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This meeting took place in 2009



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Cardiac Disease: Development, Regeneration, and Repair (D1)


Organizer(s) Michael D. Schneider and Nadia A. Rosenthal
March 15—20, 2009
Grove Park Inn Resort & Spa • Asheville, North Carolina USA
Abstract Deadline: Nov 18, 2008
Late Abstract Deadline: Dec 15, 2008
Scholarship Deadline: Nov 18, 2008
Early Registration Deadline: Jan 15, 2009

Supported by the Directors' Fund

Summary of Meeting:
Cardiac muscle death, without numerically equivalent myocyte creation, poses a formidable and inexorable challenge in both acute and chronic forms of heart disease. A regenerative medicine approach to rescue cardiac muscle cell number or instigate heart repair in other ways has moved from the esoteric fringe to the mainstream of both fundamental and patient-based cardiovascular research. However, notwithstanding the encouraging results from phase I and even phase II trials in this realm, the scientific foundations of cardiac repair largely remain to be proven on a basis that is more than empirical. By virtue of its orientation not merely to translation, but at least equally to the enabling sciences within stem cell biology, cardiovascular development, and genetics, this Keystone Symposia meeting addresses a critical unmet need in a high-impact field of current and foreseeable explosive growth.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 15

15:00—19:30
Registration

Vanderbilt Registration
18:30—19:30
Refreshments

Grand Ballroom B-C
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
George Q. Daley, HHMI/Boston Children's Hospital, USA
Reprogramming and Stem Cells in Disease and Development


MONDAY, MARCH 16

07:00—08:00
Breakfast

Grand Ballroom B-C
08:00—11:15
Stemness and Cell Fate in Pluripotent Cells
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
* Gordon M. Keller, University Health Network, MaRS Centre, Canada
Regulation of Cardiovascular Development from Mouse and Human Pluripotent Stem Cells

Sean M. Wu, Stanford School of Medicine, USA
Turning Skin into Heart: Cardiac Progenitor Cells from Induced Pluripotent Cells

Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Mesp1 and Multipotent Cardiac Progenitor Cells

Piero Anversa, Brigham and Women's Hospital, USA
Myocardial Regeneration

Michel Pucéat, INSERM, France
Short Talk: Derivation of Early Human Cardiac Progenitors from Embryonic and Induced Pluripotent Stem Cells

Li Chen, University of Houston, USA
Short Talk: Tbx1 Regulates Proliferation and Differentiation of Multipotent Heart Progenitors

09:20—09:40
Coffee Break

Grand Ballroom B-C
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Grand Ballroom B-C
13:00—22:00
Poster Viewing

Grand Ballroom B-C
16:30—17:00
Coffee Available

Grand Ballroom Foyer
17:00—19:00
Making Myocardium: Lessons from Organogenesis
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
* Margaret E. Buckingham, Institut Pasteur, France
Cardiac Progenitor Cells of the Second Heart Field

Jonathan A. Epstein, University of Pennsylvania, USA
Jagged1/Notch Signaling and Outflow Tract Development

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
MicroRNA Regulation of Cardiac Cell Fate and Morphogenesis

Caroline E. Burns, Harvard Medical School, Massachusetts General Hospital, USA
Short Talk: Cardiac Chamber Morphogenesis is Regulated by the miR143-adducin3 Pathway

19:00—20:00
Social Hour with Lite Bites

Grand Ballroom B-C
19:30—22:00
Poster Session 1

Grand Ballroom B-C

TUESDAY, MARCH 17

07:00—08:00
Breakfast

Grand Ballroom B-C
07:00—08:00
Poster Setup

Grand Ballroom B-C
08:00—11:15
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Embryonic Cells
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
Michael D. Schneider, Imperial College London, UK
The Sox17-Hhex-Cer1 Circuit Drives Heart Muscle Cell Creation in Embryonic Stem Cells

* Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Cardiac Progenitor Cell Behaviour in Development and Congenital Heart Disease

Ibrahim J. Domian, Massachusetts General Hospital, USA
Assembly of Mature Ventricular Muscle from Embryonic Stem Cell derived Progenitors

Mark Mercola, Stanford University, USA
A Chemical Genomics Strategy for Generating Cardiac Myocytes

Michael Kühl, Ulm University, Germany
Short Talk: DM-GRASP/ALCAM/CD166 in Cardiogenesis of Xenopus

Frank L. Conlon, University of North Carolina at Chapel Hill, USA
Short Talk: CASTOR Is Required for the Differentiation of Cardiomyocyte Progenitors at the Ventral Midline

09:20—09:40
Coffee Break

Grand Ballroom B-C
11:00—12:00
Lunch

Grand Ballroom B-C
12:00—14:30
Poster Session 2

Grand Ballroom B-C
14:30—16:30
Workshop 1: Human ES Cell Update

Grand Ballroom A
Joseph Gold, Beckman Research Institute, City of Hope, USA
Large-Scale Generation and Characterization of hESC-Derived Cardiomyocytes for Cell Therapy

* Lior Gepstein, Technion-Israel Institute of Technology, Israel
Myocardial Regeneration Using Human Embryonic Stem Cells

Wei-Zhong Zhu, University of Washington, USA
Induction of Human Embryonic Stem Cell Derived Cardiac Pacemaker Cells by Neuregulin Blockade

16:30—17:00
Coffee Available

Grand Ballroom Foyer
17:00—19:00
Injury and Inflammation in Muscle Regeneration
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
Nadia A. Rosenthal, The Jackson Laboratory, USA
Enhancing Cardiac Regeneration

Kenneth D. Poss, Duke University Medical Center, USA
Mechanisms of Cardiac Regeneration in Zebrafish

* Elizabeth M. McNally, Northwestern University, USA
Regeneration and Repair in Muscle

Santhosh Kumar Ghadge, Max-Delbruck Center for Molecular Medicine, Germany
Short Talk: Impaired Cardiac Function in Cardiomyocyte Specific SDF-1/CXCL12 Knockout Mice

19:00
On Own for Dinner


WEDNESDAY, MARCH 18

07:00—08:00
Breakfast

Grand Ballroom B-C
08:00—11:15
Vasculogenesis and Angiogenesis: Developmental Insights and Therapeutic Targets
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
Robert J. Schwartz, Texas A&M University, USA
The sumoylation Pathway: A Global Regulator of Cardiac Development

Mary Dickinson, Baylor College of Medicine, USA
Form Follows Flow: Where Biomechanics and Genetics Meet

Paul R. Riley, University of Oxford, UK
Epicardium-Derived Progenitors: A Source of Neovascular Repair of the Injured Adult Heart

* Brian L. Black, University of California, San Francisco, USA
A Combinatorial Transcriptional Code for Endothelial Development

Kimberly R. Cordes, Gladstone Institute, USA
Short Talk: miR-143/145 Regulates Smooth Muscle Cell Fate

Marc Tjwa, University of Frankfurt, Center for Molecular Medicine, Germany
Short Talk: Mobilization of Bone Marrow Progenitors by Ischemic Tissues Requires an Interplay between Hematopoietic Cytokines and Placental Growth Factor (PlGF)

09:20—09:40
Coffee Break

Grand Ballroom B-C
11:15
On Own for Lunch

11:00—13:00
Poster Setup

Grand Ballroom B-C
13:00—22:00
Poster Viewing

Grand Ballroom B-C
15:30—16:30
Workshop 2: 'The Vision Thing:' Imaging Sciences and Cell Tracking for Cardiac Repair

Grand Ballroom A
Karl H. Schuleri, Johns Hopkins Hospital, USA
Tomographic Imaging Applications for Myocardial Phenotyping in Cardiac Stem Cell Therapy

Joseph C. Wu, Stanford University School of Medicine, USA
Molecular Imaging of hESC Biology

16:30—17:00
Coffee Available

Grand Ballroom Foyer
17:00—19:00
Myocyte Death and Dysfunction in Heart Failure
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
Richard N. Kitsis, Albert Einstein College of Medicine, USA
Mechanisms of Cell Death in Human Disease

Jonathan G. Seidman, Harvard Medical School, USA
Mechanisms and Modifiers of the Hereditary Cardiomyopathies

* Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Molecular Logic of Cardiac Development and Disease

Ching-Pin Chang, Indiana University, USA
Short Talk: Control of Cardiac Growth, Differentiation and Hypertrophy by the BAF Complex

19:00—20:00
Social Hour with Lite Bites

Grand Ballroom B-C
19:30—22:00
Poster Session 3

Grand Ballroom B-C

THURSDAY, MARCH 19

07:00—08:00
Breakfast

Grand Ballroom B-C
08:00—11:15
Cardiac Repair in Human Trials: The Half-Full Cup?
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
Andreas M. Zeiher, University Frankfurt, Germany
Bone Marrow for Cardiac Repair: Molecular Insights and Clinical Deployment

Douglas W. Losordo, Caladrius Biosciences, Inc., USA
Targeting the Microvasculature for Ischemic Tissue Repair

Joshua M. Hare, University of Miami Miller School of Medicine, USA
Mechanisms of Action and Clinical Utility of Mesenchymal Stem Cells to Treat Ischemic Cardiomyopathy

Robert D. Simari, Mayo Clinic, USA
Bone Marrow and The Heart: Opportunities for Discovery

* Stefanie Dimmeler, University of Frankfurt, Germany
Control of Angiogenesis by microRNA

09:20—09:40
Coffee Break

Grand Ballroom B-C
11:15
On Own for Lunch

14:30—16:30
Workshop 3: Alternative Visions of the Therapeutic Landscape: Tissue Engineering, Stem Cell Mobilization, and Stem Cell Proteins

Grand Ballroom A
* Victor J. Dzau, Duke University Medical Center, USA
Paracrine Mediators of Stem Cell Reparative Action

Doris A. Taylor, Texas Heart Institute, USA
The Power of Engineering Organs: When Cells aren't Enough

Sara M. Rankin, Imperial College School of Medicine, UK
Progress Toward Selective Stem Cell Mobilization

16:30—17:00
Coffee Available

Grand Ballroom Foyer
17:00—19:00
'Get with the System:' How Systems Biology is Transforming Biomedicine
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom A
* Shoumo Bhattacharya, University of Oxford, UK
Coupling ENU Mutagenesis and High-Throughput MRI to Unmask Essential Genes that Fashion the Mouse Heart

David Hill, Dana Farber Cancer Institute, USA
The Human Interactome Project and Molecular Network Analysis

Stuart A. Cook, Duke-NUS Graduate Medical School Singapore, Singapore
Genomic Approaches to Heart Disease

Tao P. Zhong, Vanderbilt University, USA
Short Talk: Chemical Genetics Approach to elucidate Cardiomyocyte Generation and Development

19:00—20:00
Social Hour with Lite Bites

Grand Ballroom B-C
20:00—23:00
Entertainment

Grand Ballroom B-C

FRIDAY, MARCH 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL095270-01




We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Basic Cardiovascular Sciences


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676