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This meeting took place in 2009



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Allergy and Asthma (J1)


Organizer(s) Catherine M. Hawrylowicz, Stephen J. Galli and Bart N. Lambrecht
January 20—25, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 22, 2008
Late Abstract Deadline: Oct 22, 2008
Scholarship Deadline: Sep 22, 2008
Early Registration Deadline: Nov 20, 2008

Supported by the Directors' Fund

Joint Meeting: Fibrosis (J2)

Summary of Meeting:
Allergic diseases, including asthma, affect up to one third of individuals in the developed world at some time in their lifetime, causing severe loss in the quality of life and a significant healthcare burden. Current treatments are predominantly palliative and there remains an unmet need for improved and novel treatments that provide long-term relief from disease symptoms. At this meeting, clinicians and scientists from both academic and pharmaceutical research environments will discuss: (1) risk factors for disease; (2) innate mechanisms and structural cells involved in the initiation, development and manifestations of disease; (3) effector and regulatory immune mechanisms involved in the allergic process; (4) the relationship between inflammation and structural remodeling in asthma; (5) the improvement of conventional treatments; and (6) novel emerging therapeutic strategies for the control of allergic and asthmatic disease. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Fibrosis”, which will share a session with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 20

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
Stephen T. Holgate, Southampton General Hospital, UK
Overview of Asthma and Identification of Unmet Clinical Needs


Following Session is for Fibrosis (J2)

19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
TGF-beta, Microfibrils and Connective Tissue Homeostasis


WEDNESDAY, JANUARY 21

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:15
Risk Factors, Early Life Events and Innate Mechanisms
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Catherine M. Hawrylowicz, King's College London, UK

Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Innate Immune Responses To Allergens

Patrick G. Holt, University of Western Australia, Australia
Early Life Events that Influence Allergic Status

René Teich, Philipps University of Marburg, Germany
Short Talk: Epigenetic Regulation of Asthma Protection Early in Life by the Non-Pathogenic Microbe Acinetobacter lwoffii F78

* Scott T. Weiss, Brigham and Women's Hospital, USA
Vitamin D and Allergy/Asthma Prevalence

David B. Lewis, Stanford University, USA
Influence of viral infections on the development of asthma: Insights from a murine model of influenza A viral-induced allergen sensitization for allergic pathogenesis and its prevention by vaccination for influenza

Matthew E. Poynter, University of Vermont, USA
Short Talk: Airway Epithelial Activation of NF-kappaB is Sufficient to Promote Allergic Sensitization to an Innocuous Inhaled Antigen


Following Session is for Fibrosis (J2)

08:00—11:15
Cellular Basis of Fibrosis: Focus on the Lung
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Moises Selman, Instituto Nacional de Enfermedades Respiratorias, Mexico

David A. Schwartz, University of Colorado Denver, USA
Common Variants of MUC5AC and Pulmonary Fibrosis

Richard P. Phipps, University of Rochester, USA
Fibroblast Heterogeneity –Impact of Fibroblast Diversity and Differentiation

Harold A. Chapman, University of California, San Francisco, USA
Regulation of EMT and Pulmonary Fibrosis by Epithelial Integrins

Manuela Funke, Massachusetts General Hospital, USA
Short Talk: Lysophosphatidic Acid Contributes to an Apoptosis Paradox in Lung Fibrosis

Boris Hinz, University of Toronto, Canada
Myofibroblasts and Mechanical Signal Transduction

Usamah S. Kayyali, Tufts Medical Center, USA
Short Talk: MK2 Signaling in Fibroblast Biology and Pulmonary Fibrosis

09:20—09:40
Coffee Break

Longs Paek Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
14:30—16:30
Workshop 1: Genes and Gene: Environment Interactions and Innate Immunity

Grays 1-3
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA

* Donata Vercelli, University of Arizona, USA
Epigenetic Signatures of Environmental Exposures

Ulus Atasoy, University of Missouri Health Care, USA
Coordinate Posttranscriptional Regulation of Asthma Genes by the RNA Binding Protein HuR

Annerose Berndt, The Jackson Laboratory, USA
Haplotype Association Mapping for Airway Hyper-responsiveness and a Systematic Gene-identification Approach Identifies SERPINB6b

Jennifer Kearley, MedImmune, USA
Chitinase-like Protein BRP-39 is a Critical Mediator of Allergic Sensitization

Benjamin D. Medoff, Massachusetts General Hospital, USA
Adiponectin-Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling

Lisa Cameron, University of Alberta, Canada
CRTh2+1431G>C is Associated with sIgE to Food Allergens and Allele-specific Transcription Factor Binding

Sean Saunders, Trinity Institute of Biomedical Sciences, Ireland
Talk Title to be Announced


Following Session is for Fibrosis (J2)

14:30—16:30
Workshop 1: EMT, Plasticity and the Origin of Fibroblasts

Longs Peak
* Richard H. Gomer, Texas A&M University, USA

* Robert Lafyatis, University of Pittsburgh Medical Center, USA

Brandi Nicole Baird, MD Anderson Cancer Center, Houston, TX, USA
Identification and Characterization of Prospectively Isolated Candidate Stem/Progenitor Cells in the Adult Mouse Lung

Marianne E. Fairclough, University of Birmingham, UK
Diversity within Monocyte Derived Stromal Cells

Darrell Pilling, Texas A&M University, USA
Th-1 Cytokines Inhibit, and Th-2 Cytokines Promote Fibrocyte Differentiation

Kirkwood A. Pritchard Jr., Medical College of Wisconsin, USA
The Role of Matrix and Mesenchymal Transition in Fibrosis in Tight Skin Mice

Peter H. S. Sporn, Northwestern University Feinberg School of Medicine, USA
Epithelial-Mesenchymal Transition in Normal Human Bronchial Epithelial Cells Triggered by TGF-beta1, Eosinophils and Cyclic Mechanical Strain

Shangxi Liu, University of Western Ontario, Canada
Loss of Beta 1 Integrin in Mouse Fibroblasts Results in Resistance to a bleo model of Skin Sclerodermav

Gregory deHart, FibroGen, Inc., USA
Regulation of Epithelial to Mesenchymal Transition by Connective Tissue Growth Factor

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Structural and Resident Cells of the Lung
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Stephen J. Galli, Stanford University, USA

* Michael J. Holtzman, Washington University in St. Louis, USA
New Immune Pathways for Allergy and Asthma

Hamida Hammad, Ghent University & VIB, Belgium
Short Talk: TLR4 Expression on Airway Stromal Cells is Crucial for Innate and Adaptive Immunity to House Dust Mite Allergen

Maria do Carmo Leite-de-Moraes, CNRS, University Paris 5, France
NKT Cells in the Lung

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
TSLP and Allergic Inflammation


Following Session is for Fibrosis (J2)

17:00—19:00
Liver Fibrosis
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Thomas A. Wynn, Pfizer, USA

Anna Mae Diehl, Duke University Medical Center, USA
The Cellular Biology and Clinical Spectrum of Liver Fibrosis

John P. Iredale, University of Bristol, UK
Liver Fibrosis: A Dynamic Model of Inflammation and Repair

Margaret M. Mentink-Kane, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
Short Talk: Accelerated Liver Fibrosis in the Combined Absence of Interleukin-13 Regulatory Molecules: IL-13 Receptor Alpha 2, IL-10 and IL-12

Scott L. Friedman, Icahn School of Medicine at Mount Sinai, USA
Genetic Determinants of Fibrosis Progression

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 1

Quandary 1-3

THURSDAY, JANUARY 22

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:15
Effector Mechanisms and Cells
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Bart N. Lambrecht, VIB, Ghent University, Belgium

Sally Wenzel-Morganroth, University of Pittsburgh, USA
Asthma Phenotypes: Are we Closing the Loop to Pathobiology?

Stephanie C. Eisenbarth, Yale University, USA
The Role of Inflammasomes in Vaccination and Allergic Disease

Hiroshi Watarai, Riken Research Center for Allergy and Immunology, Japan
Short Talk: A novel Subset of Mouse NKT Cells Bearing the IL-17 Receptor B Responds to IL-25 and Contributes to Airway Hyperreactivity

Frances E. Lund, University of Alabama at Birmingham, USA
CD38: Modulator of the NAD Metabolome and Regulator of Inflammation

Pierre Bruhns, Institut Pasteur, France
Short Talk: FcgammaRIV as a Murine Equivalent of FcepsilonRI Expressed by Macrophages from Human Atopics in IgE-Induced inflammation

* K. Frank Austen, Harvard Medical School, USA
Leukotrienes as Therapeutic Targets in Asthma


Following Session is for Fibrosis (J2)

08:00—11:15
The Immunology and Cell Biology of Fibrosis
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* John Varga, Feinberg School of Medicine, USA

Thomas A. Wynn, Pfizer, USA
Targets of IL-13 Signaling in Inflammation and Fibrosis

Erica Herzog, Yale University School of Medicine, USA
Short Talk: Profibrotic Monocyte Subsets in Pulmonary Fibrosis

Rebecca G. Wells, University of Pennsylvania, USA
Liver Fibrosis: The Intersection of Soluble and Mechanical Factors

Paul W. Noble, Cedars-Sinai Medical Center, USA
Regulation and Lung Injury and Repair: Toll Like Receptors and Innate Immunity

Anna P. Lam, Northwestern University, USA
Short Talk: Activated Canonical Wnt/beta-catenin Signaling Mediates Lung Fibroblast Migration and Proliferation

Victor J. Thannickal, University of Alabama, Birmingham, USA
Apoptosis and Fibroblast Survival in Fibrogenesis

09:20—09:40
Coffee Break

Longs Paek Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
14:30—16:30
Workshop 2: Intercellular and Intracellular Signaling Mechanisms

Grays 1-3
* Paul B. Rothman, University of Iowa, USA

* Bart N. Lambrecht, VIB, Ghent University, Belgium

Charlotte Andreasen, Yale University, USA
TGF-beta1 Production by Alveolar Macrophages is Crucial for Controlling Inflammation in the Lung

Alison L. Budelsky, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Investigation of the Functional Roles for IL-17A, IL-25, IL-17RA, and IL-17RB in a Mouse Asthma Model

Jennifer Louten, Schering-Plough Biopharma, USA
IL-23 Signaling Negatively Regulates Th2 Responses in Asthma

Martijn C. Nawijn, University Medical Center Groningen, Netherlands
PAR2 Activation Induces Airways Hyperresponsiveness without Loss of Inhalation Tolerance

Mindy Tsai, Stanford University, USA
Thymic Stromal Lymphopoietin (TSLP) Promotes Myeloid Hyperplasia and Overproduction of Immunoglobulins, but not Skin Inflammation, in RabGEF1-deficient Mice

Nicolas Charles, INSERM U699, France
Homeostatic Control of Basophil GATA-3 Expression and TH2 Differentiation by Lyn Kinase

Wanjun Chen, NIDCR, National Institutes of Health, USA
TGF-beta in the Development of CD4+ Foxp3+ Regulatory T Cells and the Regulation of House Dust Mite Induced Asthma

Nandini Krishnamoorthy, Brigham and Women's Hospital, Harvard Medical School, USA
A Critical Role for c-kit on Dendritic Cells in Regulating in T Helper Cell Differentiation and Allergic Asthma


Following Session is for Fibrosis (J2)

14:30—16:30
Workshop 2: Model Systems for Studying Fibrosis

Longs Peak
* Andrew M. Tager, Massachusetts General Hospital, USA

* John Westwick†, Novartis Institutes for Biomedical Research, UK

Shizhong Bu, Medical University of South Carolina, USA
DhS1P has a Potent Anti-Fibrotic Effect in Scleroderma Fibroblasts via Modulation of PTEN Levels

Enrique Brandan, P. Universidad Católica de Chile, Chile
Induction of Fibrosis by Exercise on Dystrophic Muscles: Role of CTGF

Tomoko Hayashida, Northwestern University, USA
Lack of beta1 Integrin Enhances TGF-beta Stimulated Type I Collagen Synthesis via Rac1 Mediated ERK Activity that Phosphorylates Smad Linker Region

Andreas Günther, University Hospital Giessen, Germany
Role of Defective Surfactant Processing and Transport in Hermansky-Pudlak-Syndrome Associated Interstitial Pneumonia (HPSIP) and Idiopathic Pulmonary Fibrosis (IPF)

Pura Muñoz Cánoves, Center for Genomic Regulation, Spain
Fibrin-Induced Inflammation Promotes Fibrosis in Muscular Dystrophy

Joe (Jia-hui) Wang, King's College London, UK
Antisense Inhibition of Kirsten-Ras Expression Reduces Fibrosis in a Rat Model of Unilateral Ureteric Obstruction

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA

Valerie Julia, INSERM, France
Breast Milk-Mediated Transfer of an Antigen Induces Tolerance and Protection from Allergic Asthma

* Catherine M. Hawrylowicz, King's College London, UK
Regulatory T Cells in Allergy and Asthma: The Role of the Vitamin D Pathway

Yong-Jun Liu, Sanofi, USA
Cross Talk between Epithelial Cells and Dendritic Cells through TSLP/TSLPR in Allergic Inflamation

Hiromasa Inoue, Kagoshima University, Japan
Short Talk: Pulmonary SOCS1 as a Central Endogenous Inhibitor of Allergic Asthma


Following Session is for Fibrosis (J2)

17:00—19:15
Renal Fibrosis
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Michael Zeisberg, Beth Israel Deaconess Medical Center and Harvard Medical School, USA

Jeffrey B. Kopp, National Institutes of Health, USA
Overview of Renal Fibrosis

Agnes Fogo, Vanderbilt University Medical Center, USA
Animal Models and the Reversibility of Fibrosis

Jeremy S. Duffield, Vertex Pharmaceuticals, USA
Short Talk: Serum Amyloid P inhibits Renal Fibrosis through an Fc-gamma receptor dependent mechanism.

H. William Schnaper, Northwestern University, USA
TGF-beta Signaling in Renal Fibrogenesis

Jeremy S. Duffield, Vertex Pharmaceuticals, USA
Short Talk: Genetic Fate tracing reveal the stromal pericyte not EMT Generates Myofibroblasts in the Obstructive Model of Kidney Fibrosis

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 2

Quandary 1-3

FRIDAY, JANUARY 23

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
Asthma, Allergy and Tissue Remodeling (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs Peak / Grays Peak
* Cory M. Hogaboam, Cedars-Sinai Medical Center, USA

Jack A. Elias, Yale School of Medicine, USA
Insights from Transgenic Models of Lung Fibrosis

James J. Lee, Mayo Clinic Scottsdale, USA
Eosinophils Orchestrate Allergic Pulmonary Responses: Who’s your Daddy Now T Cells!

John V. Fahy, University of California, San Francisco, USA
Short Talk: Plasma Proteins Inhibit Protease-Dependent Degradation of Airway Mucus Plugs in Acute Asthma

Lauren E. Cohn, Yale University, USA
Short Talk: IFN-gamma Modulates Allergic Airway Disease through Effects on the Airway Epithelium

Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Short Talk: Basophils Resolve Inflammation through Alternate Activation of Macrophages

Jean Kim, Johns Hopkins University School of Medicine, USA
Short Talk: Involvement of VEGF in Upper Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyposis Subjects

Stephen J. Galli, Stanford University, USA
Mast Cells and Tissue Remodeling

09:20—09:40
Coffee Break

Longs Paek Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Lipid Mediators, Proteases and Cytokines in Tissue Remodeling
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA

Clare M. Lloyd, Imperial College London, UK
Cytokine Regulation of Allergic Airway Inflammation and Remodeling

* Juan Rivera, , USA
Sphingosine-1-Phosphate in Allergy and Asthma

Gunnar Pejler, Swedish University of Agricultural Sciences, Sweden
Mast Cell Chymase - A Friend or Foe?

Cara MM Williams, Wyeth Pharmaceuticals, USA
Short Talk: Cytosolic Phospholipase A2alpha Orchestrates Allergic Disease


Following Session is for Fibrosis (J2)

17:00—19:15
Environmental Cues and Cellular Responses
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Rik Derynck, University of California, San Francisco, USA
TGF-beta Signaling and Epithelial to Mesenchymal Transition

Florian Rieder, Lerner Research Institute, USA
Short Talk: Endothelial-to-Mesenchymal Transition of Intestinal Mucosal Microvascular Cells: A Novel Mechanism of Intestinal Fibrosis

Andrew D. Luster, Massachusetts General Hospital, USA
Inflammation and Fibrosis - Chemokines, LPA

Andrew M. Tager, Massachusetts General Hospital, USA
Grease on the Fire: Chemokine- Lipid cooperation in Fibrosis

* Luisa A. DiPietro, University of Illinois at Chicago, USA
Scar Formation in the Healing Wound

Keith C. Olsen, University of Rochester, USA
Short Talk: Tissue Transglutaminase as a Novel Modulator of and Potential Therapeutic Target in Pulmonary Fibrosis

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 3

Quandary 1-3

SATURDAY, JANUARY 24

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
Conventional and Novel Targets for Intervention
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Edith M. Hessel, Dynavax Technologies, USA

John A. Cidlowski, NIEHS, National Institutes of Health, USA
The Glucocorticoid Receptor: One Gene, Many Proteins – New Mechanisms for Tissue Specific Anti-Inflammatory Actions of Glucocorticoids in Health and Disease.

Marco Conti, University of California, San Francisco, USA
Cyclic AMP-Specific Phosphodiesterase Regulation as a Critical Component of the Airway Inflammatory Responses

Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Leukotriene E4-Induced Pulmonary Inflammation is Mediated by the P2Y12 Receptor

Heidi Campos Schilter, Pharmaxis, Australia
Short Talk: A Role for Fatty Acid Binding Proteins in Airway Immune Responses

Prescott G. Woodruff, University of California, San Francisco, USA
Short Talk: Presence or Absence of IL-13-Driven Inflammation Defines Major Sub-Phenotypes of Asthma

Monika Vig, Washington University School of Medicine, USA
CRACM1, a Potential Target for Inhibition of Allergic and Inflammatory Disorders


Following Session is for Fibrosis (J2)

08:00—11:15
Novel Therapeutic Targets and Biomarkers
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Michael Gilman, Padlock Therapeutics, USA

* Michael Gilman, Padlock Therapeutics, USA

Howard Y. Chang, Stanford University, USA
Genomic Encoding of Fibroblast Positional Identities: Implications for Fibrosis

Roland M. duBois, National Jewish Health, USA
Genetics of Diffuse Lung Fibrosis: Lessons Learned

Shelia M. Violette, Admirx Inc., USA
Therapeutic Potential of a Function Blocking alphavbeta6 Antibody in Fibrosis and Oncology: Transition from Research to Clinic Development

Scott M. Lonning, Cell Signaling Technology, USA
Prospects and Challenges of TGFbeta Neutralization for the Treatment of Pathologic Fibrosis

Francesco Del Galdo, Thomas Jefferson University, USA
Short Talk: Quantitative Assessment of Tissue Fibrosis in Skin Biopsies from Patients with Systemic Sclerosis Employing Confocal Laser Scanning Microscopy (CLSM). An Objective Outcome Measure for Clinical Trials

Kusum V. Pandit, University of Pittsburgh, USA
Short Talk: MicroRNAs in Lung Fibrosis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

14:30—16:30
Workshop 3: Effector Cells and Mechanisms in Asthma

Grays 1-3
* Stephen J. Galli, Stanford University, USA

Helen E. Harries, , UK
Local Clonal Expansion of IgE Producing B Cells

Yuzaburo Inoue, Graduate School of Medicine, Chiba University, Japan
Chitinase Family Members Inhibit House Dust Mite-Induced AHR Independently of Enzymatic Activity

Irene H. Heijink, University Medical Center Groningen, Netherlands
House Dust Mite-Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium

Sara Wernersson, Swedish University of Agricultural Sciences, Sweden
Protective Role of mMCP-4 in Allergic Inflammation

Mayumi Ueta, Kyoto Prefectural University of Medicine, Japan
PGE Receptor Subtype EP3 Regulates LPR of Allergic Conjunctivitis

Karin Stebbins, Amira Pharmaceuticals, USA
Novel DP2 Receptor Antagonist Decreases Allergic Inflammation

Antoon J.M. van Oosterhout, University Medical Center Groningen, Netherlands
IL-10 Producing CD11c+ Cells in SIT in Mouse Model of Asthma

Joan M. Cook-Mills, Northwestern University Feinberg School of Medicine, USA
Isoforms of Vitamin E have Opposing Immunoregulatory Function in Allergic Inflammation


Following Session is for Fibrosis (J2)

14:30—16:30
Workshop 3: Therapeutic Targets and Biomarkers

Longs Peak
* Shelia M. Violette, Admirx Inc., USA

April A. Cox, Array Biopharma, USA
Preclinical Efficacy of a PDGFR inhibitor, ARRY-768, in a Rat Model of Gadolinium-Induced Fibrosis

Francesco Del Galdo, Thomas Jefferson University, USA
A Pattern of Shared Alterations in the Secretome of Dermal Fibroblasts from Systemic Sclerosis and Nephrogenic Systemic Fibrosis: A Biomarker Signature for Fibrotic Diseases

Qihe Xu, King's College London School of Medicine, UK
Discovery of Herbal Compounds with in vitro Anti-Fibrotic Activities

Jadranka Milosevic, Simmons Center for Interstitial Lung Disease, USA
The Role of miR-154 microRNA Family in IPF

Jennifer L. Sargent, Dartmouth Medical School, USA
Overlapping and Distinct Gene Targets of TGFbeta, IL13 and IL4 in Dermal Fibroblasts are Expressed in Distinct Molecular Subsets of Systemic Sclerosis

Timothy W. Schacker, University of Minnesota, USA
Lymph Node Fibrosis Is A Significant Factor In HIV Pathogenesis And Limits Immune Reconstitution Despite Antiretroviral Therapy Suppression of Viral Replication

Oscar O. Braun, University of California San Diego, USA
Cyclic AMP can Both Block and Reverse the Fibrotic Phenotype of Cardiac Fibroblasts

Guofei Zhou, Northwestern University, USA
Elevated von Hippel-Lindau Protein Expression in Fibrotic Lungs and Its Role in Fibrogenesis

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Immune Intervention
Meeting has ended...abstracts no longer viewable online.

Grays 1-3
* Yong-Jun Liu, Sanofi, USA

Edith M. Hessel, Dynavax Technologies, USA
Effects of TLR-9 Agonists in Asthma: Moving Towards Long-Lasting Disease Modification

Lawren C. Wu, Amgen Inc., USA
Short Talk: Reduction of Serum IgE by Depletion of the IgE B Cell Lineage – a Novel Approach for the Treatment of Allergic Diseases

Bart N. Lambrecht, VIB, Ghent University, Belgium
Targeting Dendritic Cells

* Anthony J. Coyle, Pfizer, USA
Cytokine Antagonists


Following Session is for Fibrosis (J2)

17:00—19:00
Novel Therapies
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Scott M. Lonning, Cell Signaling Technology, USA

Bruce Cronstein, New York University, Langone Medical Center, USA
Venegeance is Mine. Adenosine, a Retaliatory Metabolite

Mark L. Lupher, Jr., Muregen, LLC, USA
Regulating Fibrosis with the Natural Innate Response Modifier, SAP

Claire Emson, Genentech, Inc., USA
Measurement of Collagen Synthesis by Heavy Water Labeling and its Application for Indentifying Anti-Fibrotic Therapies

Ruchi Bansal, University of Twente, Netherlands
Short Talk: A Mimetic Peptide of Interferon gamma (IFNgamma) as a Novel Anti-Fibrotic Agent

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
20:00—23:00
Entertainment

Quandary 1-3

SUNDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI081327-01




We gratefully acknowledge additional support for this conference from:

Roche Pharmaceuticals

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