggi, University of Milan, Italy

James T. Dalton, GTx, Inc., USA
Therapeutic Promise of Selective Androgen Receptor Modulators (SARMs): Preclinical and Clinical Proof-of-Concept Studies.

Francesco J. DeMayo, Baylor College of Medicine, USA
In Vivo Studies of Progesterone Receptor Action in the Uterus

Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Estrogen Receptor Action in vivo

Edwin R. Sanchez, University of Toledo College of Medicine, USA
Selective Targeting of Steroid Physiology in TPR Protein Ablated Mice

Inna I. Astapova, Beth Israel Deaconess Medical Center, USA
Short Talk: Nuclear CoRepressor (NCoR) Regulates Hepatic Thyroid Hormone Receptor Function In Vivo

Frank A. Claessens, KULeuven- Molecular Endocrinology Laboratory, Belgium
Short Talk: Loss of Androgen Receptor Binding to Selective Androgen Response Elements causes a Reproductive Phenotype in the Transgenic SPARKI Mice


Following Session is for Nuclear Receptors: Orphan Brothers (Z1)

08:00—11:15
Mechanisms of Receptor Action
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Physiology of Repression by Nuclear Receptors

David D. Moore, Baylor College of Medicine, USA
New Ligands for LRH-1 and SF-1

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Control of Metabolism through the PGC-1 and SIRT1 Cofactors

Li Wang, University of Connecticut, USA
SHP, Metabolism, Epigenetics, and Cancer

Jiandie Lin, University of Michigan Medical School, USA
Short Talk: Decoding the PGC-1 Transcriptional Network through Genome-Wide Coactivation Analyses

Susanne Mandrup, University of Southern Denmark, Denmark
Short Talk: Genome-wide ChIP-seq Profiling of PPAR/RXR Target Sites in 3T3-L1 Adipocytes

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Nuclear Receptor Biology (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B, C
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
PPARs: Bone Up on Metabolism

Adriana Maggi, University of Milan, Italy
Estrogen, Nutrition and Fertility

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown Fat Determination of Brown Fat Cells by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: The Nuclear Receptor Signaling Atlas (Nursa): A Resource for the NR Community

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/ Mountain View/ Sky Ballroom A
20:00—23:00
Entertainment

Foyer/Mountain View/Sea to Sky Ballroom A

FRIDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-02




We gratefully acknowledge additional support for this conference from:

GTx, Inc. Merck & Co., Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GTx, Inc.


The Endocrine Society


Wyeth Research Labs


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