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This meeting took place in 2009


Here are the related meetings in 2018:
Ubiquitin Signaling (A8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Many Faces of Ubiquitin (A4)


Organizer(s) Simona Polo, Christopher D. Lima and Vishva M. Dixit
January 11—16, 2009
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Sep 17, 2008
Late Abstract Deadline: Oct 14, 2008
Scholarship Deadline: Sep 17, 2008
Early Registration Deadline: Nov 11, 2008

Supported by the Directors' Fund

Summary of Meeting:
The ubiquitin (Ub) pathway controls many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death. The covalent attachment of Ub to proteins can alter their localization, activities, and ultimate fate. One of the most intriguing features of the ubiquitin pathway is its emerging involvement in functions not directly related to protein degradation. In addition, some half-dozen related ubiquitin-like (Ubl) proteins, such as SUMO, are also revealing themselves as regulators of numerous cellular pathways. The existence of this vast and dynamic array of Ub and Ubl signals raises the central question of how specificity is achieved during conjugation, recognition, and signal transduction. Indeed, the molecular requirements for generating and recognizing various Ub signals are poorly understood and form a central unresolved issue in the field. This meeting will focus attention on the biology associated with Ub/Ubl-mediated signal transduction, including its role in human disease and cancer. The goal of this meeting is to gather a diverse array of scientists, not just “ubiquitinologists”, but also biologists whose work has been touched in some way by ubiquitin or ubiquitin-like pathways. By bringing together scientists from different backgrounds who work on a wide range of systems that are regulated by Ub and Ubl conjugation, this meeting will create a fertile ground for exchange of ideas on non-conventional functions for Ub and Ubl proteins in signal transduction.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 11

15:00—19:30
Registration

Kokopelli's
18:30—19:30
Refreshments

Kokopelli's
19:30—19:45
Opening Remarks

* Vishva M. Dixit, Genentech, Inc., USA

19:45—20:45
The Cecile Pickart Memorial Lecture
Meeting has ended...abstracts no longer viewable online.

Big Horn B
Daniel J. Finley, Harvard University, USA
Regulation of Substrate Processing by the Proteasome


MONDAY, JANUARY 12

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
Signal Transduction by Ub (I)
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany

Vishva M. Dixit, Genentech, Inc., USA
Usp9x: A Stabilizing Deubiquitinase for Mcl-1

David O. Morgan, University of California, San Francisco, USA
Substrate Recognition by the Anaphase-Promoting Complex

J. Wade Harper, Harvard Medical School, USA
Genetic and Proteomic Analysis of the Ubiquitin System

Claudio A. P. Joazeiro, The Scripps Research Institute, USA
Mitochondria and the Ubiquitin System

Sirio Dupont, University of Padova, Italy
Short Talk: A Deubiquitinating Enzyme Essential for TGFbeta Signaling Controls Smad4 Monoubiquitination

Peter Kaiser, University of California, Irvine, USA
Short Talk: Inactivation of SCF by Signal-Induced Disassembly

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Big Horn C
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Big Horn C
16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Signal Transduction by Ub (II)
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Ronald T. Hay, University of Dundee, UK

Simona Polo, FIRC Institute of Molecular Oncology, Italy
Ubiquitin in Endocytosis and Signaling of EGFR

Morag Park, McGill University, Canada
Met Receptor Tyrosine Kinase: Intracellular Trafficking, Signal Polarisation and Transformation

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
and

Ming Xu, University of Texas Southwestern Medical Center, USA
Ubiquitin in the NF-kappaB Pathway

Mads Gyrd-Hansen, University of Oxford, UK
Short Talk: IAPs Contain an Evolutionarily Conserved Ubiquitin-Binding Domain that is Essential for NF-kappaB Regulation and Oncogenesis

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
19:30—22:00
Poster Session 1

Big Horn C

TUESDAY, JANUARY 13

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
Enzymes Regulation
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Morag Park, McGill University, Canada

Raymond J. Deshaies, Amgen, USA
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Mechanisms and Specificity of NEDD8ylation

Anindya Dutta, University of Virginia, USA
CRL4-Cdt2 in the Maintenance of Genome Stability

Jonathon Pines, University of Cambridge, UK
Short Talk: How is the APC/C-Cdc20 Complex Regulated in Mitosis?

Yang Xie, Yale University, USA
Short Talk: Proteolytic Regulation of the Yeast MATalpha2 Transcription Factor by a SUMO-Targeted Ubiquitin Ligase (STUbL)

R. Andrew Byrd, NCI, National Institutes of Health, USA
Short Talk: Allosteric Activation of Ubiquitin Ligase Activity by a Novel E2 Binding Region

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Big Horn C
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Big Horn C
14:30—16:30
Workshop 1: Tools and Reagents Development

Big Horn B
* Paul W. Sheppard, Vacye Associates Limited, UK
State of the Art

Christopher Tsu, Takeda Pharmaceuticals International Co., USA
Development of a Novel Charcoal Paper ATP: Pyrophosphate Exchange Assay: Kinetic Characterization of NEDD8 Activating Enzyme

Karen M. Kleman-Leyer, Bellbrook Labs, USA
Monitoring AMP Flux through the SUMOylation Cascade Using the Transcreener AMP/GMP Assay

Michael H. Tatham, University of Dundee, UK
System-Wide Analysis of Changes to the SUMO Proteome in Response to External Stimuli

Paul S. Andrews, Amgen Inc, USA
Identification of SMURF1 Substrates Utilizing Protein Microarrays

Birte Kalveram, University of Constance, Germany
Generation and Characterization of Monoclonal Antibodies Against the Ubiquitin-Like Modifier FAT10

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Various Chains, Various Signals
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Raymond J. Deshaies, Amgen, USA

Kazuhiro Iwai, Osaka University, Japan
Physiological Function of Linear Polyubiquitin Chains

Michael Rape, University of California, Berkeley, USA
The Assembly of K11-linked Ubiquitin Chains during Mitosis

Junmin Peng, Emory University, USA
Analysis of Ubiquitinated Proteins and PolyUb Linkages by Quantitative Mass Spectrometry

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
19:30—22:00
Poster Session 2

Big Horn C

WEDNESDAY, JANUARY 14

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
UBDs and UBLs Function and Specificity
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Zhijian James Chen, University of Texas Southwestern Medical Center, USA

Ivan Dikic, Goethe University Medical School, Germany
Specificity in UbiquitinSignaling Networks

Kylie J. Walters, University of Minnesota, USA
The Proteasome‘s Ubiquitin Receptors

Heran Darwin, New York University School of Medicine, USA
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

Frauke Melchior, Universität Heidelberg, Germany
Characterisation of the RanBP2 / RanGAP1*SUMO1 E3 Ligase Complex

Christian D. Schlieker, Whitehead Institute for Biomedical Research, USA
Short Talk: A Functional Proteomics Approach Links the Ubiquitin-Related Modifier Urm1 to a RNA Modification Pathway

Kate E. Stoll, University of Washington, USA
Short Talk: Interaction of the E2s yeast Ubc4 and Human UbcH5 with Ub: Functional Consequence.

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Big Horn C
11:00
On Own for Lunch

13:00—22:00
Poster Viewing

Big Horn C
14:30—16:30
Workshop 2: Animal Models

Big Horn B
* Ron R. Kopito, Stanford University, USA
Ubiquitin Homeostasis on the Edge: Lessons from Polyubiquitin Knockout Mice

Pengbo Zhou, Weill Cornell Medical College, USA
CULLIN 4A Knockout Mice

Nicholas John van Buuren, Stanford University, USA
A Novel Family Of Viral Ankyrin/F-Box Proteins Interact With The SCF Complex

Maud Demarque, Pasteur Institute, France
A Mouse Model for the Study of Sumo E2 Function

Michael R. Kuehn, National Cancer Institute, National Institutes of Health, USA
Loss of SUMO-1 in Mice is not Lethal Due to Compensation by SUMO-2/3

Jongdae Lee, University of California, San Diego, USA
STAT3 Maintains Intestinal Epithelial Barrier by Induction of Ubiquitin-Mediated Degradation of SNAI

Birgit Aerne, Cancer Research UK, UK
A Uiquitin-Related RNAi Screen in Drosophila

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Signal Transduction by UbIs
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Frauke Melchior, Universität Heidelberg, Germany

Deborah J. Lenschow, Washington University School of Medicine, USA
Regulation of the Host Antiviral Response by ISG15

Edward T.H. Yeh, University of Texas MD Anderson Cancer Center, USA
Role of Sentrin/SUMO-Specific Protease 1 (SENP1) in Angiogenesis

Ronald T. Hay, University of Dundee, UK
Regulation of Promyelocytic Leukaemia Protein by SUMO

Michael N. Boddy, The Scripps Research Institute, USA
Short Talk: New Interactions of SUMO Pathway Enzymes in Genome Stability

19:00—20:00
Social Hour with Lite Bites

Kokopelli's
19:30—22:00
Poster Session 3

Big Horn C

THURSDAY, JANUARY 15

07:00—08:00
Breakfast

Kokopelli's
08:00—11:15
Ubiquitin and UbIs in Cancer
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Ingrid E. Wertz, Genentech, Inc., USA
Ubiquitin Editing

Marcus Groettrup, University of Konstanz, Germany
The Role of FAT10 in Cancer

Lawrence R. Dick, Takeda, USA
Targeting the NEDD8 Conjugation Pathway for Cancer Chemotherapy

Roger A. Greenberg, University of Pennsylvania Perelman School of Medicine, USA
Ubiquitin Recognition and Turnover in BRCA1-Dependent DNA Repair and Tumor Suppression

Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The Fbw7 E3 Ubiquitin Ligase Controls Hematopoietic Stem Cell Self-Renewal and Transformation

Lian Li, Emory University School of Medicine, USA
Short Talk: Parkin-Mediated Ubiquitin Signaling in Regulation of the Aggresome-Autophagy Pathway

09:20—09:40
Coffee Break

Kokopelli's
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Kokopelli's
17:00—18:25
Regulation by Ub and UbIs in the Nucleus
Meeting has ended...abstracts no longer viewable online.

Big Horn B
* Edward T.H. Yeh, University of Texas MD Anderson Cancer Center, USA

Jesper Q. Svejstrup, Francis Crick Institute, UK
Ubiquitylation of RNA Polymerase II

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Regulation of DNA Repair by Monoubiquitination

Valentina Perissi, Boston University School of Medicine, USA
Short Talk: Dismissal of Distinct Corepressor Complexes from Regulated Gene Promoters is Regulated by Specific Phosphorylation of the TBL1 and TBLR1 Exchange Factors

18:25—19:15
Translational Research Lecture
Meeting has ended...abstracts no longer viewable online.

Big Horn B
Giulio F. Draetta, University of Texas MD Anderson Cancer Center, USA
Druggable Targets in the Ubiquitin Field

19:15—19:30
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Simona Polo, FIRC Institute of Molecular Oncology, Italy

19:30—20:30
Social Hour with Lite Bites

Kokopelli's
20:30—23:30
Entertainment

Big Horn C

FRIDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Boston Biochem, an R&D Systems Company

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company


ENZO LIFE SCIENCES INTERNATIONAL, INC.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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