Resort at Squaw Creek Floorplan

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This meeting took place in 2009



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Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4)


Organizer(s) Robert C. Murphy, Julie D. Saba and Michael J.O. Wakelam
April 22—27, 2009
Resort at Squaw Creek • Olympic Valley, California USA
Abstract Deadline: Dec 23, 2008
Late Abstract Deadline: Jan 26, 2009
Scholarship Deadline: Dec 23, 2008
Early Registration Deadline: Feb 23, 2009

Supported by the Directors' Fund


Summary of Meeting:
Complex lipids constitute a diverse family of biomolecules of seven general classes that serve essential roles in Biology. For example, lipids include structural phospholipids that form cellular membranes but are also the reservoirs and source of polyunsaturated fatty acids that are signaling mediators. Intense research effort over the past years has substantially changed our understanding of lipid biochemistry and lipid function in cells with the application of new tools and techniques to study these molecules. This meeting will bring together a group of individuals who have the common goal of understanding the role that lipids play in cell biology, physiology and disease processes.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 22

15:00—19:30
Registration

Lobby Alcove
18:30—19:30
Refreshments

Sierra Prefunction A,B,C,D
19:30—19:45
Welcoming and Introduction

Grand Sierra Ballroom
Julie D. Saba, Children’s Hospital Oakland Research Institute, USA

19:45—20:45
Keynote Address: 50th Anniversary JLR Lecturer
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Robert C. Murphy, University of Colorado Denver, USA
Keynote Introduction and JLR Award

Takao Shimizu, University of Tokyo, Japan
Phospholipid Metabolism: Phospholipases and Acyltransferases


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Peter M. Finan, Epidarex Capital, UK

* Lewis C. Cantley, Weill Cornell Medicine, USA

William R. Sellers, , USA
The Development of PI3K Pathway Modulators for Cancer


THURSDAY, APRIL 23

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Phosphoinositides and Signaling (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Phillip T. Hawkins, Babraham Institute, UK

* Michael J.O. Wakelam, Babraham Institute, UK

Lewis C. Cantley, Weill Cornell Medicine, USA
Growth Control by the PI3K/mTOR Pathway

Len R. Stephens, Babraham Institute, UK
Signaling via PI3Ks in Neutrophils

Kevan M. Shokat, University of California, San Francisco, USA
Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2

Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA
Functions of PH Domains and other Phosphoinositide/Phospholipid Binding Domains

09:20—09:40
Coffee Break

Sierra Prefunction A,B,C,D
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Sierra Prefunction A,B,C,D
17:00—19:00
Phospholipases and Acyl Transferases
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* H. Alex Brown, Vanderbilt University, USA

Christina C. Leslie, National Jewish Health, USA
Regulation of Cytosolic Phospholipase A2alpha by Phosphorylation and Basic Residues in the Catalytic Domain

Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation

Michael J.O. Wakelam, Babraham Institute, UK
Regulation of Phospholipase D in Normal and Diseased Cells


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

17:00—19:00
PI 3-Kinase Pathway and Inflammation
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy

Phillip T. Hawkins, Babraham Institute, UK
PI3K Regulation of the Neutrophil NADPH Oxidase

Matthias P. Wymann, University of Basel, Switzerland
PI3K Signaling in Immune Cells

Alex Berndt, MRC-Laboratory of Molecular Biology, UK
Short Talk: The Crystal Structure of the Murine Class IA PI3K p110delta in Complex with Isoform Selective Inhibitors

Tamas Oravecz, Celgene, USA
Short Talk: Phosphoinositide 3-kinase-C2alpha is Essential for Normal Renal Function in Mice

19:00—20:00
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 1

Alpine Ballroom

FRIDAY, APRIL 24

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Leukotrienes: New Frontiers
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA

Jilly F. Evans, PharmAkea Therapeutics, USA
5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target

Marc Peters-Golden, University of Michigan, USA
Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation

Robert C. Murphy, University of Colorado Denver, USA
Transcellular Biosynthesis of Leukotrienes

Colin D. Funk, Queen's University, Canada
Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

08:00—11:00
Cell Growth, Metabolism and Aging
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Lewis C. Cantley, Weill Cornell Medicine, USA

Levi A. Garraway, Eli Lilly and Company, USA
AKT-Independent Signaling in PI3 Kinase-Driven Cancers

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Crosstalk between PI3K and mTOR

Anne Brunet, Stanford University, USA
Role of FOXO Transcription Factors in Aging

Leon O. Murphy, Third Rock Ventures, USA
Amino Acid Signaling to mTOR

09:20—09:40
Coffee Break

Sierra Prefunction A,B,C,D
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Sierra Prefunction A,B,C,D
17:00—19:00
Sphingolipid Signaling
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Sarah Spiegel, Virginia Commonwealth University, USA

Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA
S1P Signaling in the Vasculature

Shaun R. Coughlin, University of California, San Francisco, USA
Compartmentalization of S1P Signaling

Richard L. Proia, National Institutes of Health, USA
Sphingosine-1-Phosphate and its Role in Physiology


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

17:00—19:00
Dissecting the Complexity of PI 3-Kinase Signaling
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Jean J. Zhao, Dana-Farber Cancer Institute, USA

Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Roles of PI3 Kinase Isoforms

Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain
Distinct Activation Requirements and Function for Phosphoinositide 3-Kinase p110alpha and beta in Cell Division

Brendan D. Manning, Harvard School of Public Health, USA
Molecular Mechanisms and Consequences of mTOR Activation Downstream of PI3K

19:00—20:00
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 2

Alpine Ballroom

SATURDAY, APRIL 25

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Ceramides, LysoPA and other Lipid Mediators
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Julie D. Saba, Children’s Hospital Oakland Research Institute, USA

Jerold J. Chun, The Scripps Research Institute, USA
Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms

Sarah Spiegel, Virginia Commonwealth University, USA
Signaling and Compartmentalization of Sphingosine-1-Phosphate

Teresa M. Dunn, Uniformed Services University of the Health Sciences, USA
Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Mapping Lipid Signaling Networks by Integrated Proteomics and Metabolomics


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

08:00—11:00
PI 3-Kinase Signaling and Cancer
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
PTEN and the Control of Tumorigenesis

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
PI 3-Kinase Signaling and Tumorigenesis

Jean J. Zhao, Dana-Farber Cancer Institute, USA
Class IA PI3K Isoforms in Signaling and Cancer

Jeffrey A. Engelman, Novartis Institutes of BioMedical Research, USA
Inhibition of PI3K in Cancers

09:20—09:40
Coffee Break

Sierra Prefunction A,B,C,D
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom

Following Session is for PI 3-Kinase Signaling in Disease (Z3)

14:30—16:30
Workshop: Targeting the PI3 Kinase Pathway: Insights from Drug Discovery Projects

Grand Sierra B,C,D
* Peter M. Finan, Epidarex Capital, UK

* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Giovanna Bergamini, Cellzome a GSK Company, Germany
Identification and Characterization of Selective PI3Kgamma Inhibitors

Xu Tao, Curis, Inc, USA
A Single Small Molecule that Inhibits Histone Deacetylase and Phosphatidylinositol-3-kinase

Sabita Sankar, Celgene Corporation, USA
Distinguishing mTOR Inhibitors from Rapamycin

Jo-Anne Pinson, Monash University, Australia
PI3-Kinase and Inhibitors: 2-Iminothiazolidinones for Targeting Isoform Selectivity

16:30—17:00
Coffee Available

Sierra Prefunction A,B,C,D
17:00—19:00
Recent Advances in PGH Synthase and 5-Lipoxygenase
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Takao Shimizu, University of Tokyo, Japan

William L. Smith, University of Michigan, USA
Allosteric Regulation of Cyclooxygenases by Fatty Acids and Inhibitors

Garret A. FitzGerald, University of Pennsylvania, USA
Translational Therapeutics of the Arachidonic Acid Cascade

Frank A. Fitzpatrick, University of Utah, USA
Akt Activation by Arachidonic Acid Metabolism

Tzipora Goldkorn, University of California, Davis, USA
Short Talk: nSMase2: Role and Molecular Mechanism in Lung Injury


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

17:00—19:00
Phosphatases and Control of the PI 3-Kinase Pathway
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Matthias P. Wymann, University of Basel, Switzerland

Alexandra C. Newton, University of California, San Diego, USA
Signal Termination: PHLiPPing the Switch in Cell Signaling

Nick Reid Leslie, Heriot Watt University, UK
The Regulation and Mechanisms of Action of PTEN

Takehiko Sasaki, Akita University School of Medicine, Japan
In vivo Role of Inositol Polyphosphate Phosphatase 4A

19:00—20:00
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 3

Alpine Ballroom

SUNDAY, APRIL 26

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Phospholipases, Kinases and Signaling Systems
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Christina C. Leslie, National Jewish Health, USA

Michael A. Frohman, Stony Brook University, USA
Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways

H. Alex Brown, Vanderbilt University, USA
Phospholipase D Signaling Pathways and Inhibitors

Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness

Julie D. Saba, Children’s Hospital Oakland Research Institute, USA
Sphingadienes Inhibit AKT-Dependent Signaling and Prevent Intestinal Tumorigenesis


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

08:00—11:00
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Paul Workman, Institute of Cancer Research, UK

Richard F. Wooster, GlaxoSmithKline, USA
GSK2126458: A Novel and Potent Small Molecule Inhibitor of Phosphoinositol 3-Kinase

Klaus Hoeflich, Genentech, Inc., USA
Targeted Therapy Combinations with Class I PI3K Inhibitor GDC-0941

Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
Dual Targeting PI3Kdelta/gamma Prevents and Reverts Immune-Mediated Inflammation

Amy Kiger, University of California, San Diego, USA
Short Talk: Roles for a Class II PI3K/Mtm Pathway for PI3P-Mediated Cellular Remodeling in Development

Charlotte Edling, Barts and the London School of Medicine, UK
Short Talk: p110gamma Upregulation Promotes Cell Growth and Drug Resistance in Pancreatic Cancer

09:20—09:40
Coffee Break

Sierra Prefunction A,B,C,D
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Sierra Prefunction A,B,C,D
17:00—19:00
Emerging Nexi
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A
* Robert C. Murphy, University of Colorado Denver, USA

Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Identification of Lipid-Protein Covalent Adducts and the Cellular Consequences of their Formation

Suzanne E. Barbour, Virginia Commonwealth University, USA
Regulation of Lipoprotein-Associated PLA2/ PAF-AH by Oxidized Phospholipids

Atsuo Kawahara, Kyoto University, Japan
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

17:00—18:45
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
* Peter M. Finan, Epidarex Capital, UK

Paul Workman, Institute of Cancer Research, UK
Drugging the PI3 Kinome for Cancer Treatment

Neill A. Giese, , USA
The Development of PI3K p110delta Inhibitors for Hematological Malignancies and Inflammation

David A. Fruman, University of California, Irvine, USA
Anti-Leukemic Effects of Novel, Orally Active mTOR Inhibitor


Following Session is for PI 3-Kinase Signaling in Disease (Z3)

18:45—19:00
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Grand Sierra B,C,D
Lewis C. Cantley, Weill Cornell Medicine, USA
Closing Remarks

19:00—20:00
Social Hour with Lite Bites

Alpine Ballroom
20:00—23:00
Entertainment

Alpine Ballroom

MONDAY, APRIL 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Journal of Lipid Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676