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This meeting took place in 2009



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Cell Death Pathways (X5)


Organizer(s) Eric H. Baehrecke and Guy S. Salvesen
March 22—27, 2009
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 25, 2008
Late Abstract Deadline: Dec 23, 2008
Scholarship Deadline: Nov 25, 2008
Early Registration Deadline: Jan 22, 2009

Supported by the Directors' Fund


Summary of Meeting:
Programmed cell death plays a critical role during development and adult homeostasis by eliminating unneeded and damaged cells, and defects in cell death can result in a wide range of diseases. While studies of apoptotic cell death have defined central regulatory mechanisms including a role for mitochondria, the relationship between core apoptosis factors, mitochondrial physiology, and how this relates to normal and aberrant development remains unsolved. The purpose of this meeting is to define the relationship between mitochondria and cell death pathways. The meeting will focus on the relationship between apoptosis regulatory pathways, mitochondrial physiology, metabolism, and non-apoptotic death mechanisms in the context of normal development and pathological situations including degenerative disorders and cancer. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting “Mitochondrial Dynamics and Physiology”, which will share a keynote address and two plenary sessions with this meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 22

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

* Janet M. Shaw, University of Utah, USA

Douglas R. Green, St. Jude Children's Research Hospital, USA
The Mitochondrial Pathway of Apoptosis

Richard J. Youle, NINDS, National Institutes of Health, USA
Mitochondrial Morphogenesis and Apoptosis


MONDAY, MARCH 23

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Mitochondrial Dynamics and Cell Death (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA

Jean-Claude Martinou, University of Geneva, Switzerland
Mechanisms of Bax Activation

Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Mitochondrial Fusion and Fission, as Regulated by the Bcl-2 homolog CED-9

Seamus J. Martin, Trinity College Dublin, Ireland
Short Talk: Mitochondrial Fission-Fusion Dynamics and Apoptosis

Luca Scorrano, University of Padova, Italy
EMBO Young Investigator Lecture: Multiple Fuctional Roles of Mitochondrial-Shaping Proteins

Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Multiple Mitochondrial Events Critical for Cell Death

David C. Chan, California Institute of Technology, USA
Mitochondrial Dynamiscs, mtDNA Stability and Tolerance of mtDNA Mutations

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Caspases and IAPs
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Seamus J. Martin, Trinity College Dublin, Ireland

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspases and Their Substrates

Domagoj Vucic, Genentech, Inc., USA
Targeting IAPs: TNFalpha and Ubiquitin Connections

Francesco Cecconi, Danish Cancer Society Research Center, Denmark
Short Talk: Molecular Analysis of Synaptic Degeneration at the Onset of Alzheimer’s Disease

Pascal Meier, Institute of Cancer Research, UK
Regulation of Caspases by Ubiquitin and Ubiquitin-like Proteins

17:00—19:00
Molecular Mechanisms of Mitochondrial Fusion
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Jodi Nunnari, University of California, Davis, USA
The Molecular Mechanism of Mitochondrial Fusion

Zhongyan Zhang, John Hopkins University School of Medicine, USA
Role of Opa1 in Pancreatic Beta Cells

György Hajnóczky, Thomas Jefferson University, USA
Short Talk: Interdependence of Mitochondrial Fusion- Fission and Motility Dynamics

Astrid C. Schauss, University of Ottawa Heart Institute, Canada
Short Talk: Characterization of a Bimolecular Complementation Assay to Quantify Mammalian Mitochondrial Fusion in vitro

19:00—20:00
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
19:30—22:00
Poster Session 1

Foyer/Mountain View/Sea to Sky Ballroom A

TUESDAY, MARCH 24

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
07:00—08:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
08:00—11:15
Cell Survival and Death Signaling during Development
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Pascal Meier, Institute of Cancer Research, UK

Joan S. Brugge, Harvard Medical School, USA
Regulation of Cell Metabolism by Extracellular Matrix

Andreas Bergmann, University of Massachusetts Medical School, USA
Genetic Regulation of Programmed Cell Death during Drosophila Development

Kim McCall, Boston University, USA
Short Talk: Cell-Autonomous Requirement for DNaseII and Lysosomal Genes during Non-Apoptotic Cell Death in the Drosophila Ovary

W. Brent Derry, Hospital for Sick Children, Canada
Genetic Regulation of Cell Death during Germline Development in C. elegans

Anatoly Nikolaev, Genentech, USA
Short Talk: Axonal Self-Destruction and Neurodegenerative Disease

Laura A. Johnston, Columbia University, USA
Competitive Interactions during Growth in Drosophila: A Mechanism for Tissue Homeostasis

08:00—11:15
Mitochondrial Fission and Evolution of the Division Apparatus
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
Janet M. Shaw, University of Utah, USA
Recruitment and Assembly of the Mitochondrial Membrane Fission Machinery

* Alexander M. van der Bliek, University of California, Los Angeles, USA
Mitochondrial Fission and Fusion in C. elegans

Heidi M. McBride, McGill University, Canada
Mitochondrial Derived Vesicles as a New Vehicle for Intracellular Transport

Tsuneyoshi Kuroiwa, Rikkyo (St. Paul’s) University, Japan
Isolation of Mitochondrial Division Machineries

Naotada Ishihara, Institute of Life Science, Kurume University, Japan
Short Talk: Fis1 Acts as Mitochondrial Receptor for Novel Protein that Regulates Mitochondrial Morphology

Sarah R. Horn, Duke University Medical Center, USA
Short Talk: Degradation of the Mitochondrial Fission Protein Drp1 by the APCcdh1 Ubiquitin Ligase

09:20—09:40
Coffee Break

Foyer
11:15—12:00
Lunch

Foyer/Sea to Sky Ballroom A
12:00—14:30
Poster Session 2

Foyer/Mountain View/Sea to Sky Ballroom A
14:30—16:30
Workshop 1: Relationship between Autophagy and Cell Death

Sea to Sky Ballroom B
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Identifying the Factors that Determine Specificity in the Autophagy Response

Ying-Chen Claire Hou, British Columbia Cancer Agency, Canada
Molecular Mechanism of Effector Caspase Dcp-1 in Starvation-Induced Autophagy

Marc Germain, University of Ottawa, Canada
MCL-1 is a Key Regulator of Autophagy

Natasha Chang, McGill University, Canada
Antagonism of Beclin 1 by Bcl-2 is Mediated by the Endoplasmic Reticulum Protein, Naf-1

Katja Simon, University of Oxford, UK
Hematopoietic Cells Require Mitophagy Mediated by the Core Autophagy Gene Atg7 for Survival in vivo

Mondira Kundu, St. Jude Children's Hospital, USA
Hsp90 Regulates Ulk1-Mediated Autophagic Clearance of Mitochondria

14:30—16:30
Workshop 1: Mitochondrial Dynamics and Parkinson’s Disease

Sea to Sky Ballroom C
* Edward A. Fon, McGill University, Canada

* Ming Guo, University of California, Los Angeles, USA

Konstanze F. Winklhofer, Physiological Chemistry, Ruhr University Bochum, Germany
A Role of Parkin and PINK1 in the Regulation of Mitochondrial Dynamics

Alex J. Whitworth, University of Sheffield, UK
Rhomboid-7 Cleaves the Parkinson Disease Factors PINK1 and Omi/HtrA2 and Promotes Mitochondrial Fission

Vanessa A. Morais, Katholieke Universiteit Leuven & VIB, Belgium
PINK1 Primarily Regulates Complex I Activity and Synaptic Function

Lian Li, Emory University School of Medicine, USA
The PINK1 Mitochondrial Signaling Pathways and Pakinson Disease

Isabella Irrcher, Ottawa Health Research Institute/University of Ottawa, Canada
Loss of the Parkinson’s Disease-Linked Gene DJ-1 Results in Abnormal Mitochondrial Dynamics

Olga Corti, INSERM, France
A Differential Proteomic Screen to Identify Proteins Altered in Abundance in Parkin-deficient Mice

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Bcl-2 Family
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Sally A. Kornbluth, Duke University Medical Center, USA

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Bcl-2 Proteins Regulate Mitochondria in Neurons and Yeast…Where the Trail Leads

Evris Gavathiotis, Albert Einstein College of Medicine, USA
Short Talk: Structural and Functional Characterization of the Trigger Mechanism for BH3-Induced Direct BAX Activation

Andreas Villunger, Medical University Innsbruck, Austria
Role and Function of the BH3-Only Protein Bmf in Development and Disease

Emily H. Cheng, Washington University Medical School, USA
The VDAC2-BAK Axis Controls Survival of Thymocytes

17:00—19:00
Regulation of Mitochondrial Dynamics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Richard J. Youle, NINDS, National Institutes of Health, USA

Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics

Andreas S. Reichert, Goethe University Frankfurt am Main, Germany
Molecular Insights into Mitochondrial Membrane Dynamics and Structure

Katsuyoshi Mihara, Kyushu University, Japan
The Physiologic Importance of Mammalian Mitochondrial Fission Factor Drp1

Daniel Tondera, Dana-Faber Cancer Institute, USA
Short Talk: Key Players and Physiological Role of Stress-Induced Mitochondrial Hyperfusion

19:00
On Own for Dinner


WEDNESDAY, MARCH 25

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Mitochondrial Factors, Cell Death and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* Eileen P. White, Rutgers University, USA

Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Metabolism and Bcl-2 Family Proteins

Ming Guo, University of California, Los Angeles, USA
Mitochondrial Pathways to Pakinson’s Disease

Nils-Goran Larsson, Max Planck Institute for the Biology of Aging, Germany
Regulation of Mammalian mtDNA Gene Expression

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of Endogenous Pro-Survival Bcl-2 Family Members in Tumor Development and Sustained Tumor Growth

David W. Andrews, Sunnybrook Research Institute, Canada
Bcl-2 Family Proteins as Therapeutic Targets

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Alternative Forms of Cell Death
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Shai Shaham, Rockefeller University, USA
A New C. elegans Cell Death Program

Francis Ka-Ming Chan, University of Massachusetts Medical School, USA
Short Talk: A RNA Interference Screen Identifies Novel Regulators of TNF-Induced Programmed Necrosis

Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal control of transformation and cell death

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Role of a Phagocytosis Receptor, Draper, in Developmental Autophagic Cell Death in Drosophila

17:00—19:15
Mitochondrial Disease in Humans and Animal Models
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Nils-Goran Larsson, Max Planck Institute for the Biology of Aging, Germany

Jeffery M. Vance, University of Miami, USA
Mitochondria and Hereditary Neurologic Disease

Marcela Votruba, Cardiff University, UK
OPA1 and OPA3 Mutations in Mouse Models of Inherited Optic Atrophy

Hugo J. Bellen, Baylor College of Medicine, USA
The Mitochondrial Methionyl-tRNA Synthetase's Role in Neurodegeneration

Francesca Maltecca, San Raffaele Scientific Institute, Italy
Short Talk: The Mitochondrial Protease AFG3L2 is a Key Player in the Development and Maintenance of Cerebellum and Spinal Cord

Dominik Mousa Haddad, University of California, USA
Short Talk: Systematic Analysis of Genes Implicated in Human Neuronal Disease

19:00—20:00
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
19:30—22:00
Poster Session 3

Foyer/Mountain View/Sea to Sky Ballroom A

THURSDAY, MARCH 26

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Cell Death and Cancer
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Andreas E. Strasser†, Walter and Eliza Hall Institute of Medical Research, Australia

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in vivo

Henning Walczak, University College London, Cancer Institute, UK
Short Talk: Identification of Axin 1 as a Factor Required for TRAIL-Induced Apoptosis

Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Characterizing HMG-CoA Reductase as a Novel Metabolic Oncogene

Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Anti-Cancer Activities of HDAC Inhibitors Used Alone and in Combination with other Pro-Apoptotic Agents

Jan Paul Medema, Academic Medical Center, Netherlands
Betulinic Acid-induced Death

Eileen P. White, Rutgers University, USA
Role of Autophagy in Cancer and Therapy

08:00—11:00
Mitochondrial Transport in Polarized Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Liza A. Pon, Columbia University Medical Center, USA
Mitochondrial Inheritance Contributes to Lifespan Control in Budding Yeast

William M. Saxton, University of California, Santa Cruz, USA
Organizing Cytoplasm via Filament-Based Transport Mechanisms

Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
The Regulation of Mitochondrial Motility by Ca++ and Other Signaling Pathways

Albert L. Misko, Washington University in St. Louis, USA
Short Talk: Mitofusin 2 is Essential for the Axonal Transport of Mitochondria

Konrad E. Zinsmaier, University of Arizona, USA
Short Talk: Drosophila Miro is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

Myrrhe van Spronsen, Erasmus Medical Center, Netherlands
Short Talk: Milton Proteins Regulate Trafficking of Mitochondria in Neurons

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch

14:30—16:30
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis and Therapy Response

Sea to Sky Ballroom B
* Henning Walczak, University College London, Cancer Institute, UK

Huseyin Mehmet, Zafgen Inc, USA
Omics Approach to Apoptosis Biomarker Discovery

Chris Peter Reutelingsperger, Maastricht University, Netherlands
Cell Surface Expressed Phosphatidylserine: A Biomarker of Cell Death

Caroline Dive, Cancer Research UK Manchester Institute, UK
Blood Borne Biomarkers of Cell Death Applied to Early Clinical Trials of Novel Mechanism Based Anticancer Drugs

Claudia Maier, Oregon State University, USA
Mitochondrial Protein Markers of Oxidative Stress

James A. Wells, University of California, San Francisco, USA
New Tools for Dissecting and Triggering Apoptosis

14:30—16:30
Workshop 2: Mitochondrial Dynamics and Mitophagy

Sea to Sky Ballroom C
Atsushi Tanaka, Yamagata University, Japan
Parkin Scavenges Damaged Mitochondria

* Koji Okamoto, Osaka University, Japan
Molecular Basis of Mitophagy, Degradation of Mitochondria via Autophagy-Related Membrane Dynamics in Yeast

* Orian S. Shirihai, University of California, Los Angeles, USA
Simulation of Mitochondrial Dynamics: Frequency and Selectivity of Mitochondrial Fusion are Key to its Quality Maintenance Function

Hagai Abeliovich, Hebrew University of Jerusalem, Israel
Regulation of Mitochondrial Autophagy in S. cerevisiae

Hector Sandoval, Baylor College of Medicine, USA
Essential Roles for Bnip3L/Nix in Autophagic Maturation of Erythroid Cells

Eun Hee Kim, Ajou University, South Korea
Superoxide Anion Induces Mitophagy in Glioma Cells

Lígia Carinha Gomes, Venetian Institute of Molecular Medicine, Italy
Mitochondrial Fusion is an Early and Protective Step of Autophagy

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Metabolism and Cell Death
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Apoptosis, Mitochondria and Cancer

Karen H. Vousden, Crick Institute, UK
p53, Metabolism and Death

Mariia Yuneva, Francis Crick Institute, UK
Short Talk: Glutamine Metabolism as a Target for Selective Elimination of Myc Over-Expressing Cells

Sally A. Kornbluth, Duke University Medical Center, USA
Regulation of Caspase 2

17:00—19:00
The Shape of Things to Come: Strategies for Remodeling Biological Membranes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK
Membrane Curvature and Mechanisms of Dynamic Cell Membrane Remodeling

Benoit Kornmann, ETH Zurich, Switzerland
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

Gia K. Voeltz, University of Colorado, Boulder, USA
Proteins that Shape the Endoplasmic Reticulum

Christian A. Wurm, MPI for biophys. Chemistry, Germany
Short Talk: Protein Distributions within Mitochondria - STED Microscopy as a Tool in Mitochondria Research

19:00—20:00
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
20:00—23:00
Entertainment

Foyer/Mountain View/Sea to Sky Ballroom A

FRIDAY, MARCH 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA138008-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. The Ellison Medical Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


Merck Research Laboratories


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press Royal Society of Chemistry

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676