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This meeting took place in 2008



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Forkhead Transcription Factor Networks in Development, Signaling, and Disease (A3)


Organizer(s) Kenneth S. Zaret, Klaus H. Kaestner and Susan E. Mango
January 13—17, 2008
Zermatt Resort & Spa - Utah • Midway, Utah USA
Abstract Deadline: Sep 12, 2007
Late Abstract Deadline: Oct 15, 2007
Scholarship Deadline: Sep 12, 2007
Early Registration Deadline: Nov 13, 2007

Supported by the Director's Fund

Summary of Meeting:
Forkhead box (FOX) transcription factors were discovered to bind target DNA sites in compacted chromatin, where many other transcription factors cannot bind, and subsequently found to play central roles in regulatory networks that control development, signaling, metabolism, and human disease. The proposed meeting will provide a rare opportunity for cross-fertilization of ideas from very different areas of biological sciences, spanning diverse model organisms and humans, all surrounding this special class of transcription factor. It is expected that the convergence of different models systems, approaches, and thinking will allow unique new insights and advances in each of the scientific domains in which FOXA factors are studied.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 13

15:00—19:30
Registration

Matterhorn Foyer
18:30—19:30
Refreshments

Matterhorn Foyer
19:30—20:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
Myles Brown, Dana-Farber Cancer Institute, USA
Connecting Forkhead Factors and Nuclear Receptors to the Genome


MONDAY, JANUARY 14

07:00—08:00
Breakfast

Schneitter's Restaurant
08:00—11:15
Development and Transcription Networks I
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Jane Mellor, University of Oxford, UK

Susan E. Mango, Harvard University, USA
Making and Shaping the Foregut in C. elegans

Peter L. J. de Keizer, Buck Institute for Research on Aging, USA
Short Talk: The Peptidyl-Isomerase Pin1 Regulates p27kip1 Expression through Inhibition of FOXO Transcription Factors

Deborah J. Andrew, Johns Hopkins University, USA
The Role of the Fox A Protein Fkh in the Drosophila Salivary Gland

Sven Enerbäck, University of Gothenburg, Sweden
A Conserved Foxi1 Regulated Genetic Circuit Operates in the Ear, Kidney and Epididymis

Siew-Lan Ang, National Institute for Medical Research, UK
Short Talk: Foxa1 and Foxa2 Regulate Midbrain Dopaminergic Neuron Development in a Dosage-Dependent Manner

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
The Foxa Genes in the Endocrine Pancreas

09:20—09:40
Coffee Break

Davos Break area
11:15—13:00
Poster Set Up for Sessions 1 & 2

Davos/ Grindelwald
13:00—22:00
Poster Viewing

Davos/ Grindelwald
16:30—17:00
Coffee Available

Davos Break area
17:00—19:00
Chromatin Remodeling and Transcription
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Susan E. Mango, Harvard University, USA

Jane Mellor, University of Oxford, UK
Yeast Fkh1 and Fkh2 Factors and Chromatin Remodeling

Lisa Ann Cirillo, Medical College of Wisconsin, USA
Chromatin Binding and Perturbation by FoxO1

David Stillman, University of Utah, USA
Short Talk: Yeast Fkh1 and Fkh2 Proteins Recruit the Sin3 HDAC to Promoters and Can Block Activation By Promoter Bound Factors

Kenneth S. Zaret, University of Pennsylvania, USA
Distinctive Chromatin Binding and Scanning Properties of Fox Factors

19:00—19:15
Discussion About the Creation of New Web Resources for Fox Factors
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA

19:15—20:15
Social Hour with Lite Bites

Davos/ Grindelwald
19:30—22:00
Poster Session 1

Davos/ Grindelwald

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Schneitter's Restaurant
08:00—11:00
Metabolism and Signaling
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Deborah J. Andrew, Johns Hopkins University, USA

Heidi Tissenbaum, University of Massachusetts Medical School, USA
Complex Regulation by C. elegans FOXO/Daf-16

Hyun Jung Park, University of Illinois at Chicago, USA
Short Talk: Cell Cycle Regulation of the Forkhead Box M1 (FoxM1) Transcription Factor

Andrew G. Dillin, University of California, Berkeley, USA
Pha4/Foxa, Diet Restriction, and Longevity

Andrei L. Gartel, University of Illinois, USA
Short Talk: Thiazole Antibiotics that Inhibit FoxM1 are Potential Anticancer Drugs

Ronald D. McKay, Lieber Institute for Brain Development, USA
Foxa2, Dopamine Neurons, and Parkinson's Disease

09:20—09:40
Coffee Break

Davos Break area
13:00—22:00
Poster Viewing

Davos/ Grindelwald
16:30—17:00
Coffee Available

Davos Break area
17:00—19:00
Structure and Evolution of Winged Helix Proteins
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Michelle C. Barton, University of Texas MD Anderson Cancer Center, USA

Paola Oliveri, University College London, UK
Fox Genes in Regulatory Networks for Embryo Development and Evolution

Lin Chen, University of Southern California, USA
Structural Insights into the Potential Role of FOXP Proteins in the Epigenetic Control of Chromatin Structure

Xiubei Liao, University of Illinois at Chicago, USA
Folding Stage Dependent Interactions Between HNF-6 and FoxD3 Hint at a Complicated Network in Transcriptional Regulation

Michael Brent, Wistar Institute, USA
Short Talk: Structure and Regulation of Human FoxO1 Transcription Factor

19:00—20:00
Social Hour with Lite Bites

Davos/ Grindelwald
19:30—22:00
Poster Session 2

Davos/ Grindelwald

WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

Schneitter's Restaurant
08:00—11:00
The Fox Genes in Human Disease
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA

H. Phillip Koeffler, Cedars-Sinai Medical Center, USA
FOXA1 and BRCA1 in Breast Cancer

Michael A. Walter, University of Alberta, Canada
FOXC1 in Axenfeld-Rieger-Syndrome and Glaucoma

Constance Scharff, Max Planck Institute for Molecular Genetics, Germany
Foxp2 in Learned Avian Vocalizations

Simon E. Fisher, Oxford University, UK
Neurogenetic Pathways Regulated by FOXP2, a Gene Involved in Speech and Language

Ping Hu, University of California, Berkeley, USA
Short Talk: A Dual Activator Mechanism Directs Myoblast Specific MyoD Transcription

09:20—09:40
Coffee Break

Davos Break area
16:30—17:00
Coffee Available

Davos Break area
18:00—19:00
Development II
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Kenneth S. Zaret, University of Pennsylvania, USA

Michelle C. Barton, University of Texas MD Anderson Cancer Center, USA
Temporal Orchestration of Chromatin Regulation by Foxa1, TGFß and p53

Peter Carlsson, Göteborg University, Sweden
FoxF Genes in Murine Embryonic Development

19:00—20:00
Social Hour with Lite Bites

Davos/ Grindelwald
20:00—23:00
Entertainment

Davos/ Grindelwald

THURSDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD057650-01




We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation
Developmental Dynamics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676