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This meeting took place in 2009



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Mechanotransduction in Physiology and Disease (A7)


Organizer(s) Martin A. Schwartz, Alpha Yap and Christopher S. Chen
January 18—23, 2009
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 18, 2008
Late Abstract Deadline: Oct 21, 2008
Scholarship Deadline: Sep 18, 2008
Early Registration Deadline: Nov 18, 2008

Supported by the Directors' Fund

Summary of Meeting:
Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; and (2) to foster multidisciplinary interactions. The meeting will address major mechanistic questions in the context of relevant clinical problems, integrating engineering/biophysics, cell biology, and physiology/disease into each session whenever possible.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 18

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Martin Chalfie, Columbia University, USA
A Protein-Lipid Complex Transduces Touch in C. elegans

20:30—21:00
Orientation for New Attendees and New Investigators

Chamisa Ballroom I

MONDAY, JANUARY 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Atherosclerosis and Flow
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Bradford C. Berk, University of Rochester Medical Center, USA
Atheroprotective Mechanisms Activated by Flow

Hanjoong Jo, Emory University, USA
Flow Regulation of Vascular Inflammation and Atherosclerosis by the BMP4 and BMPRII Signaling Axis

Stephanie Lehoux, McGill University - Jewish General Hospital, Canada
Pro-and Anti-atherosclerotic Signaling in Whole Vessels

Benoit Ladoux, University Paris Diderot, France
Short Talk: A Useful Tool for Studying Cell Forces and Transmigration Mechanisms

* Martin Schwartz, Yale School of Medicine, USA
Measuring Forces across Specific Molecules

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Osteoporosis and Bone
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Charles H. Turner, Indiana University-Purdue University Indianapolis, USA
Mechanobiology of the Skeleton

Sheldon Weinbaum, City College of New York, USA
How Do Bone Cells Feel? Flow Induced Mechanotransduction in Osteocytes

Olivier Collin, Curie Institute, France
Short Talk: Self-Organized Podosomes Are Dynamic Mechanosensors

* Lynda F. Bonewald, University of Missouri-Kansas City School of Dentistry, USA
Osteocytes, Mechanotransduction, and Osteoporosis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 20

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Hypertension and Stretch
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Steffen-Sebastian Bolz, University of Toronto, Canada
Regulation of Sphingosine-1-Phosphate Signaling as a Key Element of the Myogenic Response

Jeffrey J. Fredberg, Harvard School of Public Health, USA
Missing the Signal: Force, Fluidization, and Physical Biology

Kimberly P. Gannon, University of Mississippi Medical Center, USA
Short Talk: ASIC2 Protein is Required for Pressure-Induced Constriction in Mouse Renal Interlobar Artery

* Heather A. Drummond, University of Mississippi Medical Center, USA
Role of the ENaC Proteins in Vascular Smooth Muscle Sensing

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Transmembrane Receptors in Force Transduction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Alexander Bershadsky, Weizmann Institute of Science, Israel
Forces and Force-sensation in the Crosstalk between Cell Adhesion and the Actin Cytoskeleton

Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
The Shaping of Cells by Force and Rigidity through Protein Stretching

Cheng Zhu, Georgia Institute of Technology, USA
Short Talk: Can Catch Bonds Provide a Mechanosensing Mechanism for Integrins?

Deborah E. Leckband, University of Illinois at Urbana-Champaign, USA
Adhesion and Mechanosensing at Cell-Cell Junctions

* Alpha Yap, Institute for Molecular Bioscience, Australia
Cadherins and Myosins: Regulating the Cortical Actin Cytoskeletal at Cell-Cell Adhesions

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 21

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Hearing, Touch and Ion Channels
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Jeffrey R. Holt, Boston Children's Hospital, USA
Transduction and Adaptation in Mechanosensory Hair Cells of the Mouse Inner Ear

Owen P. Hamill, University of Texas Medical Branch, USA
Role of Stretch Activated Channels and TRPC channels in Prostate Cancer and Cell Migration

Valeria Vásquez, University of Chicago, USA
Structural Basis of Gating in Prokaryotic Mechanosensitive Channels

Ginger L. Hunter, Duke University, USA
Short Talk: Mechanically Gated Ion Channels in Drosophila Morphogenesis

* Miriam Goodman, Stanford University School of Medicine, USA
A Tale of Mechanoreceptor Neurons and Two Mechanotransduction Channels

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Development and Differentiation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Dennis E. Discher, University of Pennsylvania, USA
Forces, Matrix and Stem Cell Differentiation Kinetics

Emmanuel Farge, Institut Curie, France
Mechanical Cues in Development

Rodrigo Fernandez-Gonzalez, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Actomyosin Cables Promote Directional Cell Behaviors during Axis Elongation

* Douglas W. DeSimone, University of Virginia, USA
Adhesions-Dependent Mechanosensitive Cell Signaling and the Regulation of Morphogenesis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2

THURSDAY, JANUARY 22

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Matrix, Force Transduction and Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Yingxiao Wang, University of California, San Diego, USA
Live-Cell Imaging of Signaling Transduction in MechanoBiology

Melody A. Swartz, University of Chicago, USA
Mechano-Chemical Signal Integration in Lymphatic Transport Function

Viola Vogel, ETH, Swiss Federal Institute of Technology, Switzerland
Fibronectin as a Mechanotransducer

Shang-You Tee, University of Pennsylvania, USA
Short Talk: Establishing the Mechanism of Substrate Rigidity Sensing

* Valerie M. Weaver, University of California, San Francisco, USA
Matrix-Crosslinking, Mechanotransduction and Tumor Progression

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Cytoskeletal and Nuclear Events in Mechanotransduction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Tensegrity and Mechanotransduction

Jan Lammerding, Harvard University, USA
The Role of Nuclear Mechanisms and Nuclear Mechanical Coupling in Human Disease

Chao-Min Cheng, Carnegie Mellon University, USA
Short Talk: Probing Mechanotransduction through Syndecan-4 using Surface Modified Elastomeric Matrices

* Christopher S. Chen, Boston University, USA
Mechanotransduction at the Cellular and Multi-Cellular Level

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, JANUARY 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


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