Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2009



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Genome Instability and DNA Repair (C6)


Organizer(s) Maria Jasin, Stephen J. Elledge and Michael S. Neuberger
March 1—6, 2009
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Nov 4, 2008
Late Abstract Deadline: Dec 2, 2008
Scholarship Deadline: Nov 4, 2008
Early Registration Deadline: Jan 5, 2009

Supported by the Directors' Fund

Summary of Meeting:
DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 1

15:00—19:30
Registration

Rio Grande D
18:30—19:30
Refreshments

Rio Grande A/B/C
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Bataan
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Welcome

* Michael S. Neuberger, Medical Research Council, UK
Introduction

Michael Stratton, Wellcome Trust Sanger Institute, UK
Patterns of Somatic Mutation in Human Cancer Genomes

* Stephen J. Elledge, Harvard Medical School, USA
Introduction

Titia de Lange, Rockefeller University, USA
How Telomeres Protect Chromosome Ends


MONDAY, MARCH 2

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
Checkpoints
Meeting has ended...abstracts no longer viewable online.

Bataan
* Stephen J. Elledge, Harvard Medical School, USA
Integrative Approaches for DNA Damage and Cell Cycle Analysis

Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Sensing and Repairing a Single DNA Interstrand Crosslink

Alexander J. R. Bishop, University of Texas Health Science Center, USA
Short Talk: A Conserved DNA Damage Survival Network

Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
EMBO Young Investigator Lecture: The Function and Regulation of HCLK2/Tel2 in DNA Damage Checkpoints

Tanya T. Paull, University of Texas at Austin, USA
Mre11/Rad50 Complexes and Mechanisms of DNA Double-Strand Break Repair

R. Scott Williams, The Scripps Research Institute, USA
Short Talk: Structural Basis for Mre11/Rad50 DNA End Bridging and Nuclease Processing in DNA Double Strand Break Repair

09:20—09:40
Coffee Break

Rio Grande C/D
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
14:30—16:30
Workshop 1: Checkpoints and Genomic Rearrangements

Bataan
* Ralph Scully, Beth Israel Deaconess Medical Center, USA
Control of Non-Homologous End Joining by Mre11 in Mammalian Cells

Brendan D. Price, Dana-Farber Cancer Institute, USA
Histone Methylation Couples DNA Damage Detection to Activation of the Tip60-ATM Signaling Pathway

Yaron Galanty, Wellcome Trust, Cancer Research UK Gurdon Institute, UK
SUMO Proteins Promote Responses to DNA Double-Strand Breaks in Mammalian Cells

John L. Nitiss, University of Illinois, USA
Tdp1, Exo1 and Apn1 Collaborate to Control the Accuracy of Non-Homologous End-Joining in Yeast

Jeremy M. Stark, Beckman Research Institute of the City of Hope, USA
Mechanisms of Mammalian Alternative-NHEJ

Bernard S. Lopez, Institut Gustave Roussy, France
Initiation of Alternative NHEJ in Mammalian Cells

Karina B. Falbo, University of Texas MD Anderson Cancer Center, USA
Involvement of a Chromatin-Remodeling Complex in the DNA Damage Tolerance Pathways during DNA Replication

16:30—17:00
Coffee Available

Rio Grande C/D
17:00—19:15
DNA Repair and Chromatin
Meeting has ended...abstracts no longer viewable online.

Bataan
* Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Dynamic Organization of Signaling and Repair Machines at Damaged Chromosomes

Samantha Gail Zeitlin, University of California, San Diego, USA
Short Talk: The Centromeric H3 Variant CENP-A is Targeted by and Functions in DNA Repair

J. Wade Harper, Harvard Medical School, USA
The Mammalian SLX4 Complex: A Molecular Tool-Kit for DNA Repair

J. Wade Harper, Harvard Medical School, USA
The Mammalian SLX4 Complex: A Molecular Tool-Kit for DNA Repair

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin Assembly Factors and the Challenges of DNA Replication and Repair

Matthew D. Weitzman, Children's Hospital of Philadelphia, USA
Short Talk: A Viral Ubiquitin Ligase Targets RNF8 and RNF168 to Modulate Histone Ubiquitination and the DNA Damage Response

19:15—20:15
Social Hour with Lite Bites

Rio Grande
19:30—22:00
Poster Session 1

Rio Grande

TUESDAY, MARCH 3

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
Double-Strand Break Repair
Meeting has ended...abstracts no longer viewable online.

Bataan
* Lorraine S. Symington, Columbia University, USA
Resection and DNA Synthesis during Double-Strand Break Repair

James E. Haber, Brandeis University, USA
Genome Stability and Instability through Homologous Recombination

Toyoko Tsukuda, School of Medicine, University of New Mexico, USA
Short Talk: Chromatin Remodeling during DNA Double-Strand Break (DSB) Repair by Homologous Recombination (HR)

Stephen C. West, Francis Crick Institute, UK
Identification of Holliday Junction Resolvases from Yeast and Human Cells

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Double-Strand Break Repair in Mammalian Cells and the Role of BRCA2

Emmanuelle Passegué, Columbia University, USA
Short Talk: Differential DNA Repair in Hematopoietic Stem Cells and Myeloid Progenitors

09:20—09:40
Coffee Break

Rio Grande C/D
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
14:30—16:30
Workshop 2: Mechanisms of Repair and Replication

Bataan
* Anindya Dutta, University of Virginia, USA
RNAi Screens Identify Genes Important for Genetic Stability in Human Cells

Bik K. Tye, Cornell University, USA
A Defective MCM Helicase Predisposes Yeast to Aneuploidy and Accelerated Proliferation Independently

Judith L. Campbell, California Institute of Technology, USA
Interplay between Mre11 Nuclease and Dna2 Helicase/Nuclease in DSB Repair and at Telomeres

Gregory Ira, Baylor College of Medicine, USA
Resection of DNA Double Strand Breaks in Budding Yeast

Hannah L. Klein, New York University, USA
Regulating Rad51 Recombinase through DNA Helicases and SWI2-like Proteins

Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
miR-24-Mediated Down-Regulation of H2AX Suppresses DNA Repair in Terminally Differentiated Cells

16:30—17:00
Coffee Available

Rio Grande C/D
17:00—19:15
Replication and Genomic Stability
Meeting has ended...abstracts no longer viewable online.

Bataan
* Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
Topological Transitions at Replicating Chromosomes

Kyungjae Myung, NHGRI, National Institutes of Health, USA
Short Talk: Human ELG1 Regulates the Level of Monoubiquitinated PCNA through Interactions with PCNA and USP1

Vincenzo Costanzo, , Italy
EMBO Young Investigator Lecture: Maintaining Genome Stability during DNA Replication in Vertebrate Organisms

Karlene A. Cimprich, Stanford University, USA
Mechanisms for Maintaining Genome Stability at the Replication Fork

Carol E. Bansbach, Vanderbilt University, USA
Short Talk: A Functional Genomic Screen Identifies a Novel Replication Stress Protein

19:15—20:15
Social Hour with Lite Bites

Rio Grande
19:30—22:00
Poster Session 2

Rio Grande

WEDNESDAY, MARCH 4

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
Genomic Instability and the Immune System
Meeting has ended...abstracts no longer viewable online.

Bataan
Michael R. Lieber, University of Southern California, USA
Mechanisms of DNA Breakage and NHEJ in Human Chromosomal Translocations

* Michael S. Neuberger, Medical Research Council, UK
DNA Deaminases in Immunity

Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Specific Recruitment of Protein Kinase A to the Immunoglobulin Locus Regulates Class Switch Recombination

Frederick W. Alt, Boston Children's Hospital, USA
DNA Double Strand Breaks, Translocations and Lymphoma

Davide F. Robbiani, Rockefeller University, USA
Short Talk: Activation Induced Cytidine Deaminase is Required for the Breaks in c-myc that Lead to c-myc/IgH Chromosome Translocations

Alberto Martin, University of Toronto, Canada
Short Talk: Msh2-Deficient Emu c-myc Mice Rapidly Succumb to Pro B Cell Lymphoma

09:20—09:40
Coffee Break

Rio Grande C/D
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Rio Grande
13:00—22:00
Poster Viewing

Rio Grande
14:30—16:30
Workshop 3: DNA Repair: Part 1 - Cancer, Part 2 - The Immune System

Bataan
* David O. Ferguson, University of Michigan Medical School, USA
Roles of the Mre11 Nuclease in DNA Repair and Lymphocyte Development

Kevin D. Mills, The Jackson Laboratory, USA
Replication, Recombination, and DNA Repair: The 3 R's are Required in Lymphocytes

JoAnn M. Sekiguchi, University of Michigan, USA
Dysfunctional Artemis Nuclease Activity Leads to Partial Immunodeficiency, Genome Instability and Tumorigenesis

Bernardo Reina-San-Martin, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France

Jean-Pierre de Villartay, INSERM U768, France
Reduced Immunoglobulin Class Switch Recombination in the Absence of Artemis

Kefei Yu, Michigan State University, USA
Class Switch Recombination in NHEJ-Deficient B Cells

16:30—17:00
Coffee Available

Rio Grande C/D
17:00—19:00
Cancer and DNA Repair Defects
Meeting has ended...abstracts no longer viewable online.

Bataan
* John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Chromosome Break Metabolism

Lee Zou, Harvard Medical School, USA
Short Talk: Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Jos Jonkers, Netherlands Cancer Institute, Netherlands
Targeting Double-Strand Break Repair Defects in Conditional Mouse Models of BRCA-Associated Breast Cancer

Thomas Ludwig, Columbia University, USA
Short Talk: The E3 Ligase Activity of BRCA1 is Not Essential for Mammalian Cell Viability or Homology-Directed Repair of Double-Strand DNA Breaks

Hai Jiang, Massachusetts Institute of Technology, USA
Short Talk: The ATM-Chk2 Signaling Network Controls Alternative Cell Fates after Chemotherapy, Based on a p53 Binary Switch

19:00—20:00
Social Hour with Lite Bites

Rio Grande
19:30—22:00
Poster Session 3

Rio Grande

THURSDAY, MARCH 5

07:00—08:00
Breakfast

Rio Grande A/B/C
08:00—11:15
Genetic Variation
Meeting has ended...abstracts no longer viewable online.

Bataan
* Neil Hunter, University of California, Davis, USA
Implementing a Crossover Outcome during Meiotic Recombination

Scott Keeney, HHMI/Memorial Sloan Kettering Cancer Center, USA
Molecular Cartography: Mapping the Landscape of Meiotic Double-Strand Break Distributions

Jennifer Fung, University of California, San Francisco, USA
Short Talk: Global Analysis of Meiotic Crossover Control

James R. Lupski, Baylor College of Medicine, USA
Two is Fine, Three is a Crowd, and One Often does not Satisfy - Getting the Gene Dosage Correct in the Nervous System

Matthew Hurles, Wellcome Trust Sanger Institute, UK
Germline Structural Variation: Maps, Mechanisms and Disease

Adam Shlien, Hospital for Sick Children, Canada
Short Talk: Contribution of Constitutional DNA Copy Number Variation to the Li-Fraumeni Cancer Predisposition Syndrome and it’s Associated Tumors

09:20—09:40
Coffee Break

Rio Grande C/D
11:15
On Own for Lunch

14:30—16:30
Workshop 4: Genetic Variation and Meiosis

Bataan
* Bernard de Massy, Institut de Génétique Humaine, France
Genome Wide Control of the Distribution of Meiotic Recombination in Mice

Philippe R. Bois, The Scripps Research Institute - Scripps Florida, USA
Regulation of Mouse Recombination Hotspots

Petko M. Petkov, The Jackson Laboratory, USA
Recombination Landscape, Genetic Background and Genes Regulating Hotspot Activity

Eugenio Mancera, European Molecular Biology Laboratories, Germany
High-Resolution Mapping of Crossovers and Noncrossovers in the Yeast Genome

Catherine H. Freudenreich, Tufts University, USA
Replication Fork Restart and Checkpoint Responses at Structure-Forming CAG/CTG Trinucleotide Repeats

Kirill S. Lobachev, Georgia Institute of Technology, USA
Role of Post-Replication Repair Pathway in Cruciform Resolution in Yeast

16:30—17:00
Coffee Available

Rio Grande C/D
17:00—19:15
Sequence Elements and Genomic Instability
Meeting has ended...abstracts no longer viewable online.

Bataan
* John V. Moran, University of Michigan Medical School, USA
Studies of a Human Transposable Element

Prescott L. Deininger, Tulane University, USA
Mobile Elements, Double-Strand DNA Breaks, and the Cellular Response

Beverly S. Emanuel, University of Pennsylvania, Children's Hospital of Philadelphia, USA
The Role of Palindromic Sequences in 22q11 Rearrangements

Susanna Maxwell Lewis, Harvard Medical School, USA
Three Mechanisms for Palindrome-Associated Breaks Acquired in vivo

19:15—20:15
Social Hour with Lite Bites

Rio Grande
20:15—23:00
Entertainment

Rio Grande

FRIDAY, MARCH 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Integrated DNA Technologies

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press Royal Society of Chemistry

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676