Fairmont Waterfront Floorplan

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This meeting took place in 2009



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Extrinsic Control of Tumor Genesis and Progression (C8)


Organizer(s) Thea D. Tlsty and Mary J.C. Hendrix
March 15—20, 2009
Fairmont Waterfront • Vancouver, British Columbia Canada
Abstract Deadline: Nov 17, 2008
Late Abstract Deadline: Dec 15, 2008
Scholarship Deadline: Nov 17, 2008
Early Registration Deadline: Jan 15, 2009

Supported by the Directors' Fund

Summary of Meeting:
It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 15

15:00—19:30
Registration

Waterfront Foyer
18:30—19:30
Refreshments

Waterfront Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Norman F. Boyd, University of Toronto, Canada
Mammographic Density and Breast Cancer Risk


MONDAY, MARCH 16

07:00—08:00
Breakfast

Mackenzie Ballroom
08:00—11:00
Coding Information within the ECM
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Pepper Jo Schedin, Oregon Health & Science University, USA
Information Conveyed by ECM Proteins in the Mammary Gland

David V. Schaffer, University of California, Berkeley, USA
Molecular Engineering of Synthetic Stem Cell Microenvironments

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Tumor Microenvironment in Cancer Progression and Metastasis

Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
Reprogramming Metastatic Tumor Cells with an Embryonic Microenvironment:Convergence of Embryonic and Tumorigenic Signaling Pathways

09:20—09:40
Coffee Break

Waterfront Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Waterfront Ballroom
13:00—22:00
Poster Viewing

Waterfront Ballroom
16:30—17:00
Coffee Available

Waterfront Foyer
17:00—19:00
Key Pathways in Extrinsic Modulation
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Sheila A. Stewart, Washington University School of Medicine, USA
Short Talk: The Tumor Microenvironment: A Role for Senescent-Derived Osteopontin

Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Extrinsic Control of Intrinsic DNA Damage Response and Genomic Instability

Valerie M. Weaver, University of California, San Francisco, USA
How Matrix Topology and Stiffness Direct Tumor Progression

Harold L. Moses, Vanderbilt University, USA
TGF-beta Regulation of the Tumor Microenvironment

19:00—20:00
Social Hour with Lite Bites

Waterfront Ballroom
19:30—22:00
Poster Session 1

Waterfront Ballroom

TUESDAY, MARCH 17

07:00—08:00
Breakfast

Mackenzie Ballroom
07:00—08:00
Poster Setup

Waterfront Ballroom
08:00—11:00
Stem Cells and Their Niche
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Leanne Jones, University of California, Los Angeles, USA
Stem Cell-Niche Cell Interactions during Tumorigenesis

Gilbert H. Smith, National Cancer Institute, National Institutes of Health, USA
Reprogramming Stem and Cancer Cells is a Microenvironment Task

Tannishtha Reya, University of California, San Diego, USA
Imaging Asymmetric Division in Stem Cells and Cancer

Elsa Quintana-Fernandez, University of Michigan, USA
Tumorigenic Potential is a Common Attribute of Melanoma Cells

09:20—09:40
Coffee Break

Waterfront Foyer
11:00—12:00
Lunch

Waterfront Ballroom
12:00—15:00
Poster Session 2

Waterfront Ballroom
15:00—16:30
Workshop 1: New Tools to Study Multicellular Interactions

Waterfront Ballroom
Deborah L. Holliday, Leeds Institute of Molecular Medicine, UK
Multicellular Organotypic Models of Normal and Malignant Breast

Maribella Domenech, University of Wisconsin, Madison, USA
Multi-Chamber Platform for the Study of Paracrine and Autocrine Interactions between Cancer Cells and the Surrounding Microenvironment

Edna Cukierman, Fox Chase Cancer Center, USA
Staging Tumor-Associated Stroma to Study Epithelial 3D in vivo-like Cancer Cell Responses

David Beebe, University of Wisconsin, USA
Exploring Stromal-Carcinoma Cell Interactions in Breast Cancer via Microscale 3-Dimensional Co-Culture Systems

16:30—17:00
Coffee Available

Waterfront Foyer
17:00—19:00
Clinical Applications
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Rosa Anna DeFilippis, University of California, San Francisco, USA
Short Talk: The Biological Basis of Mammographic Density

Dorothy A. Sipkins, University of Chicago, USA
Leukemic Cells Create Bone Marrow Niches that Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cell Interactions with their Microenvironment

Morag Park, McGill University, Canada
Profiling the Breast Tumor Microenvironment

19:00
On Own for Dinner


WEDNESDAY, MARCH 18

07:00—08:00
Breakfast

Mackenzie Ballroom
08:00—11:00
Basic Biology: Molecular Mechanisms
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Michael J. Hendzel, University of Alberta, Canada
Force Transmission and the Nucleus

Thea D. Tlsty, University of California, San Francisco, USA
Early Events in Carcinogenesis

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Stromal Changes in Cancer Progression

Zena Werb, University of California, San Francisco, USA
Extrinsic and Intrinsic Mechanisms of Malignant Progression

09:20—09:40
Coffee Break

Waterfront Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Waterfront Ballroom
13:00—22:00
Poster Viewing

Waterfront Ballroom
16:30—17:00
Coffee Available

Waterfront Foyer
17:00—19:00
Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Esther N. Arwert, Francis Crick Institute, UK
Short Talk: Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate

Nancy Dumont, University of California, San Francisco, USA
Extrinsic Control of Epigenetic Modifications Associated with Mammary Tumor Progression

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Regulation of in Situ to Invasive Breast Carcinoma Progression

Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
Form Dictates Function: Modeling Normal Breast to Understand Breast Cancer

19:00—20:00
Social Hour with Lite Bites

Waterfront Ballroom
19:30—22:00
Poster Session 3

Waterfront Ballroom

THURSDAY, MARCH 19

07:00—08:00
Breakfast

Mackenzie Ballroom
08:00—11:00
Non-Transformed Cells Modulate Transformed Cells
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Judith Campisi, Buck Institute for Research on Aging, USA
Two Faces of Cellular Senescence

Lisa M. Coussens, Oregon Health & Science University, USA
Tissue-Specific Mechanisms Regulate Pro-Tumor Immunity

Sylvaine Cases, , USA
Role of Adipocytes in Mammary Gland Development and Breast Cancer: Lessons form DGAT1-Deficient Mice

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Signals

09:20—09:40
Coffee Break

Waterfront Foyer
11:00
On Own for Lunch

14:30—16:30
Workshop 2: Potential Lingages to the Tumor Microenvironment Network - Funding

Waterfront Ballroom
* Suresh Mohla†, NCI, National Institutes of Health, USA

16:30—17:00
Coffee Available

Waterfront Foyer
17:00—19:00
Progression to Metastasis
Meeting has ended...abstracts no longer viewable online.

Waterfront Ballroom
Marsha R. Rosner, University of Chicago, USA
Short Talk: Identification of Signaling Pathway Signature for Metastasis Suppressor Reveals Novel Mechanism for MicroRNA Regulation of the Microenvironment.

Douglas Hanahan, ISREC, Switzerland
Evasive Resistance: Switching from Tumor Angiogenesis to Invasion and Metastasis

Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA
Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor-Negative Cancers

Robert A. Weinberg, Massachusetts Institute of Technology, USA
Metastatic Modulation

19:00—20:00
Social Hour with Lite Bites

Waterfront Ballroom
20:00—23:00
Entertainment

Waterfront Ballroom

FRIDAY, MARCH 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA138043-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676